Clinical trials: Lumbar Degenerative Spinal Disease
Spondylosis, Spondylolisthesis
Interbody Spacers With map3® Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody Fusion
This is a single-arm post-market study in patients requiring lumbar fusion using allograft interbody spacer in conjunction with map3® Cellular Allogeneic Bone Graft in patients with degenerative disc disease (DDD).
- Conditions
- Spondylosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- NCT02628210
- Testing
- map3® Cellular Allogeneic Bone Graft
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- RTI Surgical
Lumbar Degenerative Disc Disease
Percutaneous Dynamic Stabilization (PDS) System Versus Fusion for Treating Degenerative Disc Disease
The objective of this study is to evaluate the safety and effectiveness of the PDS System compared to the surgical control of posterolateral fusion with autograft and pedicle screw fixation for the treatment of one or two levels…
- Trial name
- NCT00878579
- Testing
- PDS System, Fusion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Interventional Spine, Inc.
Lumbar Disc Herniation, Lumbar Disc Disease
GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries
The purpose of this study is to determine the optimal anesthetic routine for lumbar decompression surgery. General Anesthesia is the standard of care in spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
- Trial name
- NCT05444751
- Testing
- General anesthetic, SA + ESP
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Degenerative Disc Disease (DDD)
Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease
This study will look at the result of using the FLD device as an artificial lumbar disc. The study will compare the safety and effectiveness of the FLD artificial lumbar disc to an already approved artificial lumbar disc.
- Trial name
- FLD (NCT00775801)
- Testing
- FLD, Control
- Where
- 14 sites in United States, Germany
- Volunteers
- 300 people
- Sponsor
- AxioMed Spine Corporation
Degenerative Spinal Conditions
A Pre-market Study to Evaluate b.Bone for Posterolateral Fusion (b.Spine Clinical Trial).
Prospective, open-label, single-arm clinical investigation. The purpose of this clinical investigation is to evaluate the bone substitute b.Bone in posterolateral fusion treatment of degenerative thoracolumbar, lumbar or…
- Trial name
- NCT05906394
- Testing
- Posterolateral Fusion
- Where
- 2 sites in Germany, Italy
- Volunteers
- 16 people
- Sponsor
- GreenBone Ortho S.p.A.
Degenerative Disc Disease, Spondylolisthesis
Clinical and Radiological Outcomes of Oblique Lateral Lumbar Interbody Fusion
This study is undertaken to evaluate the outcomes of Oblique Lateral Lumbar Interbody Fusion (OLLIF). Specifically, the study seeks to measure outcomes on radiological imaging, outcomes reported by the patients on standardized…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT03726190
- Testing
- Oblique Lateral Lumbar Fusion
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Tristate Brain and Spine Institute
Lumbar Spine Degeneration, Lumbar Spinal Stenosis
LLIF Plus Posterior Decompression for Severe Lumbar Spinal Stenosis
Lateral lumbar interbody fusion (LLIF), as a minimally invasive technique, is an indirect decompression technique, and its decompression effect is not as thorough as traditional posterior decompression surgery.
- Trial name
- NCT04094220
- Testing
- Lateral lumbar interbody fusion
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Disc Disease Degenerative, Disk Degeneration
A Study Comparing the Outcome of Anterior Lumbar Fusion and Total Lumbar Disc Replacement
Total lumbar disc replacement has previously been compared to posterior fusion of the lumbar spine, showing some favor towards total disc replacement.
- Conditions
- Disc Disease Degenerative, Disk Degeneration, Disc Disease Lumbar
- Trial name
- NCT03674190
- Testing
- Anterior Lumbar Interbody Fusion, Total Disc Replacement
- Where
- Sweden
- Sponsor
- Svante Berg
Degenerative Disc Disease
Virtuos Bone Graft in Lumbar Fusion
A post-market open label study to assess the efficacy of a cellular based allograft bone graft in lumbar spinal fusion at one or two levels
- Trial name
- NCT06686017
- Where
- 9 sites in United States
- Volunteers
- 150 people
- Sponsor
- Orthofix Inc.
Lumbar Spinal Stenosis, Degenerative Lumbar Spondylolisthesis
Retrospective Comparison of Tubular Decompression ± Rhizotomy Versus TLIF in Lumbar Spinal Stenosis
This retrospective observational study examines clinical outcomes in patients with lumbar spinal stenosis who underwent minimally invasive tubular decompression, with or without subsequent multisegmental percutaneous rhizotomy…
- Conditions
- Lumbar Spinal Stenosis, Degenerative Lumbar Spondylolisthesis, Neurogenic Claudication
- Trial name
- TUBE-FUSE (NCT07489508)
- Where
- 2 sites in Spain
- Volunteers
- 246 people
- Sponsor
- University of Valencia
Lumbar Degenerative Disc Disease, Spinal Stenosis
Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease
The purpose of this study is to compare the effect and safety of NuCel to DBX on patients undergoing posteriolateral lumbar spinal fusions for degenerative disc disease.
- Conditions
- Lumbar Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Spondylosis
- Trial name
- NCT02070484
- Testing
- NuCel, Demineralized Bone Matrix
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- OhioHealth
Disc Degeneration, Low Back Pain
Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery
Low back pain (LBP) is a complex condition that affects 65-85% of the population, and is the leading musculoskeletal condition contributing to disability in the United States.
- Trial name
- NCT03442374
- Testing
- Exercise
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Degenerative Disc Disease
Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP-2/ACS/LT-CAGE® device as compared to the LT-CAGE® device with autogenous bone in patients with symptomatic degenerative disc disease using an open…
- Trial name
- NCT01491386
- Testing
- rhBMP-2/ACS/LT-CAGE® Device, Autogenous Bone/LT-CAGE® Device
- Volunteers
- 279 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Disc Disease, Lumbar Region
Orthokine Therapy in Lumbar Degenerative Disease
The aim of the trial is the comparison of the effectiveness of two methods of Orthokine administration (periradicular or epidural) in lumbar degenerative disc disease.
- Trial name
- OLDDD (NCT04734327)
- Testing
- Orthokine periradicular injection, Orthokine epidural injection
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Sutherland Medical Center
Intervertebral Disc Degeneration, Spinal Fusion
Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction
This study will be conducted at Research Institute of Traumatology and Orthopedics (NRITO) n.a. Ya.L.Tsivyan, Novosibirsk, Russia.
- Trial name
- NCT03908203
- Testing
- Minimally invasive one-level lumbar deformity correction
- Where
- Russia
- Sponsor
- Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Degenerative Disc Disease
Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF)
This study is being conducted to determine the percentage of patients with solid spinal fusions after being treated with Osteocel Plus in a TLIF procedure.
- Trial name
- NCT00947583
- Testing
- Osteocel Plus
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- NuVasive
Degenerative Lumbar Spine Diseases, Lumbar Spinal Instability
Role of Intraoperative Computed Tomography in Assessment of Spine Instability in Lumbar Degenerative Disease
This study examines how well computed tomography (CT) imaging performed during spine surgery - known as intraoperative CT - can detect instability in the lower (lumbar) part of the spine.
- Conditions
- Degenerative Lumbar Spine Diseases, Lumbar Spinal Instability, Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- INSIGHT-CT (NCT07644507)
- Testing
- Intraoperative Computed Tomography (O-arm)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Radiculopathy, Herniated Disc
Regenexx™ PL-Disc Versus Steroid Epidurals for Lumbar Radiculopathy
The primary objective of this study is to compare the improvement in subject-reported clinical outcomes for Regenexx PL-Disc vs.
- Conditions
- Radiculopathy, Herniated Disc, Disc Degeneration
- Trial name
- NCT01850771
- Testing
- Regenexx PL-Disc, Steroid Epidural
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Regenexx, LLC
Spinal Degenerative Disorder, Spinal Stenosis
Physical Activity Intervention for Patients Following Lumbar Spine Surgery
There is a critical need to target physical activity during postoperative management to optimize long-term recovery after lumbar spine surgery.
- Conditions
- Spinal Degenerative Disorder, Spinal Stenosis, Spondylosis
- Trial name
- PASS (NCT04591249)
- Testing
- Physical activity intervention, Usual care
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Degenerative Disc Disease, Discogenic Low Back Pain
A Comparative Study Between Mechanical and a Viscoelastic Disc Prosthesis in the Lumbar Spine
TDR implants for the lumbar spine are currently most 2- or 3-piece devices with a purely mechanical function that provide/restore mobility.
- Trial name
- NCT03716947
- Testing
- Device: ZACK, Device: ORBIT, Device: SASCA
- Where
- Sweden
- Volunteers
- 246 people
- Sponsor
- Karolinska Institutet