Clinical trials: Lower Extremity Pain
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with moderate to severe sciatica (pain in the lower back, hips, buttocks and legs).
- Trial name
- CLEAR 2 (NCT07579351)
- Testing
- SP-102, Dexamethasone Sodium Phosphate 10 MG/ML
- Volunteers
- 755 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Lower Limb Surgery, Pain
Role of Perineural Catheter in Pain Control and Opioid Consumption After Major Amputation of Lower Limb
The goal of this randomized controlled clinical trial is to evaluate the effectiveness of postoperative bupivacaine infusion through a perineural catheter in managing postoperative pain and to determine the opioid consumption…
- Conditions
- Lower Limb Surgery, Pain, Phantom Limb Pain After Amputation, Stump Pain
- Trial name
- NCT07896798
- Testing
- Bubpivacaine, Tramadol, Saline
- Volunteers
- 96 people
- Sponsor
- Aga Khan University
Patellofemoral Pain Syndrome, Patellofemoral Malalignment Syndrome
Influence of Selected Lower Limb Biomechanical Variables on Pain, Disability and Balance in Women With PFPS.
Purpose: The aim of this study is to figure out how does the selection of lower-extremity biomechanical variables presented by dynamic knee valgus, tibial torsion and navicular drop may influence pain, disability, and balance in…
- Trial name
- NCT05842200
- Where
- Egypt
- Volunteers
- 165 people
- Sponsor
- Cairo University
Pain Management, Perioperative Analgesia
From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma
To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.
- Conditions
- Pain Management, Perioperative Analgesia, War-Related Injuries
- Trial name
- CRA-WAR-LIMB S (NCT07474506)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Peripheral Arterial Disease, Claudication (Finding)
Cilostazol After Lower Extremity Arterial Revascularization Trial
Twenty patients will be recruited to CLEAR. Ten will be randomized to the treatment arm (Cilostazol) and tenwill be randomized to the control group. Patients randomized to the treatment arm will receive Cilostazol for 90 days.
- Trial name
- CLEAR (NCT02374957)
- Testing
- Cilostazol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Femoral Neck Fractures
Effect of Local Infiltration Anesthesia With Ropivacaine on Postoperative Pain After Hip Hemiarthroplasty
At St.Olavs Hospital each year about 400 patients are treated for femoral neck fractures, 250 of them receiving hemiarthroplasty.
- Trial name
- NCT02585011
- Testing
- Ropivacaine, Epinephrine, Saline
- Where
- Norway
- Volunteers
- 123 people
- Sponsor
- St. Olavs Hospital
Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI
Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study
Lower extremity varicose veins (LEVV) are common among elderly patients and can cause leg heaviness, pain, and swelling. In some older adults, venous congestion may contribute to knee or peri-knee pain, which is often…
- Conditions
- Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI, Knee Pain, Knee Osteoarthritis
- Trial name
- EVA-Knee-Elder (NCT07239284)
- Testing
- Endovenous Ablation for Varicose Veins
- Volunteers
- 50 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Nerve Pain, Peripheral Nerve Injuries
The Effectiveness of Neurodynamic Techniques in Patients With Nerve-Related Leg Pain
This study aims to verify if patients with nerve-related leg pain benefits from neurodynamic treatment over two weeks.
- Conditions
- Nerve Pain, Peripheral Nerve Injuries, Peripheral Nervous System Diseases, Sciatica
- Trial name
- NCT01954199
- Testing
- Neurodynamic Group
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Piriformis Syndrome
Effects of Global Hip Versus Isolated Abductors Strengthening Exercises in Patients Withsecondary Piriformis Syndrome
The study will be a randomized controlled trial. Twenty-four subjects will be assigned randomly by using the lottery method into two groups.
- Trial name
- NCT05848063
- Testing
- Global hip muscles strengthening exercises, Hip abductors strengthening exercises
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Hip Fracture
Pain Control in Elderly Hip Fracture Patients: Is Intravenous Acetaminophen Superior to Oral Administration?
The primary objective is to determine if intravenous acetaminophen decreases pain scores and the amount of morphine equivalence received as compared to oral acetaminophen in patients greater than 65 years old after sustaining a…
- Trial name
- NCT02774148
- Testing
- IV Acetaminophen, PO Acetaminophen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Corewell Health West
Lower Extremity, Nerve Block
Bupivacaine-Lidocaine vs Bupivacaine for Ultrasound-Guided Popliteal Sciatic Nerve Block
This prospective, randomized, double-blind clinical trial aims to compare the efficacy of two local anesthetic regimens for ultrasound-guided popliteal sciatic nerve block in adult patients undergoing elective distal lower…
- Conditions
- Lower Extremity, Nerve Block, Pain, Postoperative, Pain, Nerve
- Trial name
- PSSNB-BL (NCT07550348)
- Testing
- Bupivacaine-Lidocaine Combination, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Lower Extremity Problem, Surgery
Ibuprofen IV vs Acetaminophen IV for the Treatment of Pain Following Orthopaedic Low Extremity Surgery
This study aims to evaluate the efficacy of IV Ibuprofen versus IV Acetaminophen in the reduction of pain following orthopedic low extremity procedures
- Conditions
- Lower Extremity Problem, Surgery, Postoperative Pain
- Trial name
- NCT03771755
- Testing
- Ibuprofen, Acetaminophen
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Universitas Indonesia
Iliotibial Band Syndrome
Comparative Effects of Clamshells and Frog Pump Exercises
Iliotibial band syndrome is where a tendon called iliotibial band gets irritated or swollen from rubbing against hip or knee when it gets too tensed.
- Trial name
- NCT05973708
- Testing
- Clamshell Exercise, Frog pump exercise
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Postoperative Pain, Pain
Comparison of Analgesic Efficacy of Intrathecal Bupivacaine Versus Bupivacaine Plus Dexmedetomidine in Patients Undergoing Orthopedic Surgeries.
Clinical Trial Overview: Intrathecal Bupivacaine vs. Bupivacaine + Dexmedetomidine Primary Objective Duration of Analgesia:** To compare the mean duration of postoperative pain relief between hyperbaric bupivacaine alone versus…
- Conditions
- Postoperative Pain, Pain, Orthopaedic Surgery, Anesthesia, Spinal
- Trial name
- NCT07866508
- Testing
- Dexmedetomidine plus Hyperbaric Bupivacaine, Hyperbaric bupivacaine % 0.5
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheikh Khalifa Bin Zayed Al Nahyan Combined Military Hospital Muzaffarabad
Lumbar Spinal Stenosis
Dynamic Stabilization for Lumbar Spinal Stenosis With Stabilimax NZ® Dynamic Spine Stabilization System
The purpose of this trial is to assess whether the Stabilimax NZ® is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal…
- Trial name
- NCT00529997
- Testing
- Stabilimax NZ® Dynamic Spine Stabilization System
- Where
- 19 sites in United States
- Volunteers
- 480 people
- Sponsor
- Applied Spine Technologies
Varicose Veins Leg, Great Saphenous Vein Insufficiency
Calcium Dobesilate After Radiofrequency Ablation for Varicose Veins
This study evaluates whether calcium dobesilate, a venoactive drug, improves recovery after radiofrequency ablation (RFA) for varicose veins.
- Conditions
- Varicose Veins Leg, Great Saphenous Vein Insufficiency, Chronic Venous Insufficiency
- Trial name
- NCT07390097
- Testing
- calcium dobesilate
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Oguz Arslanturk
CHARCOT MARIE TOOTH DISEASE
Evaluation of the Analgesic Efficiency of the Transcutaneous Neurostimulation in the Charcot Syndrome Marie Tooth on the Pains of Lower Limbs
The Charcot syndrome Marie Tooth is the most frequent hereditary neuromuscular diseases: there is no curative treatment at present, on the other hand precautionary measures can be taken (physiotherapy, port of splints…
- Trial name
- NCT01918826
- Testing
- TENS
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sciatica Due to Intervertebral Disc Disorder
Two-leg Rotation and Sciatica
this study including the application of a specific technique of Mulligan mobilization calles 2 leg rotation on patients having lumbar discogenic lesion with sciatica.
- Trial name
- (MWM) (NCT07444125)
- Testing
- standard physical therapy, 2 leg rotation
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- University of Hail
Anterior Cruciate Ligament Injuries, Postoperative Pain
Multimodal Analgesia vs. Femoral Block in ACL Surgery
This study aims to compare the effects of a preemptive multimodal intravenous analgesia protocol and a femoral triangle block on early postoperative rehabilitation compliance in patients undergoing anterior cruciate ligament…
- Conditions
- Anterior Cruciate Ligament Injuries, Postoperative Pain, Pain, Postoperative
- Trial name
- MAPvsFTB (NCT06936995)
- Testing
- Preemptive Multimodal Intravenous Analgesia, Femoral Triangle Block
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Ankara University
Hip Fractures
PENG vs Femoral Block for Hip Fracture Analgesia
This study aims to compare the Pericapsular Nerve Group (PENG) block with femoral block for hip fracture pain. Participants presenting to the hospital with a diagnosis of hip fracture and consenting to analgesic block will…
- Trial name
- NCT07073209
- Testing
- PENG Block Administration, Femoral Block Administration, Bupivacaine , epinephrine Dexamethasone
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Weill Medical College of Cornell University