Clinical trials: Lower Extremity Dysfunction
Hemiplegia, Lower Extremity Dysfunction
Lower Extremity Pressure Splints in HP
Hemiplegia (weakness or paralysis on one side of the body) often impacts the lower extremities, making it challenging for patients to walk or move their legs effectively.
- Conditions
- Hemiplegia, Lower Extremity Dysfunction, Stroke Rehabilitation
- Trial name
- NCT06965894
- Testing
- Johnston Pressure Splint, Rehabilitation Program
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- Istinye University
Foot Injuries, Posterior Tibial Tendon Dysfunction
The CurePPaC Study - Analysing Non-surgical Treatment Strategies to Cure Pes Planovalgus Associated Complaints
Pes planovalgus, also called flat foot, is a common foot deformity characterized by a flattening of the foot's longitudinal arch and is accompanied by a dysfunction of the posterior tibial tendon ("posterior tibial tendon…
- Trial name
- NCT01839669
- Testing
- Foot Orthoses Only, Foot Orthoses and Eccentric Exercise
- Where
- 6 sites in Switzerland
- Volunteers
- 7 people
- Sponsor
- Bern University of Applied Sciences
Hamstring Muscle Strain, Adult Acquired Flatfoot Deformity
Correlation Between Soft Tissue Displacement and Functional Performance in Orthopedic Patients
The goal of this clinical trial is to investigate the correlations between dynamic soft tissue displacement, mechanical properties, and functional recovery across three studies: biceps femoris long head (BFlh) muscle injury…
- Conditions
- Hamstring Muscle Strain, Adult Acquired Flatfoot Deformity, Ulnar Collateral Ligament Sprain After Reconstruction
- Trial name
- NCT07870408
- Testing
- Nordic Hamstring Exercise Training, Custom Foot Orthoses and Exercise Therapy, Forearm Blood Flow Restriction Training
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Compartment Syndrome Nontraumatic Lower Extremity
The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics
During certain bowel surgeries for cancer (colorectal surgery), individuals frequently have to be placed in a head-down position to enable surgeons have optimal access to the cancer site.
- Trial name
- HELP (NCT06036641)
- Testing
- NIRS monitoring, Laser Doppler flowmetry, Inflammatory and Oxidative stress biomarkers
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Portsmouth
Hip Fracture
An Inpatient Rehabilitation Model of Care Targeting Patients With Cognitive Impairment
Hip fractures are a danger to an individual's mobility, independence and ability to live in the community. When patients have a cognitive impairment (such as dementia or delirium) they do not recover as well or go back to their…
- Trial name
- NCT01566136
- Testing
- Rehabilitation Model of Care
- Where
- Canada
- Volunteers
- 198 people
- Sponsor
- University Health Network, Toronto
Hip Fractures, Cognitive Impairment
A Care Model for Elderly Hip-fractured Persons With Cognitive Impairment and Their Family Caregivers
This study aims to develop and examine an innovative family-centered intervention model for managing cognitive decline, improving postoperative recovery of hip-fractured patients with cognitive impairment, and enhancing family…
- Trial name
- NCT03894709
- Testing
- family-centered care model
- Where
- Taiwan
- Volunteers
- 304 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke
Efficacy of Temporal Interference-based Deep Brain Stimulation Combined With Conventional Rehabilitation Training for Lower Limb Motor Dysfunction After Stroke
Stroke, as one of the most disabling neurological diseases worldwide, causes significant functional impairments in the lower limbs, severely affecting the quality of life of patients.
- Trial name
- NCT07833423
- Testing
- Transcranial Temporal Interference (TI) Stimulation, routine rehabilitation
- Volunteers
- 60 people
- Sponsor
- The Third People's Hospital of Huizhou
Lower Urinary Tract Symptoms, Posture Disorders in Children
Examination of Trunk and Lower Extremity Biomechanics in Children With LUTD.
This study aimed to examine trunk and lower extremity biomechanics among children with lower urinary tract dysfunction (LUTD). It was targeted to pioneer including biomechanical changes into treatment if detected in the trunk and…
- Conditions
- Lower Urinary Tract Symptoms, Posture Disorders in Children, Muscle Weakness Condition, Urinary Incontinence in Children
- Trial name
- NCT05299827
- Testing
- The same evaluation methods were used for both groups.
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Segmental Dysfunction of the Lumbar Spine, Back Pain
Clinical Correlates of Pressure Pain Thresholds in Back and Leg Pain
Objectives: The purpose of this study was to determine whether tenderness and other commonly used chiropractic measures, when operationalized, improve after lumbar chiropractic manipulative therapy (CMT) in patients with lower…
- Conditions
- Segmental Dysfunction of the Lumbar Spine, Back Pain, Leg Pain
- Trial name
- NCT06653920
- Testing
- Chiropractic, Exercise, Cryotherapy
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Leach Chiropractic Clinic
Diabetic Foot Ulcer, Temporomandibular Disorder
Temporomandibular Dysfunction in Patients With Diabetic Foot Ulcers
The aim of this observational study is to investigate the effects of the type, area and duration of ulceration on jaw pain, mandibular function limitation, TMD and swallowing in individuals with diabetic foot ulcers.The main…
- Conditions
- Diabetic Foot Ulcer, Temporomandibular Disorder, Swallowing Disorder
- Trial name
- NCT06067022
- Testing
- observation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Harran University
Sciatica, Spinal Stenosis of Lumbar Region
Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg
The hypothesis is that in the treatment of low back pain (LBP) radiating to the leg, the long-term results of prolotherapy are more effective than those of the current conventional treatment: epidural steroid injections (ESI).
- Conditions
- Sciatica, Spinal Stenosis of Lumbar Region, Degeneration of Lumbar or Lumbosacral Intervertebral Disc
- Trial name
- NCT01934868
- Testing
- prolotherapy solution of 20% dextrose, Epidural Steroid Injection
- Where
- Israel
- Volunteers
- 110 people
- Sponsor
- Hadassah Medical Organization
Diabetic Foot
Role of Adiponectine in Pathophysiology Ogf Diabetic Foot
Diabetic patients with a history of diabetic foot are considered to be a high-risk population for increased cardiovascular and all-cause mortality (1,2,3,).
- Trial name
- NCT03150901
- Testing
- no drug
- Volunteers
- 70 people
- Sponsor
- Wolfson Medical Center
Type 2 Diabetes, Peripheral Arterial Disease
Liraglutide and Peripheral Artery Disease
STARDUST is an open-label, two-arm randomized controlled trial, aimed at evaluating the effects of liraglutide on peripheral perfusion, as compared with the aggressive treatment of cardio-metabolic risk factors, in people with…
- Trial name
- STARDUST (NCT04881110)
- Testing
- Liraglutide, Control
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Hemodynamic Stability
Selective Spinal Anaesthesia With Hyperbaric Prilocain With 2%Provides Better Perioperative Hemodynamic Stability for Patients With Peripheral Vascular Disease and Cardiac Dysfunction in Lower Limb Surgery
to compare the safety and efficacy of spinal anesthesia using Hyperbaric Prilocaine 2% versus Hyperbaric Bupivacaine 0.5% for patients with peripheral vascular disease and cardiac dysfunction.
- Trial name
- NCT05877690
- Testing
- Bupivacaine 0.5% Injectable Solution, Prilocaine Hydrochloride 2% Injection
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Cardiovascular Risk Factor, Endothelial Dysfunction
Interrupting Sitting With High Intensity Exercise on Vascular Function in Adolescents Before and After a Mixed Meal
This study aims to investigate the effect of interrupting a three hour bout of prolonged sitting with high intensity interval exercise on lower limb blood vessel function in adolescents before and after a mixed meal challenge.
- Trial name
- NCT04337385
- Testing
- Interrupting 3 hours of prolonged sitting with high intensity interval exercise, 3 hours of prolonged sitting
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia, Hip Fracture
Prevalence and Pathophysiology of Sarcopenia in the Elderly Patient With Hip Fracture
Sarcopenia is the loss of muscle mass and function that accompanies aging. The term sarcopenia comes from the Greek "sarx" (flesh) and "penia" (loss).
- Conditions
- Sarcopenia, Hip Fracture, Frailty
- Trial name
- PREFISSARC (NCT01477086)
- Where
- Spain
- Volunteers
- 198 people
- Sponsor
- Hospital Viamed Valvanera, Spain
Pain in Leg, Unspecified, Knee Sprain
Efficacy of Instrumental Chiropractic Treatment Using Activator Methods for Pain and Dysfunction in Juvenile Athletes
The goal of the study is to prove efficacy of instrumental chiropractic treatment for leg pain in juvenile athletes. A randomized placebo controlled clinical trial including juvenile athletes with functional impairment and pain…
- Trial name
- NCT01449994
- Testing
- Activator IV (Activator Methods Int. Phoenix, Arizona)
- Where
- Austria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Postoperative Cognitive Deficit (POCD)
"Effects of Fluid Status and Regional Cerebral Oxygenation on Postoperative Cognitive Dysfunction in Patients Undergoing Lower Extremity Surgery Under General and Spinal Anesthesia."
We frequently encounter cognitive impairments in patients over 65 undergoing Lower extremity surgery, depending on comorbidities and the choice of anesthesia method.
- Trial name
- AECGSKD002 (NCT07302061)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Goztepe Training and Research Hospital
Stroke, Gait Disorders, Neurologic
ZEPU AI9 Exoskeleton Rehabilitation Robot
The goal of this clinical trial is to learn whether the ZEPU AI9 lower limb exoskeleton robot is feasible, safe, and effective for people with walking difficulty caused by stroke, incomplete spinal cord injury, or orthopedic…
- Conditions
- Stroke, Gait Disorders, Neurologic, Spinal Cord Injuries, Incomplete, Postoperative Complication
- Trial name
- NCT07750808
- Testing
- ZEPU-AI9 Lower Limb Exoskeleton Gait Training, Standard-of-Care Rehabilitation
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University
Stroke Patients With Hemiplegia or Hemiparesis in the Subacute Stage
The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia (COMPENSATOR-Stroke)
The goal of this study is to evaluate the effects of high frequency tPCS + TENS compared to Sham device stimulation + TENS (Control) in lower limb motor function recovery in stroke patients with hemiplegia or hemiparesis in the…
- Trial name
- COMPENSATOR (NCT06999876)
- Testing
- The AscenZ-VIII Stimulator (Investigational Medical Device)
- Where
- 2 sites in Singapore
- Volunteers
- 90 people
- Sponsor
- National University Health System, Singapore