Clinical trials: Lower Respiratory Tract Infection
Covid19
Comparing the Effects of Different Doses of Dexamethasone to Treat Inpatient COVID-19
This open label clinical trial is to evaluate two different doses of dexamethasone on the health outcome using World Health Organization ordinal scale at day 28 in hospitalized patients with COVID-19.
- Trial name
- NCT04707534
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Oklahoma
COVID-19 Lower Respiratory Infection, Microbial Colonization
Oral Probiotics and Secondary Bacterial Pneumonia in Severe COVID-19
Background and aims: Patients with severe Coronavirus Disease 2019 (COVID-19) are prone to secondary bacterial pneumonia. The use of probiotics against oral pathogens might prevent lung colonization and progression to bacterial…
- Conditions
- COVID-19 Lower Respiratory Infection, Microbial Colonization, Severe COVID-19, Secondary Bacterial Pneumonia
- Trial name
- NCT05175833
- Testing
- Oral probiotics
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Universidade de Passo Fundo
VAP - Ventilator Associated Pneumonia
Efficiency and Safety of the Prolonged Use of Heat and Moisture Exchangers in ICU
FILTRex is a single-centre, controlled, randomised, prospective, non-inferiority clinical trial to compare the efficiency and safety of prolonged (72-hours) versus standard (24-hours) duration of use for Heat and Moisture…
- Trial name
- FILTRex (NCT06410664)
- Testing
- 72-hour HME exchange interval group, 24-hour HME exchange interval group
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
Respiratory Syncytial Virus Infections
A Study on the Immune Response, Safety and the Occurrence of Respiratory Syncytial Virus (RSV)-Associated Respiratory Tract Illness After Administration of RSV OA Vaccine in Adults 60 Years and Older
The purpose of the current study is to evaluate the immune response of the RSVPreF3 OA investigational vaccine in older adults (OA) at least (>=) 60 years of age (YOA) in China compared to OA in the same age range to be enrolled…
- Trial name
- NCT06551181
- Testing
- RSVPreF3 OA investigational vaccine
- Where
- 40 sites in China, Finland and 5 more
- Volunteers
- 2,620 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Reflux Esophagitis
A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County)
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province.
- Trial name
- NCT07755384
- Testing
- Sedated gastroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
COVID-19 Lower Respiratory Infection, SARS-CoV2 Infection
Osteopathic Manipulative Therapy Effects on Prolonged Post-COVID Olfactory Dysfunction
The goal of this project is to determine the efficacy of a treatment method that increase a participants sense of smell after suffering from COVID-19 related decline in smell.
- Trial name
- NCT05112887
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio University
Children Chest Infection
Bacterial Pathogens Associated With Community-acquired Pneumonia in Children
Pediatric community acquired pneumonia (CAP) is one of the most common reasons for hospital admission, there is no reliable way of distinguishing the causative organism based on clinical features.
- Trial name
- NCT06377163
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Delta University for Science and Technology
Respiratory Tract Infections
Prevention of Respiratory Infections Among Children Under 3 Years of Age Attending Daycare Centres
The aim of this study is to evaluate the influence of Primary and Secondary Prevention of Respiratory Infections in children up to 3 years-old attending daycare.
- Trial name
- PRICAD (NCT02588963)
- Testing
- Health education session, Nasal clearance Protocol, Control
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Polytechnic Institute of Porto
Depression, Mood Disorders
Cold and Heat Investigation to Lower Levels of Depression
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body…
- Conditions
- Depression, Mood Disorders, Healthy (Controls)
- Trial name
- CHILL'D (NCT06263738)
- Testing
- Whole Body Hyperthermia, Cold Water Plunge
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Barry Sandler
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Follow-up of Covid-19 Long Term Sequelae
The protocol, in accordance with the objectives of ORCHESTRA project - Work Package 2, aims at investigating the characteristics and determinants of COVID-19 long-term sequelae.
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05097677
- Testing
- Not applicable (observational study)
- Where
- 7 sites in Belgium, France and 4 more
- Volunteers
- 7,599 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Upper Respiratory Tract Infection, Lower Respiratory Tract Infection
RI-001 in Immunosuppressed Respiratory Syncytial Virus (RSV) Infected Patients at Risk of Lower Tract RSV Illness
RSV infections can develop into serious, life threatening conditions among immunocompromised patients. The objective of this study (ADMA 001) is to evaluate the safety and efficacy of RI-001 for the prevention of lower…
- Trial name
- NCT00632463
- Testing
- RI-001
- Where
- 19 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- ADMA Biologics, Inc.
Community-acquired Pneumonia
Role of Multiplex PCR in CAP
1. role of multiplex PCR in early identifying bacteria in patients with lower respiratory tract infection. 2. effect of early starting targeted antibiotics on outcome
- Trial name
- NCT06097117
- Testing
- MultiplexPCR
- Volunteers
- 66 people
- Sponsor
- Assiut University
Respiratory Syncytial Virus Infections
A Study in India on the Immune Response and Safety of a Respiratory Syncytial Virus (RSV) Older Adults (OA) Vaccine When Given to Older Adults 60 Years of Age and Above and Adults 50-59 Years of Age at Increased Risk (AIR) of Respiratory Syncytial Virus Lower Respiratory Tract Disease (RSV-LRTD)
The purpose of the study is to evaluate the immunogenicity and safety of a single dose of investigational RSVPreF3 OA vaccine in Indian older adults 60 years of age (YOA) and above and Indian adults 50-59 YOA at increased risk of…
- Trial name
- NCT06614725
- Testing
- RSVPreF3 OA investigational vaccine
- Where
- 14 sites in India
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic or Recurrent Appendicitis
Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain
It is questionable whether elective appendectomy can effectively reduce pain in persistent or recurrent lower abdominal quadrant pain due to chronic appendicitis.
- Trial name
- NCT00413855
- Testing
- laparoscopic appendectomy or not (surgery)
- Volunteers
- 40 people
- Sponsor
- Maxima Medical Center
Healthy Young Adults, Influenza Vaccines
Characterizing the Human Airway Immune Response to FluMist Vaccination
The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine.
- Conditions
- Healthy Young Adults, Influenza Vaccines, Influenza Vaccine Response
- Trial name
- EVax-3 (NCT07177417)
- Testing
- FluMist, inactivated influenza vaccine, bronchoscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Arterial Disease of Legs, Atherosclerosis of Artery
Safety and Efficacy of Cold Laser Plaque Ablation for Lower Limb Arterial Stenosis and Occlusive Lesions
This study is a prospective, multi-center, randomized controlled study, which evaluates the effectiveness and safety of cold laser plaque ablation for lower limb arterial stenosis and occlusive lesions from intermittent…
- Trial name
- NCT06211127
- Testing
- Cold laser plaque ablation, The excimer laser
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Xuanwu Hospital, Beijing
Cold Therapy
Is Cryotherapy Beneficial After Surgical Removal of Impacted Lower Third Molars?
The present study aimed to investigate the effects of cryotherapy on postoperative parameters (pain intensity, edema, trismus, and the quality of life) after lower third molar extraction.
- Trial name
- NCT07370870
- Testing
- Cold Therapy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Henrique Tedesco
Influenza, Pneumonia
Oseltamivir Randomised Controlled Efficacy Trial
Background In preparation for a global influenza pandemic, there is an urgent need for representative data from populations and settings where the pandemic is most likely to arise.
- Conditions
- Influenza, Pneumonia, Lower Respiratory Tract Infection, Upper Respiratory Tract Infection
- Trial name
- NCT00707941
- Testing
- Oseltamivir
- Where
- Bangladesh
- Volunteers
- 1,190 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Sepsis
A Comparative Study Between Neutrophil/Lymphocyte Ratio and Lactate/Albumin Ratio as Predictive Inflammatory Markers for Sepsis
Aim of this study is to predict the prognostic values of Neutrophil/ Lymphocyte ratio and Lactate/Albumin ratio in the outcome of patients with sepsis and septic shock with lower respiratory tract infection, also to compare…
- Trial name
- NCT07089524
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Ain Shams University
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Antibiotic Consensus Trial (ProACT)
The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory…
- Trial name
- ProACT (NCT02130986)
- Testing
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician
- Where
- 13 sites in United States
- Volunteers
- 1,664 people
- Sponsor
- University of Pittsburgh