Clinical trials: Lower Extremity Dysfunction
Postoperative Cognitive Dysfunction, Hip Fractures
The Comparison of Cognition, Depression and Anxiety, and Quality of Life After Hip Fracture Surgery Under General or Regional Anesthesia
Postoperative cognitive dysfunction is a relatively common in elderly patients after hip surgery, but exact mechanism of its onset is still unclear as well as contributing factors.
- Conditions
- Postoperative Cognitive Dysfunction, Hip Fractures, Depression, Anxiety, Quality of Life
- Trial name
- NCT04518839
- Volunteers
- 140 people
- Sponsor
- University of Zagreb
Anterior Cruciate Ligament Injury, Quadriceps Dysfunction
Exercise Loading Biology Post-Traumatic OsteoArthritis Study - a Pilot and Feasibility Study
FROM RISK FACTORS TO THE PREVENTION OF LONG-TERM CONSEQUENCES AFTER CRUCIATE LIGAMENT INJURY (ACL injury) - This is a research project where we seek new knowledge about why some people have a high risk and others a low risk of…
- Conditions
- Anterior Cruciate Ligament Injury, Quadriceps Dysfunction, Knee Joint Loading, Anterior Cruciate Ligament Reconstruction
- Trial name
- ExeLoadBioPTOA (NCT06892899)
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- May Arna Risberg
Mild Cognitive Impairment
Effects of Cognicise and Arch Support Insoles in Older Adults With Mild Cognitive Impairment
The purpose of this study aims to explore the surplus effect of arch support insole to a cognicise training program on lower-extremity function in community-dwelling older adults with mild cognitive impairment (MCI).
- Trial name
- NCT05472415
- Testing
- cognicise, arch support insoles
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Hip Fractures
Effects of S-ketamine and Continuous Iliac Fascia Space Block on Perioperative Neurological Cognitive Impairment and Postoperative Rehabilitation in Elderly Patients With Hip Fracture
Elderly patients with hip fracture are older and have a high incidence of perioperative complications. the postoperative recovery of elderly patients with hip fracture is affected by hemodynamic instability and pain caused by…
- Trial name
- NCT05304559
- Testing
- S-Ketamine, Continuous iliac fascia space block, Normal saline
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Diabetic Ulcers on Both Feet, Amputation; Traumatic, Limb
The Impact of Sexual Health and Amputation Focused Education on Regulation of Glucose and Amputation Prevention
The purpose of this study is to investigate the effect of two types of education on HbA1c level and future amputations in inpatient diabetics after initial minor foot amputation
- Conditions
- Diabetic Ulcers on Both Feet, Amputation; Traumatic, Limb, Sexual Dysfunction, Diabetic Foot Ulcer Ischemic
- Trial name
- NCT04078854
- Testing
- Diabetes education
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Montefiore Medical Center
Hip Fractures
Regional vs General Anesthesia in Patients With Hip Fracture Under Treatment With Clopidogrel
This study compares general to regional anesthesia concerning morbidity and mortality in patients older than or equal to 65 years old who receive clopidogrel and are to be submitted in hip fracture surgery.
- Trial name
- NCT03596060
- Testing
- Fentanyl, Propofol, Rocuronium
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Larissa University Hospital
Hip Fracture, Geriatrics
Clinical Efficacy of Exoskeleton Robot-Assisted Rehabilitation on Lower Limb Functional Recovery in Elderly Patients With Hip Fracture
With the intensification of population aging, hip fracture, as a common bone disease, is seeing an increasing incidence rate among the elderly population.
- Conditions
- Hip Fracture, Geriatrics, Lower Extremity Dysfunction, Postoperative Rehabilitation
- Trial name
- NCT07323147
- Testing
- Exoskeleton, Conventional rehabilitation program
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Hai bao
Hip Fractures, Cognitive Impairment
Optimized Rehabilitation of Older Adults With Hip Fracture and Signs of Cognitive Impairment - Feasibility Study
Older adults suffering from a hip fracture are a significant concern, with higher incidence rates among women. Mortality rates post-hip fracture are alarming, with up to 8-fold increased risk within 3 months and significant…
- Trial name
- ENHANCE (NCT06286722)
- Testing
- Progressive, individualized and structured exercise program
- Where
- 6 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Lolland Community, Denmark
Peripheral Arterial Disease, Critical Limb Ischemia
Leg Ischaemia Management Collaboration
Single-centre prospective cohort study of patients presenting with severe limb ischaemia (SLI). The primary outcome measure will be 12 month major amputation rate.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Frailty, Cognitive Impairment
- Trial name
- LIMb (NCT04027244)
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University of Leicester
Left Ventricular Dysfunction, Femoral Fracture
Optimization Study of Cardiac Risk Patients With Hip Fracture
Elderly patients undergoing surgery for proximal hip fracture have a high risk of morbidity and mortality (M\&M) postoperatively.
- Trial name
- NCT01219712
- Testing
- Colloids, dobutamin, levosimendan
- Where
- 3 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Stroke, Spinal Cord Injuries
ZEPU-AI Series Limb Feedback Robot Training Study (ZEPUAISRCT)
The goal of this clinical trial is to learn whether robotic rehabilitation devices (ZEPU-AI2, AI4, AI6 Plus, and AI7A) are feasible, safe, and effective for adults with upper or lower limb motor problems.
- Conditions
- Stroke, Spinal Cord Injuries, Brain Injuries, Traumatic, Movement Disorder, Upper Extremity
- Trial name
- NCT07749625
- Testing
- ZEPU-AI2, ZEPU-AI4, ZEPU-AI6 Plus
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University
Measurement Properties of 5iTUG, Physical Disability
Evaluation of the Measurement Properties of a 5 Time Repeated Instrumented Timed Up and Go (5iTUG)
In order to tailor interventions, objective assessments of physical function is needed. A limitation of several of today's clinical assessments is that they require too much time and/or space.
- Conditions
- Measurement Properties of 5iTUG, Physical Disability, Balance, Cognitive Impairment
- Trial name
- 5iTUG (NCT03769220)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Venous Insufficiency of Leg, Venous Insufficiency (Chronic)(Peripheral)
Management of Endothelial Dysfunction in Patients With Chronic Venous Insufficiency After Endovenous Surgical Procedure
Endothelial dysfunction is assessed in patients with chronic venous insufficiency of lower limbs (grade C4 according to C - clinical manifestations, E - etiologic factors, A - anatomic distribution of disease, and P - underlying…
- Conditions
- Venous Insufficiency of Leg, Venous Insufficiency (Chronic)(Peripheral), Endothelial Dysfunction
- Trial name
- NCT04180137
- Testing
- Endovenous laser ablation of great saphenous vein (GSV) and microphlebectomy of varicose veins, Pharmacotherapy
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Hip Fractures
Hip Abductor Muscle Dysfunction After Nailing of Proximal Femoral Fractures, Incidence and Contributing Factors.
Proximal femoral fractures(PFFs) are common with advancing age. Proximal femoral nail (PFN) is now increasingly used to fix unstable fractures.
- Trial name
- NCT04311892
- Testing
- EMG of the hip abductor muscles
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- South Valley University
Femoral Neck Fractures, Postoperative Complications
Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty
Hip fractures incidence grows rapidly with the aging of the population. After indicated surgical treatment, hip fracture patients experience high rates of postoperative complications, postoperative delirium (PD), postoperative…
- Conditions
- Femoral Neck Fractures, Postoperative Complications, Inflammatory Response, Postoperative Delirium
- Trial name
- NCT01934049
- Testing
- hip arthroplasty, Total Intravenous Anesthesia and Peripheral nerve blocks
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Skeletal Muscle Ischemia, Severe Lower Limb Ischemia
Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans
The symptoms and severity of arterial disease is secondary to perfusion deficit. The specific alteration of the mitochondrial function of ischemic skeletal muscle plays an important role, and therapeutic enhancing mitochondrial…
- Conditions
- Skeletal Muscle Ischemia, Severe Lower Limb Ischemia, Mitochondrial Dysfunction
- Trial name
- NCT02117206
- Testing
- L-arginine (L-arginine Veyron), Nacl
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiovascular Disease Risk Reduction, Diabetes
Interval Training and Electromagnetic Therapy on Cardiovascular Disease Risk in Diabetic Elderly
Aims: To evaluate the combined effect of moderate intensity interval training and low frequency pulsed electromagnetic field therapy on cardiovascular disease risk and lower extremity functioning in the elderly with type 2…
- Conditions
- Cardiovascular Disease Risk Reduction, Diabetes, Lower Extremity Dysfunction
- Trial name
- NCT06974435
- Testing
- Interval training and electromagnetic therapy, Interval exercise training, Electromagnetic therapy
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Umm Al-Qura University
Fracture; Pelvic, Insufficiency Fractures
Real World Evidence of SI-BONE's iFuse TORQ TNT Advancing Treatment of Pelvic Ring Fractures
The purpose of this study is to evaluate outcomes in patients treated with iFuse TORQ TNT for pelvic fragility fractures.
- Conditions
- Fracture; Pelvic, Insufficiency Fractures, Fragility Fracture, Sacroiliac; Fusion
- Trial name
- REBAR (NCT07530497)
- Testing
- iFuse TORQ TNT Implant System
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- SI-BONE, Inc.
Post Stroke, Mobility
Effect of Modified Constraint-induced Movement Therapy Combined With Virtual Reality on Mobility in Post-stroke Patients: A Randomized Control Trial
This study investigates the effectiveness of combining m-CIMT and VR to improve mobility in post-stroke patients. A non-blinded randomized controlled trial will be conducted with 32 participants divided equally into experimental…
- Conditions
- Post Stroke, Mobility, Balance
- Trial name
- NCT06975904
- Testing
- m-CIMT with VR exer-games by Kinect Xbox 360, m-CIMT with Task-Specific Functional Training
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Foundation University Islamabad
Sacroiliitis, Sacroiliac Joint Dysfunction
Clinical Outcome and Fusion Results Using the SiJoin® Transfixing Sacroiliac Fusion Device
The purpose of this clinical study is to evaluate fusion of the SI joint(s) and any reduction in VAS pain scores in a prospective cohort of patients utilizing the SiJoin® Transfixing Sacroiliac Fusion Device in patients that…
- Conditions
- Sacroiliitis, Sacroiliac Joint Dysfunction, Iatrogenic Injury, Osteitis Condensans Ilii
- Trial name
- NCT05712850
- Testing
- SiJoin® Transfixing Sacroiliac Fusion Device
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- VG Innovations, LLC