Clinical trials: Lumbar Back Pain
Low Back Pain
Back Pain - Linking Phenotype to Pain Mechanism and Outcome.
To investigate whether different clinical, psychophysical and neurophysiological phenotypes can be identified among low back pain patients
- Trial name
- NCT04433299
- Testing
- no intervention, observational
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Low Back Pain, Mechanical
Short Terms Effects of Medial Branch Block vs Para-spinal Muscle Injection in Patients With Non-specific CLBP
This study compares the efficacy of medial branch block (MBB) vs. paravertebral deep intramuscular (PDI) injection for pain relief in chronic low back pain.
- Trial name
- NCT02521519
- Testing
- Medial branch block in one side, paravertebral deep intramuscular (PDI) injection
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Low Back Pain, Low Back Pain, Recurrent
Structural White and Gray Matter Correlates of Impaired Muscle Control and Deficient Pain Processing
Although the cause of persistent non-specific low back pain (LBP) remains unknown, structural and functional alterations of the brain, alterations in the lumbar muscles and dysfunction of the central nervous system have been…
- Conditions
- Low Back Pain, Low Back Pain, Recurrent, Low Back Pain, Chronic, Healthy Volunteers
- Trial name
- B~Maps (NCT06143319)
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Ghent
Cognitive Dysfunction, Low Back Pain
Frequency of Cognitive Dysfunction in Patients With Chronic Low Back Pain
This study evaluates cognitive dysfunction status and related factors in patients with chronic low back pain over the age of 60.
- Trial name
- NCT06278467
- Testing
- visual pain scale (VASpain/fatigue), Beck depression index (BDI),, Pain catastrophizing scale, sleep quality with a single Likert type question in the Pittsburgh questionnaire, Roland Morris Disability Questionnaire, quality of life with Short Form-36 ( SF-36),
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Konya Beyhekim Training and Research Hospital
Low Back Pain
Gesture Behavior and Knowledge on Low Back Pain Among Nurses
The aim of the proposed study is to evaluate knowledge on low back pain and gesture behavior among nurses with low back pain using validated measures and compare the findings to those from nurses without back pain.
- Trial name
- NCT01556295
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Chronic Low Back Pain (CLBP)
Comparison of the Immediate Effect of Passive vs. Passive-Active Hamstring Stretching on Flexibility in Patients With Chronic Low Back Pain
The goal of this clinical trial is to determine whether a combination of passive and active hamstring stretching (PAS) is more effective than passive stretching alone (PS) in improving flexibility in patients with chronic low…
- Trial name
- EFIM2 (NCT06888895)
- Testing
- Passive-active stretching (PAS), Passive hamstring stretching
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Discogenic Pain, Low Back Pain
Intradiscal Platelet Rich Plasma
To assess changes in pain and function in patients with discogenic low back pain after a standard of care intradiscal injection of Platelet-Rich Plasma (PRP).
- Conditions
- Discogenic Pain, Low Back Pain, Chronic Pain
- Trial name
- NCT04544709
- Testing
- Low back intradiscal injection of platelet rich plasma (PRP)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Chronic Low Back Pain
Patient Engagement Via Crowdsourcing
The study aims to advance pain research by exploring feasibility of crowdsourcing patient pain data via Amazon Mechanical Turk, the largest and most studied crowdsourcing platform in the U.S.
- Trial name
- PECS (NCT03264521)
- Testing
- Surveys
- Where
- United States
- Volunteers
- 8,193 people, healthy volunteers welcome
- Sponsor
- RAND
Chronic Low-back Pain
Brain Effects of Opiate Agonist and Antagonist
This study will look at the short-term effect of morphine on brain response to food.
- Trial name
- NCT04342130
- Testing
- Morphine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Muscle Spasm; Back Pain
Evaluation of Eperisone HCl in the Treatment of Acute Musculoskeletal Spasm Associated With Low Back Pain - A Double Blind, Randomised, Placebo Controlled Clinical Trial
The purpose of this study is to evaluate the efficacy of Eperisone HCl in the treatment of Acute Musculoskeletal spasm associated with Low-Back Pain.
- Trial name
- NCT00327730
- Testing
- Eperisone
- Where
- 4 sites in India
- Volunteers
- 240 people
- Sponsor
- Eisai Inc.
Low Back Pain, Chronic Low Back Pain (CLBP)
Spinery Basivertebral Nerve Ablation for Vertebrogenic Chronic Low Back Pain
The goal of this clinical trial is to learn whether the Spinery® RF Generator and its sterile single-use accessories can safely lower disability and pain in adults with long-term low back pain that is thought to come from changes…
- Trial name
- BASILEA (NCT07696507)
- Testing
- Single Bipolar Ablation, Double Parallel Bipolar Ablation, Double Cross Bipolar Ablation
- Where
- 3 sites in Italy
- Volunteers
- 69 people
- Sponsor
- Axon srl
Chronic Low Back Pain
A Pilot Trial of IV Pamidronate for Low Back Pain
INTRODUCTION Pamidronate and other bisphosphonates (bisph) have an anti-nociceptive effect in animals. In humans, IV pamidronate is analgesic in patients affected by numerous painful conditions, including cancer bone pain…
- Trial name
- NCT01210599
- Testing
- Pamidronate
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pappagallo, Marco, M.D.
Acute Lower Back Pain
Comparative Clinical Trial: Manual Therapy With and Without Radial Extracorporeal Shockwave Therapy to Treat Acute Low Back Pain
The goal of this clinical trial is to learn if the addition of radial pulse therapy to chiropractic care will help adult patients recover faster to an acute bout of low back pain.
- Trial name
- NCT06852898
- Testing
- Chiropractic Care, Radial Extracorporeal Shockwave Therapy (ESWT) - Radial Pulse Therapy
- Where
- United States
- Sponsor
- Northeast College of Health Sciences
Low Back Pain
Postural Re-education in Low Back Pain
The Global Postural Re-Education is a global approach for the treatment of musculoskeletal disease. Using specific progressive posture for stretching particular shortened chain muscle the method wants to equilibrate the…
- Trial name
- NCT00789204
- Testing
- Global Postural Re-education, Standard Exercise Training
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bologna
Chronic Low Back Pain
Erector Spinae Plane Block With or Without Thoracolumbar Fascia Injection for Chronic Low Back Pain
This study aims to investigate whether adding a thoracolumbar fascia (TLF) interfascial injection to an erector spinae plane (ESP) block improves pain relief and functional outcomes in patients with chronic axial low back pain.
- Trial name
- ESP-TLF (NCT07900347)
- Testing
- Ultrasound-Guided ESP Block, Thoracolumbar Fascia Interfascial Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Damla Yürük
Low Back Pain, Neck Pain
Pre-Visit AI Symptom-Checking and Shared Decision-Making in Spine Physical Therapy
Artificial intelligence (AI) symptom-checking tools, including large language models such as ChatGPT, are increasingly used by patients before they seek care.
- Conditions
- Low Back Pain, Neck Pain, Radiculopathy
- Trial name
- NCT07733752
- Testing
- re-visit AI symptom-checker use
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Low Back Pain, Pelvic Pain
Virtual Reality to Improve Low-back Pain and Pelvic Pain During Pregnancy
A large percentage of women suffer low back and pelvic pain both during and after pregnancy. There are several factors to which these complaints are attributed, even affecting their daily lives.
- Trial name
- NCT05571358
- Testing
- Virtual Reality (Nature Trek)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Low Back Pain
Bowen's Technique and Muscle Energy Technique on Hamstrings Tightness
The aim of this research is to find and compare the effect of Bowen's technique and Muscle energy technique on intensity of pain, active knee extension, limited forward bending and active straight leg raise on hamstrings…
- Trial name
- NCT04745858
- Testing
- Bowen's Technique, Muscle Energy Technique
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Chronic Low Back Pain
Tolerability, Safety and Pharmacokinetics of a Topical AB001 Patch in Healthy Subjects
The study evaluates the safety, tolerability and pharmacokinetics of single and repeated doses of topical AB001 patch and the bioavailability relative to the oral capsule and topical positive comparative patch.
- Trial name
- NCT03997734
- Testing
- AB001, oral capsule, positive comparative patch
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Frontier Biotechnologies Inc.
End Stage Renal Disease (ESRD), Peritoneal Dialysis Complication
The Effect of Exercise on Low Back Pain in Peritoneal Dialysis Patients
The goal of this randomized controlled trial is to find out if exercise can help reduce low back pain and improve quality of life in people receiving peritoneal dialysis (PD).
- Trial name
- NCT07000006
- Testing
- Home-based Core Stability Exercise
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Pardis Specialized Wellness Institute
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