Clinical trials: Low Risk Acute Coronary Syndrome
Acute Coronary Syndrome, Carotid Atherosclerotic Plaque With Inflammation
Comparison of High-dose Rosuvastatin Versus Low-dose Rosuvastatin Plus Ezetimibe on Carotid Plaque Inflammation in Patients With Acute Coronary Syndrome
Combination therapy of ezetimibe with a low-dose statin is occasionally used to avoid statin-related side effects in clinical practice among patients with atherosclerotic cardiovascular disease.
- Trial name
- NCT04056169
- Testing
- high-dose rosuvastatin, low-dose rosuvastatin plus ezetimibe
- Where
- 2 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Yuhan Corporation
Dyslipidemia, Atherosclerosis
Safety, Pharmacokinetic Study of RVX000222 in Healthy Subjects and Subjects With Low HDL Cholesterol
The purpose of this study is to investigate an oral formulation of RVX000222 for safety, pharmacokinetic and efficacy in healthy subjects.
- Conditions
- Dyslipidemia, Atherosclerosis, Acute Coronary Syndrome, Cardiovascular Disease
- Trial name
- NCT00768274
- Testing
- RVX000222
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Resverlogix Corp
Acute Coronary Syndromes, Acute Myocardial Infarction
Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide limitation infarct size and improvement in…
- Conditions
- Acute Coronary Syndromes, Acute Myocardial Infarction, Reperfusion Injury
- Trial name
- NCT00627809
- Testing
- Streptokinase, primary percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Acute Coronary Syndrome
Trial for the Use of Pretest Probability to Reduce Unnecessary Testing for Low-Risk Patients With Chest Pain
The purpose of this study is to evaluate if the implementation of quantitative pretest probability assessment will significantly reduce the unnecessary use of the intra-emergency department chest pain center.
- Trial name
- NCT00243516
- Testing
- PREtest Consult
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- PREtest Consult
Chest Pain, Telemetry
Telemetry for Chest Pain of Low Risk for Acute Coronary Syndrome Pts
This is a randomized controlled, multi-center, non-blinded non-inferiority study examining the utility of telemetry monitoring in patients admitted who are low risk for acute coronary syndrome.
- Conditions
- Chest Pain, Telemetry, Acute Coronary Syndrome, Health Care Resource Utilization
- Trial name
- NCT02330328
- Testing
- No Telemetry Monitoring, Telemetry Monitoring
- Sponsor
- Carilion Clinic
Stable Angina (SA), Unstable Angina (UA)
Breaking Fasts Ahead of Cardiac Caths
The goal of this clinical trial is to find out whether fasting is necessary before urgent inpatient cardiac catheterizations. For patients presenting with urgent heart-related pain or even mild heart attacks, researchers want to…
- Conditions
- Stable Angina (SA), Unstable Angina (UA), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- BACON-RCT (NCT06996639)
- Testing
- Non-Fasting, Fasting
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of South Florida
Non ST Segment Elevation Acute Coronary Syndrome
COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)
Since colchicine is known to have anti-inflammatory effects and inflammation is an early component of acute coronary syndrome (ACS), this study aims to evaluate the acute effects of low-dose colchicine, in addition to…
- Trial name
- COLOR-ACS (NCT05250596)
- Testing
- Colchicine, Atorvastatin
- Where
- 3 sites in Italy
- Volunteers
- 182 people
- Sponsor
- Azienda USL Toscana Centro
Chest Pain, Acute Coronary Syndrome
HEART Pathway Implementation
The purpose of this study is to determine the effectiveness of the HEART Pathway, a clinical decision aid for the care of patients with chest pain, in a "real-world" clinical setting.
- Conditions
- Chest Pain, Acute Coronary Syndrome, Chest Pain Atypical Syndrome, Chest Pain Rule Out Myocardial Infarction
- Trial name
- NCT02056964
- Where
- United States
- Volunteers
- 14,717 people
- Sponsor
- Wake Forest University Health Sciences
Acute Coronary Syndrome
PCSK9 Inhibitor on ACS Patients With Multivessel Disease and Relatively Low LDL-C Level in Chinese Population
The study is an open-label, multicenter, and randomized study. The objective of this study is to demonstrate the effect of PCSK9 inhibitor on ACS patients with multivessel disease and relatively low LDL-C levels or LDL-C levels…
- Trial name
- NCT05043740
- Testing
- Repatha or Praluent
- Volunteers
- 1,360 people
- Sponsor
- Second Xiangya Hospital of Central South University
Stable Angina, Unstable Angina
Impact of Low Frame Rate Fluoroscopy and Cine-angiography on Reducing Operator and Patient Dose
The investigators sought to investigate the efficacy of low frame rate (fluoroscopy at 7.5 frames per second (FPS) and Cine at 10 pulse per second (PPS) vs.
- Conditions
- Stable Angina, Unstable Angina, Acute Coronary Syndrome
- Trial name
- NCT02574949
- Testing
- Radiation: 15 FPS Cine 15 PPS, Radiation: 7.5 low Frame rate, Low Cine
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University Health Network, Toronto
Acute Coronary Syndrome, Myocardial Infarction
Tailoring Post Discharge (The TPD Study)
This randomized control trial seeks to better understand the educational needs of Acute Coronary Symptom (ACS) patients including the optimal timing and method of delivery as well as linkages with appropriate community resources…
- Trial name
- NCT05692921
- Testing
- Remote Home Monitoring (RHM), Rapid Response Nursing
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- St. Boniface Hospital
Acute Coronary Syndrome, Heart Failure
Pharmacist Intervention to Decrease Medication Errors in Heart Disease Patients (The PILL-CVD Study)
Many people who have recently left the hospital have difficulties managing their medications, and medication errors are common. Patients with low health literacy levels may have a particularly difficult time understanding…
- Trial name
- PILL-CVD (NCT00632021)
- Testing
- Pharmacist Intervention for Low-Literacy in Cardiovascular Disease
- Where
- 2 sites in United States
- Volunteers
- 862 people
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation, Acute Coronary Syndrome
Triple vs. Dual Therapy
Background: The acute coronary syndrome (ACS) is a complication of coronary artery disease (CAD) and associated with increased mortality.
- Trial name
- NCT02080858
- Testing
- Ticagrelor + Apixaban + ASA, Ticagrelor + Apixaban
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Ischemic Heart Disease
Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes
The mainstay for treatment for acute coronary syndrome (ACS) focusses on re-establishing and maintaining the patency of vessels following coronary plaque disruption, through the use of anti-platelets and anticoagulants.
- Trial name
- LILACS (NCT03113773)
- Testing
- Proleukin
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Effects of Acute, Rapid Lowering of LDL Cholesterol With Alirocumab in Patients With STEMI Undergoing Primary PCI
A randomized, double-blind, placebo controlled parallel group clinical trial evaluating the effects of acute treatment with a PCSK9 inhibitor (alirocumab) versus placebo on low-density lipoprotein (LDL) in 100 high-risk patients…
- Conditions
- ST Elevation Myocardial Infarction, Acute Coronary Syndrome, Hypercholesterolemia, Hyperlipidemias
- Trial name
- EPIC STEMI (NCT03718286)
- Testing
- Alirocumab
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Acute Myocardial Infarction, Euthyroid Sick Syndrome
Effects of N-acetylcysteine on Low T3 Syndrome
The propose of this study is to determine whether N-acetylcysteine is effective in reversing the changes in thyroid hormones seen in critical illness, known as the low T3 syndrome.
- Conditions
- Acute Myocardial Infarction, Euthyroid Sick Syndrome, Ischemic Heart Disease
- Trial name
- NCT01501110
- Testing
- N-acetylcysteine
- Where
- 2 sites in Brazil
- Volunteers
- 83 people
- Sponsor
- Federal University of Rio Grande do Sul
Acute Coronary Syndrome
LDL-C Lowering Efficacy and Safety of Rosuvastatin 20 mg/Day to10 mg/Day in Chinese ACS(Acute Coronary Syndrome) Patients
This is a 12-week, randomized, open-label,,multicenter, Phase IV study exploring LDL-C lowering efficacy of Rosuvastatin 20 mg/d compared to 10 mg/day Chinese ACS patients.The Randomized Treatment Period is preceded by a 24hours…
- Trial name
- NCT02077257
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 1,060 people
- Sponsor
- Committee of Cardio-Cerebral-Vascular Diseases of GSC