Clinical trials: Lower Extremity Function
Peripheral Arterial Disease
Functional MRI of the Lower Extremities
In this project, the investigators propose to use high-resolution magnetic resonance imaging (MRI) to measure blood perfusion in different groups of calf muscle.
- Trial name
- NCT03423316
- Testing
- Supervised exercise therapy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Effects of Exercise on Older Adults
Effects of Resistance-based Exercise Snacks With Varying Fragmentation Patterns on Lower Limb Function and Executive Cognition in Pre-frail Older Adults
This four-arm randomized pilot trial (N=48-60) compares four fragmentation patterns of a three-exercise resistance snack (sit-to-stand, squat, heel raise; 15 repetitions/exercise/day) in pre-frail older adults (Fried score 1-2…
- Trial name
- NCT07551206
- Testing
- Highly Fragmented Exercise Snack, Moderately Fragmented Exercise Snack, Lowly Fragmented Exercise Snack
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital University of Physical Education and Sports, China
Knee Osteoarthritis, Hip Osteoarthritis
Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty
This research is being done to see if there is a difference between two different spinal anesthetics (Mepivacaine vs. Bupivacaine) as it relates to reducing post-operative complications and the time it takes for subjects to…
- Trial name
- NCT03838874
- Testing
- Low-Dose Bupivacaine, Mepivacaine
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Mayo Clinic
Stroke
rTMS and Robotic Gait Training in Patients With Stroke
Patients with stroke have demonstrated abnormal muscle tone and postural control ability which affect their ambulation, activity of daily living and confident.
- Trial name
- NCT03817385
- Testing
- repetitive TMS, robotic GT
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- Changhua Christian Hospital
Healthy
Effects of Heavy-load Resistance Training
The study aims to investigate effects of 8-weeks of heavy-load resistance training on mechanical muscle function and functional performance in elite female team handball players from the Danish Women's Handball League.
- Trial name
- NCT06356935
- Testing
- RT, CON
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Aging, Asymmetry
Fall Risk in Adults Over 65: The Relevance of Morphological and Functional Lower Limb Asymmetries.
Falls among older adults represent a major public health burden. Approximately 30% of individuals aged 65 and older experience at least one fall each year.
- Conditions
- Aging, Asymmetry, Fall Risk Factors, Fall Prevention
- Trial name
- ASY&FALL (NCT07742397)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Functional Deficits, Manipulation
Effects of Mobilization in Conjunction With Therapeutic Exercise in Participants With a History of Ankle Sprain
Our purpose was to examine the combined effects of thrust mobilization of the proximal and distal ankle joints in conjunction with a six-week rehabilitation program on ankle function in subjects reporting chronic ankle…
- Conditions
- Functional Deficits, Manipulation, Rehabilitation
- Trial name
- NCT02945943
- Testing
- High Velocity Low Amplitude mobilization, Exercise Protocol
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Shenandoah University
Transcranial Direct Current Stimulation, Chronic Stroke
Effect of Home Based Transcranial Direct Current Stimulation (tDCS) With Exercise on Upper and Lower Limb Motor Functions in Chronic Stroke
The aim of the present study is to investigate the effect of home based dual tDCS combined with exercise on upper and lower limb motor functions in chronic ischemic stroke patients.
- Trial name
- NCT04226417
- Testing
- Transcranial direct current stimulation
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Physical Therapy, Orthopedic Disorder
EFFECT OF HIGH INTENSITY LASER IN PATELLOFEMORAL PAIN SYNDROME
The aim of this study is to investigate the effectiveness of high-intensity laser therapy on pain and lower extremity function in the treatment of patellofemoral pain syndrome.
- Trial name
- Laser (NCT05075525)
- Testing
- High Intensity Laser Therapy Group, Ultrasound and Transcutaneous Electrical Nerve Stimulation Group, Ultrasound and Interferential Current Stimulation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul Medipol University Hospital
Rheumatoid Arthritis, Osteoarthritis
G7 BiSpherical Acetabular Shell PMCF Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available G7 BiSpherical Acetabular Shell.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis
- Trial name
- NCT03266874
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 160 people
- Sponsor
- Zimmer Biomet
Anterior Cruciate Ligament Injury, Knee Injuries
Sensory Deficit Following ACL Reconstruction: PRF Pilot Study
Pilot, single-center, non-randomized, parallel-group clinical study designed to assess whether intraoperative application of autologous platelet-rich fibrin (PRF) at the bone-patellar tendon-bone (BPTB) donor site reduces…
- Conditions
- Anterior Cruciate Ligament Injury, Knee Injuries, Sensory Disorders, Bone-Patellar Tendon-Bone Autograft
- Trial name
- PRF-ACL (NCT07257666)
- Testing
- Platelet-rich fibrin (PRF), Standard Closure (Control)
- Where
- Serbia
- Volunteers
- 53 people
- Sponsor
- University of Belgrade
Rupture of Anterior Cruciate Ligament
Quadriceps Function Prior to Anterior Cruciate Ligament Reconstruction
Patients who are diagnosed with an isolated tear of the anterior cruciate ligament and scheduled for arthroscopic reconstruction using bone-patellar tendon-bone autograft will be recruited to participate.
- Trial name
- NCT00971451
- Testing
- cryotherapy, TENS
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Groin Strain
Comparative Effects of Copenhagen and Holmich Exercises in Hip Adductor
Groin pain that relates to the adductor muscle usually represents in the groin region specifically in superior internal thigh. Tears or strains may happen within the muscles itself, tears or strains mainly occurs at…
- Trial name
- NCT05970003
- Testing
- Copenhagen exercises, Holmich exercises
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Phantom Limb Pain
Mixed Reality Based System to Manage Phantom Pain Phantom Pain for Patients With Lower Limb Amputation
The primary goals of this pilot research project are a) to design and develop the a mixed reality based system for managing phantom pain and b) to evaluate the feasibility and preliminary functional outcomes of this system in a…
- Trial name
- MrMAPP (NCT04529083)
- Testing
- Mr. MAPP
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Dallas VA Medical Center
Healthy Adult Male, Healthy Adult Females
Investigating Sex Differences in Mitochondrial Function and Leg Blood Flow During Exercise
This study will compare mitochondrial function and leg blood flow during exercise in healthy endurance-trained females and males aged 19-35.
- Trial name
- MITOP (NCT07866651)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Postoperative Cognitive Dysfunction, Hip Fractures
The Comparison of Cognition, Depression and Anxiety, and Quality of Life After Hip Fracture Surgery Under General or Regional Anesthesia
Postoperative cognitive dysfunction is a relatively common in elderly patients after hip surgery, but exact mechanism of its onset is still unclear as well as contributing factors.
- Conditions
- Postoperative Cognitive Dysfunction, Hip Fractures, Depression, Anxiety, Quality of Life
- Trial name
- NCT04518839
- Volunteers
- 140 people
- Sponsor
- University of Zagreb
Iliotibial Band Syndrome
Clamshell and Frog Pump Exercises on Pain, Range of Motion, and Functional Disability
The study will be randomized clinical trial. This study will be conducted at the University of Lahore Teaching Hospital, Lahore, Pakistan.
- Trial name
- NCT07118371
- Testing
- Clamshell exercise, Frog pump exercises
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- University of Lahore
Osteoarthritis, Avascular Necrosis
Post-market Surveillance Study With the HYPERION Hip Endoprosthesis System in Defect Reconstruction
The study is a multi-center, prospective, non-controlled, consecutive cohort post market surveillance study. The objective of this study is to obtain survival and clinical outcome data on the Hyperion® system in primary and…
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Functional Deformities
- Trial name
- NCT03382665
- Where
- 3 sites in Germany
- Volunteers
- 70 people
- Sponsor
- Zimmer Biomet
Hip Fracture
Better Hips- Better Function
The focus of this project are elderly people who have experienced hip fracture and need at least two weeks rehabilitation after discharge from hospital.
- Trial name
- NCT02815254
- Testing
- High intensity functional exercise, Low intensity functional exercise
- Where
- Norway
- Volunteers
- 105 people
- Sponsor
- Oslo Metropolitan University
Functional Ankle Instability
Effects of Taping on Performance in Adolescent Volleyball Players With Patient-Reported Ankle Instability
The purpose of this study is to investigate the effects of different types of taping application to functional performancein adolescent volleyball players with functional ankle instability.
- Trial name
- NCT07165613
- Testing
- Kinesiotape, Dynamic tape
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yeditepe University