Clinical trials: Lumbar Spine Degenerative Changes
Degenerative Lumbar Disc Disease, Spondylolisthesis
Spine Fusion Instrumented With BMP-2 vs Uninstrumented With Infuse BMP-2 Alone
The goal of spinal fusion is to relieve pain and/or increase stability in painful or unstable spine joints. A patient may or may not receive rods and screws with the use of bone graft materials to facilitate bone growth and a…
- Conditions
- Degenerative Lumbar Disc Disease, Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT00405600
- Testing
- Device used in surgery with or without instrumentation
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Degenerative Disc Disease
Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion
The objective of this study is to evaluate the performance of Induce Biologics NMP™ when used to promote interbody fusion for degenerative disease of the lumbar spine.
- Trial name
- NCT05972616
- Testing
- Natural Matrix Protein (NMP)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Induce Biologics USA Inc.
Lumbar Spine Degenerative Changes, Lumbar Spine Surgery
Rehabilitation With Empowered STrategies to Optimize REcovery
The main goal of this clinical trial is to understand the benefits of remotely delivered Empowered Relief in patients undergoing lumbar spine surgery.
- Trial name
- RESTORE (NCT07406997)
- Testing
- Empowered Relief, Education
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Lumbar Disc Disease, Lumbar Spine Degeneration
The Six-Minute Walking Test (6WT) and Timed-Up-and-Go (TUG) Test as Measures of Objective Functional Impairment in Patients Undergoing Interlaminar or Transforaminal Epidural Steroid Injection for Lumbar Degenerative Disc Disease (DDD)
The primary objective is to determine the validity of the Six-Minute-Walking Test (6WT) and Timed-Up and Go (TUG) test to measure objective functional impairment (OFI) in patients undergoing either interlaminar epidural steroid…
- Conditions
- Lumbar Disc Disease, Lumbar Spine Degeneration, Lumbar Spinal Stenosis
- Trial name
- NCT04062942
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
Degenerative Disc Disease (DDD)
Retro Comparison of Subsidence Following Interbody Devices in Lumbar Spine
The objective of this retrospective study is an investigational clinical follow-up, of patients treated with interbody fusion devices (IBFD), both expandable (EXP) and static (STC), according to their intended use and cleared…
- Trial name
- NCT05536453
- Testing
- Lumbar Interbody Fusion Devices
- Where
- 4 sites in United States
- Volunteers
- 465 people
- Sponsor
- Spine and Scoliosis Research Associates
Degenerative Changes, Stenosis
Accell Evo3™ Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion
The objective of this study is to prospectively evaluate the performance of Integra Accell Evo3 Demineralized Bone Matrix as an adjunct for instrumented posterolateral spine fusion, as compared to local autograft.
- Conditions
- Degenerative Changes, Stenosis, Spondylosis
- Trial name
- NCT02018445
- Testing
- Posterolateral Fusion
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- SeaSpine, Inc.
Lumbar Spine Stenosis, Lumbar Spine Degeneration
OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
- Trial name
- NCT05452694
- Where
- 3 sites in United States
- Volunteers
- 235 people
- Sponsor
- OpalGenix, Inc
Degenerative Lumbar Spinal Stenosis, Lumbarsacral Orthosis
Is Postoperative Bracing Necessary After Spine Surgery for Degenerative Conditions
This study was started from Oct. 2015. This study aimed to evaluate the outcome of bracing following transforaminal lumbar interbody fusion (TLIF) in patients with degenerative lumbar spine diseases.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Lumbarsacral Orthosis, Transforaminal Lumbar Interbody Fusion
- Trial name
- NCT03560401
- Testing
- Knight-Taylor [chairback] brace
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Lumbar Degenerative Disc Disease
Percutaneous Dynamic Stabilization (PDS) System Versus Fusion for Treating Degenerative Disc Disease
The objective of this study is to evaluate the safety and effectiveness of the PDS System compared to the surgical control of posterolateral fusion with autograft and pedicle screw fixation for the treatment of one or two levels…
- Trial name
- NCT00878579
- Testing
- PDS System, Fusion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Interventional Spine, Inc.
Degenerative Disc Disease, Lumbar Region
Orthokine Therapy in Lumbar Degenerative Disease
The aim of the trial is the comparison of the effectiveness of two methods of Orthokine administration (periradicular or epidural) in lumbar degenerative disc disease.
- Trial name
- OLDDD (NCT04734327)
- Testing
- Orthokine periradicular injection, Orthokine epidural injection
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Sutherland Medical Center
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Degenerative Disc Disease
Interbody Systems: Post Market Clinical Follow-up Study
This is a prospective, multi-center study of subjects who will undergo spinal fusion surgery utilizing Stryker Interbody Systems that require post market clinical follow up (PMCF).
- Trial name
- NCT04911257
- Testing
- Cervical or Lumbar Spinal fusion
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- K2M, Inc.
Degenerative Disease of the Lumbosacral Spine
Transforaminal Lumbar Interbody Fusion (TLIF)
This is a global, multi-center, prospective, randomized, blinded, controlled pivotal study. Clinical and radiological evaluation will be performed preoperatively and postoperatively up to 24 months; and endpoint success will be…
- Trial name
- TLIF (NCT04073563)
- Testing
- Infuse™ Bone Graft (Infuse™), Intervertebral body fusion device and Medtronic posterior Fixation Systems
- Where
- 46 sites in United States, China
- Volunteers
- 600 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Lumbar Disease
Decision Making in Degenerative Lumbar Spine : CT vs. MRI
To identify the optimal imaging modality involved in decision making in patients with degenerative lumbar spine using CT vs. MRI.
- Trial name
- NCT04130035
- Volunteers
- 30 people
- Sponsor
- Assiut University
Degenerative Disc Disease, Spinal Stenosis
Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine
nanOss Bioactive is approved for use in the U.S. The purpose of this study is to compare fusion results in the posterolateral spine using nanOss Bioactive mixed with autograft bone and bone marrow aspirate (BMA) on one side and…
- Conditions
- Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
- Trial name
- NCT01968993
- Testing
- nanOss Bioactive - posterolateral gutter
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Pioneer Surgical Technology, Inc.
Intervertebral Disc Degeneration
Safety and Performance of the Hexanium TLIF System in the Treatment of Degenerative Disc Disease
The goal of this observational study is to confirm the safety and efficacy of the Hexanium TLIF system in the treatment of skeletally mature patients suffering from degenerative disc disease (disease that occurs when the spinal…
- Trial name
- TLIF (NCT05997121)
- Testing
- Transforaminal lumbar interbody fusion
- Where
- 6 sites in France, Switzerland
- Volunteers
- 187 people
- Sponsor
- SPINEVISION SAS
Degenerative Disc Disease
Multicenter Study of the Avenue L Interbody Spinal Fusion System Using VerteBRIDGE Plating and Posterior Fixation
The purpose of this prospective clinical study is to examine the short-term safety and efficacy of the Avenue®- L interbody Spinal Fusion System with VerteBRIDGE® plating to treat one and two level degenerative disc disease…
- Trial name
- NCT02068768
- Testing
- Avenue® L Interbody Fusion System (LDR Spine)
- Where
- 4 sites in United States
- Volunteers
- 13 people
- Sponsor
- LDR Spine USA
Degeneration Spine
Primary Sacroiliac Fusion Versus Fusion to the Sacrum for Degenerative Disease of the Lumbar Spine
To prove that the use of additional S2alar-iliac screws for pure lumbar fusions due to degenerative lumbar disease provides superior outcome compared to the standard procedure of fusion to S1.
- Trial name
- PSEUDOLUSE (NCT04308018)
- Testing
- S2alar-iliac screws, S1 screws
- Volunteers
- 148 people
- Sponsor
- Technical University of Munich
Lumbar Degenerative Disease
Erector Spinae Plan Block (ESPB) with Dexmedetomidine and Dexamethasone in Lumbar Spine Fusion
This study wants to understand if using a pre-operative anesthetic injection could contribute to better pain relief after the surgery. This injection is referred to as an erector spinae plane block (ESPB, or "Block" for short).
- Trial name
- ESPB (NCT06658054)
- Testing
- Adjuvant analgesia, Control (Standard treatment)
- Volunteers
- 46 people
- Sponsor
- University of Southern California
Spine Degeneration
Risk Factors of Paraspinal Muscles in Degenerative Lumbar Spondylolisthesis
This is a retrospectively observational study. The goal of this observational study is to analyze the risk factors of paraspinal muscles associated with the occurrence of spondylolisthesis in patients with degenerative lumbar…
- Trial name
- RFPMDLS (NCT06797700)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The First People's Hospital of Yunnan