Clinical trials: Lumbar Fusion
Complications, Postoperative
A Prospective, Randomized Comparison Of Drainage Techniques After One- Or Two-Level Open Posterior Lumbar Decompression Or Decompression And Fusion
This project is being done to understand if a drain reduces recovery problems after surgery, such as infection or the need for more surgery.
- Trial name
- NCT06820736
- Testing
- Drain
- Where
- United States
- Volunteers
- 975 people
- Sponsor
- Twin Cities Spine Center
Degenerative Lumbar Spondylolisthesis
Study of OP-1 Putty in Uninstrumented Posterolateral Fusions
This study is to provide additional data to support the safety and efficacy of OP-1 Putty as a replacement for autograft in patients undergoing posterolateral spinal fusion.
- Trial name
- NCT00678353
- Where
- 22 sites in United States, Canada
- Volunteers
- 202 people
- Sponsor
- Olympus Biotech Corporation
Spinal Fusion
Safety and Efficacy of Subdermal Betadine During Posterior Spinal Fusion
Bacterial in the subdermal layer of the skin, such as in hair follicles and sweat glands, may contaminate surgical wounds. The goal of this study is to learn about povidone-iodine and its ability to prevent infections…
- Trial name
- NCT06744907
- Testing
- 10% Povidone-Iodine Arm, Saline Arm
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Akron Children's Hospital
Degenerative Lumbar Spondylolisthesis
Study With NVDX3 for Treatment of Low Grade Degenerative Lumbar Spondylolisthesis
Prospective, single arm, single-center clinical study to test NVDX3 in patients suffering from low grade one level degenerative lumbar (L1 - S1) spondylolisthesis. NVDX3 will be implanted during a single surgical intervention.
- Trial name
- NCT05961956
- Testing
- NVDX3
- Where
- Luxembourg
- Volunteers
- 5 people
- Sponsor
- Novadip Biosciences
Spinal Fusion, Lumbar Fusion
Lumbar Fusion With Porous Versus Non-Porous Cages
The objective of this single site, randomized controlled trial is to assess and compare radiographic and clinical outcomes in patients who are to undergo lumbar interbody fusion procedures (TLIF), supplemented with pedicle screw…
- Conditions
- Spinal Fusion, Lumbar Fusion, Arthrodesis, Spondylolisthesis
- Trial name
- NCT05583864
- Testing
- CONDUIT Porous Titanium Spinal Cage, PROTI 360 Titanium-Coated PEEK Spinal Cage
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Francis Farhadi
Single Level Stable Thoracolumbar Fracture Type AO A3, Multiple Level Stable Thoracolumbar Fracture Type AO A3
Spine FA3 - a Prospective, International, Multicenter Cohort Study on Treatment of of AO A3 Thoracolumbar Fractures
Thoracolumbar fractures are the most common spinal fractures with an average annual incidence between 18 and 30 per 100'000 inhabitants. The majority of these fractures are AO type A3 ("burst fractures").
- Trial name
- FA3 (NCT01751633)
- Testing
- Surgical, Conservative treatment
- Where
- 8 sites in Brazil, Chile and 4 more
- Volunteers
- 38 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Degenerative Lumbar Spinal Stenosis
Comparison of Bioactive Glass Ceramics Spacer and PEEK Cages in Posterior Lumbar Interbody Fusion: A Prospective, RCT
The authors aimed to compare the clinical efficacy and safety of CaO-SiO2-P2O5-B2O3 glass ceramics with PEEK cage that is widely used for posterior lumbar interbody fusion (PLIF) surgery in the clinical field.
- Trial name
- Novomax (NCT03302520)
- Testing
- NovoMax, BioAlpha Inc, Seong-nam, Korea, PEEK cage
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Seoul National University Hospital
Degenerative Disc Disease, Spine Fusion
Post Marketing Study of MagnetOs Putty Compared to Local Autograft in Patients Undergoing Posterolateral Lumbar Fusion
This is a phase IV post-marketing study for MagnetOs Putty. MagnetOs Putty is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with leg pain and/or back pain and undergoing…
- Trial name
- PARTNER (NCT04679896)
- Testing
- MagnetOs Putty
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kuros Biosurgery AG
Degenerative Disc Disease
Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion
Among existing surgical techniques, spinal fusion is considered as the gold standard to treat a broad spectrum of degenerative spine disorders, including spondylolisthesis and scoliosis, with regard to pain reduction and…
- Trial name
- NCT02205138
- Testing
- ALLOB® cells with ceramic scaffold
- Where
- 8 sites in Belgium
- Volunteers
- 38 people
- Sponsor
- Bone Therapeutics S.A
Degenerative Disc Disease, Lumbar Disc Disease
LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)
The objective of this study is to evaluate the safety and effectiveness of LDGraft (investigational device) compared to 100% human tissue product allograft bone (control) when applied in an ALIF procedure in the treatment of…
- Conditions
- Degenerative Disc Disease, Lumbar Disc Disease, Spine Disease, Lumbar Spine Degeneration
- Trial name
- RESTORE (NCT06462729)
- Testing
- LDGraft, Allograft Bone
- Where
- 4 sites in United States, Australia
- Volunteers
- 40 people
- Sponsor
- Locate Bio Pty Ltd
Degenerative Osteoarthritis, Degenerative Lumbar Vertebra
Efficacy and Safety Study of Lumbar Interbody Fusion With MatriTMBONE Associated With Autologous Bone Marrow
The main objective of this clinical study is the estimation of the rate of intersomatic fusion observed 12 months after lumbar interbody fusion by posterior approach with PEEK interbody cage of fusion in PEEK performed with…
- Trial name
- MatriBone (NCT01335243)
- Testing
- The Transforaminal Lumbar Interbody Fusion (TLIF) surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Bordeaux
Degeneration of Lumbar Intervertebral Disc
OptiMesh® for Lumbar Interbody Fusion Trial (OLIF)
The purpose of this study was to collect data to demonstrate the safety and effectiveness of the OptiMesh 1500S to contain and reinforce bone graft materials in patients with Degenerative Disc Disease (DDD) whose condition…
- Trial name
- OLIF (NCT00764491)
- Testing
- Structural Allograft Spacer, OptiMesh 1500S
- Where
- 11 sites in United States
- Volunteers
- 156 people
- Sponsor
- Spineology, Inc
Spine Surgery
Effect of Protein Supplement on Paraspinal Muscles in Spine Surgery
Protein intake in spinal fusion surgery can prevent paraspinal muscle atrophy by maintaining muscle mass, regeneration, and growth.
- Trial name
- NCT04300517
- Testing
- Three sachet of protein supplement to be mixed in with water used daily
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University
Degenerative Disc Disease
Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion
The objective of this study is to evaluate the performance of Induce Biologics NMP™ when used to promote interbody fusion for degenerative disease of the lumbar spine.
- Trial name
- NCT05972616
- Testing
- Natural Matrix Protein (NMP)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Induce Biologics USA Inc.
Adjacent Segment Degeneration
Extended One-level Interbody Fusion for Adjacent Vacuum Phenomenon in Lumbar Degenerative Disc Disease
The main objective of this study was to validate the clinical effectiveness of interbody fusion with a one-segment extension for the treatment of adjacent segmental space discs in the surgical treatment of lumbar degeneration.
- Trial name
- NCT06029764
- Testing
- extended one-level interbody fusion
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Xuanwu Hospital, Beijing
Lumbar Fusion Surgery, Fusion of Joint
Evaluation of the Efficacy and Safety of Absorbable vs Traditional Bone Wax for Facet Fusion After Lumbar Fusion Surgery
Hemorrhage on the surface of cancellous bone presents a significant challenge in orthopedic surgery. Traditional bone wax, commonly utilized for hemostasis in bone wounds, is non-absorbable and associated with various…
- Trial name
- NCT07040293
- Testing
- Absorbable bone wax for hemostasis in the osteotomy surface of the facet joint, Traditional bone wax for hemostasis in the osteotomy surface of the facet joint
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Changzheng Hospital
Fusion of Spine, Lumbar Region
Trunk Forward Ability in Patients With Lumbar Fusion
The hypotheses of this study are as follows: 1. There is no significant muscle activity difference of each muscle in patients between pre and post operation. 2.
- Trial name
- NCT01585337
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Degenerative Disc Disease, Degenerative Spondylolisthesis
Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion
The purpose of this study is to evaluate the safety and preliminary efficacy of NeoFuse in subjects with a diagnosis of degenerative disc disease (DDD) in 1 or 2 adjacent vertebral levels between L1 and S1.
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT00996073
- Testing
- Lumbar Interbody Fusion with Autograft, Lumbar Interbody Fusion with NeoFuse
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- Mesoblast, Ltd.
Lumbar Degenerative Spondylolisthesis
Clinical Study on the Therapeutic Efficacy of Biportal Endoscopic Decompression Spine Surgery and Lumbar Decompression Fusion Surgery in the Treatment of Degenerative Lumbar Spondylolisthesis
This study aims to systematically evaluate the therapeutic efficacy of dual-channel endoscopic spinal decompression versus lumbar decompression with fusion for degenerative lumbar spondylolisthesis.
- Trial name
- NCT07289737
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Disc Degeneration, Spinal Deformity
MDT-0123 Japan Study
The purpose of this clinical trial is to compare the efficacy and safety of this investigational device with autologous iliac bone graft (ICBG) in patients who are deemed to require bone fusion through spinal fixation at two…
- Trial name
- NCT07414745
- Testing
- MDT-0123, ICBG
- Where
- 14 sites in Japan
- Volunteers
- 140 people
- Sponsor
- Medtronic Spinal and Biologics