Clinical trials: Lumbar Degenerative Diseases
Degenerative Disc Disease, Spine Fusion
MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion
This is a phase IV post-marketing study for MagnetOs Flex Matrix. MagnetOs Flex Matrix is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with degenerative disc disease and…
- Conditions
- Degenerative Disc Disease, Spine Fusion, Leg Pain and/or Back Pain
- Trial name
- PRECISE (NCT05037968)
- Testing
- MagnetOs Flex Matrix, Trinity Elite
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- Kuros Biosurgery AG
Low Back Pain, Physical Therapy
Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings
Low back pain is a common musculoskeletal disorder associated with substantial disability and reduced quality of life. Although magnetic resonance imaging (MRI) is frequently used to identify structural spinal abnormalities, the…
- Conditions
- Low Back Pain, Physical Therapy, Lumbar Degenerative Disc Disease, Lumbar Disc Herniation
- Trial name
- NCT07648927
- Testing
- Standard Physical Therapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bahçeşehir University
Lower Back Pain Chronic, Lumbar Degenerative Disease
Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain
Background Degenerative disc disease (DDD) is the leading cause of lower back pain and disability, which prevalence increasing with age. When conservative treatment fails, surgical methods of spinal fusion are employed.
- Conditions
- Lower Back Pain Chronic, Lumbar Degenerative Disease, Lumbar Disc Degeneration, Degenerative Disc Disease(DDD)
- Trial name
- MID-MIS (NCT07127380)
- Testing
- Midline Lumbar Interbody Fusion (MIDLIF), Minimally Invasive Transforaminal Lumbar Interbody Fusion (mini-TLIF)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Copernicus Memorial Hospital
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease
Effect of RECK in Posterior Spinal Fusion
"RECK" is a combination of local anesthesia medications, used for the purpose of pain control. RECK is an acronym which stands for Ropivacaine, Epinephrine, Clonidine, and Ketorolac.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Disease
- Trial name
- NCT06447194
- Testing
- Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Lumbar Disc Degeneration, Low Back Pain
Interleukin-1β (rs 1143627 T/C) Gene Polymorphism May Increase the Risk of Developing LDD in Turkish Population
This study aims to show the association between the Interleukin-1β (rs 1143627 T/C) gene polymorphism and the patient's pain level, radiological features, functional disability, and spinal flexibility.
- Conditions
- Lumbar Disc Degeneration, Low Back Pain, Inflammation
- Trial name
- NCT05601739
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Spinal Stenosis, Spondylolisthesis
RAMP Study: A Study Comparing Two Lumbar Fusion Procedures
This is a post-marketing, on-label Efficacy, Effectiveness and Safety Study designed in a Multicenter, Randomized, Prospective format.
- Conditions
- Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- RAMP (NCT01716182)
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Baxano Surgical, Inc.
Degenerative Lumbar Spine Diseases
Outcomes of Surgery for Degenerative Lumbar Spine Diseases
The purpose of this study is to determine the effectiveness of surgery on the elderly patients with DSD.
- Trial name
- NCT06540274
- Testing
- lumbar surgery
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Assiut University
Spondylolisthesis
Posterior Lateral Fusion (PLF) With Dynesys
The primary purpose of this study is to track and document the clinical outcomes of patients with radicular pathology following posterior lateral fusion with the Dynesys Spinal System.
- Trial name
- NCT00791180
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Zimmer Biomet
Degenerative Disc Disease, Spondylolisthesis
Clinical and Radiological Outcomes of Oblique Lateral Lumbar Interbody Fusion
This study is undertaken to evaluate the outcomes of Oblique Lateral Lumbar Interbody Fusion (OLLIF). Specifically, the study seeks to measure outcomes on radiological imaging, outcomes reported by the patients on standardized…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT03726190
- Testing
- Oblique Lateral Lumbar Fusion
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Tristate Brain and Spine Institute
Degenerative Disc Disease
rhBMP-2/CRM/CD HORIZON® Spinal System Pilot Study (2-Level)
The purpose of this study is to evaluate the feasibility of using the investigational implant (rhBMP-2/CRM with the CD HORIZON® Spinal System) as a method of facilitating posterolateral lumbar spinal fusion at two adjacent…
- Trial name
- NCT01491568
- Testing
- rhBMP-2/CRM/CD HORIZON® Spinal System
- Volunteers
- 29 people
- Sponsor
- Medtronic Spinal and Biologics
Spinal Stenosis Lumbar, Spondylolisthesis
Randomized Control Trial of Quadratus Lumborum Block for Lumbar Spine Decompression and Fusion Surgery
Lumbar spinal decompression and fusion is a commonly performed procedure fro neural impingement and back pain from a variety of pathologies.
- Conditions
- Spinal Stenosis Lumbar, Spondylolisthesis, Fusion of Spine, Lumbar Region, Degeneration Spine
- Trial name
- NCT04447950
- Testing
- Type 2/posterior Quadratus Lumborum block
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assuta Medical Center
Degenerative Lumbar Spine Diseases
Digital Health for Lumbar Degeneration
This study will integrate wireless wearable sensors, smartphone imaging, and multimodal artificial intelligence (AI) to address the rehabilitation needs of patients with lumbar degeneration.
- Trial name
- NCT07133724
- Testing
- AI-Based Smart Assessment and Rehabilitation Training
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Spine Injuries and Disorders
Which Markers of Musculoskeletal Health Can Explain Complications in Spinal Surgery?
The present study is related to the project "ORTHOSPINE FITNESS: WHICH MARKERS OF MUSCULOSKELETAL HEALTH CAN EXPLAIN COMPLICATIONS IN SPINE SURGERY?", winner of the Ministry of Health Call, financed by the European Union…
- Trial name
- NCT06736106
- Testing
- screening
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Ortopedico Rizzoli
Stenosis, Spondylolisthesis
Evaluation of Radiographic and Patient Outcomes Following Lumbar Spine Fusion Using Demineralized Bone Matrix (DBM) Mixed With Autograft
The purpose of this study is to compare Optecure™ as an autograft extender (treatment) to autograft alone (control) in patients undergoing 1 or 2 level fusion of the lumbar spine(one level is defined as two adjacent vertebrae)…
- Conditions
- Stenosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- NCT00254852
- Testing
- Posterior Lateral Fusion (PLF), Anterior Lumbar Interbody Fusion (ALIF), Transforaminal lumbar interbody fusion (TLIF)
- Where
- 6 sites in United States
- Volunteers
- 94 people
- Sponsor
- Exactech
Lumbar Spine Disease, Instabilities Lumbar
Registry for Evaluation of Lumbar Arthrodesis Sagittal alignmEnt
The study goal of RELApSE is to evaluate the relationships between radiological data and patients reported outcome. Restoration of Sagittal alignment and Pelvic Index (PI)-Lumbar Lordosis (LL) mismatch is closely associated with…
- Conditions
- Lumbar Spine Disease, Instabilities Lumbar, Lumbar Spine Instability
- Trial name
- RELAPSE (NCT05448092)
- Where
- 8 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Unit of neurosurgery, Departement of Neurosciences, University of Torino
Degenerative Disc Disease, Degenerative Spondylolisthesis
Lumbar Interbody Implant Study
The objective of this study is to evaluate the safety and performance of NuVasive interbody implants when used during thoracic and/or lumbar spine surgery as measured by reported complications, radiographic outcomes, and…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis
- Trial name
- NCT04418830
- Where
- 16 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- NuVasive
Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1
PMCF Study Fortilink-TS Ti
This study is setup to be able to gather information on the safety and performance of the Fortilink-TS Ti cage of Paradigm Spine GmbH, up to one-year after the surgery.
- Trial name
- NCT07834736
- Testing
- Posterior lumbar interbody fusion surgery
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- BAAT Medical Products B.V.
Degenerative Disc Disease
Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain
The objective of this study is to evaluate the safety and efficacy of viable allograft transplantation for the treatment of patients with symptomatic disc degeneration and tissue loss.
- Trial name
- VAST (NCT03709901)
- Testing
- Active Allograft
- Where
- 13 sites in United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- VIVEX Biologics, Inc.
Lumbar Spinal Stenosis, Spondylolisthesis
Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis
Lumbar spinal stenosis (LSS), is a common disorder of narrowing of the spinal canal in the lower part of the back. This causes discomfort in the legs when standing or walking because of pressure on the spinal nerves.There are…
- Conditions
- Lumbar Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- NCT01455805
- Testing
- Minuteman Fusion Implant, surgical decompression
- Where
- 4 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- Spinal Simplicity LLC
Degenerative Disc Disease, Lumbar
Osteocel® Plus in Anterior Lumbar Interbody Fusion (ALIF)
This study is being conducted to determine the percentage of patients with solid spinal fusions after being treated with Osteocel Plus in an ALIF procedure.
- Trial name
- NCT00948831
- Testing
- Osteocel Plus
- Where
- 7 sites in United States
- Volunteers
- 51 people
- Sponsor
- NuVasive