Clinical trials: Lower Limb Lymphedema
Lymphedema
Compression Stockings for Lymphedema Prevention in Gynecologic Cancer Patients
The goal of this clinical trial was to evaluate whether compression stockings (23-32 mmHg) reduce the incidence of postoperative lymphedema and accompanying symptoms, as well as to assess the comfort of using compression in women…
- Trial name
- csplwgm (NCT06873984)
- Testing
- compression products
- Where
- 2 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Joanna Kurpiewska-Pieniążek
Lymphedema
CVR Registry Evaluating Flexitouch Plus and Conservative Care vs Conservative Care Only for Treatment of Lymphedema
Subjects with lower extremity lymphedema will be prescribed, per standard of care, to either Flexitouch Plus with conservative care or conservative care only and be followed for 12 months.
- Trial name
- NCT04116099
- Testing
- Conservative care, Flexitouch Plus
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- Tactile Medical
Lymphedema, Lymphedema of Leg
The Impact of Supermicrosurgery Intervention on Patients with Lower Extremity Lymphedema Using Groin-Only Approach Lymphaticovenous Anastomosis
This study employs a propensity score-matched analysis to compare the treatment outcomes, focusing on percentage volume reduction between the conventional multi-incision lymphaticovenous anastomosis (LVA) technique and the novel…
- Trial name
- NCT06685926
- Testing
- Supermicrosurgical LVA, Groin Approach Only (lymphatic vessel to recipient vien lumen-to-lumen anastomosis), Supermicrosurgical LVA, Conventional Multiple Access Approach Only (lymphatic vessel to recipient vien lumen-to-lumen anastomosis)
- Where
- Taiwan
- Volunteers
- 189 people
- Sponsor
- Chang Gung Memorial Hospital
Lower Extremity Lymphedema
Diaphragmatic Exercises and Fascial Release Techniques on the Treatment of Lower Extremity Lymphedema
The aim of this study is to determine the effect of multidimensional breathing exercises and fascial release techniques performed in addition to the conventional treatment program on the treatment of lymphatic fluid in women with…
- Trial name
- NCT05483569
- Testing
- Complex Decongestive Physiotherapy, Multidimensional Diaphragmatic Breathing Exercises, Facial Release Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Medeniyet University
Uterine Cervical Neoplasms, Endometrial Neoplasms
Early Intervention to Prevent Lower Limb Lymphedema of Gynecological Malignancy
This study is a prospective, randomized, controlled clinical trial of a single center in China and plans to enroll 400 patients. 1.
- Conditions
- Uterine Cervical Neoplasms, Endometrial Neoplasms, Lymphedema, Treatment Effectiveness
- Trial name
- NCT05793749
- Testing
- Prophylactic lymphedema treatment
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chongqing University Cancer Hospital
Lymphedema, Lipedema
Multimodal Ultrasound for Differentiating Lymphedema and Lipedema
The aim of this observational study is to evaluate the diagnostic value of multimodal ultrasonography in differentiating between lymphedema and lipedema.
- Trial name
- NCT07489248
- Testing
- Multimodal Ultrasound Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Lymphedema, Obesity & Overweight
TECAR and ESWT in Obesity-Related Lower Limb Lymphedema
This randomized controlled trial evaluates the effectiveness of adding TECAR therapy or extracorporeal shock wave therapy (ESWT) to complex decongestive therapy (CDT) in the treatment of bilateral lower-limb lymphedema in…
- Trial name
- NCT07520942
- Testing
- Complex Decongestive Therapy, TECAR Therapy, Extracorporeal Shock Wave Therapy
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Applied Science Private University
Lymphedema
The Effect of Resistance Exercise in Patients With Lower Limb Lymphedema (the LymphEx Study)
The aim of the study is to investigate the short-term (within 2 weeks) effects of resistance exercise with and without compression garments on lower limb lymphedema(LLL).
- Trial name
- LymphEx (NCT07558317)
- Testing
- Resistance exercise
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Carsten Bogh Juhl
Lymphedema
Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema
Juxta-Fit is used for compression treatment. Juxta-Fit is an inelastic compression device which can be easily adjusted to the circumference of the limb and is usually used during the maintenance phase of lymphedema treatment.
- Trial name
- NCT01068431
- Testing
- bandaging with trico as active controller
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Nij Smellinghe Hosptial
Lymphedema
Ubenimex in Adult Patients With Lymphedema of The Lower Limb (ULTRA)
This proof-of-concept study is designed as a randomized, double-blind, placebo-controlled study comparing ubenimex at 150 mg, 3 times daily (total daily dose of 450 mg) with placebo for 6 months treatment period in patients with…
- Trial name
- NCT02700529
- Testing
- ubenimex
- Where
- 4 sites in United States, Australia
- Volunteers
- 54 people
- Sponsor
- Eiger BioPharmaceuticals
Lower Extremity Lymphedema
Platelet Rich Plasma, Complex Decongestive Physiotherapy and Low Level Laser in Treatment of Lower Extremity Lymphoedema
At the end of the study, comparative information about the effects of PRP, complex decongestive physiotherapy and low level laser on edema volume, range of motion, muscle strength, functional capacity and quality of life will be…
- Trial name
- NCT03080207
- Testing
- PRP method, Low Level Laser, Complex Decongestive Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Lower Extremity Lymphedema, Endometrial Cancer
Lymphedema in Endometrial Cancer
Objectives: (1) To determine the incidence of lower-extremity lymphedema after staging surgery for endometrial cancer; (2) to describe lymphedema-related morbidity after staging surgery for endometrial cancer and (3) to evaluate…
- Trial name
- NCT01914276
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Lower Extremity Lymphedema
Respiratory and Relaxation Training in Lower Extremity Lymphedema
This randomized controlled trial aims to investigate the effectiveness of respiratory and relaxation training added to standard complex decongestive therapy (CDT) on muscle oxygenation, functional capacity, and limb volume in…
- Trial name
- NCT07697482
- Testing
- Complex Decongestive Therapy, Respiratory and Relaxation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Toros University
Lymphedema, Secondary Lymphedema
Efficacy of Complete Decongestive Therapy for Limb Lymphedema: Response Profile and Predictive Modeling
Background: Complete decongestive therapy (CDT) is the standard treatment for lymphedema, but response varies by localization and laterality.
- Conditions
- Lymphedema, Secondary Lymphedema, Breast Cancer-Related Lymphedema, Upper Extremity Lymphedema
- Trial name
- LYMPH-PROG (NCT07878598)
- Testing
- Intensive phase of Complete Decongestive Therapy
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Ryazan State Medical University
Lymphedema
Lymphedema Study for Arm or Leg Lymphedema
This study compares the effectiveness of a study drug versus placebo in the treatment of lymphedema.
- Trial name
- NCT02257970
- Testing
- Ketoprofen
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Stanford University
Lymphedema
Effects of Complex Decongestive Therapy Applied on Patients With Lower Extremity Lymphedema
The aim of this study is to investigate the effects of complex decongestive therapy applied to patients with lymphedema in the lower extremities on body awareness, functionality and quality of life.
- Trial name
- NCT05239273
- Testing
- Complex Decongestive Therapy, Control
- Volunteers
- 40 people
- Sponsor
- Ankara Yildirim Beyazıt University
Urinary Bladder Neoplasms, Prostatic Neoplasms
Lymphedema After Urologic Surgery
Lymphedema of the extremities is common after lymph node surgery in treating several forms of cancer, e.g., breast cancer. However, very little is known of the occurrence of lymphedema of the lower extremities after urologic…
- Conditions
- Urinary Bladder Neoplasms, Prostatic Neoplasms, Testicular Neoplasms, Penile Cancer
- Trial name
- NCT05264337
- Testing
- Self-reported lymphedema, Dielectric constant ratio, Limb volume
- Where
- 2 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Vastra Gotaland Region
Lymphedema, Lower Limb
Shock Wave Therapy for Lower Limb Lymphedema
This is a double-blind randomized clinical trial to compare the effect of shock wave therapy on lower limb lymphedema. There are two arms: A) complex decongestive therapy + extracorporeal shock waves therapy; B) complex…
- Trial name
- NCT06454734
- Testing
- Extracorporeal shock wave therapy by radial device, DLT
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Parc de Salut Mar
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 3
The current best practice is a three-stage classification consensus guideline as published by the International Society of Lymphology (ISL).
- Trial name
- EvaLymph-Leg3 (NCT05757284)
- Testing
- Lower Limb Lymhedema assessment
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 140 people
- Sponsor
- KU Leuven
Lymphedema of Leg
Establishing Guidelines for Manual Lymphatic Drainage
The purpose of this study is to establish optimal guidelines for Manual Lymphatic Drainage in participants with lower extremity lymphedema.
- Trial name
- MLD (NCT05509062)
- Testing
- Pressure
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Colorado, Denver