Clinical trials: Lower Extremity Artery Disease, open to volunteers
Peripheral Artery Disease, Peripheral Vascular Diseases
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Peripheral artery disease (PAD) is associated with elevated oxidative stress, and oxidative stress has been implicated as the cause of reduced endothelial reactivity in individuals with PAD.
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Diseases, Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease
- Trial name
- NCT06319339
- Testing
- Vumerity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Diabetes Mellitus, Claudication, Intermittent
Additional Hyperbaric Oxygen After Lower Extremity Amputation
This study evaluates the effect of additional hyperbaric oxygen therapy after lower extremity amputation. The patients will be randomized after amputation to either a treatment group receiving hyperbaric oxygen therapy, or…
- Conditions
- Diabetes Mellitus, Claudication, Intermittent, Critical Limb Ischemia, Osteomyelitis
- Trial name
- AHOLEA (NCT03594344)
- Testing
- Hyperbaric oxygen therapy
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
PAD, PAD - Peripheral Arterial Disease
Home-Based Lower-Extremity Heat Therapy for Walking Function in Peripheral Artery Disease
Lower-extremity peripheral artery disease is associated with impaired walking ability, reduced lower-extremity function, and decreased quality of life.
- Trial name
- NCT07653243
- Testing
- Lower-Extremity Heat Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aquilo Sports, LLC
Diabetic Foot Ulcers (DFU), Lower Extremity Arterial Occlusion
Efficacy and Safety of Cold Atmospheric Plasma Combined With Endovascular Intervention for Diabetic Foot Ulcers With Lower Extremity Arterial Occlusion
The goal of this clinical trial is to evaluate whether cold atmospheric plasma (CAP) combined with endovascular intervention can accelerate wound healing and improve safety outcomes in patients aged 18 to 80 years with diabetic…
- Trial name
- NCT07198061
- Testing
- Cold Atmospheric Plasma (CAP), Infrapopliteal Endovascular Revascularisation, Guideline-Based Standard DFU Care
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenyang Medical College
Diabetic Foot Ulcer (DFU)
Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers
The goal of this clinical trial is to learn if using FoundationDRS Solo improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT07290673
- Testing
- FoundationDRS Solo, Standard of Care
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Samaritan Biologics
Peripheral Arterial Disease
Development and Validation of the Modified Version of VascuQol Scale in Patients With Lower Extremity Peripheral Arterial Disease.
The purpose of this study is to assess the utility of the Modified version of VascuQol Scale as an effective biopsychosocial assessment tool for patients suffering from lower extremity peripheral arterial disease.
- Trial name
- NCT06223217
- Testing
- Surveys and Questionnaires
- Where
- China
- Volunteers
- 480 people
- Sponsor
- RenJi Hospital
Arterial Disease of Legs, Below-the-knee Obstruction
Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease
This is a Pivotal, Prospective, randomized, two arm, placebo controlled, single-blind, multicenter trial that will be conducted at approximately 80 sites; approx.
- Conditions
- Arterial Disease of Legs, Below-the-knee Obstruction, PAD - Peripheral Arterial Disease
- Trial name
- MAGICAL BTK (NCT06182397)
- Testing
- MagicTouch PTA Sirolimus drug coated balloon
- Where
- 29 sites in United States
- Volunteers
- 368 people
- Sponsor
- Concept Medical Inc.
Transtibial Amputation, Peripheral Artery Disease
Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation
The population of older Veterans with non-traumatic lower limb amputation is growing. Following lower limb amputation, asymmetrical movements persist during walking and likely contribute to disabling sequelae including secondary…
- Conditions
- Transtibial Amputation, Peripheral Artery Disease, Diabetes Mellitus
- Trial name
- GEM (NCT03995238)
- Testing
- Error-augmentation gait training, Error-correction gait training, Supervised walking
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Peripheral Arterial Disease
Vascular Trial Associated Registry Pilot
The purpose of this investigator-initiated, multicenter, open label, randomized trial is to evaluate 1 month vs. 6 months of dual antiplatelet therapy (DAPT) in patients undergoing lower extremity endovascular revascularization.
- Trial name
- VSTAR-P (NCT07076082)
- Testing
- Clopidogrel (Plavix) Pharmacogenetic Test Reagents
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- Corewell Health West
Peripheral Artery Disease (PAD)
Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease
This study is researching 2 different experimental drugs called REGN7508 and REGN9933. The study is focused on people who have Peripheral Artery Disease (PAD), which means that the blood vessels in their arms and legs have become…
- Trial name
- ROXI-PALISADE (NCT07318610)
- Testing
- REGN7508, REGN9933, Rivaroxaban
- Where
- 32 sites in United States, United Kingdom
- Volunteers
- 7,050 people
- Sponsor
- Regeneron Pharmaceuticals
Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer
Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia
The goal of this clinical trial is to learn whether Seltoplasmid Injection can improve outcomes after lower-extremity revascularization. Revascularization is a procedure used to restore blood flow to the leg.
- Conditions
- Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer, Infrapopliteal Arterial Occlusive Disease
- Trial name
- NCT07827521
- Testing
- Lower-Extremity Revascularization, Donaperminogene Seltoplasmid
- Where
- 6 sites in China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Peripheral Arterial Disease, Critical Limb Ischemia
Leg Ischaemia Management Collaboration
Single-centre prospective cohort study of patients presenting with severe limb ischaemia (SLI). The primary outcome measure will be 12 month major amputation rate.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Frailty, Cognitive Impairment
- Trial name
- LIMb (NCT04027244)
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University of Leicester
Lower Extremity, Photoacoustic
Photoacoustic Tomography in Assessment of Lower Extremity Artery Disease
Lower extremity artery disease (LEAD) is characterized by low awareness rate and high missed diagnosis rate, leading to low treatment rate and high disabling mortality rate.
- Trial name
- NCT06579326
- Testing
- Photoacoustic imaging
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Lower Extremity Artery Disease
Validation of a Magnetic Sensor in Arterial Flow Recording, Compared With the Reference Method, at Various Peripheral Arterial Sites
The measurement of magnetic fields emitted by cardiac activity has already been studied in magneto-cardiography. To date, however, this technology has never been evaluated in the peripheral circulation.
- Trial name
- COMADO (NCT06274697)
- Testing
- Evaluation by magnetic sensor
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus, Peripheral Arterial Disease
Construction and Empirical Research of a Risk Prediction Model for Preventing Lower Extremity Arteriosclerosis Obliterans in Diabetic Patients Based on the HAPA Model
In this study, Logistic regression analysis was used to construct a risk prediction model for ASO in diabetic patients. Guided by the HAPA model, a nursing intervention plan for preventing ASO in diabetic patients was constructed…
- Trial name
- NCT07881588
- Testing
- Routine Care, Experimental group intervention
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Peripheral Artery Disease (PAD)
A Study to Evaluate the Safety and Effectiveness of the FastWave Artero™ Peripheral Intravascular Lithotripsy (IVL) System in Adults With Peripheral Artery Disease (PAD)
The purpose of this clinical study is to learn if the FastWave Artero™ Peripheral Intravascular Lithotripsy (IVL) System is safe and works well to help people with peripheral artery disease (PAD) who have hard, calcium-filled…
- Trial name
- SPARC (NCT07209085)
- Testing
- FastWave Artero™ Peripheral IVL System
- Volunteers
- 110 people
- Sponsor
- FastWave Medical
Diabetes Mellitus, Transfemoral Amputation
Effectiveness of an Inpatient Rehabilitation and Prosthetic Training Model in Patients With Vascular and Metabolic Transfemoral Amputation
Patients with vascular and metabolic transfemoral amputations experience substantial functional limitations and high rates of prosthetic abandonment.
- Conditions
- Diabetes Mellitus, Transfemoral Amputation, Peripheral Arterial Disease, Vascular Thrombosis
- Trial name
- NCT07665775
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Diabetic Lower Extremity Arterial Disease
Evidence-Based Evaluation of Classic Herb Pair (Chuanxiong Rhizoma and Salviae Miltiorrhizae) for Preventing Recurrence of Diabetic Lower Extremity Arterial Disease
Taking the approach of promoting qi circulation and activating blood as the entry point, this study targets lower extremity arterial disease（LEAD） patients with TCM syndrome pattern of blood stasis due to qi stagnation.
- Trial name
- NCT07139639
- Testing
- Guanxinning Tablets
- Volunteers
- 350 people
- Sponsor
- Zheng Liu
Diabetic Foot, Diabetes Mellitus
Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS)
The planned study is a Randomized Controlled Monocentric Trial, which will provide evidence on whether early angiography in percutaneous transluminal angioplasty (PTA) readiness ("immediate" treatment, within 48h) has advantages…
- Conditions
- Diabetic Foot, Diabetes Mellitus, Peripheral Arterial Disease, Diabetic Neuropathies
- Trial name
- PTA-DFS (NCT06124586)
- Testing
- Percutaneous transluminal angioplasty
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Peripheral Arterial Disease, Coronary Artery Disease
Selective Coronary Revascularization in Peripheral Artery Disease Patients (SCOREPAD Trial)
The primary objective of this study is to determine whether among symptomatic Peripheral Arterial Disease (PAD) patients with no known Coronary Artery Disease (CAD) who had undergone lower-extremity revascularization, a strategy…
- Trial name
- NCT06250790
- Testing
- Coronary CT angiography and FFRct analysis
- Where
- Latvia
- Volunteers
- 600 people
- Sponsor
- Pauls Stradins Clinical University Hospital