Clinical trials: Lower Extremity Function
Magnetic Resonance Imaging, Hip Fractures
fMRI Feasibility Older Hip Fracture Surgery
An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery
- Conditions
- Magnetic Resonance Imaging, Hip Fractures, Postoperative Delirium
- Trial name
- NCT05081726
- Testing
- Functional MRI
- Volunteers
- 10 people
- Sponsor
- University of Nottingham
Patella-Dislocation
Functional Surface Electromyogram of Knee Extensors in Healthy Humans and Patients With Patella-dislocation.
The activation of the knee extensors in adults after patella dislocation. The kneecap can dislocate due to an accident or also only due to an interior turn in the stretched knee joint out of its sliding bearing. E.
- Trial name
- NCT00288847
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Peripheral Arterial Disease, Peripheral Artery Disease
Impacts of Mitochondrial-targeted Antioxidant on Peripheral Artery Disease Patients
Peripheral artery disease (PAD) is a common cardiovascular disease, in which narrowed arteries reduce blood flow to the limbs, causing pain, immobility and in some cases amputation or death.
- Trial name
- NCT03506633
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Nebraska
Spinal Cord Injuries, Stroke
Restorative Neuromodulation for Lower Extremity Functions
The overall objective of the proposed study is to restore lower-extremity functions of paraplegic individuals. Paralysis following Stroke or spinal cord injury (SCI) result harsh sufferings including lifelong dependence on…
- Conditions
- Spinal Cord Injuries, Stroke, Paralysis
- Trial name
- NCT04171375
- Testing
- trans-spinal Electrical Stimulation (tsES)
- Where
- Hong Kong
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Stroke
Effect of Lower Limb Proprioceptive Neuromuscular Facilitation Combined With Core Stability Training Versus Proprioceptive Neuromuscular Facilitation Alone on Balance and Functional Mobility in Chronic Stroke Survivors
This randomized controlled trial compares lower limb proprioceptive neuromuscular facilitation (PNF) combined with core stability training versus lower limb PNF alone in chronic stroke survivors.
- Trial name
- NCT07887360
- Testing
- Lower Limb PNF Combined with Core Stability Training, Lower Limb PNF alone
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Ibadat International University, Islamabad
SMA - Spinal Muscular Atrophy
HABIT-ILE + FST in Children With SMA
This single-arm pilot study will assess the feasibility and preliminary effectiveness of an intensive motor skill intervention (HABIT-ILE) combined with functional strength training (FST) in children with SMA who are receiving…
- Trial name
- NCT07223320
- Testing
- Combined Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) + functional strength training (FST)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Teachers College, Columbia University
Spinal Cord Injuries (SCI)
Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury
This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI).
- Trial name
- DOSA-SCI (NCT07739992)
- Testing
- Acute Intermittent Hypoxia (AIH) 15, Acute Intermittent Hypoxia (AIH) 23
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milap Sandhu
Knee Osteoarthritis
FAST and PSFS: Assessment and Validation of Two Functional Scales in Patients With Knee OA in Singapore
The new National One-Rehab framework mandates the use of the Patient-Specific Functional Scale (PSFS) as an outcome measure to track patients' rehabilitation progress.
- Trial name
- NCT05590663
- Testing
- Physiotherapy
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- SingHealth Polyclinics
Ischemic Stroke
Effectiveness of Theta Burst Stimulation For Upper and Lower Extremity Recovery in Stroke
This single-center, single-blind, randomized, sham-controlled clinical trial will include 60 patients aged >45 years who are within 3 months of a first-ever middle cerebral artery ischemic stroke.
- Trial name
- NCT07834333
- Testing
- Continuous Theta Burst Stimulation (cTBS), Intermittent Theta Burst Stimulation (iTBS)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Chronic Stroke, Subacute Stroke
Effect of Lower Limb Constraint Induced Movement Therapy Using a Torque-Assisted Exoskeletal Wearable Device
The aim of this study was to investigate the effects of lower limb constraint induced motor therapy using the robotic rehabilitation device on ambulatory function in chronic stroke patients.
- Trial name
- CIMT (NCT06830707)
- Testing
- experimental group
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Samsung Medical Center
Muscle Physiology
Whole Body Vibration Induced Muscle Activity and Effect of the Changes in Length of Soleus Muscle and Angle of Ankle
Previous studies reported that myoelectrical activity increased during whole body vibration (WBV). The investigators hypothesized that the change in soleus muscle length does not affect the whole body vibration induced soleus…
- Trial name
- WBVIMR-SL (NCT02468011)
- Testing
- vibration
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Pain, Hip Fractures
Improving Pain and Function in Hip Fracture
The purpose of this study is to compare two different methods of treating pain after a hip fracture.
- Trial name
- NCT00749489
- Testing
- Femoral Nerve Block
- Where
- 3 sites in United States
- Volunteers
- 164 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ankle Fractures
Ankle Fracture vs Ankle Fracture-Dislocation
The purpose of this study is to compare outcomes of patients with an ankle fracture to those with ankle fracture-dislocations. We hypothesize that long-term clinical outcomes for patients sustaining ankle fracture dislocations…
- Trial name
- NCT02198768
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis
Effects of Shock Absorbing Insoles on Knee Pain and Walking in Persons With Knee Osteoarthritis
Osteoarthritis (OA) is a progressive, chronic disease affecting more than 20 million Americans. There is no known cure for OA and management includes pain control and prevention of functional decline.
- Trial name
- NCT02018380
- Testing
- Shock Absorbing Insole (SofSole Athletes Plus)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Winston Salem State University
Lower Limb Amputation Above Knee (Injury)
C-Leg 3 and C-Leg 4 Study in Transfemoral Amputees
The aim of this post-market study is to confirm that the microprocessor controlled prosthetic knee components (C-Leg 3 and C-Leg 4) in comparison to mechanical knee joints can bring additional benefit to the users primarily on…
- Trial name
- NCT02765035
- Testing
- C-Leg 4, C-Leg 3
- Where
- 2 sites in Austria, Belgium
- Volunteers
- 18 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Phantom Limb Pain
Phantom Limb Pain Triggered by Micturition
Phantom Limb Pain ( PLP) is pain that is perceived and referred to a region of the body that is no longer present. in most patients, severity and frequency of phantom pain attacks gradually decrease over several weeks to 2 years…
- Trial name
- NCT03855930
- Testing
- functional MRI
- Where
- 2 sites in Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loewenstein Hospital
Traumatic Amputation of Lower Extremity
Functional Electrical Stimulation Use in Trans-tibial Amputations
The purpose of this study is to demonstrate the efficacy of functional electrical stimulation (FES) for trans-tibial amputees. The investigators aim to demonstrate that providing three months of FES intervention will increase…
- Trial name
- NCT02931396
- Testing
- FES
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Alicia Koontz
Chronic Low Back Pain
A Comparative Study: Non-Surgical Spinal Decompression and Spinal Manipulative Therapy- Utilizing a Quantifiable Musculoskeletal Functional Assessment Risk Analysis Tool (MSDR®) in Patients With Chronic Low Back Pain
To administer the MSDR® (Musculoskeletal Disorder Reporting) instrument to document the musculoskeletal profile of patients with chronic low back pain, a prospective, non-randomized, multicenter treatment trial
- Trial name
- NCT00732394
- Testing
- MSDR
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- MedAppraise, Inc.
Total Knee Arthroplasty
Comparison Between Brainlab Knee 3 Computer-assisted Navigation Systems and Conventional Instruments in TKA: a Prospective Cohort Study.
This is a a prospective cohort study. According to the inclusion criteria, volunteers were recruited from patients undergoing total knee arthroplasty.
- Trial name
- NCT04960345
- Testing
- Brainlab Knee 3
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Osteoarthritis, Knee, Quality of Life
Yoga for Managing Knee Osteoarthritis in Older Women: a Feasibility Study
The study hypothesized that it is feasible and safe to use Hatha yoga in older women with knee osteoarthritis (OA), and practicing Hatha yoga regularly will help reduce pain and stiffness, enhance physical function, and improve…
- Conditions
- Osteoarthritis, Knee, Quality of Life, Poor Quality Sleep, Physical Impairment
- Trial name
- NCT01832155
- Testing
- Hatha yoga
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota