Clinical trials: Lung; Congestive
Severe Sepsis, Malaria
Monitoring of Perfusion in Sepsis and Malaria
Sepsis and severe malaria together contribute to an estimated 13 million deaths annually, a great burden of which is in low-income countries.
- Trial name
- PERFuSE (NCT03641534)
- Testing
- Lung Ultrasound examination, Compression ultrasonography (CUS), Echocardiography
- Where
- Bangladesh
- Volunteers
- 103 people
- Sponsor
- University of Oxford
Pulmonary Edema, Congestive Heart Failure
DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure
DECONGEST-AHF compares three initial treatments for adults admitted with suspected pulmonary congestion due to acute heart failure: intravenous furosemide, intravenous isosorbide dinitrate, or both medicines together.
- Conditions
- Pulmonary Edema, Congestive Heart Failure, Acute Heart Failure
- Trial name
- DECONGEST-AHF (NCT05276219)
- Testing
- Furosemide Injection, Isosorbide Dinitrate, Furosemide and isosorbide dinitrate
- Where
- 5 sites in Denmark
- Volunteers
- 1,041 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Failure, Congestive Heart Failure
Effect of High-flow Nasal Oxygen on Extubation Outcome
The purpose of this study is to determine whether high flow nasal cannula is effective in lowering the reintubation rate after extubation for high risk patients in medical intensive care unit
- Conditions
- Respiratory Failure, Congestive Heart Failure, COPD
- Trial name
- NCT02290548
- Testing
- high flow nasal cannula
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Mackay Memorial Hospital
Transcatheter Aortic Valve Replacement, Lung Ultrasound
LUS in Aortic Stenosis Patients Undergoing TAVR
1. Introduction and aims: Transcatheter aortic valve replacement (TAVR) is the gold standard for the treatment of elderly patients with severe aortic valve stenosis (AS).
- Conditions
- Transcatheter Aortic Valve Replacement, Lung Ultrasound, Severe Aortic Valve Stenosis, Pulmonary Congestion
- Trial name
- NCT05024942
- Testing
- Transfemoral TAVR (Transcatheter aortic valve replacement)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Catholic University of the Sacred Heart
Heart Failure, Congestive
Influence of Angiotensin Converting Enzyme (ACE) Genotype on Lung Diffusion in Heart Failure
In patients with chronic heart failure ACE-inhibitor treatment improves lung diffusion and prevents pulmonary edema after fluid overload. In the western country, 3 population types of ACE genotypes exist (DD, ID, II).
- Trial name
- NCT00361127
- Testing
- isotonic saline infusion
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Piergiuseppe Agostoni
Pneumonia, Diabetes
Social Incentives to Increase Mobility
This study aims to assess the effectiveness of a social incentive-based gamification intervention to increase physical activity in the 3 months after hospital discharge.
- Conditions
- Pneumonia, Diabetes, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- MOVE IT (NCT03321279)
- Testing
- Social Incentive
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- University of Pennsylvania
Outcome, Fatal
Oxygen Pulse and Its Curve Patterns in Male Patients With Heart Failure and Chronic Obstructive Pulmonary Disease With and in Healthy Men
Background: In non-invasive cardiopulmonary exercise testing (CPET), oxygen pulse (O2P) is defined as oxygen uptake divided by heart rate and is equal to the product of stroke volume and oxygen extraction by cells.
- Trial name
- NCT05189301
- Testing
- first pass study, cardiopulmonary exercise testing
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chung Shan Medical University
Hypertension, Diabetes Mellitus, Type 2
Enhancing Community Health Through Patient Navigation, Advocacy and Social Support
Some patients who have multiple long-term health conditions have significant challenges accessing needed services despite available primary care and social services resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT03077386)
- Testing
- ENCOMPASS Intervention
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University of Calgary
Aortic Stenosis
Association Between Changes in Aortic Valve Area and Pulmonary Congestion After Transcatheter Aortic Valve Implantation
This prospective, single-center observational study aims to evaluate the relationship between changes in aortic valve hemodynamics and pulmonary congestion in patients undergoing elective transfemoral transcatheter aortic valve…
- Trial name
- NCT07794436
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istanbul University - Cerrahpasa
Angina, Stable, Congestive Heart Failure
Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
This feasibility trial will focus on older adults 60+ who are candidates for cardiac or pulmonary rehabilitation and who are vulnerable, mildly or moderately frail.
- Conditions
- Angina, Stable, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05562037
- Testing
- Stepped Care
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- Peter Lindenauer, MD
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
A Culturally Sensitive Values-Guided Aid for End of Life Decision-Making
The goal of this research agenda is to improve the quality of end-of-life care by explicitly identifying values that will guide the decision-making process, with a particular emphasis on the role of ethnic, racial and cultural…
- Conditions
- Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Cirrhosis, Colon Carcinoma
- Trial name
- Aim3 (NCT00122135)
- Testing
- Values Inventory (VI)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus, Type 2, Congestive Heart Failure
Improving Patient Prioritization During Hospital-homecare Transition
This research work is focused on building and evaluating one of the first evidence-based clinical decision support tools for homecare in the United States.
- Conditions
- Diabetes Mellitus, Type 2, Congestive Heart Failure, Obstructive Pulmonary Disease, Dyspnea
- Trial name
- PREVENT (NCT04136951)
- Testing
- PREVENT clinical decision support
- Where
- 2 sites in United States
- Volunteers
- 1,915 people
- Sponsor
- Columbia University
Coronary Artery Bypass Surgery, Coronary Heart Disease
An Efficacy and Safety Study for Nesiritide in Heart Failure Patients With Reduced Kidney Function Undergoing Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass (CPB Pump or Heart Lung Machine)
The purpose of this study is to assess whether nesiritide compared to placebo when given with standard of care therapies, helps preserve kidney function in heart failure (HF) patients undergoing heart bypass graft surgery that…
- Conditions
- Coronary Artery Bypass Surgery, Coronary Heart Disease, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
- Trial name
- NCT00530361
- Testing
- Nesiritide
- Sponsor
- Scios, Inc.
Chronic Obstructive Pulmonary Disease, Asthma
Evaluation of ST2 and IL-33 in Patients Presenting to the Emergency Department With Trouble Breathing
Trouble breathing (dyspnea) is a nonspecific symptom associated with many diseases such as chronic obstructive pulmonary disease (lung disorder in which the flow of air to the lungs is blocked), asthma, pneumonia, pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Pulmonary Embolism, Pneumonia
- Trial name
- NCT00707811
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- The Cleveland Clinic
Metastatic Cancer, Congestive Heart Failure
Reducing Disparities in the Quality of Advance Care Planning for Older Adults
This study compares the effectiveness of two different approaches to advance care planning among older African Americans and older Whites living in the community.
- Conditions
- Metastatic Cancer, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Parkinson Disease
- Trial name
- EQUALACP (NCT03516994)
- Testing
- Respecting Choices First Steps, Five Wishes Form
- Where
- 4 sites in United States
- Volunteers
- 790 people
- Sponsor
- Duke University
SECONDARY PULMONARY HYPERTENSION, MITRAL STENOSIS
Bosentan for Severe Mitral Valve Dysfunction
Vasoconstrictive signaling via endothelin receptors is not limited to primary pulmonary arterial hypertension, but has also been documented in secondary pulmonary hypertension due to congestive heart failure, including cardiac…
- Conditions
- SECONDARY PULMONARY HYPERTENSION, MITRAL STENOSIS, CHILDHOOD RHEUMATOID FEVER, CONGESTIVE HEART FAILURE
- Trial name
- BOSMIVAR (NCT01270750)
- Testing
- BOSENTAN
- Where
- Greece
- Volunteers
- 10 people
- Sponsor
- General Hospital of Chalkida
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Early Warning System
The study will begin in 2013 whereby patients having an early warning system (EWS) alert will be randomized to be seen by the rapid response team (RRT) for triage versus usual care.
- Conditions
- Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Cancer, Diabetes Mellitus
- Trial name
- NCT01741480
- Testing
- Early warning system monitoring., routine care
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Congestive Heart Failure
Relative Impacts on Preventative Primary Care--a Longitudinal Evaluation of COVID-19:Phase 1
The goal of this observational study is to describe the impacts of COVID-19 on primary care chronic condition management in Canada within various patient populations.
- Conditions
- Diabetes Mellitus, Congestive Heart Failure, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease
- Trial name
- RIPPLE-C (NCT05813652)
- Testing
- Pre-pandemic time period (Jun 22, 2018 to March 12, 2020), Peri-pandemic time period (March 13, 2020 to December 3, 2021)
- Where
- Canada
- Volunteers
- 919,928 people
- Sponsor
- McMaster University
Heart Failure, Edema
Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure
The primary objective of this study is to learn whether a morning dose of extended-release torsemide enhances renal sodium excretion after lunch (4-8 hours after dosing) compared to immediate-release torsemide.
- Conditions
- Heart Failure, Edema, Pulmonary Congestion, Fluid Overload
- Trial name
- NEXT-HF (NCT06995144)
- Testing
- Extended Release Torsemide Tablets, Immedate Release Torsemide Tablets
- Where
- United States
- Sponsor
- Sarfez Pharmaceuticals, Inc.
Respiratory Syncytial Virus, Chronic Obstructive Pulmonary Disease, Congestive Heart Failure
An Observational Study to Assess RSV-associated Illness in Adults With COPD and/or CHF
The primary objective of this observational study is to determine the incidence of medically attended (inpatient or outpatient) acute respiratory illnesses or events leading to worsening cardiorespiratory status (ie, acute…
- Trial name
- CD-1089 (NCT01455402)
- Where
- 60 sites in United States, Bulgaria and 7 more
- Volunteers
- 476 people
- Sponsor
- MedImmune LLC