Clinical trials: Low-grade Inflammation
Periodontal Diseases, Periodontal Attachment Loss
Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment
The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Periodontal Disease, AVDC Stage 3, Periodontal Inflammation
- Trial name
- NCT05233501
- Testing
- low level laser therapy, non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Type 2 Diabetes Mellitus, Inflammation, Chronic Low-Grade
Lifestyle Intervention and Its Effects on Inflammatory Cytokines and Oxidative Stress Markers in Diabetic Chronic Kidney Disease Patients: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of a 12-week structured lifestyle intervention-including supervised aerobic exercise and a calorie-restricted diet-on inflammatory cytokines and oxidative stress…
- Conditions
- Type 2 Diabetes Mellitus, Inflammation, Chronic Low-Grade, Chronic Kidney Disease, Stage 3 Chronic Kidney Disease
- Trial name
- Lifestyle Inte (NCT07119892)
- Testing
- Lifestyle Modification (Exercise + Diet)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sinai University
Type 2 Diabetes Mellitus
Metformin and Pioglitazone Effects on YKL-40 Concentrations in Type 2 Diabetes Patients
Patients with type 2 diabetes are at an increased risk for developing atherosclerosis, largely due to the underlying insulin resistance and chronic low grade inflammation.
- Trial name
- NCT01963663
- Testing
- Metformin, Pioglitazone
- Where
- Iran
- Volunteers
- 84 people
- Sponsor
- Tehran University of Medical Sciences
Type 2 Diabetes Mellitus
The HOME Trial: Hyperinsulinaemia: the Outcome of Its Metabolic Effects, a Randomized Controlled Trial
The HOME-trial is a prospective, randomized controlled trial. The purpose of this study is to investigate the effects of metformin HCL in patients with type 2 diabetes mellitus intensively treated with insulin on the quality of…
- Trial name
- NCT00375388
- Testing
- Metformin on top of intensive insulin therapy
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Bethesda General Hospital, Hoogeveen
Diabetic Retinopathy, Inflammation
Study Investigating the Levels and Effects of Low-grade Inflammation in Diabetic Retinopathy of Type 1 Diabetes
There is much evidence that localized low grade inflammatory processes may contribute to the microvascular complications of type 1 and type 2 diabetes mellitus including sight-threatening diabetic retinopathy.
- Trial name
- NCT00880139
- Testing
- Blood sampling, Noninvasive measurement of systemic hemodynamics, Visual acuity assessment
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Medical University of Vienna
Cerebral Infarction
Physical Activity After Stroke: How Does it Effect Chronical Inflammation and Insulin Sensitivity
Decreased insulin sensitivity is and independent risk factor for stroke despite glycemic control. It is known that physical exercise increases insulin sensitivity in healthy subjects.
- Trial name
- NCT00376207
- Testing
- Physical exercise
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Bispebjerg Hospital
Inflammatory Disease, Aging Problems
Umbilical Cord Mesenchymal Stem Cell for Aging-related Low-grade Inflammation
The goal of this single-group, open-label, phase I/II clinical trial is to evaluate the safety and efficacy of the transplantation of umbilical cord mesenchymal stem cells in aging-related low-grade inflammation patients'…
- Conditions
- Inflammatory Disease, Aging Problems, Obese, Lipid Metabolism Disorders
- Trial name
- NCT06448052
- Testing
- umbilical cord mesenchymal stem cell
- Where
- Vietnam
- Volunteers
- 72 people
- Sponsor
- Nguyen Ton Ngoc Huynh
Biomarker
Exploring the Potential of Finger Prick Blood for Assessment of BIOmarkers for LOw Grade Inflammation and CVD Risk
There are currently no minimally invasive techniques for the measurement of lipopolysaccharide (LPS) and Apo-B48 that can be used in samples collected in field settings.
- Trial name
- BIOLOGIC (NCT04996589)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Wageningen University and Research
Irritable Bowel Syndrome
Effects of Activia in IBS
The purpose of this study is to investigate the association between gut microbiota, immunology and typical pathophysiological factors in patients with IBS (all subtypes) AND to assess the effect of Activia consumption on GI…
- Trial name
- MOSAIC (NCT01252550)
- Testing
- Activia® (125g/pot), Acidified non-fermented dairy product
- Where
- 3 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma
NexCAR19 (Talikabtagene Autoleucel) in Relapsed/Refractory B-Cell Malignancies (NexCAR19)
The NexCAR19 study is a national, open-label, multicenter Phase 2-3 clinical trial designed to evaluate the efficacy and safety of the anti-CD19 chimeric antigen receptor (CAR) T-cell product, Talikabtagene Autoleucel, in…
- Conditions
- Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma (DLBCL), High-grade B-cell Lymphoma (HGBCL)
- Trial name
- NexCAR19 (NCT07502118)
- Testing
- Talikabtagene Autoleucel
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Health Institutes of Turkey
Glucose Metabolism Disorders, Lipid Metabolism Disorders
Metabolic Complications Following Knee Injury in Young and Middle Aged Patients
Introduction This study evaluates the effect on glucose, lipid and bone metabolism following knee orthopedic procedures in healthy and physically active individuals.
- Conditions
- Glucose Metabolism Disorders, Lipid Metabolism Disorders, Sedentary Lifestyle
- Trial name
- OrthoMetKnee (NCT02573662)
- Testing
- Blood and Urine sampling, DXA scan, OGTT
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Haugaard, Steen Bendix, M.D., DMSc
Metabolic Syndrome, Inflammation
Impacts of Aronia on Inflammation and the Gut Microbiome
The overall goal of this project is to determine the inflammation lowering impact of anthocyanin-rich Aronia berries. Inflammation is an underlying mechanism driving the development of several diseases.
- Conditions
- Metabolic Syndrome, Inflammation, Hypertriglyceridemia, Obesity
- Trial name
- NCT04128839
- Testing
- Aronia berry juice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Montana State University
Turner Syndrome, Cardiovascular Diseases
Lymphedema, Low-grade Inflammation and the Vasculature in Turner Syndrome
100 women with karyotype verified TS, previously examined at 4 study visits during a 19-year period will be asked to participate in a 5th study visit. Healthy age-matched females will be included as controls in a ratio 2:1.
- Conditions
- Turner Syndrome, Cardiovascular Diseases, Lymphedema, Inflammation
- Trial name
- TSCOR_V (NCT06325618)
- Testing
- No intervention other than obtaining biopsies, Indocyanine green (ICG)
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Obesity, Metabolic Diseases
Fibrosis a New Pathological Actor in Adipose Tissue
Adipose tissue (AT) has specific alterations in obesity in particular increased fibrosis amount compared to lean subjects. Fibrosis amount measured by immunohistochemistry on adipose biopsies appears to to predict weight loss…
- Conditions
- Obesity, Metabolic Diseases, Fibrosis, Body Weight
- Trial name
- fibrota (NCT01655017)
- Testing
- biopsy
- Where
- 2 sites in France
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome, Obesity
Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue
This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in…
- Conditions
- Metabolic Syndrome, Obesity, Insulin Sensitivity
- Trial name
- NCT00774488
- Testing
- Glucose dependent insulinotropic polypeptide (GIP)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Obesity, Metabolic Diseases
Adaptation of Human Gut Microbiota to Energetic Restriction
Gut microbiota ecology is altered in obesity and could link obesity and its complications. Bariatric surgery enables a major and sustained weight loss therefore improving obesity related disease.
- Conditions
- Obesity, Metabolic Diseases, Nutrition Disorders, Body Weight
- Trial name
- microbaria (NCT01454232)
- Testing
- stools sampling, adipose tissue biopsy
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes, Insulin Resistance
Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans
We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduction of chronic low grade…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity
- Trial name
- NCT00422253
- Testing
- dietary intervention
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Irritable Bowel Syndrome
A Randomized Controlled Pilot Trial of Mesalazine in Patients With Irritable Bowel Syndrome
Emerging evidence indicates the presence of low-grade mucosal inflammation and its pathogenetic role in IBS. The aim of this pilot study is to provide that mesalazine treatment of IBS patients reduces low grade colonic…
- Trial name
- NCT00774007
- Testing
- mesalazine
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- SOFAR S.p.A.
Overweight or Obesity, Healthy
Anti-inflammatory Effect and Associated Mechanisms of Mango Consumption
The primary objective of this project is to provide new knowledge through a comprehensive set of analyses that investigate the complex interplay between regular mango intake, gut microbial structure/ function, mechanisms of…
- Trial name
- MG2 (NCT04726293)
- Testing
- Mango, Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology