Clinical trials: Lower Extremity Dysfunction
Posterior Tibial Tendon Dysfunction, Pes Planus
Frequency of Pes Planus and Posterior Tibial Tendon Dysfunction in Patients With Ankylosing Spondylitis
This investigation aims to investigate the frequency of pes planus and posterior tibial tendon dysfunction in patients with ankylosing spondylitis.
- Conditions
- Posterior Tibial Tendon Dysfunction, Pes Planus, Spondylitis, Ankylosing
- Trial name
- NCT04810715
- Testing
- Patients with Ankylosing Spondylitis
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Afyonkarahisar Health Sciences University
Stroke, Incomplete Spinal Cord Injury (SCI)
ZEPU-2000 Limb Rehabilitation Trainer Study (ZEPU2000RCT)
The goal of this clinical trial is to learn whether the ZEPU-2000A, ZEPU-2000D and ZEPU-2000E robotic rehabilitation trainers help people with weakness or movement problems in their arms and legs.
- Conditions
- Stroke, Incomplete Spinal Cord Injury (SCI), Traumatic Brain Injury, Upper Extremity Motor Dysfunction
- Trial name
- NCT07749612
- Testing
- ZEPU-2000A, ZEPU-2000D, ZEPU-2000E
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University
Necrosis of Femoral Head, Knee Osteoarthritis
Probiotics Attenuate Postoperative Cognition Decline
The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Neck of Femur, Lumbar Disc Herniation
- Trial name
- NCT04017403
- Testing
- Bifidobacterium triple live capsule
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- RenJi Hospital
Lower Extremity Motor Dysfunction, Spinal Cord Injury
Evaluation of the Effectiveness and Safety of AI-Robotics
Evaluation of the effectiveness and safety of the lower extremity exoskeleton rehabilitation training robot
- Trial name
- ART (NCT03452059)
- Testing
- AiLegs, AiWalker and HKAFO
- Where
- China
- Volunteers
- 40 people
- Sponsor
- AI-Robotics Technology Co., Ltd
Hip Fractures
Anesthesia And Post-operative Mortality After Proximal Femur Fractures
This study evaluates the effect of anesthesia on mortality after surgical repair of proximal femur fracture. Patients will receive either a subarachnoid block or a combination of peripheral nerve blocks and light general…
- Trial name
- NCT02406300
- Testing
- Subarachnoid Anesthesia, PNB/GA, ropivacaine
- Where
- Portugal
- Volunteers
- 57 people
- Sponsor
- Centro Hospitalar do Porto
Hip Fractures, Cognitive Impairment
Hip Fracture Exercise and Rehabilitation Post Hip Fracture Study
This pilot study will look at whether it is possible to give better physical therapy to people with cognitive limitations who have had a hip fracture.
- Trial name
- HipERS (NCT03247205)
- Testing
- HipERS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Flatfoot, Flexible, Sports Physical Therapy
Neurophysiology-based Intervention of Foot Dysfunction in Sportive Children
The goal of the clinical trial study is to test the effect of the individual complex physiotherapy intervention program in the children actively playing soccer with flatfoot or valgus foot. The aims are: 1.
- Conditions
- Flatfoot, Flexible, Sports Physical Therapy, Child Development
- Trial name
- NCT05902091
- Testing
- Neurophysiology-based intervention
- Where
- Czechia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Cardiac Surgery
Study of Perioperative Evolution of Right Heart Dysfunction and Preload Responsiveness in Open Heart Cardiac Surgery
The aim of the study was to assess the ability a Lung Recruitment Maneuver (LRM) with a stepwise increase of PEEP to predict fluid responsiveness and right cardiac dysfunction in mechanically ventilated patients in open heart…
- Trial name
- NCT04711798
- Testing
- passive leg raising maneuver (PLR), lung recruitment maneuver (LRM), echographic evaluation of the right cardiac function
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Spinal Cord Injuries
Efficacy of a Wearable Noninvasive Neuromodulation Device
The aim of this study is to investigate the potential of transcutaneous neuromodulation (TNM) to treat slow colonic transit and constipation, termed the Neurogenic bowel dysfunction (NBD), in people with SCI.
- Trial name
- NCT07171489
- Testing
- TNM at a leg point (AccelBand)- randomized arm, TNM at a leg point (AccelBand)- open-label
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Cognitive Decline, Delirium
CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium
The aim of this study is to assess whether citicoline (TRAUSAN), a neuroprotective agent involved in membrane phospholipid synthesis and neurotransmission, can prevent or attenuate cognitive decline in older adults who develop…
- Trial name
- CITADEL (NCT07804498)
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- University of Milano Bicocca
Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
This phase III trial compares the effect of sentinel lymph node mapping to standard lymph node dissection in reducing the risk of swelling in the legs (lymphedema) in patients undergoing a hysterectomy for stage I endometrial…
- Trial name
- NCT05646316
- Testing
- Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy
- Where
- 60 sites in United States, South Korea
- Volunteers
- 428 people
- Sponsor
- NRG Oncology
Anesthesia, Spinal, Elderly
Influence Of Low Dose Intrathecal Naloxone On Bupivacaine - Fentanyl Spinal Anaesthesia For Lower Limb Orthopedic Surgery In Elderly Patients
Fentanyl is a safer alternative than morphine in the management of postoperative pain in elderly. However, pruritus, nausea and vomiting are unwanted side effects of intrathecal fentanyl administration, that can decrease patient…
- Trial name
- NCT04673812
- Testing
- Bupivacaine-fentanyl
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Kasr El Aini Hospital
Peripheral Artery Disease, Heart Failure
Myocardial Dysfunction Evaluation in Lower Extremity Arterial Disease Patients With Deformation Analysis
Single centre observational study to assess lower extremity arterial disease (LEAD) patients' cardiac dysfunction with strain analyses and to assess connections between cardiac dysfunction, metabolomic changes and target organ…
- Trial name
- MEDAL (NCT06215248)
- Where
- Estonia
- Volunteers
- 162 people
- Sponsor
- Tartu University Hospital
Postoperative Cognitive Dysfunction, Orthopedic Procedures
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia.
- Conditions
- Postoperative Cognitive Dysfunction, Orthopedic Procedures, Postoperative Pain Management, Hip Fracture
- Trial name
- REMIND-ORTHO (NCT07113483)
- Testing
- Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO]
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Somatic Dysfunction of Sacral Region, Somatic Dysfunction of Both Sacroiliac Joints
An Osteopathic Assessment of Lower Extremity Somatic Dysfunction in Runners
Runners often experience acute/chronic pain due to pre-existing structural somatic dysfunction and/or acquired various overuse injuries of the lower extremity, specifically affecting the ligaments, tendons, muscles and bones.
- Conditions
- Somatic Dysfunction of Sacral Region, Somatic Dysfunction of Both Sacroiliac Joints, Somatic Dysfunction of Bilateral Lower Extremities
- Trial name
- NCT05132894
- Testing
- Osteopathic Assessment
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- The Touro College and University System
Hip Fractures
Early Femoral Block in Elderly With Hip Fracture
Assess if the addition of an early femoral nerve block (performed within 2 hours from the admission in emergency department through a femoral nerve catheter) in the elderly patients (> 70 years) with hip fracture, reduces the…
- Trial name
- NCT03092466
- Testing
- femoral nerve catheter, femoral group, control group
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- ASST Gaetano Pini-CTO
Stress, Job, PTSD
The Sequestration of Holistic Stress Management Techniques for Adults
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life.
- Conditions
- Stress, Job, PTSD, Hypervigilance, Hyperthyroidism
- Trial name
- NCT06098755
- Testing
- Holistic Medicine (HM)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Goddess Zena I. Jones
Cognitive Impairment, Femoral Fractures
Sedation and Postoperative Cognitive Functions
Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study.
- Trial name
- NCT05737459
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Lymphedema, Gait Dysfunction
Impact of Virtual Reality (VR) Based Exercises on Lower Limb Lymphedema Outcomes (LELO)
This randomized controlled study aims to investigate the effects of virtual reality (VR)-assisted gait training, in addition to Complex Decongestive Therapy (CDT), on gait parameters, physical function, quality of life, and edema…
- Conditions
- Lymphedema, Gait Dysfunction, Physical Rehabilitation, Chronic Edema
- Trial name
- VR-LELO (NCT07472543)
- Testing
- Complex Decongestive Therapy (CDT) plus virtual reality (VR)-assisted gait training group, Complex Decongestive Therapy alone group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Endothelial Dysfunction
Effect of Local Heat Stress Via Leg Bath on Artery Function
Arteries are flexible in their structure and function and change in response to a variety of factors. Endothelial cells, are the skin type cells that form a layer inside arteries, and they are very important for arterial health.
- Trial name
- HEAT (NCT03618524)
- Testing
- Lower limb hot water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University