Clinical trials: Lower Extremity Pain
Hip Fracture, Pain Management
Comparison of the Efficacy of Ultrasound-guided Supra-inguinal Fascia Iliaca and Lumbar Erector Spina Plan Block in Hip Fractures
The aim of our study was to evaluate the efficacy and patient satisfaction level of SI-FIB and lumbar ESPB for positioning and postoperative analgesia during spinal anesthesia in patients undergoing hip fracture surgery.
- Conditions
- Hip Fracture, Pain Management, Multimodal Analgesia, Peripheral Nerve Block
- Trial name
- NCT07639762
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
ACL Injury, Post Operative Pain
iPACK for Post-op Pain Following ACL Reconstruction
This study will consist of patients 12 years and older undergoing ACL reconstruction using a quadriceps or bone-patella tendon bone (BTB) graft.
- Trial name
- NCT05498870
- Testing
- Adductor Canal Block (ACB) Only, Adductor Canal Block (ACB) + iPACK Block
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Medical University of South Carolina
Groin Strain
Comparative Effects of Copenhagen and Holmich Exercises in Hip Adductor
Groin pain that relates to the adductor muscle usually represents in the groin region specifically in superior internal thigh. Tears or strains may happen within the muscles itself, tears or strains mainly occurs at…
- Trial name
- NCT05970003
- Testing
- Copenhagen exercises, Holmich exercises
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pelvic Girdle Pain
Predictive Value of the Active Straight Leg Raise on the Efficacy of a SJB in Posterior PGP During Pregnancy
During pregnancy, women often experience musculoskeletal pain, specifically in their low back and/or pelvic girdle. Pelvic girdle pain (PGP) is defined as pain between the posterior iliac crest and gluteal fold, particularly in…
- Trial name
- NCT03518840
- Testing
- SIJ Belt
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Loyola University
Arterial Occlusive Diseases
Ischemic Pain Control With Analgesic Methods Clinical Trial
This project is one of four components of a thematic project that aims to evaluate the use of ultrasound in regional blocks, called "Use of ultrasound in regional blocks and injections for the treatment of acute and chronic…
- Trial name
- ISCHAEMIC (NCT02841488)
- Testing
- Continuous peripheral sciatic nerve block, Fentanyl, Ropivacaine
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo General Hospital
Knee; Injury, Meniscus (Lateral) (Medial), Meniscus Tear
Clinical Efficacy of Exosome in Degenerative Meniscal Injury
Comparison of intra-articular administration of synovial fluid-derived mesenchymal stem cells-derived exosomes with synovial fluid-derived mesenchymal stem cells on the same patient.
- Conditions
- Knee; Injury, Meniscus (Lateral) (Medial), Meniscus Tear, Meniscus Lesion, Meniscus; Degeneration
- Trial name
- KNEEXO (NCT05261360)
- Testing
- SF-MSC-EX, SF-MSC
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Pain, Acute
Exploration of Gait Biomechanics and Muscle Pain of the Lower Extremity
This interventional study aims to test gait biomechanics in healthy individuals with and without experimental muscle pain in the lower extremities.
- Trial name
- NCT06411197
- Testing
- Hypertonic saline injection, Isotonic saline injection
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kristian Kjær Petersen
Pain, Diabetic Neuropathy
Safety and Efficacy of Dextromethorphan and Quinidine in the Treatment of the Pain of Diabetic Neuropathy
The purpose of this study is to determine whether dextromethorphan (Neurodex) and quinidine are effective in the treatment of pain of diabetic neuropathy.
- Trial name
- NCT00113620
- Testing
- Neurodex
- Where
- 44 sites in United States
- Volunteers
- 450 people
- Sponsor
- Avanir Pharmaceuticals
Varicose Veins Leg, Great Saphenous Vein Insufficiency
Calcium Dobesilate After Radiofrequency Ablation for Varicose Veins
This study evaluates whether calcium dobesilate, a venoactive drug, improves recovery after radiofrequency ablation (RFA) for varicose veins.
- Conditions
- Varicose Veins Leg, Great Saphenous Vein Insufficiency, Chronic Venous Insufficiency
- Trial name
- NCT07390097
- Testing
- calcium dobesilate
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Oguz Arslanturk
Disc Herniation
Discogen for Low Back Pain
This study will be a double-blinded, two-arm, prospective, randomized controlled pilot feasibility study in 40 evaluable subjects (20 in each arm) at one study site within the United States.
- Trial name
- NCT06611397
- Testing
- Discogen Low pulsed ultrasound treatment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Columbia University
Chronic Pain Management, Chronic Pain and Comorbid Emotional Problems
EFFECT OF TRANSCUTANEOUS ELECTRONEURO-STIMULATION OF THE VAGUS NERVE ON JOINT PAIN SEQUELAE OF CHIKUNGUNYA FEVER IN THE LOWER LIMBS
This study aims to evaluate the efficacy of transcutaneous electrical nerve stimulation (taVNS) in reducing chronic lower limb joint pain in individuals with sequelae of Chikungunya fever.
- Trial name
- NCT07523126
- Testing
- Transcutaneous vagus nerve electrical stimulation, Transcutaneous eletrical nerve stimuation, Transcutaneous electrical nerve stimulation
- Where
- Brazil
- Volunteers
- 51 people
- Sponsor
- Universidade Federal de Pernambuco
Phantom Limb Pain
Massage Therapy for Phantom Limb Pain: Feasibility and Pilot Study
Massage therapy is a treatment self-reported by those with phantom limb pain (PLP) as moderately to extremely effective, but no research to date has been specifically designed to examine such efficacy or effectiveness in this…
- Trial name
- NCT03372668
- Testing
- massage therapy combined with components of mirror therapy
- Volunteers
- 3 people
- Sponsor
- Indiana University
ACL Tear, Post Operative Pain
Impact of Opioid Avoidance Protocol for ACL Reconstruction
This is a prospective, quasi-experimental, cohort study comparing patients treated with one of two postoperative pain management protocols.
- Trial name
- NCT06340932
- Testing
- Iovera, Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Matthew Varacallo
Orthopedic Procedures, Pain, Postoperative
Risk Model for Severe Rebound Pain After Lower Limb Orthopedic Surgery Involving Single-Shot Sciatic Nerve Blocks
Rebound pain is a well-recognized phenomenon after the effects of a nerve block wear off. Severe rebound pain can happen after outpatient surgery, with patients often needing to come back to the hospital or use other health care…
- Conditions
- Orthopedic Procedures, Pain, Postoperative, Surgery, Nerve Block
- Trial name
- NCT05018104
- Testing
- This is not an interventional study
- Where
- Canada
- Volunteers
- 1,270 people
- Sponsor
- University of British Columbia
Diabetic Foot, Plantar Fasciitis
Joints Mobilization Versus Myofascial Release on Diabetic Patients With Painful Heel
Diabetes mellitus (DM) increases stiffness and thickness of foot structures. This may alter the foot's biomechanics and increase plantar pressure distribution, mainly on the forefoot region.
- Trial name
- NCT03851848
- Testing
- Joint mobilization (JM), Myofascial release (MFR)
- Where
- Saudi Arabia
- Volunteers
- 46 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Analgesia, Femur Fracture
Comparison Between Pericapsular Nerve Group Block (PENG) and Morphine Infusion
The pericapsular nerve group block (PENG) is a regional anaesthetic technique that was developed in 2018, primarily for total hip arthroplasties (THA) as a postoperative analgesia modality with motor sparing benefits.
- Trial name
- NCT05023473
- Testing
- Pericapsular nerve group block, Morphine Sulfate
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Suez Canal University
Iliotibial Band Syndrome
Effects of Posterior Oblique Sling Strengthening Exercises on Pain & Flexibility Among Runners With
The popularity of recreational running and rate of running related injuries are increasing. Research has shown that iliotibial band syndrome (ITBS) is one of the most common knee injuries among runners alongside plantar…
- Trial name
- ITBS (NCT05915754)
- Testing
- Hip abductors stretching and strengthening exercises, Posterior oblique sling strengthening exercises
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Acute Pain
A Study to Evaluate the Efficacy and Safety of K-285 Compared With Menthol Gel for the Treatment of Delayed Onset Muscle Soreness (DOMS) in the Lower Extremity
The purpose of this study to evaluate the efficacy and safety of K-285 compared with menthol gel for the treatment of delayed onset muscle soreness (DOMS) in the lower extremity.
- Trial name
- NCT04484428
- Testing
- K-285, Menthol
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
Amputation
AMI Construction in Lower Extremity Residual Limbs
This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy
- Trial name
- NCT04063592
- Testing
- Residual limb revision
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Patellofemoral Pain, PFP, Flatfeet
Comparison Between Foot Segment Mulligan Mobilization and Ilium Mulligan Mobilization in Treatment Patellofemoral Pain Patients With Flatfeet: a Randomized Controlled Comparative Study
This three-arm, parallel-group randomized controlled trial will investigate the comparative effects of adding Mulligan foot-segment mobilization or Mulligan ilium mobilization to a standardized hip-knee focused exercise program…
- Trial name
- PFP (NCT07806929)
- Testing
- mobilization with movement of the foot segment, Mobilization with movement of the Ilium, Hip-knee focused exercises
- Where
- Jordan
- Volunteers
- 90 people
- Sponsor
- Cairo University