Clinical trials: Lumbar Degenerative Disease
Intervertebral Disc Degeneration
Safety and Performance of the Hexanium TLIF System in the Treatment of Degenerative Disc Disease
The goal of this observational study is to confirm the safety and efficacy of the Hexanium TLIF system in the treatment of skeletally mature patients suffering from degenerative disc disease (disease that occurs when the spinal…
- Trial name
- TLIF (NCT05997121)
- Testing
- Transforaminal lumbar interbody fusion
- Where
- 6 sites in France, Switzerland
- Volunteers
- 187 people
- Sponsor
- SPINEVISION SAS
Facet Joint Pain, Facet Syndrome of Lumbar Spine
Injections in the Diagnosis and Treatment of Lumbar Facet Syndrome
In suspected facet joints pain, it is recommended to perform nerve blocks to establish the diagnosis with positive results being and indicator of successful of most permanent treatment of facet pain by rhizolysis.
- Conditions
- Facet Joint Pain, Facet Syndrome of Lumbar Spine, Facet Joints; Degeneration
- Trial name
- NCT03871192
- Testing
- FACET JOINT UNDER CT GUIDANCE, NERVE BLOCK UNDER CT GUIDANCE, FACET JOINT UNDER FLUOROSCOPY GUIDANCE
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Complejo Hospitalario Universitario de Granada
Degenerative Cervical Disc Disease, Degenerative Lumbar Diseases
Observational Study to Evaluate the STALIF® C FLX, STALIF® M FLX, STALIF® L FLX Cages and FORTOS-C®
Post-operative clinical outcome data on the devices used to treat spinal diseases are collected and evaluated in order to analyze the safety and performance of the implants used.
- Trial name
- NCT06876311
- Testing
- Anterior Cervical Interbody Fusion, Anterior lumbar Interbody Fusion, Lateral Lumbar Interbody Fusion
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Silony Medical GmbH
Chronic Low Back Pain, Degenerative Disc Disease
Disc Prosthesis Versus Multidisciplinary Rehabilitation
Surgical methods offered to patients with chronic low back pain are controversial. In addition, new and expensive treatment methods like total disc replacemet (TDR) are a challenge for the health care services.
- Trial name
- NCT00394732
- Testing
- Total Disc Prosthesis, Multidisciplinary rehabilitation program
- Where
- 5 sites in Norway
- Volunteers
- 179 people
- Sponsor
- Ullevaal University Hospital
Prolapsed Lumbar Disc, Prolapsed Cervical Disc
Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device
The registry has been designed as a prospective, observational program for patients undergoing lumbar or cervical fusion using VariLift device with the ultimate goal to aid in the development of strategic treatment pathways and…
- Conditions
- Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1
- Trial name
- NCT01944345
- Where
- 3 sites in United States
- Volunteers
- 69 people
- Sponsor
- Wenzel Spine
Lumbar Degenerative Disease
CONDUIT™ Anterior Lumbar Interbody Fusion (ALIF) Cage System in Lumbar Degenerative Disease
This will be a prospective, multi-centre study at a National Tertiary Referral Centre for spinal trauma and spinal cord injuries, serving a catchment area of 5 million people.
- Trial name
- NCT06940453
- Testing
- CONDUIT
- Where
- Ireland
- Volunteers
- 35 people
- Sponsor
- University College Dublin
Degenerative Lumbar Spine Disease
Combination Therapy With Atelocollagen in Epidural Nerve Block
"In this study, the investigators plan to evaluate muscle mass and pain relief 4 weeks after performing epidural nerve block and Type I porcine atelocollagen injection into multifidus muscle in patients with chronic low back pain…
- Trial name
- NCT05014945
- Testing
- (atelocollagen group)
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Gangnam Severance Hospital
Lumbar Degenerative Disease
Erector Spinae Plan Block (ESPB) with Dexmedetomidine and Dexamethasone in Lumbar Spine Fusion
This study wants to understand if using a pre-operative anesthetic injection could contribute to better pain relief after the surgery. This injection is referred to as an erector spinae plane block (ESPB, or "Block" for short).
- Trial name
- ESPB (NCT06658054)
- Testing
- Adjuvant analgesia, Control (Standard treatment)
- Volunteers
- 46 people
- Sponsor
- University of Southern California
Lumbar Disc Degeneration, Surgical Procedure, Unspecified
Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease
Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease
- Trial name
- NCT02496364
- Testing
- Observational
- Sponsor
- Vinicius Magno da Rocha, MD, MSc
Degenerative Disc Disease, Spondylolisthesis
A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced.
The purpose of this trial is to collect clinical outcomes including radiographic and CT outcomes in patients who undergo spinal fusion using the Keos Lumbar Interbody Fusion Device.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Retrolisthesis
- Trial name
- NCT04416321
- Testing
- Surgery with the Keos Lumbar Interbody Fusion Device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Invibio Ltd
Degenerative Lumbar Disc Disease, Spondylolisthesis
Spine Fusion Instrumented With BMP-2 vs Uninstrumented With Infuse BMP-2 Alone
The goal of spinal fusion is to relieve pain and/or increase stability in painful or unstable spine joints. A patient may or may not receive rods and screws with the use of bone graft materials to facilitate bone growth and a…
- Conditions
- Degenerative Lumbar Disc Disease, Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT00405600
- Testing
- Device used in surgery with or without instrumentation
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Degenerative Disc Disease
A Pivotal Study of rhBMP-2/ACS/INTER FIX™ Device for Posterior Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
The purpose of this clinical trial is to assess the safety and effectiveness of the rhBMP-2/ACS/INTER FIX™ device as compared to the autograft/INTER FIX™ device in patients with symptomatic degenerative disease.
- Trial name
- NCT01491464
- Testing
- rhBMP-2/ACS/INTER FIX™, Autogenous bone/INTER FIX™
- Volunteers
- 67 people
- Sponsor
- Medtronic Spinal and Biologics
Lumbar Spinal Stenosis
Effect of the Posterior Ligamentous Complex on the Adjacent Segments Degeneration After Lumbar Surgery
To investigate whether destroying the adjacent posterior ligamentous complex (PLC) has an effect on adjacent segment degeneration (ASD) after L5/S1 posterior lumbar interbody fusion (PLIF)
- Trial name
- NCT04946487
- Testing
- total laminectomy
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Disc Degeneration, Spinal Deformity
MDT-0123 Japan Study
The purpose of this clinical trial is to compare the efficacy and safety of this investigational device with autologous iliac bone graft (ICBG) in patients who are deemed to require bone fusion through spinal fixation at two…
- Trial name
- NCT07414745
- Testing
- MDT-0123, ICBG
- Where
- 14 sites in Japan
- Volunteers
- 140 people
- Sponsor
- Medtronic Spinal and Biologics
Spine Degeneration, Fusion of Spine (Disease)
Lumbar Discopathy Decompression with Lateral Interbody Fusion: Radiological and Clinical Outcomes
The aim of the study was to introduce a single-segment lumbar spine decompression and fusion with intervertebral implants through modified by the authors lateral lumbar approach.
- Trial name
- NCT06719349
- Where
- Poland
- Volunteers
- 38 people
- Sponsor
- Podkarpackie Oncological Center
Spondylolisthesis, Spinal Stenosis
Thoracic-Lumbar Arthrodesis- Implanet Jazz
Establish a data repository of patients who have undergone single, two-, or three-level lumbar instrumented arthrodesis procedures supplemented by the Implanet Jazz System.
- Conditions
- Spondylolisthesis, Spinal Stenosis, Degenerative Disease
- Trial name
- NCT05366140
- Testing
- Prospective follow-up of patients who have received instrumented lumbar arthrodesis supplemented the Implanet Jazz System(TM)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Francis Farhadi
Spinal Stenosis Lumbar, Spinal Canal Stenosis
Degenerative Lumbar Stenosis Conservative Treatment
The trial aims to compare the effectiveness of three methods of conservative treatment of degenerative lumbar spine stenosis (DLSS): GOLDIC autologous serum epidural injections, steroid epidural injections and manual therapy.
- Trial name
- GOLDSTEN (NCT04492774)
- Testing
- Goldic serum, Steroid injections, Manual therapy
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Sutherland Medical Center
Lumbar Degenerative Disc Disease
CARES Lumbar Artificial Disc Registry
The purpose of the registry is to assess outcomes following treatment with lumbar total disc replacement (TDR) in patients outside the clinical trial setting.
- Trial name
- NCT02139527
- Testing
- Total Disc Replacement
- Volunteers
- 120 people
- Sponsor
- DePuy Spine
Degenerative Spine, Degeneration of Lumbar Intervertebral Disc
Percutaneous Trans-facet Spine Fixation
Percutaneous Trans-facet Fixation Massoud-Goel Technique and Theory for Treatment of Degenerative Spine
- Conditions
- Degenerative Spine, Degeneration of Lumbar Intervertebral Disc, Degenerative Cervical Disc Disease, Ligamentum Flavum Hypertrophy
- Trial name
- Massoud-Goel (NCT07001969)
- Testing
- Massoud-Goel Technique and Theory, Percutaneous Trans-facet Fixation for Treatment of Degenerative Spine
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- Mahmoud Massoud
Recurrent Low Back Pain, Degenerative Disc Disease (DDD)
Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive
This will be a multicenter, prospective, double blind, randomized phase 2/3 trial comparing culture-expanded allogeneic adult BM-MSCs with sham-treated controls.
- Trial name
- RESPINE (NCT03737461)
- Testing
- Allogenic BM-MSCs Injection
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 113 people
- Sponsor
- University Hospital, Montpellier