Clinical trials: Lung; Disease
Advanced Solid Tumors
A Study of the Effects of ALKS 4230 (Nemvaleukin Alfa) on Subjects With Solid Tumors
To better understand the safety and tolerability of ALKS 4230 in humans
- Trial name
- NCT02799095
- Testing
- ALKS 4230, ALKS 4230 + pembrolizumab
- Where
- 31 sites in United States, Australia and 5 more
- Volunteers
- 243 people
- Sponsor
- Mural Oncology, Inc
COVID-19, Asymptomatic Pregnant
COVID-19 PCR Test Results in Asymptomatic Pregnants
In order to prevent contamination from the pregnant women hospitalized in this clinic, the RT-PCR test is performed from the oropharyngeal and nasal swab sample taken before hospitalization.
- Trial name
- NCT04410939
- Testing
- Reverse transcription polymerase chain reaction
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Asthma Acute, Asthma Exacerbation
45th Multicenter Airway Research Collaboration
The study is a randomized controlled trial on the effect of emergency department initiation of Airsupra on acute asthma "recurrence" at 3 months and other related outcomes (acute asthma relapse, asthma control).
- Conditions
- Asthma Acute, Asthma Exacerbation, Asthma, Asthma Control Level
- Trial name
- MARC-45 (NCT07166939)
- Testing
- Airsupra
- Where
- United States
- Volunteers
- 1,860 people
- Sponsor
- Massachusetts General Hospital
Obesity, Interstitial Lung Disease
Feasibility of Semaglutide in Advanced Lung Disease
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question[s] it aims to answer are: 1.
- Conditions
- Obesity, Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease, Sarcoidosis, Pulmonary
- Trial name
- NCT05746039
- Testing
- Semaglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Brain Cancer, Lung Cancer (Diagnosis)
Head-to-Head Evaluation of the Cancer Ontology Supervised Multimodal Orchestration (COSMO) AI System Versus Pathologist-Only Review
This study evaluates the diagnostic performance of the Cancer Ontology Supervised Multimodal Orchestration (COSMO) AI system for cancer subtype classification and compares it head-to-head with pathologist-only review.
- Conditions
- Brain Cancer, Lung Cancer (Diagnosis), Renal Cancer
- Trial name
- COSMO (NCT07307157)
- Testing
- Digital Pathology Evaluation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
COPD, Periodontitis
Oral Health and Severe COPD
This case-control study aims to investigate the association of severe COPD with oral health.
- Conditions
- COPD, Periodontitis, Caries, Quality of Life
- Trial name
- NCT05311657
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Heidelberg University
Lung Neoplasms, Quality of Life
Impact on Quality of Life From Multi-modality Lung Cancer
The investigators aim to explore how lung cancer patients and their family carers are affected by different types of cancer treatment. The investigators are focusing on a particular type of lung cancer called Stage III N2.
- Trial name
- PIONEER (NCT04540757)
- Testing
- Surgery, No surgery
- Where
- 2 sites in United Kingdom
- Volunteers
- 66 people
- Sponsor
- The Christie NHS Foundation Trust
Pneumothorax, Biopsy Wound
Pneumothorax After CT-guided Lung Biopsy: Standard vs Autologous Blood Patching
The aim of this prospective, randomized study is to compare the rate of postoperative pneumothorax between standard CT-guided core needle biopsy (CNB) versus CNB followed by autologous blood patch injection (ABPI).
- Trial name
- BloodyBiopsy (NCT03804957)
- Testing
- Autologous blood patch injection (ABPI), CT-guided core needle biopsy (CNB)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Humanitas Clinical and Research Center
COVID-19
Epidemiology of IgA Selective Deficiency - Clinical Manifestations and Risk of Transmission
The management of patients with a selective IgA deficiency currently consists of symptomatic treatment with treatment of infections by occasional or prolonged antibiotic therapy, immunosuppressive treatments for autoimmune…
- Trial name
- EpIgA (NCT06125457)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Strasbourg, France
Non-Small Cell Lung Cancer, Adjuvant Chemotherapy
New Adjuvant Trial of Chemotherapy vs Chemo-immunotherapy
This is an open-label, randomised, two-arm, phase III, multi-centre clinical trial. 210 stage IB-IIIA, completely resected, non-small cell lung cancer patients will be enrolled in this trial to evaluate the disease free survival…
- Trial name
- NADIM-ADJUVANT (NCT04564157)
- Testing
- Carboplatin, Paclitaxel, Nivolumab
- Where
- 30 sites in Spain
- Volunteers
- 210 people
- Sponsor
- Fundación GECP
Respiratory Distress Syndrome (RDS), PreTerm Neonate
Breathing Patterns in Infants Before and After Extubation
The primary objective of this study is to compare work of breathing indices before and after extubation in intubated premature infants admitted to the Christiana Care Neonatal Intensive Care Unit.
- Trial name
- NCT07542301
- Testing
- Observation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Stage III Non-Small Cell Lung Cancer AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7
Collection of Blood Samples in Patients With Non-small Cell Lung Cancer
This pilot research trial studies the collection of blood samples in monitoring tumor specific mutations in patients with non-small cell lung cancer that has spread to other places in the body or cannot be removed by surgery.
- Conditions
- Stage III Non-Small Cell Lung Cancer AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7, Stage IIIB Non-Small Cell Lung Cancer AJCC v7, Stage IV Non-Small Cell Lung Cancer AJCC v7
- Trial name
- NCT03492801
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Idiopathic Pulmonary Fibrosis
Safety, Tolerability, and Efficacy Study of Idiopathic Pulmonary Fibrosis
To evaluate the safety and tolerability of FG-3019 in subjects with Idiopathic Pulmonary Fibrosis (IPF) and the efficacy of FG-3019 for attenuating fibrosis in these subjects.
- Trial name
- FGCL-3019-049 (NCT01262001)
- Testing
- FG-3019
- Where
- 18 sites in United States
- Volunteers
- 90 people
- Sponsor
- Kyntra Bio
Carcinoma, Non-Small-Cell Lung
Study of Apatinib as 3rd/4th Line Treatment in Patients With Advanced Non-Squamous Non-small Cell Lung Cancer Harboring Wild-type Epidermal Growth Factor Receptor (EGFR)
Apatinib is a new kind of selective Vascular Endothelial Growth Factor Receptor 2(VEGFR-2) tyrosine kinase inhibitor (TKI). The investigators have finished the preclinical,phase I and phase II clinical studies and found its…
- Trial name
- ANSWER (NCT02332512)
- Testing
- Apatinib
- Where
- 2 sites in China
- Volunteers
- 417 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
COVID-19 Pnemonia
Clinical Trial of the Use of Anakinra in Cytokine Storm Syndrome Secondary to Covid-19 (ANA-COVID-GEAS)
Phase 2/3 randomized, parallel group, 2-arm study (treatment vs. control), investigating the efficacy and safety of intravenous administration of anakinra, an interleukin 1 receptor antagonist ( IL-1), added to standard…
- Trial name
- ANA-COVID-GEAS (NCT04443881)
- Testing
- Anakinra 149 MG/ML Prefilled Syringe [Kineret]
- Where
- 12 sites in Spain
- Volunteers
- 179 people
- Sponsor
- Fundacion Miguel Servet
Bronchiolitis
Chest Physiotherapy in Bronchiolitis
Randomized trial of chest physiotherapy in outpatients with bronchiolitis under two years of age, during two consecutive seasonal outbreaks.
- Trial name
- NCT04260919
- Testing
- Chest physiotherapy
- Volunteers
- 45 people
- Sponsor
- Universidade do Porto
Pain, Constipation
A Study to Demonstrate Improvement in Symptoms of Constipation in Subjects That Require Around-the-clock Opioid Pain Killer Therapy
The primary research objective is to demonstrate that subjects taking OXN PR have improvement in symptoms of constipation as measured by the Bowel Function Index (BFI) compared to subjects taking OxyPR tablets alone with cancer…
- Trial name
- NCT01438567
- Testing
- oxycodone/naloxone prolonged release (OXN PR) tablets, oxycodone prolonged release (OxyPR) tablets
- Where
- United Kingdom
- Volunteers
- 270 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Asthma
Examining the Effects of a Remote Pulmonary Rehabilitation Program in the Severe Asthma Population.
This is a randomized control trial evaluating the effect of a novel mobile application-delivered pulmonary rehabilitation program in adult severe asthma patients.
- Trial name
- STAPLE (NCT06150300)
- Testing
- Pulmonary rehab program
- Volunteers
- 34 people
- Sponsor
- University of Saskatchewan
Covid19, Acute Cardiovascular Disease
Russian Cardiovascular Registry of COVID-19
This is a Russian multicenter observational study aimed to assess the mid-term and long-term prognosis in patients recovered from COVID-19 with the involvement of the cardiovascular system or with baseline severe cardiovascular…
- Conditions
- Covid19, Acute Cardiovascular Disease, Cardiovascular Diseases
- Trial name
- NCT04724707
- Where
- Russia
- Volunteers
- 900 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Pulmonary Embolism
Replication of the EINSTEIN-PE Anticoagulant Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT04879407
- Testing
- Rivaroxaban, Warfarin
- Where
- United States
- Volunteers
- 98,947 people
- Sponsor
- Brigham and Women's Hospital
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