Clinical trials: Lower Gastrointestinal Disorder
Urothelial Carcinoma, Renal Cell Carcinoma
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
This is a multicenter Phase 1b, open-label study to assess safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of cabozantinib taken in combination with atezolizumab in subjects with multiple tumor types…
- Conditions
- Urothelial Carcinoma, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Castration-resistant Prostate Cancer
- Trial name
- NCT03170960
- Testing
- cabozantinib, atezolizumab
- Where
- 124 sites in United States, Australia and 7 more
- Volunteers
- 914 people
- Sponsor
- Exelixis
Rectal Neoplasms
Exercise Training for Rectal Cancer Patients
Cancer treatments often cause acute toxicity during treatment, and late toxicity after treatments have ended. Bowel dysfunctions, incontinence (anal and urinary) and dysfunction are late side effects associated with cancer…
- Trial name
- NCT02538913
- Testing
- Exercise training, Usual care
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Cystic Fibrosis (CF)
Sweat Testing in Infants: Comparing Sweat Collection on Upper Vs Lower Limbs
The goal of this study is to compare the rate of Quantity Not Sufficient (QNS) during sweat collection in infants under 6 months of age, using the Macroduct Advanced device for sweat testing.
- Trial name
- NCT06902363
- Testing
- Macroduct Advanced
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Sexual Function Disturbances, Pelvic Organ Prolapse
Pelvic Floor Disorders Among Sexual Minoritized Women
The investigators aim to perform cognitive interviews to assess how pelvic floor disorders impact sexual functioning in women who have sex with women (WSW).
- Conditions
- Sexual Function Disturbances, Pelvic Organ Prolapse, Urinary Incontinence, Fecal Incontinence
- Trial name
- PRIDE (NCT05072158)
- Testing
- None, this is an observational study
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of New Mexico
Pharyngeal Dysfunction, Esophageal Dysfunction
Opioids and Esophageal Function
The purpose of this study is to evaluate if opioid-induced effects on the pharynx and esophagus is centrally or peripherally mediated.
- Trial name
- NCT01012960
- Testing
- methylnaltrexone
- Where
- 2 sites in Sweden
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Gastrointestinal Diseases
Evaluation of People With Gastrointestinal Disease
Background: Gastrointestinal diseases and disorders affect the throat, stomach, and intestines. There are many different kinds of these diseases. Clinical trials are being developed to study new ways to treat them.
- Trial name
- NCT01639924
- Where
- United States
- Volunteers
- 2,761 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Crohn's Disease
Cimzia Versus Mesalamine for Crohn's Recurrence
Hypothesis: Cimzia provides superior reduction in endoscopic and clinical recurrence rates compared to mesalamine in the treatment of Crohn's disease one-year following ileocolectomy for Crohn's disease. 1.
- Trial name
- NCT01696942
- Testing
- Cimzia, Mesalamine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Milton S. Hershey Medical Center
Colorectal Cancer
Radiation Therapy on Pelvic Floor Disorders in Women
Investigators propose a retrospective cohort study to examine the impact of radiation therapy on the global pelvic floor function of women who have completed the immediate surveillance period for colorectal cancer
- Trial name
- RadPFD (NCT04623515)
- Testing
- REDCap Questionnaires
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Gastroesophageal Reflux Disease
Diagnostic of Transient Lower Esophageal Sphincter Relaxation With Combined Impedance and High Resolution Manometry in Patients With GERD
The aim of this study is to establish and validate High resolution manometry (HRM) criteria for the definition of transient lower esophageal sphincter relaxations (tLESRs) in gastroesophageal reflux disease (GERD) patients.
- Trial name
- HRM RTSIO (NCT01844440)
- Testing
- High resolution manometry
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Bordeaux
Gastro Esophageal Reflux
Effect of Citalopram on Reflux Episodes in Healthy Volunteers
Citalopram is sometimes used in the treatment for gastro-esophageal reflux disease, however, there are no empirical data to support this.
- Trial name
- NCT03746691
- Testing
- Citalopram HCl
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stress Urinary Incontinence, Fecal Incontinence
Effects of Single Dose Citalopram and Reboxetine on Urethral and Anal Closure Function on Healthy Female Subjects
This study will investigate if citalopram, a selective serotonin reuptake inhibitor, is reducing the opening pressure of the urethra and possibly causing or worsening stress urinary incontinence.
- Trial name
- NCT04097288
- Testing
- Citalopram 40mg, Reboxetine 8 mg
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Esophageal Cancer
Bortezomib, Paclitaxel, and Carboplatin in Treating Patients With Unresectable, Metastatic Cancer of the Esophagus or Gastroesophageal Junction
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor…
- Trial name
- NCT00107341
- Testing
- bortezomib, carboplatin, paclitaxel
- Volunteers
- 37 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cirrhosis, Liver
Propofol Versus Midazolam for Lower Gastrointestinal Endoscopy
propofol versus use of midazolam as sedative agent in patients with liver cirrhosis presented for lower gastrointestinal endoscopy
- Trial name
- NCT03388151
- Testing
- Midazolam, Propofol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sherief Abd-Elsalam
Pelvic Floor Disorders
Pelvic Floor Function Evaluation of Singleton Primiparae After Vaginal Delivery and Cesarean Section
Objective of this longitudinal observational cohort study was to analyze incidence of pelvic floor dysfunction (PFD) symptoms, including pelvic organ prolapse (POP), urinary incontinence (UI), and fecal incontinence (FI), seven…
- Trial name
- NCT02661867
- Testing
- delivery
- Volunteers
- 865 people
- Sponsor
- Brno University Hospital
Urinary Urge Incontinence (UUI), Urinary Frequency (UF)
F15 Recharge Free Axonics SNM System Clinical Study
Multicenter, prospective, non randomized, single arm evaluation of patients with overactive bladder (OAB) and/or fecal incontinence (FI) employing the Axonics recharge free SNM System.
- Conditions
- Urinary Urge Incontinence (UUI), Urinary Frequency (UF), Fecal Incontinence (FI)
- Trial name
- NCT06186765
- Testing
- Axonics SNM System (Model 4101)
- Where
- 16 sites in United States, Netherlands and 1 more
- Volunteers
- 144 people
- Sponsor
- Axonics, Inc.
Hypertriglyceridemic Acute Pancreatitis, Acute Pancreatitis, Hypertriglyceridemia-induced
Bacillus Subtilis and Enterococcus Faecium Probiotic Plus Lipid-Lowering Therapy for Hypertriglyceridemic Acute Pancreatitis: A Prospective RCT
Background: Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) has become the second most common cause of acute pancreatitis in China, accounting for up to 42.4% of cases, with high recurrence rates and substantial…
- Conditions
- Hypertriglyceridemic Acute Pancreatitis, Acute Pancreatitis, Hypertriglyceridemia-induced, Hyperlipidemia
- Trial name
- NCT07720232
- Testing
- Live Combined Bacillus subtilis and Enterococcus faecium Enteric-coated Capsules (LCBE), Standard Care (in control arm)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Jianyin Zhou
Cirrhosis, Portal Hypertension
A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis
Endothelin is a human hormone which has been associated with increased portal pressure in patients with liver cirrhosis (also called portal hypertension). Ambrisentan blocks the effects of endothelin.
- Conditions
- Cirrhosis, Portal Hypertension, Ascites
- Trial name
- NCT03827200
- Testing
- Ambrisentan
- Where
- 6 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Noorik Biopharmaceuticals AG
Diverticulitis, Colonic
Unexpected Diagnosis in Right Lower Quadrant Pain: Right Colon Diverticulitis
BACKGROUND: Acute right lower quadrant pain is a common symptom in emergency departments. The most common etiology is thought to be acute appendicitis. Other etiologies may be overlooked.
- Trial name
- NCT06153030
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Esophageal Cancer, Thoracic Diseases
Generation of a Surgical Field in the Left Lateral Decubitus Position
The generation of a good surgical field at the mid-lower mediastinum during thoracoscopic esophagectomy in the left lateral decubitus position is often complicated.
- Trial name
- NCT04683601
- Testing
- Thoracoscopic esophagectomy in left decubitus
- Volunteers
- 154 people
- Sponsor
- Shizuoka Cancer Center
Uterine Prolapse, Urinary Incontinence
Delivery Method and Risk for Urogenital Prolapse 15-20 Years Later
The lifetime risk for a woman to undergo surgery for either vaginal prolapse or urinary incontinence is high. Previous studies have shown that pregnancy and childbirth are risk factors for developing prolapse.
- Conditions
- Uterine Prolapse, Urinary Incontinence, Fecal Incontinence
- Trial name
- uropro (NCT01766193)
- Testing
- vaginal delivery, forceps extraction, vacuum extraction
- Where
- Norway
- Volunteers
- 1,641 people
- Sponsor
- Norwegian University of Science and Technology