Clinical trials: Lower Urinary Tract Symptoms (LUTS)
Benign Prostate Obstruction (BPO)
SteamOne - Prospective Database for Rezum Water Vapor Therapy of the Prostate
This study is to assess the clinical data of Rezum (water vapor therapy) in patients with BPO (benign prostate obstruction) and male LUTS (lower urinary tract symptoms) in terms of efficacy, durability and safety in a large…
- Trial name
- SteamOne (NCT05495633)
- Testing
- Collection and evaluation of clinical (CROMs) and patient-reported outcomes (PROMs), Analysis of uroflowmetry data by EmanoFlow Mobile Application (App) and Emano Clinic Portal
- Where
- 19 sites in Austria, Germany and 1 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Basel, Switzerland
HoLEP, Trifecta Achievement
Predictors of Trifecta Achievement After HoLEP
Holmium laser enucleation of the prostate (HoLEP) is a surgical treatment option for men experiencing bothersome lower urinary tract symptoms due to an enlarged prostate.
- Conditions
- HoLEP, Trifecta Achievement, Urinary Incontinence Following Surgical Procedure, Clavien Dindo Surgical Complication Scale
- Trial name
- ReMIUS-BPO (NCT07429994)
- Testing
- Transurethral Holmium Laser Enuclation of the Prostate
- Where
- Turkey (Türkiye)
- Volunteers
- 604 people
- Sponsor
- Ondokuz Mayıs University
Urinary Bladder, Overactive, Urinary Bladder Neck Obstruction
Association With Low Compliance Bladder in Women With LUTS
Hypothesis / aims of study The clinical and urodynamic features on the severity of low compliance bladder in neurologically intact women with lower urinary tract symptoms are indeterminate.
- Conditions
- Urinary Bladder, Overactive, Urinary Bladder Neck Obstruction, Pelvic Organ Prolapse, Urinary Incontinence
- Trial name
- NCT06210477
- Testing
- medical treatment for lower urinary tract symptoms
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Prostate Cancer, Benign Prostatic Hyperplasia
BOTOX in Men With Prostate Cancer With Lower Urinary Tract Symptoms(LUTS)/Benign Prostatic Hyperplasia (BPH)
This is a pilot study examining biological endpoints in men with localized prostate cancer who are scheduled to have radical prostatectomies and men with Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS)…
- Conditions
- Prostate Cancer, Benign Prostatic Hyperplasia, Enlarged Prostate With Lower Urinary Tract Symptoms (LUTS)
- Trial name
- NCT01520441
- Testing
- BOTOX
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Safety, Efficacy
Tamsulosin Monotherapy Versus Combination Therapy With Tadalafil (2.5 mg vs 5 mg) in Managing Male LUTS Secondary to BPH
This study aims to evaluate the short-term impact and clinical outcomes of tamsulosin monotherapy versus combination therapy with tamsulosin plus tadalafil (2.5 mg vs.
- Conditions
- Safety, Efficacy, Tamsulosin, Monotherapy
- Trial name
- NCT07722884
- Testing
- Tamsulosin 0.4 mg + Tadalafil 2.5 mg, Tamsulosin 0.4 mg + Tadalafil 5 mg, Tamsulosin 0.4 mg
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Benign Prostatic Hyperplasia (BPH), Minimal Invasive Surgery
Minimally Invasive Prostate Interventions Registry (MIST Study)
This study is a multicenter prospective patient registry designed to evaluate clinical, functional, and safety outcomes after minimally invasive prostate interventions (MIST) performed for benign prostatic obstruction (BPO)…
- Conditions
- Benign Prostatic Hyperplasia (BPH), Minimal Invasive Surgery, LUTS
- Trial name
- MIST (NCT07242807)
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Necmettin Erbakan University
BPH (Benign Prostatic Hyperplasia), Lower Urinary Tract Symptoms (LUTS)
Safety and Effectiveness Study of the Zenflow Spring System
Evaluate the safety and effectiveness of the Zenflow Spring System in relieving LUTS associated with BPH.
- Trial name
- BREEZE (NCT04987138)
- Testing
- Zenflow Spring System
- Where
- 7 sites in United States
- Volunteers
- 279 people
- Sponsor
- Zenflow, Inc.
Benign Prostatic Hyperplasia (BPH), Obstructive Lower Urinary Tract Symptoms (LUTS)
Prospective Post Market Clinical Trial for the Zenflow Spring System - A Minimally Invasive Treatment for LUTS Associated With BPH.
This is a prospective, randomized, open-label, parallel-group post-market clinical trial (PMCT). The overall objective of this PMCT is to compare the effectiveness, durability, and patient-centered outcomes of the Zenflow Spring…
- Conditions
- Benign Prostatic Hyperplasia (BPH), Obstructive Lower Urinary Tract Symptoms (LUTS), Enlarged Prostate
- Trial name
- NCT07797348
- Testing
- Zenflow Arm: Zenflow Spring System implant procedure, Medical Therapy Tamsulosin
- Volunteers
- 110 people
- Sponsor
- Zenflow, Inc.
Prostatic Hyperplasia
Benign Prostatic Hyperplasia (BPH) Screening Tool Case Finding Study in Subjects >=50 Years
This non-randomized, interventional study will be conducted in a general practice setting to assess the utility of a benign prostatic enlargement (BPE)/benign prostatic obstruction (BPO) screening tool in conjunction with…
- Trial name
- NCT02757963
- Testing
- Benign prostatic enlargement (BPE)/Benign prostatic obstruction (BPO) screening tool, International Prostate Symptom Score (IPSS) screening tool
- Where
- 45 sites in France, Germany and 3 more
- Volunteers
- 1,679 people
- Sponsor
- GlaxoSmithKline
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
Evaluation of the Safety, Tolerability, and Efficacy of the Omega System for the Treatment of LUTS Due to BPH
This is a prospective, two-stage, multi-center, pilot clinical study to evaluate the safety/tolerability/efficacy of the Omega System device.
- Trial name
- Omega (NCT05757687)
- Testing
- Omega device
- Where
- 5 sites in Georgia
- Volunteers
- 11 people
- Sponsor
- ProArc Medical
Lower Urinary Tract Symptoms
Comparison of 2 Extracts of Saw Palmetto Versus Placebo on Lower Urinary Tract Symptoms (LUTS) and Urinary Frequency
A randomized, double-blind, placebo-controlled, parallel group study to compare 2 extracts of saw palmetto versus placebo on lower urinary tract symptoms and urinary frequency in 120 generally healthy participants, 45 - 80 years.
- Trial name
- NCT06266000
- Testing
- Saw palmetto extract 320mg per day, Commercial Saw palmetto extract 320mg per day, Palm Oil capsule
- Where
- Australia
- Volunteers
- 89 people
- Sponsor
- RDC Clinical Pty Ltd
Lower Urinary Tract Symptoms
UK ROPE Register Study
This registry study enables us to collect data on the treatment of LUTS using prostate artery embolisation (PAE), and other surgical methods to answer the following questions posed by NICE in 2013: Is PAE a safe and effective…
- Trial name
- UK ROPE (NCT02434575)
- Where
- 17 sites in United Kingdom
- Volunteers
- 318 people
- Sponsor
- Cardiff and Vale University Health Board
Lower Urinary Tract Symptoms (LUTS)
Effects of Macanity on Urinary Health in Males With Lower Urinary Tract Symptoms
The goal of this study is to evaluate the effects of Macanity on urinary health in males experiencing LUTS. Males aged over 40 years of age who experience LUTS will be recruited and assigned to a study treatment which they will…
- Trial name
- NCT07816172
- Testing
- Maca Root
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Benign Prostatic Hyperplasia (BPH) Mobile Application Pilot Study
This study assesses the feasibility, and acceptability of a (mobile) application for men presenting at their physician's office with LUTS/BPH; starting with medical therapy and naïve for treatment.
- Trial name
- NCT03228485
- Testing
- MyBPH Care mobile app
- Where
- 5 sites in Greece, Italy and 3 more
- Volunteers
- 200 people
- Sponsor
- Société Internationale d'Urologie
Lower Urinary Tract Symptoms, Prostatic Hyperplasia
To Evaluate LUTS and Complications Between Indwelling Catheter and Temporary Prostatic Stent in Patients Undergoing Minimally Invasive Procedures for the Treatment of Localized Prostate Cancer or Benign Prostatic Hyperplasia (HERMES)
The goal of this single-centre prospective randomized clinical trial is to compare the post-operative use of temporary prostatic stent (Group 1) vs indwelling catheter (Group 2) in patients undergoing cryotherapy for targeted…
- Conditions
- Lower Urinary Tract Symptoms, Prostatic Hyperplasia, Prostatic Cancer, Urinary Retention
- Trial name
- HERMES (NCT05851521)
- Testing
- Temporary prostatic stent (Exime®), Indwelling catheter
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Lyx Institute
Cerebral Palsy, Lower Urinary Tract Symptoms
Applicability of Uroflowmetry in Children with Cerebral Palsy
Until now, the use of invasive urodynamics with use of catheters is still the gold standard for lower urinary tract evaluation in subjects with CP.
- Trial name
- NCT05017415
- Testing
- uroflow measurement, Bladder ultrasound
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University Hospital, Ghent
Female Stress Urinary Incontinence
Stress Urinary Incontinence Study to Assess Safety and Efficacy of Muvon's Muscle Precursor Cell Therapy
The objective of the SUISSE MPC 2 study is to treat stress urinary incontinence in adult women.
- Trial name
- SUISSE MPC2 (NCT05534269)
- Testing
- autologous muscle precursor cells
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Benign Prostatic Hyperplasia (BPH)
French Aquablation Clinical Investigation Using Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue
Single arm, multi-center prospective clinical trial to determine the safety and effectiveness of the AQUABEAM System in the treatment of benign prostatic hyperplasia (BPH) in men 45 to 80 years of age.
- Trial name
- NCT03191734
- Testing
- AQUABEAM System
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- PROCEPT BioRobotics
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Effect of Different Dosing Regimens of Tadalafil or Tamsulosin Combined With 5α-Reductase Inhibitors on Urinary and Sexual Outcomes in Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) is a common condition among aging men that causes lower urinary tract symptoms (LUTS) and may negatively affect sexual function.
- Conditions
- Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms, Erectile Dysfunction
- Trial name
- DTT-BPH (NCT07715448)
- Testing
- Tamsulosin, Tadalafil, 5-Alpha Reductase Inhibitor
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Beni-Suef University
Lower Urinary Tract Symptoms, Nocturia
Myrbetriq™ (Mirabegron) to Improve Disordered Sleep in Subjects With Lower Urinary Tract Symptoms (LUTS)
The objective of this exploratory pilot study is to assess whether Mirabegron (Myrbetriq™) will improve the quality of sleep and Lower Urinary Tract Symptoms (LUTS) in men and women presenting with LUTS and disordered sleep.
- Trial name
- NCT02410135
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Southern Illinois University