Clinical trials: Low Ejection Fraction
Dietary Exposure
Feasibility of Low Energy Diet in HFpEF and Type 2 Diabetes
Open, Single arm intervention, feasibility study
- Trial name
- ALLEVIATE (NCT04173117)
- Testing
- Low energy meal replacement plan (12 weeks)
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- University of Leicester
Acute Heart Failure
Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure
Single center, prospective, randomized, non-blinded research study comparing intravenous vasodilator infusion vs. inotropic infusion in patients admitted to the hospital or in the emergency room at Montefiore Medical Center…
- Trial name
- PRIORITY-ADHF (NCT02767024)
- Testing
- Sodium nitroprusside, Dobutamine, Furosemide
- Where
- United States
- Sponsor
- Montefiore Medical Center
Cardiac Disease
A Multi-Center Study of Detection of Low Ventricular Ejection Fraction
This is a multi-site, retrospective study to evaluate the performance of a locked AI-based algorithm for detection of left ventricular systolic dysfunction.
- Trial name
- NCT04963218
- Testing
- AI Algorithm to detect LVEF in ECG
- Where
- 4 sites in United States
- Volunteers
- 16,000 people
- Sponsor
- Mayo Clinic
Aortic Stenosis
Speckle Tracking Imaging in Patients With Low Ejection Fraction Aortic Stenosis (SPArKLE-AS)
In patients with aortic stenosis and low ejection fraction, how can we predict who will recover their ejection fraction after aortic valve replacement? We plan to observe 50 patients with Low EF aortic stenosis and perform serial…
- Trial name
- SPArKLE-AS (NCT00535899)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Asymptomatic Left Ventricular Systolic Dysfunction (Disorder), Heart Failure
ECG AI-Guided Screening for Low Ejection Fraction
This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of left ventricular systolic dysfunction.
- Trial name
- EAGLE (NCT04000087)
- Testing
- AI-enabled ECG-based Screening Tool
- Where
- United States
- Volunteers
- 358 people
- Sponsor
- Mayo Clinic
Heart Failure
Biomarkers and Therapeutic Modelisation in Heart Failure
The telemonitoring systems for congestive HF did not yet prove their efficacy despite initial encouraging results. Decongestion is one of the main objectives in Congestive HF, but an appropriate titration of diuretics is…
- Trial name
- BIOMIC (NCT01655134)
- Testing
- Blood simples, Capillary punction, Urine simples
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure With Reduced Ejection Fraction (HFrEF), Low T3 Syndrome
Developing Oral LT3 Therapy for Heart Failure - HFrEF
Investigation of the safety, feasibility, and preliminary efficacy of thyroid hormone therapy with Liothyronine (LT3) in individuals with heart failure with reduced ejection fraction (HFrEF) and low triiodothyronine (T3) syndrome…
- Trial name
- DOT3HF-HFrEF (NCT04112316)
- Testing
- Liothyronine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Pennsylvania
Heart; Functional Disturbance
Hand Injected Ventriculography vs. Power Injected Left Ventriculography
The purpose of the study is to directly compare two methods of evaluating heart function at the time of your angiogram. In both methods contrast dye is injected into the main heart chamber during the angiogram while x-ray images…
- Trial name
- NCT01310517
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Loma Linda University
Heart Failure With Reduced Ejection Fraction
Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy
The investigators aim to compare the risk of mortality of Non-implantable carioverter defibrillator (ICD) vs. ICD management in patients with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- CONTEMP-ICD (NCT06543446)
- Testing
- ICD implantation
- Where
- 15 sites in United States, Canada
- Volunteers
- 3,290 people
- Sponsor
- University of Rochester
Congestive Heart Failure, Renal Dysfunction
Study of Low Dose Nesiritide With or Without Sildenafil in Congestive Heart Failure Patients With Renal Dysfunction
The purpose of the study is to show that low dose recombinant BNP coupled with phosphodiesterase V inhibition will improve renal dysfunction and promote relief of volume overload in patinets with acute decompensated heart failure…
- Trial name
- BNP+PDEVI (NCT00818701)
- Testing
- low dose Nesiritide, nesiritide, Sildenafil
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Heart Failure, Systolic, Robotic Surgery
Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery.
The field of robotic-assisted laparoscopic surgery increases all the time. Older and more fragile patients which are not suitable for major open surgery could be scheduled for robotic- assisted surgery.
- Trial name
- NCT06336746
- Testing
- Esophageal Doppler
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karlstad Central Hospital
Left Ventricular Dysfunction
IMpella-Protected cArdiaC Surgery Trial (IMPACT)
The purpose of this Trial is to demonstrate the safety and effectiveness of the use of Impella 5.5 in high-risk cardiac surgery patients, with the overall aim to evaluate if using Impella 5.5 with SmartAssist (Impella 5.5)…
- Trial name
- IMPACT (NCT05529654)
- Testing
- Impella 5.5 with SmartAssist
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Abiomed Inc.
Cardiac Disease, Cardiac Failure
Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery
The aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery
- Conditions
- Cardiac Disease, Cardiac Failure, Cardiac Surgery, Inotropes
- Trial name
- NCT04635293
- Testing
- preoperative infusion of levosimendan, no preoperative infusion of levosimendan
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aretaieion University Hospital
Moderate Aortic Stenosis
Comparison of Myval THV Series With Guideline-Directed Medical Therapy in Participants With Moderate Aortic Stenosis
The primary objective of this trial is to evaluate the safety and effectiveness of Meril's Myval THV series in comparison to Guideline-Directed Medical Therapy in participants with moderate aortic stenosis.
- Trial name
- NCT07532317
- Testing
- Transcatheter aortic valve Implantation
- Volunteers
- 778 people
- Sponsor
- Meril Life Sciences Pvt. Ltd.
Sudden Cardiac Death, Sudden Cardiac Arrest
Heart Failure Optimization Study
This study is designed as a multi-center prospective observational study of newly diagnosed Heart Failure (HF) patients to test the hypothesis that additional Ejection Fraction (EF) recovery occurs between 90 and 180 days as…
- Conditions
- Sudden Cardiac Death, Sudden Cardiac Arrest, Heart Failure, Heart Failure Low Output
- Trial name
- HF-Opt (NCT03016754)
- Testing
- Wearable Cardioverter Defibrillator
- Where
- 67 sites in United States, Austria and 2 more
- Volunteers
- 602 people
- Sponsor
- Zoll Medical Corporation
HFrEF - Heart Failure With Reduced Ejection Fraction
Electronic Medical Record Alerts to Optimize Medical Therapy in Heart Failure and Reduced Ejection Fraction
OPTIMAL-HF is a pragmatic, cluster randomized, single-blind intervention trial that will be conducted at an outpatient clinic in Argentina.
- Trial name
- OPTIMAL-HF (NCT06166823)
- Testing
- EMR alert
- Volunteers
- 240 people
- Sponsor
- Instituto Cardiovascular de Buenos Aires
Heart Failure Low Output
LBBP + CSP Versus LBBP Alone for Cardiac Resynchronization Therapy
The purpose of this pilot clinical trial is to evaluate whether a novel cardiac resynchronization strategy, called LOT-CRT, is more effective than standard physiological pacing alone (LBBAP) in patients with heart failure.
- Trial name
- LOTTO-CRT (NCT07664189)
- Testing
- Left Bundle Branch Optimized CRT, Stimulation of the left bundle branch area (LBBAP)
- Where
- Colombia
- Volunteers
- 10 people
- Sponsor
- Clinica Cardio VID
Transfusional Iron Overload, Transfusional Hemosiderosis
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload
This is a clinical research study in patients who have iron overload in the heart due to chronic blood transfusions. The study will have 2 treatment groups and will compare the safety and efficacy of chelation therapy with a…
- Trial name
- CORDELIA (NCT00600938)
- Testing
- Core Study: Deferasirox, Core Study: Deferoxamine, Extension: deferoxamine to deferasirox
- Where
- 21 sites in Canada, China and 9 more
- Volunteers
- 197 people
- Sponsor
- Novartis Pharmaceuticals
Ventricular Ejection Fraction
A Multicenter Pragmatic Implementation Study of ECG-AI-Based Clinical Decision Support Software to Identify Low LVEF
A prospective, cluster-randomized, care-as-usual controlled trial to evaluate the impact of an ECG-based artificial intelligence (ECG-AI) algorithm to detect low left ventricular ejection fraction (LVEF) on diagnosis rates of…
- Trial name
- AIM ECG-AI (NCT05867407)
- Testing
- Anumana Low EF AI-ECG Algorithm, Care-as-Usual
- Where
- 5 sites in United States
- Volunteers
- 11,610 people
- Sponsor
- Anumana, Inc.
Ventricular Fibrillation, Ventricular Tachycardia
Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction
This study assesses the 18-month incidence of inappropriate shocks in subjects implanted with the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD) for primary prevention of sudden cardiac death.
- Conditions
- Ventricular Fibrillation, Ventricular Tachycardia, Low Cardiac Output
- Trial name
- UNTOUCHED (NCT02433379)
- Testing
- EMBLEM S-ICD System
- Where
- 110 sites in United States, Belgium and 11 more
- Volunteers
- 1,173 people
- Sponsor
- Boston Scientific Corporation