Clinical trials: Lung; Disease
Cystic Fibrosis
Resting Energy Expenditure in Patients With Cystic Fibrosis: A Pilot Study
Cystic fibrosis is an inherited disorder that causes severe damage to the lungs, digestive system, and other organs in the body.
- Trial name
- NCT03699982
- Testing
- Daily calorie target based on resting energy expenditure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- CAMC Health System
Lung Cancer
Proteomic Profiling in Diagnosing Non-Small Cell Lung Cancer in Patients Who Are Undergoing Lung Resection for Suspicious Stage I Lung Lesions
RATIONALE: Evaluating specific proteins in the blood may be an effective and noninvasive procedure to help doctors determine if a patient has early non-small cell lung cancer.
- Trial name
- NCT00077324
- Testing
- proteomic profiling, surface-enhanced laser desorption/ionization-time of flight mass spectrometry, biopsy
- Where
- 73 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Severe Asthma, Allergy to House Dust Mites
Potency of HDM Sublingual AIT Tablets in Assuring the Persistency of Asthma Control in HDM Allergic Patients With Severe Asthma, Treated With Tezepelumab
The aim of this drug trial is to evaluate the annualized asthma exacerbation rate under treatment with Acarizax versus placebo. The trial is intended for adults aged 18 to 65 with severe uncontrolled asthma and a house dust mite…
- Trial name
- TEZEPAIT (NCT07013123)
- Testing
- Tezepelumab, Acarizax
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Covid19, SARS-CoV Infection
COVID-19 in Polish Ice Swimmers.
Ice swimming is an increasingly common phenomenon in Poland. It has been confirmed that it has a beneficial effect on health by increasing the natural non-specific immunity to infections.
- Conditions
- Covid19, SARS-CoV Infection, Resistance, Disease, Hypothermia
- Trial name
- ICE (NCT04817280)
- Testing
- Ice Swimming
- Where
- 3 sites in Poland
- Volunteers
- 2,534 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
COVID-19
Phase II Clinical Trial of Recombinant COVID-19 Variant Vaccine (Sf9 Cell)
A single-center, randomized, double-blind, controlled clinical trial to evaluate the safety and immunogenicity of booster vaccination of Recombinant COVID-19 variant vaccine (Sf9 cell) in healthy people aged 18 years and older…
- Trial name
- NCT05770180
- Testing
- Recombinant COVID-19 variant vaccine (Sf9 cell), Recombinant COVID-19 vaccine (CHO cell), Recombinant COVID-19 vaccine (Sf9 cell)
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- WestVac Biopharma Co., Ltd.
HER2-positive Breast Cancer, HER2 Gene Mutation
Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene
Open-label, Phase I-II, first-in-human (FIH) study for A166 monotherapy in HER2-expressing or amplified patients who progressed on or did not respond to available standard therapies.
- Conditions
- HER2-positive Breast Cancer, HER2 Gene Mutation, HER-2 Gene Amplification, HER2 Positive Gastric Cancer
- Trial name
- NCT03602079
- Testing
- A166
- Where
- 10 sites in United States
- Volunteers
- 49 people
- Sponsor
- Klus Pharma Inc.
Small Cell Lung Cancer
PEI REGIMEN: A Therapeutic Option in Small Cell Lung Cancer? A Monoinstitutional Experience of 46 Consecutive Cases
ABSTRACT Objectives Combination chemotherapy is very active in small cell lung cancer (SCLC), although no improvement in overall survival (OS) has been done in the last 25 years , with Cisplatin-Etoposide (PE) still considered…
- Trial name
- NCT02324296
- Testing
- ifosfamide
- Volunteers
- 46 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Venous Insufficiency
Venavine Intensive® in the Treatment of Symptoms Associated With Chronic Venous Insufficiency
Chronic Venous Insufficiency (CVI) occurs when the veins in the lower limbs can no longer sufficiently pump enough blood back to the heart.
- Trial name
- NCT02483962
- Testing
- Gelatine capsule, Venavine Intensive®
- Where
- South Africa
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Johannesburg
Cell Lung Cancer, Sleep Disorders
Identification and Characterisation of Sleep Disorders in a Population of Patients With Non-small Cell Lung Cancer
This exploratory study will identify and characterise disorders frequently reported by patients as contributing to or altering their quality of life.
- Trial name
- SomOncoP (NCT06495346)
- Testing
- self-questionnaires exploring
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Pulmonary Disease, Chronic Obstructive
Digihaler in Chronic Obstructive Pulmonary Disease (COPD)
This is a multi-center 3-month study to determine the variation in ProAir Digihaler metrics [peak inspiratory flow (PIF), inhalation volume, number of inhalation events] amongst COPD patients in the ambulatory setting.
- Trial name
- NCT05241288
- Testing
- Albuterol eMDPI DS
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of North Carolina, Chapel Hill
Asthma
Genotype Stratified Pharmacokinetic Study of Montelukast
Leukotriene receptor antagonists (LTRAs) are frequently prescribed to reduce the symptoms associated with asthma. Singulair (montelukast), manufactured by Merck, is a popular LTRA, however its effectiveness varies greatly between…
- Trial name
- GSPOM (NCT01086527)
- Testing
- 10 mg tablet of montelukast (Singulair)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Asthma, Perennial Allergic Rhinitis
Biomarkers of Cockroach Sublingual Immunotherapy 2
This trial is a follow-up study of the ICAC-12 Phase I/II trial (NCT00829985), and is designed to study biomarkers of the immune response to allergen immunotherapy and the safety of this therapy in a pediatric population.
- Trial name
- BioCSI-2 (NCT01380327)
- Testing
- Cockroach Sublingual Immunotherapy (SLIT) - Low Dose, Cockroach Sublingual Immunotherapy (SLIT) - High Dose
- Where
- 5 sites in United States
- Volunteers
- 99 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis)
Pulmonary Embolism in Patients With Acute Heart Failure (PEHF Study)
This study focuses on two serious and common medical conditions: heart failure and pulmonary embolism (a blood clot in the lungs).
- Conditions
- Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis), Venous Thromboembolism
- Trial name
- PEHF (NCT07499661)
- Testing
- Systematic screening for pulmonary embolism in all patients using a guideline-recommended diagnostic algorithm
- Where
- 10 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Angers
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Changes in Cytokine Levels During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether there is a statistical association between changes in sputum serial levels of two cytokines, interleukin (IL)-17 and IL-6, during the treatment course of a severe acute…
- Trial name
- NCT00281242
- Testing
- blood draw
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Michigan
Long COVID
Consequences of COVID-19 Infection for Child Health and Wellbeing: Protocol for a Prospective, Observational, Longitudinal Study in Children
Prospective follow-up of children with SARS-CoV-2
- Trial name
- NCT05799508
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sleep Quality, Relaxation
Benson Relaxation Exercises and Sleep Quality in Lung Cancer Patients
The aim of this study is to investigate the effect of Benson Relaxation Exercises on sleep quality in hospitalized patients diagnosed with lung cancer. It is planned to be conducted as a randomized controlled trial.
- Conditions
- Sleep Quality, Relaxation, Canser, Benson Exercise
- Trial name
- NCT07212517
- Testing
- benson relaxation exercise
- Volunteers
- 60 people
- Sponsor
- Uskudar University
Non-small Cell Lung Cancer
Study of BMS-275183 in Patients With Pretreated Locally Advanced or Metastatic NSCLC (Non Small Cell Lung Cancer)
BMS-275183 given orally twice weekly to patients pretreated for locally advanced or metastatic NSCLC will show anti-tumor activity in any of the 3 separate cohorts of the patients enrolled: Cohort I: Patients previously treated…
- Trial name
- NCT00359450
- Testing
- BMS-275183 (oral taxane)
- Where
- 30 sites in United States, Belgium and 6 more
- Volunteers
- 186 people
- Sponsor
- Bristol-Myers Squibb
COVID-19
Efficacy of KOVIR Capsule in the Combination Regimen With Background Treatment in COVID-19 Patients
The acute pneumonia pandemic caused by a new strain of corona virus 2019, namely as COVID-19 by the World Health Organization (WHO), is a pandemic caused by SARS-CoV-2 virus.
- Trial name
- NCT05044650
- Testing
- KOVIR capsule combined with background treatment
- Where
- Vietnam
- Volunteers
- 1,000 people
- Sponsor
- Sao Thai Duong Joint Stock Company
Lung Cancer, Precancerous Condition
ACAPHA in Preventing Lung Cancer in Former Smokers With Bronchial Intraepithelial Neoplasia
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of ACAPHA, a combination of six herbs, may prevent lung cancer from forming in former smokers with bronchial intraepithelial neoplasia.
- Trial name
- NCT00522197
- Testing
- multi-herbal agent ACAPHA, Sugar Pill
- Volunteers
- 90 people
- Sponsor
- British Columbia Cancer Agency
Lung Cancer
Clinical Study on the Prevention of Driver Gene Negative Ib-IIIb Lung Cancer Recurrence and Metastasis by Staged Chinese Herbal Medicine Combined With Chemotherapy and Immune Checkpoint Inhibitors
This project adopts a prospective, multicenter, randomized controlled clinical study to investigate the treatment of TCM in postoperative patients with driver gene negative lung cancer, according to two phases of postoperative…
- Trial name
- NCT05834413
- Testing
- chemotherapy plus TCM 1&ICIs plusTCM2
- Where
- China
- Volunteers
- 367 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
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