Clinical trials: Lumbar Degenerative Diseases
Degenerative Disc Disease
Lumbar Degenerative Disc Disease Treatment With Bone Marrow Autologous Mesenchymal Stem Cells (MSV)
This trial pretends to validate for clinical use a bioengineered product composed of mesenchymal stem cells produced by the Instituto de Biologia y Genetica Molecular (IBGM), Valladolid (MSV, which have already been approved by…
- Trial name
- MSV-DISC (NCT02440074)
- Testing
- Autologous bone marrow mesenchymal stem cells
- Sponsor
- Red de Terapia Celular
Degenerative Lumbar Spinal Stenosis
Segmental Decompression Versus Wide Decompression With Fixation for Degenerative Lumbar Canal Stenosis
The purpose of this study is to compare two different surgical techniques for treating degenerative lumbar canal stenosis, a condition where the lower spinal canal narrows and puts pressure on the spinal nerves.
- Trial name
- NCT07542054
- Testing
- Segmental Decompression, Wide Decompression with Fixation
- Volunteers
- 56 people
- Sponsor
- Assiut University
Degenerative Spinal Stenosis, Disk Herniation
Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy
The aim of this Phase II trial is to evaluate safety and efficacy of Hyalospine in patients undergoing lumbar laminectomy or laminotomy for degenerative spinal stenosis or disk herniation.
- Trial name
- Hyalospine (NCT00939406)
- Testing
- Hyalospine
- Where
- 3 sites in Germany, Netherlands and 1 more
- Volunteers
- 45 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Lumbar Disc Herniation, Spondylolisthesis
The Spine PROMCO Study
Our primary objective is to design a cohort to determine the treatment outcome of different surgical interventions of the degenerative lumbar spine highlighting the expediency and value of the current surgical treatment program.
- Conditions
- Lumbar Disc Herniation, Spondylolisthesis, Spinal Stenosis
- Trial name
- Spine PROMCO (NCT05963815)
- Testing
- Spine surgery
- Where
- Netherlands
- Volunteers
- 4,000 people
- Sponsor
- Park Medical centrum
Spondylolisthesis, Scoliosis
A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP®
OsteoAMP is a novel allograft bone graft substitute (BGS) that has been processed to retain multiple endogenous growth factors for use in spinal fusion.
- Conditions
- Spondylolisthesis, Scoliosis, Intervertebral Disc Disease
- Trial name
- NCT02225444
- Testing
- OsteoAMP
- Where
- 9 sites in United States
- Volunteers
- 42 people
- Sponsor
- Bioventus LLC
Spondylolisthesis, Degenerative, Spondylolisthesis, Isthmic
Spinal Fusion and Rehabilitation Study
The aim of the present study is to analyse the significance of postoperative combined strength and aerobic training for outcome of the lumbar fusion patients compared to usual care (patients with isthmic or degenerative…
- Trial name
- NCT00834015
- Testing
- Outcome of lumbar spinal fusion patients and significance of postoperative exercise therapy: A randomized controlled trial
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Jyväskylä Central Hospital
Cognitive Impairment, Alzheimer Disease
Impact of Hypno-analgesia on Pain During a Lumbar Puncture for Diagnosis of Alzheimer's Disease
One of the missions of the Memory of Resources and Research Center (CMRR) is to establish a diagnosis of expertise in patients with amestic, language or behavioral cognitive complaint.
- Trial name
- PLHYMANEDE (NCT03352024)
- Testing
- Relational care, Hypno-analgesia
- Sponsor
- University Hospital, Montpellier
Degenerative Changes, Stenosis
OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion
The objective of this study is to prospectively evaluate the performance of Integra's OsteoStrux Collagen Ceramic Scaffold combined with bone marrow aspirate as an adjunct for instrumented posterolateral spine fusion, as compared…
- Conditions
- Degenerative Changes, Stenosis, Spondylosis
- Trial name
- NCT01873586
- Testing
- Posterolateral Fusion
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- SeaSpine, Inc.
Spinal Stenosis
A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis
The purpose of this study is to evaluate the safety and effectiveness of the In-Space compared to the X STOP Interspinous Process Distraction (IPD) device ("X STOP") for the treatment of patients experiencing intermittent…
- Trial name
- In-Space (NCT00697827)
- Testing
- Interspinous Spacer device, Interspinous Process Distraction Device
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- Synthes USA HQ, Inc.
Degenerative Lumbar Disease
Comparing Lumbar Fusion With and Without Stress Endplate Augmentation in Patients With Low Bone Mass
Degenerative lumbar disease can cause back pain, leg pain, and difficulty with daily activities. Some patients require lumbar fusion surgery.
- Trial name
- NCT07891663
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Degenerative Disc Disease, Spondylolisthesis
Clinical and Radiological Outcomes of Oblique Lateral Lumbar Interbody Fusion
This study is undertaken to evaluate the outcomes of Oblique Lateral Lumbar Interbody Fusion (OLLIF). Specifically, the study seeks to measure outcomes on radiological imaging, outcomes reported by the patients on standardized…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT03726190
- Testing
- Oblique Lateral Lumbar Fusion
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Tristate Brain and Spine Institute
Disc Degeneration, Low Back Pain
Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery
Low back pain (LBP) is a complex condition that affects 65-85% of the population, and is the leading musculoskeletal condition contributing to disability in the United States.
- Trial name
- NCT03442374
- Testing
- Exercise
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Lumbar Spinal Stenosis, Intervertebral Disc Degeneration
Minimally Invasive Decompression and Fusion Versus Open for Degenerative Lumbar Stenosis
The purpose of this study is to determine the effectiveness of minimally invasive decompression and fusion over the traditional open decompression and fusion in patients with single-level lumbar stenosis caused by degenerative…
- Trial name
- NCT04594980
- Testing
- lumbar fusion
- Where
- Russia
- Volunteers
- 96 people
- Sponsor
- N.N. Priorov National Medical Research Center of Traumatology and Orthopedics
Low Back Pain, Spondylolisthesis
Facet Tropism in Low Back Pain Patients
This retrospective study investigates the relationship between lumbar facet tropism and the occurrence of disc herniation and spondylolisthesis in patients with low back pain who underwent lumbar MRI.
- Conditions
- Low Back Pain, Spondylolisthesis, Degenerative Disc Disease, Lumbar
- Trial name
- NCT06982118
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Degenerative Disc Disease, Lumbar
Osteocel® Plus in Anterior Lumbar Interbody Fusion (ALIF)
This study is being conducted to determine the percentage of patients with solid spinal fusions after being treated with Osteocel Plus in an ALIF procedure.
- Trial name
- NCT00948831
- Testing
- Osteocel Plus
- Where
- 7 sites in United States
- Volunteers
- 51 people
- Sponsor
- NuVasive
Lumbar Degenerative Disease, Shared Decision Making
Effectiveness of Implementing Shared Decision-Making on Quality of Care Among Patients With Lumbar Degenerative Diseases.
Background: Shared decision making (SDM) is a patient-centered and evidence-based model of clinical decision making. The feature of SDM is that clinicians work together with patients to plan the most appropriate and practical…
- Conditions
- Lumbar Degenerative Disease, Shared Decision Making, Patient Decision Aids, Evidence-based Medicine
- Trial name
- NCT03679494
- Testing
- Shared decision making support tool
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Foraminal Stenosis, Degenerative Disc Disease
Clinical and Radiographic Outcomes of TLIF w/3D Printed Cellular Implant
This study is designed to evaluate clinical outcomes and spine fusion rates for patients undergoing transforaminal lumbar interbody fusion using the CONDUIT 3D printed titanium TLIF cage.
- Conditions
- Foraminal Stenosis, Degenerative Disc Disease, Lumbar Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- NCT05023733
- Testing
- CONDUIT™ Interbody Platform composed of the EIT (Emerging Implant Technologies) Cellular Titanium®
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Farhan Karim
Lumbar Disc Degeneration
Application of Internet Plus Nursing Intervention in Postoperative Rehabilitation of Patients With Lumbar Disc Herniation
The purpose of this observational study is to understand the influence of rehabilitation guidance through Internet plus mini program on the compliance of patients at home rehabilitation exercise who have undergone lumbar…
- Trial name
- NCT07547410
- Testing
- Internet plus applet
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Intervertebral Disk Degeneration
Efficacy and Safety of K-rod Dynamic Stabilization System in the Repair of Lumbar Degenerative Diseases
To conduct a prospective, single-center, self-controlled, clinical trial to verify the efficacy and safety of K-Rod dynamic stability system in the repair of lumbar degenerative diseases following 2 years follow-up, aiming to…
- Trial name
- NCT03214042
- Testing
- K-rod dynamic stabilization system
- Volunteers
- 67 people
- Sponsor
- Shenyang Orthopedic Hospital
Spinal Stenosis, Lumbar Region, With Neurogenic Claudication
Bilateral Transforaminal Epidural Steroid Injections for Degenerative Lumbar Spinal Stenosis
The most common forms of injection used for the treatment of degenerative lumbar spinal stenosis (DLSS) patients with neurogenic claudication (NC) are the caudal and inter-laminar epidural injections of anesthetic and steroid.
- Trial name
- NCT01995461
- Testing
- bilateral transforaminal epidural steroid injections
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Marshfield Clinic Research Foundation