Clinical trials: Lower Extremity Artery Disease
Artery Disease, Muscle Disorder
In Vivo Analysis of Muscle Stem Cells in Chronic and Acute Lower Limb Ischemia (MyostemIschemia)
Skeletal muscle regenerates after injury, due to the satellite cells (SCs), the muscle stem cells that activate, proliferate, differentiate and fuse to form new myofibers.
- Trial name
- NCT03942445
- Testing
- Gastrocnemius muscle biopsy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Peripheral Artery Disease (PAD), Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Hemodynamic Parameters in People With Atherosclerotic Vascular Disease Referred to a Secondary Prevention and Cardiovascular Rehabilitation Program
The main purpose of this study is to evaluate the hemodynamic changes in the forefoot of patients with coronary, cerebrovascular or peripheral atherosclerotic disease referred a 12-week cardiovascular rehabilitation program (PREV…
- Conditions
- Peripheral Artery Disease (PAD), Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Cerebrovascular Atherosclerosis
- Trial name
- NCT06701032
- Testing
- Cardiovascular rehabilitation program
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Laval University
Chronic Total Occlusion of Artery of the Extremities
FastWire REvascularisation of Extremities, (For LOWer Limbs) - FREEFLOW
This study is to assess the safety and efficacy of the FastWire System. It is intended to assess that the FastWire System can facilitate the intra-luminal placement of conventional guidewires or treatment devices beyond…
- Trial name
- NCT06492733
- Testing
- FastWire System - Peripheral
- Where
- 6 sites in United States
- Volunteers
- 65 people
- Sponsor
- Versono Medical Ltd
Thrombosis, Arterial Occlusive Diseases
Thromboelastography With Platelet Mapping to Guide Antiplatelet Therapy After Lower Extremity Revascularization
The goal of this clinical trial is to learn if a blood clotting test called thromboelastography with platelet mapping (TEG-PM) can guide blood-thinning medication decisions in adults more than 60 years and older with peripheral…
- Conditions
- Thrombosis, Arterial Occlusive Diseases, Thromboelastography (TEG), Peripheral Arterial Disease(PAD)
- Trial name
- TARGET (NCT07597239)
- Testing
- Aspirin, Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Massachusetts General Hospital
Chronic Wounds, Obliterating Arteriopathy of the Lower Limbs
Clinical Evaluation of an Innovative Non-contact Optical Device for Skin Oxygenation Imaging
According to international consensus, information on the level of skin oxygenation is necessary for the diagnostic management of chronic wounds.
- Trial name
- IMOXY (NCT05187676)
- Testing
- Oxygen saturation measurement using the IPAM device, Transcutaneous oxygen partial pressure (TcPO2) using the PeriFlux6000 device
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
Peripheral Arterial Disease, Venous Thormboembolism
VTE Incidence After Rivaroxaban + Aspirin or SAPT After Lower-limb Revascularization
Venous thromboembolism (VTE) has a high prevalence in patients with multiple comorbidities undergoing complex surgical procedures.
- Conditions
- Peripheral Arterial Disease, Venous Thormboembolism, Cardiovascular Diseases, Vascular Surgery Patient with PAD / Carotid Stenosis
- Trial name
- RESOLUTION (NCT06873321)
- Testing
- rivaroxaban 2.5 mg bid + aspirin 100 mg, clopidogrel 75 mg od for 3 months followed by aspirin 100 mg od for endovascular procedures or aspirin for open procedures
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Science Valley Research Institute
PAD - Peripheral Arterial Disease, Lumbar Spinal Stenosis
CLE-PAD : Prevalence of PAD in Patients With Surgically Lumbar Spinal Stenosis
The goal of this interventional study is to evaluate the rate of existing lower limb peripheral artery disease (PAD) in patients with surgically lumbar spinal stenosis (LSS).
- Conditions
- PAD - Peripheral Arterial Disease, Lumbar Spinal Stenosis, Lower Limb Arterial Disease
- Trial name
- CLE-PAD (NCT07469020)
- Testing
- contrast-enhanced CT scan
- Where
- 3 sites in France
- Volunteers
- 49 people
- Sponsor
- Rennes University Hospital
Peripheral Arterial Occlusive Disease Fontaine Stage IIa
Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication
The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited.
- Trial name
- NCT05111379
- Where
- Estonia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tartu