Clinical trials: Lumbosacral Radiculopathy
Radicular Pain Related to Lumbosacral Disc Disease
Milnacipran for Lumbosacral Radicular Pain
This study investigates whether milnacipran reduces radicular pain ("sciatica") in patients with lumbosacral disc disease.
- Trial name
- NCT01777581
- Testing
- Milnacipran
- Volunteers
- 13 people
- Sponsor
- Duke University
Cervical Lordosis Rehabilitation
Does Improvement Towards a Normal Cervical Sagittal Configuration Aid in the Management of Lumbosacral Radiculopathy
A randomized controlled study with six months follow-up will be conducted to investigate the effects of sagittal head posture correction on 3D spinal posture parameters, back and leg pain, disability, and S1 nerve root function…
- Trial name
- NCT05553002
- Testing
- Deneroll cervical extension traction, Traditional treatment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Lumbar Spine Degeneration
INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine
This investigation will provide safety and effectiveness information on the use of INFUSE® Bone Graft with the CAPSTONE® Spinal System and CD HORIZON® Spinal System with a Transforaminal Lumbar Interbody Fusion (TLIF) surgical…
- Trial name
- TLIF (NCT01415908)
- Testing
- INFUSE Bone Graft, Iliac Crest Bone Graft
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Medtronic Spinal and Biologics
Lumbosacral Radicular Pain, Lumbar Radiculopathy
Determination of Sensitivity and Specificity of Straight Leg Raise Test Via Transforaminal Nerve Root Block
This study aims to evaluate the diagnostic accuracy of the straight leg raise test in patients with suspected lumbosacral radicular pain.
- Conditions
- Lumbosacral Radicular Pain, Lumbar Radiculopathy, Straight Leg Raise
- Trial name
- NCT07696312
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Marmara University
Lumbar Radiculopathy
Safety and Efficacy of SX600 Administered by Lumbosacral Transforaminal Epidural Injection for Radicular Pain
This is a Phase I/II, double-blind, parallel-group, randomized, placebo-controlled multi-centre trial in 180 patients randomized 1:1:1 to receive the IMP (Dexamethasone acetate microspheres for extended-release injectable…
- Trial name
- SALIENT (NCT03952377)
- Testing
- SX600
- Where
- 10 sites in Australia
- Volunteers
- 56 people
- Sponsor
- SpineThera Australia PTY LTD
Sciatica, Lumbosacral Radiculopathy
A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy
The primary objectives of this clinical trial are to investigate the pharmacokinetics and safety of MDT-15 pellets in escalating sequential doses administered to different cohorts.
- Trial name
- NCT01917825
- Testing
- MDT-15
- Where
- 6 sites in United States
- Volunteers
- 54 people
- Sponsor
- Medtronic Spinal and Biologics
Compression of Spinal Nerve Root, Spinal Disorder
Soleus H-Reflex in Different Sitting Postures
The purpose of this study was to examine the effect of prolonged sitting duration and three different sitting postures (erect, slumped, and slouched sitting postures) on spinal nerve root function by measuring the soleus (SOL)…
- Conditions
- Compression of Spinal Nerve Root, Spinal Disorder, Low Back Pain
- Trial name
- NCT01744899
- Testing
- Sitting posture
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Lumbosacral Radiculopathy
Augmented Posterior Oblique Sling Activation on Lumbopelvic Recruitment Pattern in Lumbosacral Radiculopathy
The current study aims to determine the impact of augmented posterior oblique sling activation on lumbopelvic recruitment pattern and functional outcomes in patients with unilateral lumbosacral radiculopathy.
- Trial name
- NCT06558383
- Testing
- augmented posterior oblique sling activation, selected physical therapy program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Lumbar and Other Intervertebral Disc Disorders With Radiculopathy
Epidural Clonidine for Lumbosacral Radiculopathy
This was a randomized, blinded study of transforaminal epidural injection of clonidine versus a similar injection of corticosteroid for acute lumbosacral radiculopathy.
- Trial name
- NCT00588354
- Testing
- Clonidine, Triamcinolone hexacetonide, Lidocaine HCl
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lumbosacral Radiculopathy
Effects of Mackenzie Extension and William Flexion Exercises in Lumbo-sarcal Radiculopathy
Lumbosacral radiculopathy (LR) is among most common disorder caused due to irritation or compression of nerve pathway leading to symptoms of pain, numbness and tingling sensations along the nerve root.
- Trial name
- NCT05654428
- Testing
- Mckenzie Extension Exercises, William Flexion Exercises
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Neuro Counsel Hospital, Pakistan
Radiculopathy, Lumbosacral Region, Radiculopathy Lumbar
The Effect of High-power Laser Therapy on Pain, Functional Disability, Range of Motion and Pressure Pain Threshold in Subjects With Radicular Low Back Pain Due to Intervertebral Disc Herniation
Low back pain is the predominant cause of disability on a global scale. In the year 2015, the worldwide point prevalence of activity-limiting low back pain stood at 7·3%, suggesting that at any given moment, 540 million…
- Trial name
- NCT06151704
- Testing
- High intensity laser therapy, Motor control exercise
- Where
- Iran
- Volunteers
- 36 people
- Sponsor
- Iran University of Medical Sciences
Neuropathic Pain From Lumbosacral Radiculopathy
Single Ascending Doses Study of KLS-2031 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
Escalating single-dose design study to determine the safety, tolerability, and analgesic activity of KLS-2031
- Trial name
- NCT04238793
- Testing
- KLS-2031
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Kolon Life Science
Radiculopathy Lumbar, Radiculopathy Sacral
Impact of Direct Current Electrical Stimulation on Treatment of Lumbosacral Radiculopathy
This study will compare two methods of electrical stimulation (alternating current and direct current) as an adjunctive therapy to treating lumbosacral radiculopathy.
- Conditions
- Radiculopathy Lumbar, Radiculopathy Sacral, Radiculopathy Multiple Sites
- Trial name
- NCT06421558
- Testing
- Neubie Direct Current Electrical Stimulation Device, Transcutaneous Electrical Stimulation
- Where
- 16 sites in United States
- Volunteers
- 150 people
- Sponsor
- NeuFit - Neurological Fitness and Education
Lumbar Radiculopathy
MORE in the Management of Lumbosacral Radiculopathy Symptoms: A Randomized Controlled Trial
INTRODUCTION: Chronic low back pain (CLBP) is a ubiquitous musculoskeletal (MSK) complaint that often presents as a chronic and difficult to treat condition.
- Trial name
- MORE (NCT04818606)
- Testing
- Mindfulness Oriented Recovery Enhancement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National University of Natural Medicine
Herniated Lumbar Disc
High Power Laser Therapy for Herniated Disc and Lumbosacral Radiculopathy
To determine the effect of high-power laser therapy on the size of herniated disc and functional outcome in patients with lumbosacral radiculopathy.
- Trial name
- NCT06831227
- Testing
- High power Laser Therapy, physical therapy exercise program and hot pack
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Lumbosacral Radiculopathy
US vs FL-Guided Lumbar Nerve Root Injections
The goal of this clinical trial is to learn if ultrasound-guided nerve root injections work as well as fluoroscopy (X-ray)-guided injections to treat lower back and leg pain caused by irritated nerves (lumbosacral radiculopathy)…
- Trial name
- NCT07627308
- Testing
- Ultrasound-Guided Selective Lumbar Nerve Root Injection, Fluoroscopy-Guided Selective Lumbar Nerve Root Injection
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Tanta University
Radiculopathy, Lumbosacral Region
Diagnostic Validity of the Neurodynamic or Orthopedic Tension Tests
The objective of the present study is to analyse the diagnostic validity of 8 neurodynamic and/or orthopedic tension tests using magnetic resonance imaging as the Gold Standard.
- Trial name
- NCT04485572
- Testing
- Straight Leg Raise test (SLR) and Bragard test (B), Fajersztajn test (F) and Sicard test (S), Passive Neck Flexion test (PNF)and Kernig test (K)
- Volunteers
- 1,887 people
- Sponsor
- University of Extremadura
Painful Lumbosacral Radiculopathy
Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)
The purpose of the study is to evaluate the efficacy and safety of VX-548 in treating participants with PLSR.
- Trial name
- NCT06176196
- Testing
- VX-548
- Where
- 54 sites in United States
- Volunteers
- 218 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Sciatica, Radiculopathy
Steroids Versus Gabapentin
The purpose of this study is to determine whether pharmacotherapy or epidural steroid injections are a better treatment for lumbosacral radicular pain.
- Trial name
- NCT01495923
- Testing
- epidural steroid injection, Gabapentin
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- Johns Hopkins University
Radicular Pain, Lumbar Surgery
Return to Work After Lumbar Surgery: a Nationwide Survey of Spinal Surgeons' Practices
This national cross-sectional survey investigates the current practices and perceptions of Belgian spinal surgeons regarding return to work (RTW) after lumbar surgery for radicular pain.
- Conditions
- Radicular Pain, Lumbar Surgery, Radicular Pain Related to Lumbosacral Disc Disease, Fusion of Spine, Lumbar Region
- Trial name
- NCT07193758
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven