Clinical trials: Lumbar Pain
Intervertebral Disc Displacement, Intervertebral Disc Degeneration
Safety and Efficacy With NOVOCART® Disc Plus (ADCT) for the Treatment of Degenerative Disc Disease in Lumbar Spine
NOVOCART® Disc plus is being investigated to explore its clinical applicability, safety and efficacy in the repair of a herniated disc with an indication for an elective sequestrectomy, and of the adjacent degenerated disc, if…
- Trial name
- NDisc (NCT01640457)
- Testing
- NOVOCART® Disc plus, NOVOCART® Disc basic
- Where
- 10 sites in Austria, Germany
- Volunteers
- 120 people
- Sponsor
- Tetec AG
Low Back Pain, Neck Pain
Wearable Spine Assessment in Adults With and Without Low Back or Neck Pain
This is a single-site, prospective, observational, single-visit feasibility and validity study. Adult participants with and without low back or neck pain will be screened, consented, and enrolled to undergo a structured…
- Trial name
- AxiSens-01 (NCT07643207)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Ashkan Vaziri
Chronic Pain, Chronic Back Pain
Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)
Participants with chronic back pain will complete an online Qualtrics eligibility survey. After signing a consent form, eligible participants enter a two-week baseline period ("Baseline Period"), during which they complete two…
- Conditions
- Chronic Pain, Chronic Back Pain, Chronic Lower Back Pain (CLBP)
- Trial name
- NCT07033195
- Testing
- Skills-based Virtual Reality Therapy, Distraction-based Virtual Reality Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- CognifiSense Inc.
Back Pain Lower Back Chronic
An Open Label Extension Study of Duloxetine (LY248686) in Participants With Chronic Low Back Pain
The purpose of the study is to assess the long term safety of duloxetine in participants with Chronic Low Back Pain (CLBP).
- Trial name
- NCT01914666
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 151 people
- Sponsor
- Eli Lilly and Company
Degenerative Disc Disease
Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease
The goal of this study is to evaluate the safety and tolerability of TG-C in subjects with chronic discogenic lumbar back pain due to degenerative disc disease.
- Trial name
- NCT06144970
- Testing
- TG-C High Dose, TG-C Mid Dose, TG-C Low Dose
- Volunteers
- 24 people
- Sponsor
- Kolon TissueGene, Inc.
Radiculopathy Lumbar
Spinal Decompression Therapy in Radicular Chronic Low Back Pain
The study design was randomized control trial and sampling technique was lottery method. After inclusion and exclusion criteria, sample populations were divided into experimental (group A) and control group (group B).
- Trial name
- NCT04701879
- Testing
- Spine decompression with core stability exercises, Spine decompression
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Low Back Pain
Connective Tissue Motion Measure
The goal of this project is to develop a biomarker - the Connective Tissue Motion Measure (CTMM) -quantifying the functional behavior of perimuscular connective tissues.
- Trial name
- CTMM1 (NCT01413997)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Stromatec, Inc.
Back Pain Without Radiation
Duloxetine Versus Placebo in Chronic Low Back Pain
The primary purpose of your participation in this study is to help answer the following research question, and not to provide you treatment for your condition--Whether duloxetine once daily can help patients with Chronic Low Back…
- Trial name
- NCT00408876
- Testing
- Duloxetine
- Where
- 4 sites in United States
- Volunteers
- 404 people
- Sponsor
- Eli Lilly and Company
Low Back Pain
Comparing Efficacy and Safety Between Eperisone a BID and a TID Regimen in Acute Low Back Pain Patients
Multi-center Study to Compare Efficacy and Safety between Eperisone a BID and a TID Regimen in Acute Low Back Pain Patients during 7 days.
- Trial name
- NCT01806818
- Where
- 5 sites in South Korea
- Volunteers
- 98 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Lower Back Pain
Comparison of Electronic Calipers to Conventional Calipers and X-ray Measurement of Spinal Tilt
The objective is to compare the accuracy and reproducibility of measurements taken with electronic calipers and conventional calipers.
- Trial name
- NCT02920255
- Testing
- Diagnostic
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KKT Orthopedic Spine Center
Back Pain Lower Back Chronic
Safety of BTDS in Subjects With Low Back Pain: A 52-Week Extension Phase of BUP3015
The purpose of the extension phase is to evaluate the long-term safety and tolerability of buprenorphine transdermal system (BTDS).
- Trial name
- NCT01125917
- Testing
- Buprenorphine transdermal patch
- Where
- 84 sites in United States
- Volunteers
- 354 people
- Sponsor
- Purdue Pharma LP
Chronic Low Back Pain
Oxycodone DETERx™ Versus Placebo in Chronic Low Back Pain (CLBP)
The purpose of this study is to evaluate the analgesic efficacy of Oxycodone DETERx compared with placebo in opioid-experienced and opioid-naive subjects with moderate-to-severe chronic low back pain requiring around-the-clock…
- Trial name
- NCT01685684
- Testing
- Oxycodone DETERx
- Where
- 45 sites in United States
- Volunteers
- 740 people
- Sponsor
- Collegium Pharmaceutical, Inc.
Low Back Pain, Neuropathic Pain
Comparison of Increasing Doses of Tapentadol Versus a Combination of Tapentadol and Pregabalin
The main objective of the study is to evaluate the effectiveness, safety, and tolerability of increasing doses of tapentadol prolonged release (PR) (500 mg per day) versus a combination of tapentadol PR (300 mg per day) and…
- Trial name
- NCT01352741
- Testing
- Tapentadol Prolonged Release, Tapentadol Prolonged Release with Pregabalin, Tapentadol Prolonged Release open label maintenance
- Where
- 59 sites in Austria, Belgium and 5 more
- Volunteers
- 622 people
- Sponsor
- Grünenthal GmbH
Back Pain, Lower Back Pain
Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain
The study includes back pain of the cervical, thoracic, and the lumbar regions.
- Conditions
- Back Pain, Lower Back Pain, Cervical Pain
- Trial name
- NCT01415895
- Testing
- Naltrexone and Clonidine Combination
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Annette C. Toledano MD
Low Back Pain
A Single Ascending Dose Study of Safety and Tolerability of STA363 Compared to Placebo in 15 Patients With Chronic Discogenic Low Back Pain
A phase I, randomized, double-blinded, placebo-controlled, single ascending dose study to investigate the safety, local tolerability and transformation of nucleus pulposus following intradiscal injection of STA363 or placebo in…
- Trial name
- NCT03055845
- Testing
- STA363
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Stayble Therapeutics
Back Pain Lower Back Chronic, Chronic Pain
Examining the Impact of a Digital Health Program and TENS Device for Patients With Chronic Low Back Pain
The goal of this study is to examine the extent to which Hinge Health, a digital musculoskeletal program, and Enso, a wearable pain relief device, have clinically significant impact on the pain, function, and health care use…
- Conditions
- Back Pain Lower Back Chronic, Chronic Pain, Musculoskeletal Pain
- Trial name
- NCT07011537
- Testing
- Digital Musculoskeletal (MSK) Program, Transcutaneous Electrical Nerve Stimulation (TENS), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Hinge Health, Inc
Chronic Low Back Pain
Long-Term Safety Study of Bicifadine for the Treatment of Chronic Low Back Pain
The primary objective of the study is to evaluate the safety and efficacy of bicifadine 400 mg BID for up to one year in patients with moderate to severe chronic low back pain.
- Trial name
- NCT00281645
- Testing
- Bicifadine, Standard of Care (pharmacological analgesic treatment)
- Volunteers
- 1,250 people
- Sponsor
- DOV Pharmaceutical, Inc.
Low Back Pain
Efficacy and Safety of GRT6005 in Patients With Chronic Low Back Pain.
The purpose of this trial is to evaluate the safety and efficacy of once daily orally administered GRT6005 in a total of 3 fixed doses compared to placebo in subjects with moderate to severe chronic Low Back Pain (LBP).
- Trial name
- NCT01725087
- Testing
- Low Dose GRT6005, Medium Dose GRT6005, High Dose GRT6005
- Where
- 79 sites in Austria, Belgium and 9 more
- Volunteers
- 1,089 people
- Sponsor
- Tris Pharma, Inc.
Low Back Pain
Safety And Efficacy Of Celecoxib Versus Sodium Diclofenac In The Treatment Of Acute Low Back Pain
To evaluate the safety and efficacy of celecoxib versus sodium diclofenac in subjects with acute low back pain
- Trial name
- NCT00640432
- Testing
- Diclofenac, Celecoxib
- Where
- 9 sites in Brazil
- Volunteers
- 244 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Chronic Pain
Efficacy and Safety of Oxmorphone Extended Release in Chronic Non-malignant Pain
The purpose of this study is to evaluate the analgesic efficacy and safety of oxymorphone extended release in non-cancer patients with chronic low back pain.
- Trial name
- NCT00225797
- Testing
- Oxymorphone Extended Release
- Where
- 33 sites in United States
- Volunteers
- 160 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company