Clinical trials: Lumbar Decompression
Degeneration, Spinal Stenosis
Vertebropexy - Randomized-controlled Trial
To assess the need for additional fusion surgery versus the risk of a revision surgery in patients with degenerative lumbar spinal disease and to assess efficacy and risk of the ligamentous fixation technique (vertebropexy)
- Conditions
- Degeneration, Spinal Stenosis, Fusion of Spine
- Trial name
- VPRCT (NCT06024785)
- Testing
- Vertebropexy
- Where
- Switzerland
- Volunteers
- 164 people
- Sponsor
- Balgrist University Hospital
Opioid Use, Lumbar Spinal Stenosis
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
This study seeks to evaluate the impact of intra-operative topical epidural steroid usage in patients undergoing 1-2 level lumbar laminectomy.
- Conditions
- Opioid Use, Lumbar Spinal Stenosis, Pain, Postoperative, Pain, Back
- Trial name
- NCT05058287
- Testing
- Depo-Medrol 40Mg/Ml Suspension for Injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Spine Disc Herniation
Targeted Disc Decompression (TDD) for Contained Herniated Lumbar Discs
The prospective Clinical Series (CS) aims to prove the hypothesis that Targeted Disc Decompression (TDD) reduces the pain in patients suffering from radicular leg pain secondary to a contained focal disc protrusion…
- Trial name
- TDD (NCT01429363)
- Testing
- Targeted disc decompression
- Where
- 3 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- Rijnstate Hospital
Degenerative Lumbar Spondylolisthesis
Long-term Reoperations After Lumbar Spinal Stenosis Surgery
Severe and persisting pain and disability due to a degenerative narrowing of the spinal canal, lumbar spinal stenosis, can be operated with a simple surgical decompression.
- Trial name
- NCT06407063
- Testing
- Micro-decompression alone, Decompression and instrumented fusion
- Where
- Norway
- Volunteers
- 794 people
- Sponsor
- University Hospital of North Norway
Lumbar Spinal Stenosis, Radiculopathy
Treatment of Lumbar Spinal Stenosis; Comparison of Two Different Surgical Methods; Mini-invasive Decompression to X-stop
The purpose of this study is to compare two surgery methods on lumbar spinal stenosis: minimal invasive decompression and X-stop.
- Trial name
- LSSS (NCT00546949)
- Testing
- Minimal invasive decompression, Interspinous Process Decompression (IPD)
- Where
- Norway
- Volunteers
- 96 people
- Sponsor
- Norwegian University of Science and Technology
Lumbar Decompression
Ambulatory Geriatric Endoscopic Spine
The research focuses on evaluating the clinical outcomes of endoscopic lumbar decompression surgery performed in an outpatient setting for patients over 75 years old.
- Trial name
- AGES (NCT06523426)
- Testing
- Patient treated by spinal endoscopy
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Spinal Stenosis, Lumbar Region, With Neurogenic Claudication
The MiDAS ENCORE Study
Study Objective: To compare patient outcomes following treatment with either the MILD procedure or epidural steroid injections (ESIs) in patients with painful lumbar spinal stenosis exhibiting neurogenic claudication and having…
- Trial name
- NCT02093520
- Testing
- MILD Procedure, Epidural Steroid Injection
- Where
- 12 sites in United States
- Volunteers
- 302 people
- Sponsor
- Vertos Medical, Inc.
Lumbar Spinal Stenosis
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as well as harms associated with the MILD procedure, at 24 months…
- Trial name
- NCT03072927
- Testing
- MILD, Interspinous Process Decompression
- Where
- 2,392 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Stryker Instruments
Lumbar Spinal Stenosis
The Vertos MILD™ Preliminary Patient Evaluation Study
This is a single-center, open label, prospective clinical study to assess the clinical application and functional outcomes of symptomatic patients undergoing the Minimally Invasive Lumbar Decompression (MILD™) treatment for…
- Trial name
- NCT00749073
- Testing
- Minimally Invasive Lumbar Decompression (MILD™)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Vertos Medical, Inc.
Spinal Stenosis, Spondylolisthesis
Decompression vs. Fusion for Stable Degenerative Spondylolisthesis
The purpose of this study is to assess the feasibility of a full-scale multicenter randomized, controlled trial comparing the effectiveness of two surgical treatments for a condition associated with lumbar spinal stenosis called…
- Trial name
- NCT02348645
- Testing
- Spinal fusion, Spinal decompression
- Where
- 8 sites in Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Herniated Disc
Radiofrequency Nucleoplasty vs Percutaneous Nucleotomy vs Decompression Catheter in Lumbar Disc Herniation
The purpose of this study is to learn which of three minimally invasive procedures is the most effective for treatment of contained lumbar disc herniation.
- Trial name
- NCT00300898
- Testing
- Nucleoplasty, Percutaneous decompression, Intervertebral electrothermal disc decompression (IDET)
- Sponsor
- The Cleveland Clinic
Radiculopathy, Spondylolisthesis
Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression
The purpose of this study is to evaluate the clinical performance of a decompression using the FDA cleared iO-Flex® System on-label in treating patients with spinal stenosis and stable grade I degenerative lumbar…
- Conditions
- Radiculopathy, Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- STRiDE (NCT01338766)
- Testing
- Decompression using the iO-Flex® system
- Where
- 14 sites in United States
- Volunteers
- 100 people
- Sponsor
- Baxano Surgical, Inc.
Lumbar Disc Herniation, Lumbar Disc Disease
GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries
The purpose of this study is to determine the optimal anesthetic routine for lumbar decompression surgery. General Anesthesia is the standard of care in spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
- Trial name
- NCT05444751
- Testing
- General anesthetic, SA + ESP
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Spinal Stenosis
Efficiency of Surgical Treatment for Lumbar Spinal Stenosis
Decompression surgery has proved to be effective for Lumbar Spinal Stenosis (LSS) with persistent pain. But the efficiency of the surgery for degenerated LSS remain uncertain and is the subject of this study.
- Trial name
- NCT03365401
- Testing
- decompression surgery, nonsurgical treatment
- Volunteers
- 150 people
- Sponsor
- Peking University People's Hospital
Spinal Stenosis
Physical Therapy vs Surgical Decompression for Lumbar Spinal Stenosis
This is a randomized controlled multicenter trail comparing physical therapy to surgical decompression in patients with lumbar spinal stenosis.
- Trial name
- PTvsSD (NCT04552145)
- Testing
- surgery, Physiotherapy
- Where
- 3 sites in Norway
- Volunteers
- 232 people
- Sponsor
- Norwegian University of Science and Technology
Lumbar Spine Degeneration, Lumbar Spinal Stenosis
LLIF Plus Posterior Decompression for Severe Lumbar Spinal Stenosis
Lateral lumbar interbody fusion (LLIF), as a minimally invasive technique, is an indirect decompression technique, and its decompression effect is not as thorough as traditional posterior decompression surgery.
- Trial name
- NCT04094220
- Testing
- Lateral lumbar interbody fusion
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lumbar Spinal Stenosis, Radiation Exposure
Radiation Exposure Reduction Protocol for Minimally Invasive Lumbar Decompression (mild) Techniques
To evaluate the efficacy of radiation reduction techniques to minimize clinician and patient exposure during minimally invasive lumbar decompression (MILD) procedure.
- Trial name
- NCT06651138
- Testing
- Fluoroscopy
- Where
- United States
- Sponsor
- University of Kansas Medical Center
Lumbar Spinal Stenosis, Degenerative Lumbar Spondylolisthesis
Retrospective Comparison of Tubular Decompression ± Rhizotomy Versus TLIF in Lumbar Spinal Stenosis
This retrospective observational study examines clinical outcomes in patients with lumbar spinal stenosis who underwent minimally invasive tubular decompression, with or without subsequent multisegmental percutaneous rhizotomy…
- Conditions
- Lumbar Spinal Stenosis, Degenerative Lumbar Spondylolisthesis, Neurogenic Claudication
- Trial name
- TUBE-FUSE (NCT07489508)
- Where
- 2 sites in Spain
- Volunteers
- 246 people
- Sponsor
- University of Valencia
Lumbar Degenerative Spondylolisthesis
The NORDSTEN Study - Degenerative Spondylolisthesis
Lumbar Degenerative Spondylolisthesis (LDS) is a slippage of one vertebra over another caused by degeneration of facet joints, ligaments and intervertebral discs.
- Trial name
- NORDSTEN/DS (NCT02051374)
- Testing
- Decompression alone, Decompression followed by fusion with instrumentation
- Where
- Norway
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Lumbar Disc Herniation, Lumbar Radiculopathy
PLDD With or Without Transforaminal Epidural Steroid Injection in Lumbar Disc Herniation
This prospective observational study aims to evaluate the clinical outcomes of patients with single-level lumbar disc herniation who undergo routine percutaneous laser disc decompression (PLDD).
- Trial name
- PLDD-TFESI (NCT07400068)
- Testing
- Percutaneous Laser Disc Decompression (PLDD), Transforaminal Anterior Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Mersin University