Clinical trials: Lower Extremity Function
Unilateral Lower Limb Suspension (Simulated Microgravity)
Unloaded Minds - How Prolonged Unloading Shapes Human Performance in Lunar Gravity
During spaceflight and lunar missions, reduced gravitational loading causes the muscles and nervous system to decondition rapidly.
- Trial name
- UnloadedMinds (NCT07607340)
- Testing
- Unilateral lower limb suspension
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Trimalleolar Fracture, AO Weber C Fractures
Fixation of the Posterior Malleolus in Trimalleolar AO Weber C Fractures.
In AO Weber type C fractures, there is a combination of a proximal fibular fracture, a medial fracture or ruptured deltoid ligament, and a syndesmotic injury.
- Conditions
- Trimalleolar Fracture, AO Weber C Fractures, Syndesmotic Stability, Open Reduction and Internal Fixation
- Trial name
- POSTFIX-C (NCT02599285)
- Testing
- Fixation, NO Fixation
- Where
- 4 sites in Netherlands
- Volunteers
- 54 people
- Sponsor
- Medical Center Haaglanden
Tibial Fractures, Lower Extremity Fracture
Blood Flow Restriction Training in Patients With Lower Extremity Fractures
This study will look at the effect of using a blood flow restriction device during low load strengthening exercises on patients with tibial shaft fractures, compared to patients performing exercise without the device.
- Trial name
- NCT06496035
- Testing
- Blood Flow Restriction with low load exercise, Therapeutic Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Rupture of Anterior Cruciate Ligament, Complete Tear, Knee, Anterior Cruciate Ligament
Comparison of Dynamic Knee Stability and Functional Outcomes in Anatomical ACL Reconstruction at AM or Central Position
This is a prospective, randomized and double-blind clinical trial about anatomical single-bundle anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT02074917
- Testing
- Anatomical ACL reconstruction
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Ankle Injuries and Disorders
Effects of Hip Strength Training and Neuromuscular Electrical Stimulation on Functional Ankle Instability
The goal of this clinical trial is to compare the effects of two methods of elevating hip muscle strength on functional ankle instability(FAI). .
- Trial name
- NCT06125158
- Testing
- Conventional ankle training, Hip strength training, Neuromuscular electrical stimulation
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Tianjin University of Sport
Stroke, Hemiparesis;Poststroke/CVA
Effectiveness of Paretic Lower Limb Loading During Over-ground Training Among Stroke Survivors
Post-stroke gait deviations contribute to significant functional disability, impaired walking ability and poor quality of life. Prior studies suggest that gait training with paretic lower limb loading may improve gait parameters…
- Trial name
- NCT05097391
- Testing
- Warm-up (5 minutes), Conventional physiotherapy exercise (15 minutes), Over-ground training with lower limb loading (15-25 minutes)
- Where
- Nigeria
- Volunteers
- 48 people
- Sponsor
- Bayero University Kano, Nigeria
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Reconstruction
Comparison Between Combined ALLR With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction
The goal of this clinical trial is to test and compare different surgical techniques in patients with anterior cruciate ligament (ACL) injuries.
- Trial name
- ALLR (NCT06341192)
- Testing
- Single-bundle ACL combined anterolateral ligament reconstruction, Double-bundle ACL combined anterolateral ligament reconstruction
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Hip Fractures, Femoral Neck Fractures
Functional Outcome After ORIF or Arthroplasty for Femoral Neck Fracture
Aim To investigate the effect of internal fixation versus hip arthroplasty on physical function and pain in elderly patients. Methods This is a substudy of an on-going nationwide multicenter registry-based RCT named HipSTHeR…
- Conditions
- Hip Fractures, Femoral Neck Fractures, Undisplaced Fracture, Treatment Complication
- Trial name
- HipFunct (NCT06152198)
- Testing
- Treatment
- Where
- Sweden
- Volunteers
- 340 people
- Sponsor
- Uppsala University
Incomplete Spinal Cord Injury
Non-invasive Brain Stimulation Paired With FES Cycling Post SCI
This project is randomized controlled trial which will explore the effect of pairing repetitive Transcranial Magnetic Stimulation (rTMS) with Functional Electrical Stimulation (FES) Cycling on lower extremity function in people…
- Trial name
- NCT05975606
- Testing
- repetitive transcranial magnetic stimulation (rTMS), functional electrical stimulation (FES) cycling
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Western University, Canada
Periprosthetic Fracture of the Upper or Lower Limb, Peri-implant Fracture of the Upper or Lower Limb
Peri-Implant and Peri-Prosthetic Fractures: Epidemiology, Morbidity, Mortality, Treatment and Outcome Analysis
This study supports Spanish data collection and analysis on Periprosthetic and Peri-implant fractures of the upper and lower limb. Treatment and clinical management of this fractures are complex and goes along with complications.
- Conditions
- Periprosthetic Fracture of the Upper or Lower Limb, Peri-implant Fracture of the Upper or Lower Limb, Periprosthetic Fractures, Peri-implant Fracture
- Trial name
- PIPPAS (NCT04663893)
- Where
- 7 sites in Spain
- Volunteers
- 2,500 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
ACL Injury
A Prehab Strengthening Program Prior to ACL Surgery on Lower Limb Structure and Function
Atrophy and weakness are ubiquitous after a ACL rupture and associated with a worsened long-term recovery of individual capacities, despite surgery and rehabilitation.
- Trial name
- ACL-Strong (NCT05374382)
- Testing
- Strengthening, Conventional
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Université de Nantes
Knee Injuries
Effect of Electromyographic Biofeedback on Quadriceps Neuromuscular Function in Patients With Quadriceps Inhibition
Muscle inhibition prevents optimal contraction of the quadriceps muscle due to changes in the nervous system after knee joint injury.
- Trial name
- NCT02095223
- Testing
- Electromyographic Biofeedback, Traditional Exercise
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Miami
Anterior Cruciate Ligament (ACL) Injury, Athletic Injuries
Correlation Between Psychological Readiness, Knee Function, and Isokinetic Performance After Anterior Cruciate Ligament Reconstruction (ACLR) Using Peroneus Longus Tendon Graft (PL-ACL-2025)
This clinical trial aims to investigate the correlation between psychological readiness, knee function, and isokinetic performance after anterior cruciate ligament reconstruction (ACLR) using the Peroneus Longus tendon graft…
- Conditions
- Anterior Cruciate Ligament (ACL) Injury, Athletic Injuries, Knee Injuries
- Trial name
- PL-ACLR (NCT07201597)
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Ankle Injuries
Balance Training With Progressive Intermittent Visual Occlusions in Chronic Ankle Instability(RCT)
Based on the purpose of this study, the following hypotheses were established: There will be a significant difference in balance changes within and between groups following balance training with progressive intermittent visual…
- Trial name
- BTPIVO-CAI (NCT07108491)
- Testing
- Balance Training with Stroboscopic Glasses, Balance Training without Glasses
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Sahmyook University
Lower Extremity Dysfunction, Stroke
Sensitivity to Change of the Lower Extremity Functional Scale in Patients With Stroke
The purpose of this study was to investigate the reliability, construct validity, and sensitivity to change of the Lower Extremity Functional Scale (LEFS) in individuals affected by stroke.
- Trial name
- NCT01536990
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Foot Function Index, Flat Foot, Dynamic Plantar Pressure, Reliability, Validity
The Clinical Study of Foot Function Index in Adolescent Flatfoot
Using dynamic plantar pressure data during walking, combined with the FFI scores of adolescents, aids doctors and rehabilitation therapists in conducting more accurate, objective, and scientific evaluations of the functional…
- Trial name
- NCT06407960
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Bone Neoplasm, Rehabilitation
Functional Recovery of Patients Undergoing Resection and Reconstruction of the Lower Limbs for Bone Tumor.
The aim of the present study is to describe the course of functional recovery of patients with musculoskeletal tumours and undergone resection and reconstruction operations of lower limbs in the first six months post-surgery…
- Trial name
- FISIO-ONCO (NCT06376539)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Lipedema
Transcutaneous Auricular Vagus Nerve Stimulation-Enriched Rehabilitation in Individuals With Lipedema
Lipedema is a chronic inflammatory disorder of adipose tissue that predominantly affects women and is associated with estrogen-mediated mechanisms.
- Trial name
- LipoVNS (NCT07857499)
- Testing
- Active taVNS, Aerobic Exercise, Complex Decongestive Therapy (CDT)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Gait
The Mobility Toolkit: Electronically Augmented Assessment of Functional Recovery Following Lower-extremity Trauma
The study will prospectively enroll and follow 300 participants ages 18-60 surgically treated for a lower-extremity articular injury including fractures of the tibial plateau, pilon, ankle, and calcaneus.
- Trial name
- MBTK (NCT04047030)
- Testing
- None- Observational Study
- Where
- 10 sites in United States
- Volunteers
- 244 people
- Sponsor
- Major Extremity Trauma Research Consortium
Ankle Sprain
Cast Immobilization Versus Functional Therapy for Acute, Severe Lateral Ankle Sprains
Acute, severe lateral ankle sprains are estimated to comprise between 3-5% of emergency department visits and are the most common musculoskeletal injury in the physically active population.
- Trial name
- NCT01446341
- Testing
- Below knee plaster casting, Functional rehabilitation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia