Clinical trials: Lung; Node
Non-small Cell Lung Cancer
Video-assisted Thoracoscopic Surgery for Stage IIIA Non-Small Cell Lung Cancer
The purpose of this study is to examine the feasibility of video-assisted thoracoscopic surgery (VATS) major pulmonary resection with systematic node dissection (SND) for clinical stage IIIA non-small cell lung cancer.
- Trial name
- NCT00862004
- Testing
- VATS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Cancer, Non Small Cell Lung Cancer
The Development, Safety, and Feasibility of an Artificial Intelligence-Powered Platform (NodeAI) for Real-Time Prediction of Mediastinal Lymph Node Malignancy During Endobronchial Ultrasound Staging for Lung Cancer
Lung cancer is the leading cause of annual cancer deaths globally, more than breast, prostate, and colon cancers combined. The staging of chest lymph nodes (LNs) is a crucial step in the lung cancer diagnostic pathway because it…
- Trial name
- NodeAI (NCT06540196)
- Testing
- NodeAI, Surgeon
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Lung Non-Small Cell Carcinoma
A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment
This phase II trial compares the effect of intensity-modulated post-operative radiation therapy (I²-PORT) followed by standard of care therapy (chemotherapy or immunotherapy) to standard of care therapy alone in treating patients…
- Trial name
- NCT07293247
- Testing
- Chemotherapy, Immunotherapy, Intensity-Modulated Radiation Therapy
- Where
- 111 sites in United States
- Volunteers
- 164 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Lung; Node, Adenocarcinoma of Lung
Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung Cancer
This study is an observational study of blood and tissue biomarkers. Investigators plan to evaluate the accuracy of lung cancer biomarkers found in the blood in determining if a lung nodule is cancer or benign.
- Trial name
- NCT05665504
- Testing
- DetermaRX
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Lymph Node Metastases, Non-small Cell Lung Cancer Stage I
Mediastinal Staging Accuracy of a Selective Lymphadenectomy Strategy in Early Stage NSCLC (ECTOP-1003)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1003. Systemic mediastinal lymphadenectomy is deemed indispensable in lung cancer surgery for accurate staging and complete…
- Trial name
- NCT03216551
- Testing
- Intra-operative frozen section
- Where
- China
- Volunteers
- 1,076 people
- Sponsor
- Fudan University
Malignant Neoplasm of Breast, Hodgkin Disease
Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved Image Quality
Identify the best combination of predictive variables that influence ionizing radiation dose and improved image quality through analysis and quantification of PET-CT images in simulators and patients.
- Conditions
- Malignant Neoplasm of Breast, Hodgkin Disease, Non-Hodgkin Lymphoma, Follicular (Nodular), Malignant Neoplasm of Bronchus and Lung
- Trial name
- pet-ct (NCT02378337)
- Testing
- Image quantify
- Where
- Brazil
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Hospital Sao Rafael
Lung; Node, Lung Cancer
Using e-Nose Technology to Identify Early Lung Cancer
The purpose of this study is to test the ability of a new technology called breathprinting, or electronic nose (e-nose), to detect early-stage lung cancer.
- Trial name
- NCT04734145
- Testing
- Breathprinting test
- Where
- 7 sites in United States
- Volunteers
- 119 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Metastatic Cancer, Soft Tissue Sarcoma
A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors
This is a Phase I/IIa, multicenter, open-label, consecutive cohorts, dose-escalation study of BT-001 with repeated IT administrations alone and in combination with IV infusions of pembrolizumab.
- Conditions
- Metastatic Cancer, Soft Tissue Sarcoma, Merkel Cell Carcinoma, Melanoma
- Trial name
- NCT04725331
- Testing
- BT-001, Pembrolizumab [KEYTRUDA®]
- Where
- 5 sites in Belgium, France
- Volunteers
- 31 people
- Sponsor
- Transgene
Lung Cancer, Lung; Node
Low-dose Computed Tomography-guided Core Needle Biopsy for Lung Nodules
Investigators aim to compare the diagnostic accuracy and radiation exposure between low-dose and standard-dose computed tomography-guided core needle biopsy for lung nodules.
- Trial name
- NCT04217655
- Testing
- Low-dose computed tomography, Standard-dose computed tomography
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuzhou Central Hospital
Lung; Node
Airway Navigation Database Asia for Diagnosis of Peripheral Pulmonary Nodules
The study is designed to evaluate the efficacy and safety of Augmented Reality Navigation System through intra-airway navigation system to guide bronchoscopy in the diagnosis of peripheral pulmonary nodules and explore the…
- Trial name
- ANDA (NCT04740606)
- Testing
- Augmented Reality Navigation System
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Non-small Cell Lung Cancer
Deep Learning Signature for Predicting Occult Nodal Metastasis of Clinical N0 Lung Cancer
The purpose of this study is to evaluate the performance of a PET/CT-based deep learning signature for predicting occult nodal metastasis of clinical stage N0 non-small cell lung cancer in a multicenter prospective cohort.
- Trial name
- NCT05425134
- Testing
- PET/CT-based Deep Learning Signature
- Where
- 4 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Lung Diseases, Lung Neoplasm
The Use of Artificial Intelligence to Predict Cancerous Lymph Nodes for Lung Cancer Staging During Ultrasound Imaging
This study aims to determine if a deep neural artificial intelligence (AI) network (NeuralSeg) can learn how to assign the Canada Lymph Node Score to lymph nodes examined by endobronchial ultrasound transbronchial needle…
- Trial name
- NCT03849040
- Testing
- Endobronchial Ultrasound
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Non-small Cell Lung Cancer
Preoperative Chemoradiotherapy Versus Chemotherapy Alone in Nonsmall Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases
The main objective of this trial is to compare feasibility and efficacy of sequential neoadjuvant chemoradiotherapy with 44Gy concomitant boost to neoadjuvant chemotherapy alone.
- Trial name
- NCT01187290
- Testing
- neoadjuvant chemoradiotherapy
- Volunteers
- 80 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Lung Neoplasms, Lung Diseases
EBUS Score Validation for Malignancy
Surgical removal of a tumour in the lung offers the best chance for survival in early stage lung cancers. One main criteria of surgical eligibility is the absence of cancer spread to the lymph nodes; rendering the staging process…
- Trial name
- NCT02793713
- Testing
- Endobronchial Ultrasound
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Carcinoma, Non-small Cell Lung Cancer
Anatomical Location and Metastasis Pattern of Intrapulmonary Lymph Nodes in NSCLC (ECTOP-1010)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1010. Anatomical Location and Metastasis Pattern of Intrapulmonary Lymph Nodes (Group 11-13) in Non-small Cell Lung Cancer: a…
- Trial name
- NCT05094882
- Testing
- pulmonary lobectomy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fudan University
Non Small Cell Lung Cancer
Preoperative Lymph Node Staging With EBUS-TBNA in Clinical N0 Non Small-cell Lung Cancer
The introduction of modern staging systems has increased the detection of small peripheral lung cancers at an early stage [1]. Stage I non-small-cell lung cancers (NSCLCs) are confined to the lung without lymph node involvement…
- Trial name
- NCT04828850
- Testing
- Endobronchial ultrasound transbronchial needle aspiration lymph node staging
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Lung Neoplasms
Endobronchial Ultrasound Guided Transbronchial Lung Biopsy With or Without Guide Sheath in Lung Tumors and the Analysis of Echoic Patterns of Lung Tumors and Mediastinal Lymph Nodes, and the Association Between Diagnostic Yield of Transbronchial Lung Biopsy and EBUS Echoic Features.
1. Endobronchial ultrasonography (EBUS) is useful in localizing peripheral lung lesions. The EBUS, further combined with the guide sheath (GS) technique, has been reported to increase the yield of transbronchial biopsy.
- Trial name
- NCT00415337
- Testing
- endobronchial ultrasound
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Lung Cancer (NSCLC)
Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes
EBUS-guided cryobiopsy of mediastinal and hilar lymph nodes has shown to be a useful diagnostic tool to obtain tissue for histological analysis and further targeted therapies in lung malignancies.
- Trial name
- NCT06921681
- Testing
- Cryobiopsy of lymph nodes group 6 sec, Cryobiopsy lymphnode group 3 sec
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University of Zurich
Lymphadenopathy, Lung Cancer
Prevalence and Malignant Involvement of Calcified Intrathoracic Lymph Nodes in Patients Undergoing Endosonography
The presence of calcifications, which is a relatively common feature in intrathoracic lymph nodes, typically contributes to confer them a heterogeneous aspect during endosonographic B-mode examination, but their prevalence and a…
- Conditions
- Lymphadenopathy, Lung Cancer, Sarcoidosis, Tuberculosis
- Trial name
- NCT04743583
- Testing
- Endosonography B-mode examination
- Where
- Italy
- Volunteers
- 362 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
NSCLC, Lymph Node Metastases
Lymphadenectomy in NSCLC With and Without Adjuvant Therapy
Adjuvant therapy in patients affected by NSCLC is indicated in surgically treated cases of N2 disease, while the actual guidelines reported the possibility of a case-by-case decision in case of N1 involvement.
- Trial name
- NCT04419935
- Testing
- lymphadenectomy
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS