Clinical trials: Lung; Disease
Cystic Fibrosis
Primary Nasal Cell Culture as a Tool for Personalized Therapy in Cystic Fibrosis
characterization of CFTR function and expression in nasal primary cells collected from patients with cystic fibrosis in comparison to their parents, healthy heterozygotes and healthy controls
- Trial name
- Epiithelix (NCT03652090)
- Testing
- cell sampling
- Volunteers
- 112 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Depression, Anxiety, Cognitive Impairment
Telehealth Intervention Program for Older Adults
COVID-19 is having profound effects on older adults' due to social isolation measures which may negatively impact individuals' mental and physical health.
- Conditions
- Depression, Anxiety, Cognitive Impairment, Stress
- Trial name
- TIP-OA (NCT04523610)
- Testing
- Telehealth phone calls, Volunteer of TIP-OA Program, Stakeholder of TIP-OA Program
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Pulmonary Disease, Chronic Obstructive
An Exercise Endurance Study to Evaluate the Effects of Treatment of Chronic Obstructive Pulmonary Disease (COPD) Patients With a Dual Bronchodilator: GSK573719/GW642444.Study B
This is a phase III multicenter, randomized, double-blind, placebo-controlled, combination and component, two-period, incomplete block design cross-over study using GSK573719/GW642444.
- Trial name
- COPD (NCT01323660)
- Testing
- GSK573719/GW642444 125/25, GSK573719/GW642444 62.5/25, GSK573719 125
- Where
- 53 sites in United States, Canada and 5 more
- Volunteers
- 307 people
- Sponsor
- GlaxoSmithKline
Interstitial Lung Disease, Connective Tissue Diseases
Allogeneic Bone Marrow Mesenchymal Stem Cells for Patients With Interstitial Lung Disease (ILD) & Connective Tissue Disorders (CTD)
Researchers are trying to find out more about the safety of a new treatment, Allogeneic (coming from a healthy donor) Bone Marrow Derived Mesenchymal Stem Cells (BMD-MSCs) which is still experimental, for Interstitial Lung…
- Trial name
- NCT03929120
- Testing
- Allogeneic Bone Marrow Derived Mesenchymal Stem Cells (BMD-MSCs)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
COVID-19
Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting
This is a randomized, open-label trial to assess the safety and efficacy of hydroxychloroquine, and zinc in combination with either azithromycin or doxycycline in a higher risk COVID-19 positive outpatient population.
- Trial name
- NCT04370782
- Testing
- Hydroxychloroquine, Azithromycin, Zinc Sulfate
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- St. Francis Hospital, New York
Immune Mediated Anemia, Immune Mediated Thrombocytopenia
Extension Study (Extended Access) of Syk-inhibition Using Fostamatinib to Treat Posttransplant Immune-mediated Cytopenias
Background: People who have a blood stem cell transplant can sometimes develop cytopenia. This means that their levels of one or more types of blood cell, such as the red cells or platelets, are lower than they should be.
- Conditions
- Immune Mediated Anemia, Immune Mediated Thrombocytopenia, Chronic GVHD
- Trial name
- NCT05509582
- Testing
- fostamatinib
- Where
- United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COVID-19
Austrian CoronaVirus Adaptive Clinical Trial (COVID-19)
The Austrian Coronavirus Adaptive Clinical Trial (ACOVACT) is a randomized, controlled, multicenter, open-label basket trial that aims to compare various antiviral treatments for COVID-19.
- Trial name
- ACOVACT (NCT04351724)
- Testing
- Chloroquine or Hydroxychloroquine, Lopinavir/Ritonavir, Best standard of care
- Where
- 9 sites in Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Anosmia, Asymptomatic COVID-19
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
The purpose of this study is to learn more about how to better track smell recovery in people who have been infected with the SARS-CoV-2 virus (which causes COVID-19).
- Conditions
- Anosmia, Asymptomatic COVID-19, COVID-19 Respiratory Infection, Influenza
- Trial name
- NCT05040659
- Testing
- AROMHA Longitudinal Smell Test
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cystitis / Pyelonephritis / Cystic Fibrosis / Anthrax
Special Drug Use Investigation of Ciproxan Injection in Pediatrics
The objective in this study is collecting post-marketing information on the safety and efficacy of Ciproxan injection under the routine clinical practice.
- Trial name
- NCT02555059
- Testing
- Cipro (Ciprofloxacin, BAYQ3939)
- Where
- Japan
- Volunteers
- 48 people
- Sponsor
- Bayer
NSCLC, Stage III
Neoadjuvant of Tislelizumab Combined With Chemotherapy Followed by Surgery in Unresectable Stage Ⅲ NSCLC
The purpose of this conversion therapy study is to evaluate the safety and efficacy of neoadjuvant of Tislelizumab combined with platinum doublet for stage III unresectable locally advanced NSCLC.
- Trial name
- NCT05611879
- Testing
- Tislelizumab, Pemetrexed (Nonsquamous NSCLC) or Paclitaxel/Nab-paclitaxel(Squamous NSCLC), Carboplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
COVID-19
A Bridging Study of FB2001 in Healthy Subjects
In the first human clinical trial conducted in the United States, single and multiple dosing of FB2001 in multiple dose groups were partially completed，and FB2001 demonstrated good safety and tolerability.
- Trial name
- NCT05197179
- Testing
- FB2001
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Frontier Biotechnologies Inc.
Pulmonary Nodule Persistent, Malignant Neoplasm of the Respiratory System
Assessment of Probe Based Confocal Laser Endo-microscopy for In-vivo Diagnosis of Peripheral Lung Nodules and Masses.
Solitary pulmonary nodule has become a major challenge in respiratory clinical practice. According to published guidelines, their management often requires close CT follow up, PET CT and invasive procedures to obtain a definite…
- Conditions
- Pulmonary Nodule Persistent, Malignant Neoplasm of the Respiratory System, Benign Neoplasms of the Respiratory System
- Trial name
- NODIVEM (NCT01931579)
- Testing
- confocal endo-microscopy
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Rouen
Bronchial Asthma
Risk of Chronic Kidney Disease in Bronchial Asthma
the study aims to determine the frequency and factors associated with chronic kidney disease among asthmatic patients in order to determine persons who are at risk of developing chronic kidney disease and require strict follow up…
- Trial name
- NCT06472596
- Testing
- CBC, CRP ,ESR, ABG , interleukin 6, tumor necrotic factor alpha
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cystic Fibrosis
Safety and Efficacy of Inhaled OligoG CF-5/20 for the Treatment Cystic Fibrosis
Cystic fibrosis (CF) is a disease caused by a mutation in the gene that makes the cystic fibrosis transmembrane regulator protein.
- Trial name
- NCT00970346
- Testing
- OligoG CF-5/20
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AlgiPharma AS
Respiratory Distress Syndrome
Comparing Bubble and Ventilator Nasal CPAP in Preterm Infants
There are various methods to generate the pressure needed for Nasal CPAP. Some neonatal intensive care units (NICU) use an underwater bubbling system and others use a ventilator to generate the pressure.
- Trial name
- NCT02003846
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Maimonides Medical Center
Non Small Cell Lung Cancer, Pulmonary Metastases
Radiofrequency Ablation of Pulmonary Tumors Response Evaluation
The study hypothesis is that the radiofrequency (RF) ablation is a safe and effective treatment for malignant lung tumors.
- Trial name
- RAPTURE (NCT00690703)
- Testing
- RF ablation (Rita Medical Systems Model 1500x)
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 106 people
- Sponsor
- Angiodynamics, Inc.
SARS-CoV2 Infection
Expanded Access Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection (COVID-19)
The primary objective of this study is to provide expanded access of remdesivir (RDV) for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV2) infection.
- Trial name
- NCT04323761
- Testing
- Remdesivir
- Where
- 272 sites in United States, Australia and 25 more
- Sponsor
- Gilead Sciences
COVID-19
Study of SHEN26 Capsule in Patients With Mild to Moderate COVID-19
This is a multicenter, randomized, double-blind, placebo-parallel-controlled phase II clinical trial. It is designed to evaluate the efficacy, safety, tolerability, and pharmacokinetic (PK) profile of SHEN26 capsules in Chinese…
- Trial name
- NCT05676073
- Testing
- SHEN26 dose 1, SHEN26 dose 2
- Where
- 4 sites in China
- Volunteers
- 91 people
- Sponsor
- Shenzhen Kexing Pharmaceutical Co., Ltd.
Thromboembolic Disease Recurrent, Deep Vein Thrombosis
Clinical Predictors for Venous Thromboembolism in Patients With a History of Thrombosis (PREDICTORS)
Patients with a history of blood clots are at risk of developing additional clots in the future. Doctors use a tool called a clinical decision rule to tell them how likely it is that a patient has a blood clot and if they should…
- Conditions
- Thromboembolic Disease Recurrent, Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- PREDICTORS (NCT02297373)
- Where
- 9 sites in Canada, Netherlands and 1 more
- Volunteers
- 744 people
- Sponsor
- Ottawa Hospital Research Institute
SARS-CoV2 Infection, COVID-19
Viral Dynamics of Omicron in Children
SARS-CoV-2 transmission is dependent on multiple factors, which may be related to either host-virus interaction or the environment.
- Trial name
- NCT05240183
- Testing
- Daily SARS-CoV-2 PCR Testing for 10 days
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- The Hospital for Sick Children
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