Clinical trials: Lower Gastrointestinal Disorder
Gastroesophageal Reflux Disease
A Study to Evaluate the Role of Alternative Medicine in Difficult to Treat GERD Patients
Patients with refractory GERD on BID PPI's assigned to the acupuncture group will have significant improvement in their symptoms after receiving acupuncture for 6 weeks as compared to sham acupuncture given for the same duration.
- Trial name
- NCT00591877
- Testing
- Acupuncture, Yoga
- Where
- United States
- Sponsor
- Midwest Biomedical Research
Intestinal Diseases, Irritable Bowel Syndrome
Biomarkers for Intestinal Permeability in Patients With Constipation
Our overall objective with this study is firstly to provide a comprehensive assessment of intestinal permeability, mucosal barrier function using existing biomarkers and secondly to explore novel biomarkers for measuring…
- Conditions
- Intestinal Diseases, Irritable Bowel Syndrome, Constipation
- Trial name
- NCT02246647
- Testing
- Permeability measurement, Esophagogastroduodenoscopy, Flexible sigmoidoscopy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Urologic Injuries, Urologic Diseases
Bladder Morphology Using 2 Different Catheter Designs
Demonstrate and compare the 3D morphology of the bladder wall in full and drained states with 2 different kinds of bladder catheters in place. (Foley Catheter vs. Cystosure Catheter)
- Conditions
- Urologic Injuries, Urologic Diseases, Bladder Infection, Urinary Tract Infections
- Trial name
- NCT03108079
- Testing
- Cystosure Urinary Access System, Foley Catheter
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The Pelvic Floor Institute
Rectum Cancer
Reconstruction of the Pelvic Floor and Perineal Wound After Rectal ELAPE
A multicenter, cohort, randomized, controlled study is being conducted since the 1of September, 2023 whereby the immediate and long-term results of pelvic floor and perineal wound plastic surgery after extralevatory…
- Trial name
- NCT06066931
- Testing
- Plastic surgery of the pelvic floor and perineal wound with counter-displaced skin-subcutaneous fascial flaps after extralevatory abdominal-perineal extirpation of the rectum, Plastic surgery of the pelvic floor and perineal wound with local tissues, Plastic surgery of the pelvic floor and perineal wound with mesh endoprosthesis
- Volunteers
- 150 people
- Sponsor
- Kuban State Medical University
GERD
Stretta Versus Conservative Treatment
Gastroesophageal reflux disease (GERD) is one of the most common diseases of the gastrointestinal tract. Obesity is a significant risk factor for GERD; however, treatment outcomes in obese patients remain challenging.
- Trial name
- NCT05781347
- Testing
- Radiofrequency Energy to the LES (Stretta Procedure), Stretta
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- Military University Hospital, Prague
Reflux, Gastroesophageal, Achalasia
The Effect of Physiotherapy on Post POEM Reflux
Per-oral endoscopic myotomy has been used as a treatment method of esophageal achalasia. Patients who undergo POEM as a treatment of achalasia are often presented with development of reflux as a side effect of the surgery.
- Conditions
- Reflux, Gastroesophageal, Achalasia, Esophagitis
- Trial name
- NCT05326113
- Testing
- Physiotherapy, Control group
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Dysphagia, Fecal Incontinence
Evaluation of Potential Vitamin D Effects on Muscle: a Pilot Study
People who do not have adequate amounts of vitamin D develop weakness of leg and arm muscles. This study will determine if vitamin D supplementation benefits muscle functions important for swallowing, bladder and bowel function.
- Conditions
- Dysphagia, Fecal Incontinence, Urinary Incontinence
- Trial name
- NCT00593996
- Testing
- Ergocalciferol (vitamin D2)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Achalasia
Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia
Achalasia is a primary esophageal motility disorder where the lower esophageal sphincter fails to relax in response to swallowing with no well understood underlying cause.
- Trial name
- NCT01302288
- Testing
- Per oral endolumenal myotomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Oregon Clinic
Breast Cancer, Prostate Cancer
Survivorship Promotion In Reducing IGF-1 Trial
This is a prospective, single-center randomized trial with three arms, and an allocation ratio of 1:1:1. The study design is an efficacy study to evaluate the effect of metformin and coach-directed behavioral weight loss versus…
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Colon Cancer
- Trial name
- SPIRIT (NCT02431676)
- Testing
- Metformin, Coach Directed Behavioral Weight Loss, Self-control weight loss
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Advanced Heart Failure, Left Ventricular Assist Devices
Trial of Low-intensity Anticoagulation to Reduce GI or Other Bleeding Complications With Equivalent Therapeutic Efficacy in HeartMate 3 LVAD Patients
The TARGET trial is a prospective, single-center, randomized, open-label, active-controlled inequality clinical trial designed to evaluate the safety and efficacy of low-intensity anticoagulation therapy (target INR 1.5-2.0)…
- Conditions
- Advanced Heart Failure, Left Ventricular Assist Devices, Anticoagulation Treatment, Bleeding Complications
- Trial name
- TARGET (NCT07081035)
- Testing
- Warfarin (low-intensity anticoagulation), Warfarin (standard anticoagulation)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Asan Medical Center
HIV/AIDS
Quantification of Estradiol's Impact on Nucleotides in Cellular Populations of the Lower GI Tract
Purpose: To Assess the impact of high and low in vivo estradiol exposure on PrEP (Pre-exposure prophylaxis) nucleotide concentrations in different cellular populations of the lower GI (gastrointestinal) tract and to quantify the…
- Trial name
- NCT03917420
- Testing
- Tenofovir 300Mg Oral Tablet, Emtricitabine 200 MG
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Fecal Incontinence, Dyssynergic Defecation
Home Biofeedback Therapy for Dyssynergic Defecation, Fecal Incontinence and Urinary Incontinence
Biofeedback therapy is an effective treatment for the management of patients with dyssynergic defecation and constipation, urinary incontinence (UI), and fecal incontinence (FI).
- Conditions
- Fecal Incontinence, Dyssynergic Defecation, Urinary Incontinence
- Trial name
- Bioanatoner (NCT05771597)
- Testing
- Home Biofeedback therapy, Office biofeedback therapy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Augusta University