Clinical trials: Lower Respiratory Infection
Lower Respiratory Tract Infection
The Effect of a Family-Centered Care Approach on Infants Receiving High-Flow Nasal Oxygen Therapy
This research is an experimental study of randomized control with pre-test - post-test control group. The aim of this study is to determine the effect of family-centered care approach on physiological parameters and follow-up…
- Trial name
- NCT07183553
- Testing
- maintenance training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Healthy
Study to Evaluate the Safety of MEDI-534 Vaccine Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in Healthy Children
This is a randomized, double-blind, placebo-controlled, dose-escalation, Phase 1, multi-center study to evaluate the safety, tolerability, immunogenicity, and viral shedding of MEDI-534 in healthy children 1-9 years of age who…
- Trial name
- NCT00345670
- Testing
- MEDI-534
- Where
- 12 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Bronchiolitis, Noninvasive Ventilation
Point-of-Care Lung Ultrasound for Prognosis in Critically Ill Infants With Acute Lower Respiratory Tract Infection
Prospective, observational multicentric study which aims at identifying lung POCUS (Point of Care UltraSound) findings associated with failure of noninvasive ICU-LRS (Intensive Care Unit Level Respiratory Support) (defined as…
- Trial name
- Bacon-Pocus (NCT06425107)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Vittore Buzzi Children's Hospital
Influenza
Safety and Efficacy of Oseltamivir in Children Younger Than One Year of Age
Currently, there is no standard treatment for influenza with related lower respiratory tract infection (LRTI) in children younger than one year of age, even though influenza related LRTI is a potentially fatal illness in these…
- Trial name
- NCT01037634
- Testing
- Oseltamivir
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Otitis Media, Febrile Illness
Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life
HYPOTHESES: 1. That infants receiving PHiD-CV10 as a booster at 12 months of age, compared to controls having no PHiD-CV10 booster (i.e.
- Conditions
- Otitis Media, Febrile Illness, Cough, Lower Respiratory Tract Infection
- Trial name
- PREV-IX_B (NCT01735084)
- Testing
- Prevenar13, Synflorix
- Where
- Australia
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Aided Antimicrobial Therapy vs Standard of Care
Antibiotic resistance is driven by overuse, especially for viral respiratory infections. Procalcitonin (PCT), a biomarker for bacterial infections, helps guide antibiotic therapy more precisely, reducing unnecessary use and…
- Trial name
- PCT (NCT06960044)
- Testing
- Procalcitonin-guided antibiotic management, Standard of care
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Diarrhea, Pneumonia
Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children
Zinc deficiency is common in developing country children, as food intakes are often low, foods from animal sources are infrequently used, the bioavailability of zinc from staple cereal-based diets is limited and zinc losses occur…
- Conditions
- Diarrhea, Pneumonia, Acute Respiratory Tract Infection
- Trial name
- NCT00272116
- Testing
- Zinc and vitamin A single dose at enrollment
- Where
- India
- Volunteers
- 2,482 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Lower Respiratory Tract Infection
The Clinical Value of FA in AHLRI Patients
LRTI (Lower respiratory tract infection) is a severe disease in China. The fast and accurate diagnosis of pathogens, bacteria or viruses that cause the infection is critical for the therapy.
- Trial name
- FALRI (NCT03391076)
- Testing
- FilmArray Respiratory Panel
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Bin Cao
Covid19, Hypoxia
Higher vs. Lower Doses of Dexamethasone for COVID-19 and Severe Hypoxia
We aim to assess the benefits and harms of higher (12 mg) vs lower doses (6 mg) of dexamethasone on patient-centered outcomes in patients with COVID-19 and severe hypoxia.
- Trial name
- COVIDSTEROID2 (NCT04509973)
- Testing
- Dexamethasone
- Where
- 53 sites in Denmark, India and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Scandinavian Critical Care Trials Group
Pneumonia, Lower Respiratory Tract Infection
Recurrent Pneumonia in Children
This study aimed to analyses the clinical characteristics, risk factors and underlying causes as predictors of recurrent pneumonia in children attending AUCH
- Conditions
- Pneumonia, Lower Respiratory Tract Infection, Chest Infection
- Trial name
- NCT06583317
- Volunteers
- 53 people
- Sponsor
- Assiut University
Chest Infection, Pulmonary Edema - Acute
Grasshopper: a Novel Clinical Dashboard for Radiologists
Does a radiology clinical dashboard increase radiologist use of specific reporting language for chest X-rays (CXRs) and thereby decrease rates of unnecessary Emergency Department (ED) prescriptions and follow-up imaging?
- Trial name
- Grasshopper (NCT06785246)
- Testing
- Grasshopper dashboard
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Severe Pneumonia
Detection and Characterization of Lower Respiratory Infections in Critically Ill Patients
This study is a prospective observation study for lower respiratory tract infections in medical intensive care unit. Microbiologic and clinical characteristics and outcomes of patients with severe pneumonia in medical intensive…
- Trial name
- NCT01068990
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Respiratory Infection (for Example, Pneumonia, Bronchitis)
Treatment of Upper and Lower Respiratory Tract Infections in Young Children Using Probiotic
This project aims to study the benefits of probiotics namely Bifidobacterium lactis M8 in treatment of upper and lower respiratory tract infections in young children, which are found common among children in Malaysia aged from…
- Trial name
- NCT04122495
- Testing
- Probiotic
- Where
- Malaysia
- Volunteers
- 120 people
- Sponsor
- Universiti Sains Malaysia
Respiratory Tract Infections
TRACE E-learning Implementation in Belgium
Antibiotic resistance is a worldwide health care problem. Increasing use of antibiotics is associated with an increase in the prevalence of bacteria resistant to the antibiotic used.
- Trial name
- NCT03265028
- Testing
- TRACE e-learning
- Where
- 11 sites in Belgium
- Volunteers
- 15,802 people
- Sponsor
- Universiteit Antwerpen
Lower Respiratory Tract Infection, Pneumonia
Reducing Overuse of Antibiotics With Decision Support
Eliminating inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTI) is the central focus of this research.
- Conditions
- Lower Respiratory Tract Infection, Pneumonia, Asthma, Bronchiolitis, Viral
- Trial name
- ROADS (NCT06788093)
- Testing
- ED Clinical Decision Support (CDS-ED), Transitions Clinical Decision Support (CDS-Tr)
- Where
- 3 sites in United States
- Volunteers
- 2,800 people
- Sponsor
- Vanderbilt University Medical Center
Lower Respiratory Tract Infection, Unspecified Fever
Assess a Diagnostic Tool to Distinguish Between Bacterial and Viral Infection
In the past 70 years antibiotics have served as the first line of defense against infectious diseases. However, antibiotics are only effective against bacterial infections and are not the solution for infections caused by viruses…
- Trial name
- OPPORTUNITY (NCT01931254)
- Where
- 3 sites in Israel, Netherlands
- Volunteers
- 777 people
- Sponsor
- UMC Utrecht
Covid19, COVID-19 Pneumonia
Efficacy and Safety of Antimicrobial Stewardship Intervention in Hospitalized COVID-19 Patients (COVASP)
COVID-19 is respiratory disease caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), a novel coronavirus which has spread rapidly across the world with over 149.9 million laboratory confirmed cases and over 3.1…
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Lower Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- COVASP (NCT04896866)
- Testing
- Antimicrobial stewardship prospective audit and feedback
- Where
- 3 sites in Canada
- Volunteers
- 833 people
- Sponsor
- University of Alberta
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Antibiotic Consensus Trial (ProACT)
The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory…
- Trial name
- ProACT (NCT02130986)
- Testing
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician
- Where
- 13 sites in United States
- Volunteers
- 1,664 people
- Sponsor
- University of Pittsburgh
Lower Respiratory Tract Infection
Recovery Time in Children With Lower Respiratory Tract Infections Treated With Klacid® Granules for Oral Suspension.
Klacid Granules for Oral Suspension provides short symptoms' recovery time in Thai children with lower respiratory tract infections.
- Trial name
- NCT01076166
- Testing
- clarithromycin (Klacid) granules for oral suspension
- Where
- 16 sites in Thailand
- Volunteers
- 337 people
- Sponsor
- Abbott
Nosocomial Pneumonia, Ventilator Associated Pneumonia
Characteristics of Lower Respiratory Tract Escherichia Coli Isolates in Mechanically Ventilated Intensive Care Patients
Prospective, multicenter observational study to collect Escherichia coli (E. coli) isolates originating from mechanically ventilated intensive care unit (ICU) patients; in order to characterize phenotype and genotype of E.
- Conditions
- Nosocomial Pneumonia, Ventilator Associated Pneumonia, Escherichia Coli Infections, Escherichia Coli Pneumonia
- Trial name
- COLOCOLI (NCT03303937)
- Volunteers
- 289 people
- Sponsor
- Hôpital Louis Mourier