Clinical trials: Lower Urinary Tract Symptoms
Overactive Bladder Syndrome, Overactive Bladder
Comparing Number of Injection Sites of In-office Intravesical Onabotulinumtoxin A Treatments for Overactive Bladder: A Randomized Controlled Trial
Overactive bladder (OAB) is a syndrome characterized by urinary urgency, with or without urinary incontinence, nocturia, and urinary frequency.
- Trial name
- NCT05157295
- Testing
- OnabotulinumtoxinA
- Volunteers
- 100 people
- Sponsor
- Augusta University
Overactive Bladder, Deprescribing
Deprescribing dRrugs for Overactive Bladder in General Practice (DROP)
The objective is to understand and evaluate the effectiveness of a deprescribing intervention in primary care, specifically targeting medications for overactive bladder in individuals aged 65 or older.
- Conditions
- Overactive Bladder, Deprescribing, PIMS
- Trial name
- DROP (NCT06110975)
- Testing
- deprescribing-intervention
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Anne Estrup Olesen
Bladder Pain Syndrome, Interstitial Cystitis
Intravesical Injection of Dextrose to Improve Lower Urinary Tract Symptoms Caused by Chronic Cystitis
The pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC) is currently unclear. Scholars have put forward different hypotheses, including the function of the extracellular matrix surface of the glycosaminoglycan…
- Trial name
- NCT04821882
- Testing
- Dextrose
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- National Defense Medical Center, Taiwan
Overactive Bladder
Predictive Utility and Mechanisms of Sacral Evoked Responses in Sacral Neuromodulation
Electrical stimulation of the sacral nerve can help with bladder problems and pelvic pain but researchers don't understand exactly how the stimulation helps.
- Trial name
- NCT06983470
- Testing
- SNM based on visual-motor responses (VMRs), SNM based on sacral evoked responses (SERs)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Hydrodissection-Assisted Bipolar Prostatic Enucleation Versus Conventional Bipolar Enucleation
This prospective randomized study will compare two surgical techniques for treating benign prostatic hyperplasia. Participants will be assigned to either hydrodissection-assisted bipolar prostatic enucleation-enucleoresection…
- Trial name
- NCT07749794
- Testing
- Hydrodissection-Assisted Bipolar Prostatic Enucleation-Enucleoresection, Conventional Bipolar Prostatic Enucleation-Enucleoresection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Fecal Incontinence
Treatment of Fecal Incontinence After Obstetric Anal Sphincter Injuries
Fecal incontinence (FI), the involuntary loss of solid or liquid stool, is a stigmatising condition. It can have a distressing impact and restriction on quality of life.
- Trial name
- KISS (NCT01528995)
- Testing
- Medtronic Interstim II-3058, Anal bulking injection
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- University Hospital of North Norway
Urinary Incontinence, Sexual Dysfunction
The Effect of the Distance Between Mesh and the Urethra on Sexuality in Patients Who Underwent Transobturator Tape.
Urinary incontinence, commonly observed among women aged 30 to 60, encompasses Stress Urinary Incontinence (SUI), responsible for the majority of cases.
- Conditions
- Urinary Incontinence, Sexual Dysfunction, Ultrasonography
- Trial name
- NCT06211894
- Testing
- transobturator tape
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Overactive Bladder Syndrome
Fesoterodine "add-on" Male Overactive Bladder Study
To evaluate the efficacy and safety of fesoterodine on overactive bladder symptom improvement when added to ongoing alpha blocker treatment.
- Trial name
- NCT00546637
- Testing
- Fesoterodine
- Where
- 137 sites in United States, Belgium and 17 more
- Volunteers
- 947 people
- Sponsor
- Pfizer
Stress Urinary Incontinence
Serial Changes in Micturition Symptoms, Urine Flow and Bladder Voiding Efficiency Following Transobturator Tape Surgery
The aim of this study was to identify the serial changes in lower urinary tract symptoms (LUTS), urine flow and bladder voiding efficiency after transobturator tape (TOT) surgery for treatment of female stress urinary…
- Trial name
- NCT02242422
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- DongGuk University
Urinary Incontinence, Anal Incontinence
Prenatal Pelvic Floor Prevention (3PN)
Objective: Compare pelvic floor disorders (urinary incontinence, anal incontinence, genital prolapse, perineal pain, sexual troubles) 12 month after a first delivery between a group of women with prenatal pelvic floor exercises…
- Conditions
- Urinary Incontinence, Anal Incontinence, Genital Prolapse
- Trial name
- NCT00551551
- Testing
- Pelvic floor muscle training with physiotherapist, Written information about kegel exercises
- Where
- 5 sites in France
- Volunteers
- 280 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Pelvic Organ Prolapse, Stress Urinary Incontinence
Colpocleisis for Advanced Pelvic Organ Prolapse
Pelvic organ prolapse occurs when the pelvic organs (e.g., the uterus or bladder) fall or slide down into the vagina. Pelvic organ prolapse can be corrected with surgery.
- Trial name
- NCT00271037
- Testing
- Colpocleisis prolapse repair surgery, sling or other to treat or prevent stress incontinence
- Where
- 6 sites in United States
- Volunteers
- 152 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Urinary Bladder, Overactive
A Long-term Study of YM178 in Symptomatic Overactive Bladder Patients
The study is intended to test the safety, tolerability, and efficacy of long-term treatment with YM178 in patients with overactive bladder symptoms.
- Trial name
- NCT00840645
- Testing
- YM178
- Where
- 2 sites in Japan
- Volunteers
- 204 people
- Sponsor
- Astellas Pharma Inc
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
AQUABEAM® Robotic System and Ultrasound Accessories
Lower urinary symptoms (LUTS) affect many older men and their frequency and severity increase with age. In the age group between 65 and 79 years the rate of men with moderate and severe LUTS is 20 - 25% (Hunter et al. 1994).
- Trial name
- AQUA (NCT05157529)
- Testing
- AQUABEAM Robotic System, Apogee 2300 digital color doppler ultrasound imaging system
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Urodynamic Stress Incontinence
Tension Free Vaginal Tape (TVT) Versus the Miniarc Sling
The aim of this study is to assess whether the Miniarc suburethral sling is equivalent to the TVT in the treatment of women with urodynamic stress incontinence (USI).
- Trial name
- NCT00843908
- Testing
- Tension Free Vaginal Tape, Miniarc
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Medway NHS Foundation Trust
Stress Urinary Incontinence, Female Urinary Incontinence
Effect of Modified Mesh on Surgical Success in Transobturator Tape Surgery
This study is a single-blind, randomized controlled trial evaluating whether changing the width of the surgical tape (mesh) used in transobturator tape (TOT) surgery improves treatment results in women with stress urinary…
- Conditions
- Stress Urinary Incontinence, Female Urinary Incontinence, Pelvic Floor Dysfunction
- Trial name
- MOTOT (NCT06924450)
- Testing
- 1.2 cm Mesh TOT, 1.0 cm Mesh TOT
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Izzet Celegen
Healthy Volunteer, Pharmacokinetics of YM178
A Study to Investigate the Food Effect on the Pharmacokinetics of YM178 in Healthy, Non-elderly Volunteers
The purpose of the study is to evaluate the effect of food intake on the pharmacokinetics of YM178 in healthy, non-elderly adult subjects.
- Trial name
- NCT00965926
- Testing
- YM178
- Where
- Japan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Overactive Detrusor, Neurogenic Bladder
Safety and Efficacy Evaluation of Oxybutynin Topical Gel In Children With Neurogenic Bladder
This study will evaluate the safety and efficacy of Oxybutynin Chloride 10% Topical Gel in children 3 to less than 17 years old, who have overactive bladder due to a neurogenic condition.
- Trial name
- NCT01192568
- Testing
- Oxybutynin
- Where
- 10 sites in United States
- Volunteers
- 52 people
- Sponsor
- AbbVie
Rectal Neoplasms, Sexual Dysfunction
Robotic Versus Laparoscopic Low Anterior Resection for Rectal Cancer
Prospective randomized trial comparing robotic versus laparoscopic Low anterior resection for rectal cancer. Primary endpoint: Compare urinary dysfunction between robotic and laparoscopic approach.
- Conditions
- Rectal Neoplasms, Sexual Dysfunction, Urinary Incontinence, Quality of Life
- Trial name
- RAR (NCT03209076)
- Testing
- Robotic, Laparoscopic
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Urinary Incontinence, Stress
Treatment of Stress Urinary Incontinence by Injection of Autologous Muscle Fibers Into the Urethral Sphincter.
This pilot study examines safety and efficacy of a simple procedure for treatment of stress urinary incontinence. A muscle biopsy is taken from the thigh, minced and injected into the urethral sphincter.
- Trial name
- NCT01323426
- Testing
- Periurethral injection
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital at Herlev
Overactive Bladder Syndrome
Safety and Efficacy of AV608 in Subjects With Idiopathic Detrusor Overactivity
The purpose of this study is to assess the effects of AV608, a neurokinin 1 (NK-1) antagonist, in subjects with Idiopathic Detrusor Overactivity.
- Trial name
- NCT00335660
- Testing
- AV608
- Where
- 13 sites in Netherlands, United Kingdom
- Volunteers
- 62 people
- Sponsor
- Avera Pharmaceuticals