Clinical trials: Lumbar Degenerative Diseases
Back Pain Lower Back Chronic, Lumbar Disc Degenerative Disease
Effect Of Paraspinal Muscle Thickness On The Benefit Of Core Stabilization
This study investigates whether the effects of core muscle strengthening exercises on chronic low back pain and deep back muscle (multifidus) thickness differ in patients with different baseline muscle thicknesses.
- Trial name
- NCT06969508
- Testing
- core stabilitation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Disk Herniated Lumbar, Disc Disease Degenerative
Clinical Outcome and Fusion Rate of 3D Printed Interbody Fusion Cages and Titanium Coated PEEK Cages
Prospective, Randomized, Single-Blind Study for the Evaluation of the Clinical Outcome and the Fusion Rate of 3D Printed Interbody Fusion Cages and Titanium Coated PEEK Cages in Transforaminal Lumbar Interbody Fusion
- Conditions
- Disk Herniated Lumbar, Disc Disease Degenerative, Spondylolisthesis
- Trial name
- PRINTLIF (NCT05237908)
- Testing
- Transforaminal Lumbar Interbody Fusion
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Aesculap AG
Degenerative Disc Disease
Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration
The purpose of this study is to compare the safety and preliminary efficacy of intradiscal injections of two doses of IDCT (Discogenic Cells + Sodium Hyaluronate vehicle) and one sham control in subjects with chronic low back…
- Trial name
- NCT03955315
- Testing
- IDCT
- Where
- 6 sites in Japan
- Volunteers
- 38 people
- Sponsor
- DiscGenics, Inc.
Lumbar Spine Degeneration
Development of a Patient-reported Outcome Instrument for Patients With Lumbar Degenerative Disease After Lumbar Fusion
The commonly used scales (ODI+JOA-29+VAS) lack the assessment of lumbar stiffness, and there is no scale for evaluating lumbar stiffness in China.Based on the Delphi method and the analytic hierarchy process, this study will…
- Trial name
- DPROIPLDDALF (NCT04781517)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Disc Degenerative Disease, Spine Fusion for Degenerative Spine Disease
Comparison of Posterior Cellular Bonegraft Options for Single Level Lumbar Spinal Fusion
This study involves the assessment of alternatives to iliac bone graft during spinal fusion surgery. Four types of bone graft alternatives are being compared to iliac bone graft during the posterior portion of an…
- Trial name
- NCT07187362
- Testing
- Use iliac bone graft, use bone morphogenetic protein, use bone derived allograft MSCs
- Volunteers
- 119 people
- Sponsor
- Midwest Spine & Brain Institute
Degenerative Disc Disease
Pilot Study of rhBMP/BCP With or Without the TSRH® Spinal System for Posterolateral Lumbar Fusion in Patients With Degenerative Disc Disease
The purpose of this pilot clinical trial is to evaluate both device designs (rhBMP-2/BCP and rhBMP-2/BCP/TSRH® spinal System) as methods of facilitating spinal fusion as compared to instrumented fusion with autograft in patients…
- Trial name
- NCT01494441
- Testing
- rhBMP-2/BCP, rhBMP-2/BCP/TSRH® Spinal System, Autograft/TSRH® Spinal System
- Volunteers
- 27 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Disc Disease
A Pilot Study of rhBMP-2/ACS With the INTERFIX™ Device for the AnteriorLumbar Interbody Fusion in Patients With Degenerative Disc Disease
The purpose of this pilot clinical trial is to evaluate the device design as a method of facilitating spinal fusion.
- Trial name
- NCT01491451
- Testing
- rhBMP-2/ACS/INTERFIX™, Autogenous bone/INTERFIX™
- Volunteers
- 45 people
- Sponsor
- Medtronic Spinal and Biologics
Low Back Pain, Lumbosacral Radiculopathy
A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief
The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of…
- Conditions
- Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation
- Trial name
- NCT03514277
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Lumbar Spine Degeneration, Arthrosis; Spine
Postoperative Bracing Patterns After Lumbar Surgery
A variety of postoperative bracing are routinely applied after spinal procedures but there are limited data regarding their efficacy, especially with the increasing use of internal fixation.Currently, no data are available…
- Conditions
- Lumbar Spine Degeneration, Arthrosis; Spine, Surgery
- Trial name
- NCT03427281
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Radiculopathy, Herniated Disc
Regenexx™ PL-Disc Versus Steroid Epidurals for Lumbar Radiculopathy
The primary objective of this study is to compare the improvement in subject-reported clinical outcomes for Regenexx PL-Disc vs.
- Conditions
- Radiculopathy, Herniated Disc, Disc Degeneration
- Trial name
- NCT01850771
- Testing
- Regenexx PL-Disc, Steroid Epidural
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Regenexx, LLC
Degenerative Disc Disease
Post Marketing Clinical Follow up Study for MagnetOs Putty in Patients With Degenerative Disc Disease
This study is a post-marketing clinical follow-up study for MagnetOs Putty. MagnetOs Putty is a synthetic bone-like material which is routinely used by surgeons as a treatment for patients with degenerative disc disease who will…
- Trial name
- PROGRESS (NCT04128852)
- Testing
- MagnetOs Putty
- Sponsor
- Kuros Biosurgery AG
Degenerative Disc Disease
Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease
Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients with Lumbar Degenerative Disc Disease : A Pivotal, Randomized, Prospective, Multi-Center Study
- Trial name
- NCT07017634
- Testing
- Novosis Putty, Standard of Care
- Where
- 10 sites in United States
- Volunteers
- 316 people
- Sponsor
- CGBio Inc.
Biomechanical; Lesion
INVESTIGATING THE EFFECTS SACROILIAC JOINT DYSFUNCTION ON GAIT IN INDIVIDUALS WITH BACK PAIN
Sacroiliac joint dysfunction (SJD) is a common problem in individuals with lumbar herniation nucleus pulposus (LHNP) plus back pain.
- Trial name
- NCT03426852
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Degenerative Disc Disease Lumbar
FLXfit Post Market Outcome Study Protocol
This investigation will provide safety and effectiveness information on the use of the FLXfit™ Cage. Data will be used for Post Market follow-up of the FLXfit™ system by evaluating: Safety as measured by the rate of serious…
- Trial name
- TLIF (NCT02882243)
- Testing
- FLXfit Cage for fusion
- Volunteers
- 40 people
- Sponsor
- Foundation for Orthopaedic Research and Education
Chronic Low Back Pain, Chronic Sciatica
A Zhineng Qigong Intervention for Patients With Chronic Low Back Pain and/or Leg Pain
The purpose of this study is to evaluate a Zhineng Qigong intervention for patients with chronic low back pain and/or leg pain, and to test feasibility aspects.
- Conditions
- Chronic Low Back Pain, Chronic Sciatica, Lumbar Spinal Stenosis, Lumbar Disc Herniation
- Trial name
- NCT04520334
- Testing
- Zhineng Qigong intervention
- Where
- 9 sites in Sweden
- Volunteers
- 55 people
- Sponsor
- Lund University
Spine Surgery
3rd-year Post-surgical Evaluation of Adjacent Segment Disc Degeneration Onset in Lumbar Spine (Spinal Fusion vs. Lumbar Arthroplasty With Disc Replacement)
The main objective of the study is to compare the onset of adjacent segment disk degeneration in two groups of patients (one "spinal fusion group" and one "lumbar arthroplasty with disc replacement" group) with each patient…
- Trial name
- ARTHRO-DEGE (NCT05561322)
- Testing
- Consultation involving pain evaluation, questionnaires and the Lasègue Manoeuver, Magnetic Resonance Imaging of the lumbar spine
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Degenerative Disc Disease, Back Pain, Low
The SPINUS I Study: Spinal Fusion for a Single Level SPECT/CT Positive Lumbar Degenerative Disc Disease
The aim of the present study is to find out whether fusion of a sinlge level SPECT/CT positive degenerative disc disease leads to a significant improvement of pain and disability.
- Trial name
- NCT04876586
- Testing
- Lumbar fusion
- Where
- 2 sites in Czechia
- Volunteers
- 38 people
- Sponsor
- Military University Hospital, Prague
Recurrent Low Back Pain, Degenerative Disc Disease (DDD)
Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive
This will be a multicenter, prospective, double blind, randomized phase 2/3 trial comparing culture-expanded allogeneic adult BM-MSCs with sham-treated controls.
- Trial name
- RESPINE (NCT03737461)
- Testing
- Allogenic BM-MSCs Injection
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 113 people
- Sponsor
- University Hospital, Montpellier
Adjacent Segment Disease, Adjacent Segment Degeneration
Evaluation of the Effect of Revision Surgery of Lumbar Adjacent Segment Degeneration
The purpose of this study was to investigate postoperative imaging changes and clinical symptom improvement in patients undergoing revision surgery for adjacent segment degeneration.
- Trial name
- NCT04970862
- Testing
- reversion surgery
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Lumbar Disc Herniation, Lumbar Disc Degeneration
The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease
The goal of this study is to clarify the role of the bacterium Cutibacterium acnes in the development of degenerative disc disease in patients with lumbar disc herniation who underwent microdiscectomy as part of their regular…
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Degeneration, Cutibacterium Acnes, Low Back Pain
- Trial name
- NCT07085247
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Masaryk University