Clinical trials: Lower Extremity Surgical Amputation
Amputation Wound, Amputation Stump Complication
RCT on NPWT for Incisions Following Major Lower-limb Amputation to Reduce Surgical Site Infection
Surgical site infections following lower extremity amputations have been reported in up to 40% of patients. Surgical site infections have significant morbidity and even mortality in terms of emergency room visits, length of…
- Conditions
- Amputation Wound, Amputation Stump Complication, Amputation Stump; Infection, Infection
- Trial name
- NCT03144726
- Testing
- Negative pressure wound therapy, Standard dressing
- Volunteers
- 290 people
- Sponsor
- London Health Sciences Centre
Limb Salvage, Diabetes Complication
This Observational Study Evaluates the Clinical Outcomes of Patients With Diabetes Who Utilize a Specialized Dietary Supplements for Foot Ulcer Healing. The Study Documents the Rate of Complete Wound Closure and the Prevention of Lower Extremity Amputations in a Real-world, At-home Setting.
This observational study evaluates the clinical outcomes of patients with diabetes who utilize a specialized dietary supplements for foot ulcer healing.
- Conditions
- Limb Salvage, Diabetes Complication, Dietary Supplements, Healed Ulcer
- Trial name
- NCT07442110
- Testing
- Diabetic foot ulcer treatment by dietary supplements
- Where
- Algeria
- Volunteers
- 35 people
- Sponsor
- Amar h Zireg
Amputation, Anesthesia, Local
Use of Long-acting Bupivacaine In Lower Extremity Amputation
The purpose of this investigator-initiated study is to assess the use of liposomal bupivacaine in major extremity amputation and its effects on post-operative opioid narcotic use, length of stay, and in-hospital costs.
- Conditions
- Amputation, Anesthesia, Local, Opioid Use
- Trial name
- NCT04360421
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Loma Linda University
Diabetic Foot Infection, Surgical Wound
Optimal Antibiotics for Operated Diabetic Foot Infections
Diabetic foot problems, especially infections (DFI), require multiple resources including iterative surgeries and amputations, long-lasting antibiotic therapies, education, off-loading and eventually revascularization and…
- Conditions
- Diabetic Foot Infection, Surgical Wound, Antibiotic Side Effect, Infection
- Trial name
- NCT04081792
- Testing
- Antibiotic therapy
- Where
- Switzerland
- Volunteers
- 643 people
- Sponsor
- Balgrist University Hospital
Diabetic Foot, Amputation, Surgical
Analyzing Anesthetic Techniques in Diabetic Foot Amputation
Diabetic Foot Amputations: A Comprehensive Review of Anesthetic Procedures and Outcomes Introduction: Diabetic foot is a severe complication of diabetes, often resulting in ulceration, osteomyelitis, and gangrene.
- Trial name
- NCT06552910
- Testing
- Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people
- Sponsor
- Ankara City Hospital Bilkent
Abdominal Aortic Aneurysm, Carotid Atherosclerosis
Preconditioning Shields Against Vascular Events in Surgery
Major vascular surgery involves operations to repair swollen blood vessels, clear debris from blocked arteries or bypass blocked blood vessels.
- Conditions
- Abdominal Aortic Aneurysm, Carotid Atherosclerosis, Critical Lower Limb Ischaemia
- Trial name
- SAVES-F (NCT02097186)
- Testing
- Remote ischaemic preconditioning
- Where
- 6 sites in Ireland
- Volunteers
- 400 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Symptomatic Neuroma, Phantom Limb Pain After Amputation
Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees
This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas.
- Conditions
- Symptomatic Neuroma, Phantom Limb Pain After Amputation, Residual Limb Pain, Neuropathic Pain
- Trial name
- RPNI-AMPUTEE (NCT07420192)
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
Abdominal Aortic Aneurysm, Carotid Atherosclerosis
Preconditioning Shields Against Vascular Events in Surgery
Major vascular surgery involves operations to repair swollen blood vessels, clear debris from blocked arteries or bypass blocked blood vessels.
- Conditions
- Abdominal Aortic Aneurysm, Carotid Atherosclerosis, Critical Lower Limb Ischaemia
- Trial name
- SAVES (NCT01691911)
- Testing
- Remote preconditioning
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Lower Limb Surgery, Pain
Role of Perineural Catheter in Pain Control and Opioid Consumption After Major Amputation of Lower Limb
The goal of this randomized controlled clinical trial is to evaluate the effectiveness of postoperative bupivacaine infusion through a perineural catheter in managing postoperative pain and to determine the opioid consumption…
- Conditions
- Lower Limb Surgery, Pain, Phantom Limb Pain After Amputation, Stump Pain
- Trial name
- NCT07896798
- Testing
- Bupivacaine Infusion, Opioid Infusion, Saline
- Volunteers
- 96 people
- Sponsor
- Aga Khan University
Lower Extremity Surgical Amputation, Post-amputation Phantom Limb Pain
Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
When a limb is amputated, pain perceived in the part of the body that no longer exists often develops, called "phantom limb" pain.
- Trial name
- NCT03461120
- Testing
- Experimental continuous peripheral nerve blocks, Control continuous peripheral nerve blocks
- Where
- 8 sites in United States
- Volunteers
- 208 people
- Sponsor
- University of California, San Diego
Amputation, Surgical, Amputation, Traumatic
Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
When a limb is severed, pain perceived in the part of the body that no longer exists often develops and is called "phantom limb" pain.
- Conditions
- Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
- Trial name
- NCT06071715
- Testing
- ACTIVE cryoneurolysis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Negative-Pressure Wound Therapy, Amputation
The Effect of Negative Pressure Wound Therapy on Wound Healing in Major Amputations of the Lower Limb
The socioeconomic costs of problematic and delayed wound healing following lower limb amputations are enormous to the society. Lower limb amputations is one of the longest known surgical treatments, but also one of the least…
- Conditions
- Negative-Pressure Wound Therapy, Amputation, Wound Heal
- Trial name
- NCT04618406
- Testing
- PICO VAC, Standard care
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- University of Southern Denmark
Acute Pain Management, Analgesic, Nonopioid
A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery
The purpose of this pilot study is to test the safety of oral ketamine to treat acute pain after amputation surgery. The objective of the proposed research is to conclusively determine if oral ketamine is a safe alternative…
- Conditions
- Acute Pain Management, Analgesic, Nonopioid, Amputation of Lower Extremity, All Causes
- Trial name
- NCT02341963
- Testing
- Oral Ketamine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Arthroplasty Complications, Amputation
Clinical Trial Comparing Negative Pressure Wound Therapy and Standard Dry Dressings
Negative pressure dressings are currently widely used in wound management. Their use is gradually being extended to surgical scars.
- Conditions
- Arthroplasty Complications, Amputation, Prosthesis-Related Infections
- Trial name
- BERLYTZ (NCT04520841)
- Testing
- Prevena TM, Dry dressing
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals