Clinical trials: Lung; Disease
Chronic Obstructive Pulmonary Disease
The Effect of Reflective Breathing Therapy Compared With Conventional Breathing Therapy in Patients With Chronic Obstructive Pulmonary Disease (COPD) III-IV
The purpose of this study is to determine whether different types of breathing therapies in patients with COPD III-IV decrease dyspnea and increase activity.
- Trial name
- NCT01478646
- Testing
- conventional breathing therapy, reflectory breathing therapy
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Asthma
Safety of Bronchial Thermoplasty Performed With the Alair® System During Two Treatment Sessions to Treat Severe Asthma
The objective of this multicenter, single-arm, open-label clinical study is to evaluate the safety of performing bronchial thermoplasty with the Alair® System during two treatment sessions to treat severe asthma.
- Trial name
- 3to2 (NCT00803088)
- Testing
- The Alair System
- Sponsor
- Boston Scientific Corporation
Ventilator Associated Pneumonia
Clinical Impact of Lung Ultrasound Monitoring for Diagnosis of VAP
The study evaluates whether lung ultrasound monitoring could lead to earlier detection of ventilator associated pneumonia and influence outcome.
- Trial name
- NCT03917888
- Testing
- lung ultrasound
- Where
- Nepal
- Volunteers
- 88 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Pulmonary Arterial Hypertension
Ventavis® Registry Protocol
The Ventavis® (iloprost) Registry is a multicenter, observational, U.S.-based study that longitudinally follows patients with pulmonary arterial hypertension (PAH) who have been receiving therapy with Ventavis® for at least 3…
- Trial name
- RESPIRE (NCT00902603)
- Testing
- Commercial Ventavis® (iloprost)
- Volunteers
- 148 people
- Sponsor
- Actelion
COPD, Oxygen Therapy
Closed-loop System for Oxygen Delivery and Exercise in Chronic Obstructive Pulmonary Disease
The purpose of this study is to investigate the benefit of Closed-loop System for Oxygen Delivery (FreeO2) as compared with fixed oxygen flow during endurance shuttle walking test in patients with Chronic obstructive pulmonary…
- Conditions
- COPD, Oxygen Therapy, Hypercapnia
- Trial name
- FreeO2-rehab (NCT01575327)
- Testing
- Automated settings on the oxygen delivery device, Manual settings with FreeO2 system in collection mode
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- AGIR à Dom
Covid19
A Study to Evaluate Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long COVID)
This is a phase I study to evaluate the safety and efficacy of inhaled Ampion on patients with prolonged respiratory symptoms due to COVID-19 (Long COVID).
- Trial name
- NCT04880161
- Testing
- Ampion
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Respiratory Tract Infection, Bronchitis
A Multi-Site Clinical Evaluation of the ARIES Flu Assay in Symptomatic Patients
The ARIES Flu Assay is a real-time PCR based qualitative assay for the direct detection and differentiation of respiratory viral nucleic acid in nasopharyngeal swabs specimens.
- Conditions
- Respiratory Tract Infection, Bronchitis, Pneumonia
- Trial name
- NCT02087761
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Luminex Corporation
Post-Surgical Pain, Chronic, Post-traumatic Pain, Chronic
Uncovering the Mechanism of Pain Relief by Peripheral Transcutaneous Magnetic Stimulation
This research aims to uncover the Mechanisms of pain relief through the FDA-cleared peripheral transcutaneous magnetic stimulation (pTMS) device by MagVenture.
- Trial name
- NCT07199361
- Testing
- Peripheral Transcutaneous Magnetic Stimulation from MagVenture
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Florida International University
Cystic Fibrosis
Pharmacokinetics of Omadacycline in Cystic Fibrosis
The purpose of this study is to characterize the pharmacokinetics of intravenous and oral omadacycline in patients with cystic fibrosis.
- Trial name
- NCT04460586
- Testing
- Omadacycline Injection [Nuzyra], Omadacycline Oral Tablet [Nuzyra]
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Paul Beringer
Malnutrition, Pneumonia
Trial in Childhood Pneumonia With Malnutrition
The impetus for this study came from the findings of the investigators' recently published study entitled "Day-care management of severe and very severe pneumonia, without associated co-morbidities such as severe malnutrition, in…
- Trial name
- NCT00968370
- Testing
- Day-care clinic, Hospital Management
- Where
- Bangladesh
- Volunteers
- 440 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
COVID-19
Immuno-bridging and Broadening Study of a Whole, Inactivated COVID-19 Vaccine BBV152 in Healthy Adults
A randomized, observer-blind, placebo-controlled immuno-bridging, and broadening study to demonstrate the equivalence of the immune response between participants enrolled in Phase 3 efficacy trial in India and demographically…
- Trial name
- NCT05258669
- Testing
- BBV152
- Where
- 10 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ocugen
Chronic Obstructive Pulmonary Disease
Enabling Independent Living by Expanding Access to Home-Based Pulmonary Rehabilitation
The purpose of this study is to test an existing home-based pulmonary rehab program with the addition of video chat and a capability of a Spanish version.
- Trial name
- NCT04479969
- Testing
- Video Chat
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Glaucoma, Pulmonary Hypertension
Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy
There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve.
- Trial name
- NCT00452283
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Chronic Heart Failure, Pulmonary Disorder, Chronic Obstructive
Method To Measure Protein Digestion & Absorption
The aim of the present study is to validate a new method in healthy volunteers and those diagnosed with COPD and CHF that is able to measure protein digestion and absorption simultaneously.
- Trial name
- NCT02065141
- Testing
- sip feeding with stable isotope infusion
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Interstitial Lung Disease (ILD)
Nasal High-flow Oxygen Therapy During Rehabilitive Exercise Training in ILD
Although uncommon, interstitial lung diseases (ILDs), and particularly idiopathic pulmonary fibrosis (IPF), are progressive, irreversible, and ultimately fatal without treatment.
- Trial name
- PID-OX (NCT07679854)
- Testing
- Pulmonary rehabilitation with NHFO2, Pulmonary rehabiltation with conventional oxygen therapy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Frédéric Hérengt
Asthma
Asthma and Osteopathic Manipulative Technique
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications.
- Trial name
- NCT07071194
- Testing
- OMT, Light touch
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Lung Cancer (NSCLC)
Local Ablative Therapy to Oligoresidual Metastasis in EGFR Mutated Non-small Cell Lung Cancer
This is an open-label, multicentre, randomized phase II clinical trial. Patients with stage IV (AJCC 9th edition) non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or exon 21 L858R mutation, who had less than or…
- Trial name
- NCT07379476
- Testing
- Local ablative therapy, Osimertinib alone
- Where
- Hong Kong
- Volunteers
- 64 people
- Sponsor
- Chinese University of Hong Kong
Psoriasis
A Long Term Study To Evaluate The Safety, Tolerability And Efficacy Of CP-690,550 In Patients With Moderate To Severe Plaque Psoriasis And/Or Psoriatic Arthritis
The main objective of this study is to evaluate the long term safety of CP-690,550 in patients being treated for moderate to severe plaque psoriasis and/or psoriatic arthritis.
- Trial name
- NCT01519089
- Testing
- CP-690,550, CP-690, 550
- Where
- 16 sites in Japan
- Volunteers
- 95 people
- Sponsor
- Pfizer
Asthma
Dose Ranging Study of the Salmeterol Component of Fluticasone /Salmeterol Spiromax Compared to Fluticasone Spiromax and Advair Diskus in Asthma Subjects
The primary objective of this study is to evaluate the dose response, efficacy, and safety of 4 different doses of salmeterol Spiromax (6.25, 12.5, 25, and 50 mcg) each combined with a fixed dose of fluticasone propionate (100…
- Trial name
- NCT01772368
- Testing
- Fp MDPI, FS MDPI, Advair Diskus
- Where
- 10 sites in United States
- Volunteers
- 72 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Staphylococcus Aureus Pneumonias
Panton Valentine Leucocidin
Staphylococcus aureus expresses a variety of virulence factors, including Panton Valentine leukocidin (PVL), a cytotoxin. PVL is specifically associated with primary skin and soft-tissue infections and severe necrotizing…
- Trial name
- PVL (NCT02798497)
- Testing
- Serum and Blood samples
- Where
- France
- Volunteers
- 234 people
- Sponsor
- Hospices Civils de Lyon
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