Clinical trials: Lower Extremity Wound
Diabetic Foot Ulcer
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System in the Healing of Diabetic Foot Ulcers
This is a randomized controlled multi center study on diabetic patients with the aim of evaluating the efficacy of the adipose tissue processed with the SyntrFuge™ system in diabetic patients with diabetic foot ulcers.
- Trial name
- NCT05519501
- Testing
- Syntrfuge Microfragmented Fat, Standard of Care
- Volunteers
- 62 people
- Sponsor
- Syntr Health Technologies, Inc.
Pressure Ulcer, Arterial Ulcers
Suprasorb® A + Ag in the Treatment of Wounds at Risk of Infection and Infected Wounds
The aim of this post market clinical follow up (PMCF) study is to confirm the performance of Suprasorb® A + Ag wound dressing and rope, to collect safety data regarding expected adverse events and to detect potential unexpected…
- Conditions
- Pressure Ulcer, Arterial Ulcers, Venous Leg Ulcer, Diabetic Ulcers
- Trial name
- NCT05646121
- Testing
- Suprasorb® A + Ag wound dressing and rope
- Where
- 8 sites in Poland
- Volunteers
- 99 people
- Sponsor
- Lohmann & Rauscher
Chronic Wounds, Venous Leg Ulcers (VLUs)
Efficacy of Carbonlife Amniotic Tissue Product in the Treatment of Chronic Wounds
Chronic wounds constitute a significant global health burden, affecting millions of individuals and contributing to increased morbidity, diminished quality of life, and rising healthcare costs.
- Conditions
- Chronic Wounds, Venous Leg Ulcers (VLUs), Diabetic Foot Ulcers (DFUs), Arterial Ulcers
- Trial name
- NCT07223892
- Testing
- Amniotic Tissue Allograft
- Volunteers
- 600 people
- Sponsor
- Bardia Anvar
Stroke, Incomplete Spinal Cord Injury
ZEPU-AI5 Strength Training Study (ZEPUAI5RCT)
The goal of this clinical trial is to learn if robot-assisted lower-limb strength and gait training can improve safety, feasibility, and functional recovery in adults aged 18-60 years with lower-limb motor dysfunction due to…
- Conditions
- Stroke, Incomplete Spinal Cord Injury, Gait Impairment Following Orthopedic Surgery
- Trial name
- NCT07735702
- Testing
- Robotic lower-limb gait training (ZEPU-AI5), Standard-of-care rehabilitation (conventional physiotherapy)
- Where
- Bangladesh
- Volunteers
- 51 people
- Sponsor
- Bangladesh Medical University
Diabetic Foot Ulcer
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers
Diabetic foot ulcer (DFU) is one of the most invalidating complication of diabetes and represents a big economic burden for the society.
- Trial name
- DEFEHU (NCT03137966)
- Testing
- Deferoxamine
- Volunteers
- 174 people
- Sponsor
- Karolinska University Hospital
Chronic Wounds
Chronic Wound Care of Lower Limb in M@diCICAT Center at CHU de Martinique
Chronic wound of lower limb. In developed countries, the prevalence of chronic wounds is linked to the ageing of the population and the increase in chronic diseases such as diabetes, obesity and cardiovascular disease.
- Trial name
- VALRESCIC (NCT05491291)
- Testing
- Patients with chronic wound of the lower limbs
- Where
- Martinique
- Volunteers
- 120 people
- Sponsor
- University Hospital Center of Martinique
Wound Healing Disorder
Lipofilling for Healing of Chronic Wounds
Chronic wounds remain a therapeutic and financial challenge for physicians and the health care systems. Innovative, cheap and effective treatment methods would be of immense value.
- Trial name
- NCT05509673
- Testing
- Lipofilling (sublesional fat grafting)
- Volunteers
- 34 people
- Sponsor
- University of Witten/Herdecke
Traumatic Lower Limb Injury
The Effects of Heel Distraction Height on Foot Loading With Carbon Fiber Custom Dynamic Orthoses
Carbon fiber custom dynamic orthoses (CDOs) and unloading ankle foot orthoses (AFOs) have shown varying levels of success in reducing forces acting on different regions of the bottom of the foot during gait.
- Trial name
- CDODistract (NCT06127316)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Diabetic Foot Ulcer (DFU), Venous Leg Ulcers (VLUs)
Real-World Effectiveness of Amniotic Membrane Allografts Versus Standard Wound Care in DFU, VLU, and PU
This observational study will evaluate the real-world effectiveness of four amniotic membrane-based products (Zenith™, Orion™, SurGraft FT™, Complete ACA™) in addition to standard care, compared with standard care alone.
- Conditions
- Diabetic Foot Ulcer (DFU), Venous Leg Ulcers (VLUs), Pressure Ulcers, Bedsores, Decubitus Ulcer
- Trial name
- NCT07223281
- Where
- 4 sites in United States
- Volunteers
- 2,400 people
- Sponsor
- Legacy Medical Consultants
Hand Injuries
Comparison of Upper Extremity and Lower Extremity Function and Quick DASH
Patient reported outcome measure (PROM) are a method by which to assess outcomes from a patient perspective. The QuickDASH is a commonly used PROM.
- Trial name
- NCT04291170
- Testing
- QDASH, KOOSJR
- Sponsor
- Stanford University
Wound
Doubleblinded RCT of the Omnilux on Lower Extremity Surgical Wounds Left to Heal by Second Intention
The goal of the study is to evaluate the effectiveness of the light-emitting diode (LED) in promoting healing of the wound on lower leg as a result of surgery.
- Trial name
- NCT02383056
- Testing
- Omnilux
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Miami
Musculoskeletal Injury, Spinal Injuries
Predictive Models for Spine and Lower Extremity Injury After Discharge From Rehab
The purpose of this study is to develop algorithms that will help predict future injury and/or re-injury after being returned to duty from a musculoskeletal injury.
- Conditions
- Musculoskeletal Injury, Spinal Injuries, Leg Injuries
- Trial name
- MP3-RD (NCT02776930)
- Where
- 4 sites in United States
- Volunteers
- 480 people
- Sponsor
- Brooke Army Medical Center
Spinal Cord Injury/Disorder, Stroke
Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis
The purpose of this research study is to evaluate the effectiveness of an exercise training intervention (24-36 sessions) to improve muscle strength and endurance in the lower limbs of individuals with paralysis.
- Conditions
- Spinal Cord Injury/Disorder, Stroke, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT07768761
- Testing
- Exercise with Electrical Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Louis Stokes VA Medical Center
Tibial Fractures
Safety Study of Treatment of Leg Fractures
This study evaluates the safety of the EVOS SMALL Plating system in patients who have a fracture of the tibia requiring surgery.
- Trial name
- EVOS SMALL (NCT03881241)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Smith & Nephew, Inc.
Knee Injuries, Athletic Injuries
Risk Factors for Anterior Cruciate Ligament (ACL) Injury
The anterior cruciate ligament (ACL) is located inside the knee joint and provides stability to the knee. ACL injuries occur more frequently in women than men; the reason for this is unknown.
- Trial name
- NCT00124319
- Where
- 3 sites in United States
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- Steve Marshall
Diabetic Foot Ulcers, Diabetic Wound
The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer
The aim of this study is to evaluate the chance of non-healing diabetic foot ulcers repair by improving the condition of lack of oxygen or hypoxia in the wound area caused by diabetes using methylene blue along with the use of…
- Trial name
- NCT05850611
- Testing
- Methylene Blue, Milk (control), Methylene Blue and Platelet-Rich Plasma-Fibrin Glue
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Ulcer Venous, Wound Heal
Observational Study to Investigate the Use of Sterilized Porcine Placental Tissue in the Treatment of Chronic VLU
The study is a multi-center, prospective, clinical trial designed to evaluate the use of InnovaMatrix AC sterilized porcine placental ECM to treat chronic VLUs .
- Trial name
- NCT06400875
- Testing
- InnovaMatrix® AC Sterilized, Porcine Placental Extracellular Matrix (ECM)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- ConvaTec Inc.
Diabetic Foot Ulcers, Wound
Topical Oxygen Therapy for Diabetic Wounds
This is a pilot study which is intended to collect data to calculate an adequate sample size for a larger registered clinical trial.
- Trial name
- NCT02313428
- Testing
- Topical Oxygen Chamber for Extremities
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Diabetic Foot Ulcer
Efficacy Study of IZN-6D4 Gel for the Treatment of Diabetic Foot Ulcers
The purpose of this study is to determine if topical application of a hydrogel that contains plant extracts will improve healing of diabetic foot ulcers when compared to treatment with a hydrogel alone.
- Trial name
- NCT01427569
- Testing
- IZN-6D4 Gel
- Where
- Israel
- Volunteers
- 82 people
- Sponsor
- Izun Pharma Ltd
Critical Lower Limb Ischemia, Critical Limb Ischemia
Evaluation of Carbothera in the Treatment of Foot Ulcers
Foot ulceration usually precedes more serious foot complications such as infection, gangrene or amputation. The risk of developing foot ulcers has been estimated to be higher in individuals with kidney disease.
- Conditions
- Critical Lower Limb Ischemia, Critical Limb Ischemia, Foot Ulcer, Skin Ulceration
- Trial name
- NCT02239419
- Testing
- CO2-Enriched Tap Water (Carbothera), Non-CO2-Enriched Tap Water
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba