Clinical trials: Lung Biopsy
Interstitial Lung Disease
Open Label Trial of Utility of Cryobiopsy in the Multidisciplinary Diagnosis of Idiopathic Interstitial Lung Disease
A multicenter, multinational, prospective study to clarify, whether the addition of cryobiopsy can avoid surgical lung biopsy in a clinically relevant proportion of patients with suspected Idiopathic Interstitial Pneumonia
- Trial name
- NCT02563730
- Testing
- Lung biopsy
- Where
- 6 sites in Germany, Italy and 2 more
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
iNod™ Ultrasound-Guided Needle Biopsy System Study
The purpose of this study is to collect information on the iNod™ System's safety and ability to see the iNod™ biopsy needle in real-time in endobronchial lesions, peripheral lung nodules, or lung masses.
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Biopsy, Fine-Needle
- Trial name
- NCT05804435
- Testing
- iNod™ System
- Sponsor
- Boston Scientific Corporation
Lung Nodule
Epigenetic Nucleosomes in Plasma for Pulmonary Nodule Differentiation
Investigators aim to evaluate the diagnostic accuracy of the Nu.Q blood test for lung cancer in the Taiwanese population and compare its diagnostic performance with low-dose computed tomography (LDCT) or computed tomography (CT).
- Trial name
- NCT06838806
- Testing
- blood draw
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Lung Diseases
Defining a Technique for the Use of Cryogenic Catheters for Biopsy and Ablation for the Diagnostic and Treatment of Pulmonary Lesions: An Ex-Vivo Human Lung Model Study.
Developing a standardized methodology for the use of novel cryogenic catheters for transbronchial cryobiopsy and cryoablation of pulmonary lesions.
- Trial name
- CT0129 (NCT05948904)
- Testing
- Cryo Ex Vivo
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Covid19, Postmortem Changes
COVID-19 and Tissue Damage in Vital Organs
The study will be conducted in Dokuz Eylül University Hospital, COVID-19 (Coronavirus Disease 2019) intensive care unit. Three primary conditions will be sought for participants: 1.
- Trial name
- NCT04678687
- Testing
- Liver, lung, heart and kidney biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Dokuz Eylul University
Lung Diseases
Cryoprobe Versus Forceps for Transbronchial Biopsy
The purpose of this study is to compare the effectiveness of transbronchial biopsy done by a 1.1mm cryoprobe versus the standard 2.0mm forceps.
- Trial name
- FROSTBITE-2 (NCT05751278)
- Testing
- ERBECRYO® 2 Cryosurgical Unit and Accessories - K190651, Radial Jaw 4 Pulmonary Biopsy Forceps
- Where
- 9 sites in United States
- Volunteers
- 500 people
- Sponsor
- Johns Hopkins University
Sarcoidosis, Pulmonary
An RCT of NBI vs. White Light Guided Endobronchial Biopsy in Suspected Sarcoidosis
In the diagnosis of patients with sarcoidosis, there is paucity of literature on the diagnostic yield of the endobronchial biopsies obtained with narrow band imaging (NBI) bronchoscopy.
- Trial name
- NABS (NCT05311150)
- Testing
- Narrow band imaging bronchoscopy guided endobronchial biopsy, White light bronchscopy guided endobronchial biopsy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Lung Ground-Glass Opacity
The Efficacy and Safety of TBCB vs TBFB in Diagnosis of GGO
The aim of this study is to investigate the difference of efficacy and safety between transbronchial cryobiopsy (TBCB) and transbronchial forceps biopsy (TBFB) in the diagnosis of lung ground-glass opacity.
- Trial name
- NCT04727190
- Testing
- Transbronchial Cryobiopsy, Transbronchial Forceps Biopsy
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Shanghai Chest Hospital
Sarcoidosis
A Study to Evaluate the Efficacy and Safety of Fenestrated Cup Forceps Versus Fenestrated Alligator Forceps for Performing Transbronchial Lung Biopsy in Patients With Sarcoidosis
Sarcoidosis is a systemic disease that results from granulomatous inflammation that involves multiple body organs. The diagnosis requires the presence of compatible clinicoradiological features along with histologic evidence that…
- Trial name
- NCT02405897
- Testing
- Cup forceps, Alligator forceps
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Lung Transplant Rejection
Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation
Objective: To evaluate the potential impact of molecular phenotyping of transbronchial biopsies in lung transplant recipients with allograft dysfunction, and the potential for developing a safer endobronchial mucosal biopsy…
- Trial name
- INTERLUNG (NCT02812290)
- Testing
- Lung transplant biopsy bites.
- Where
- 11 sites in United States, Australia and 4 more
- Volunteers
- 700 people
- Sponsor
- University of Alberta
Pulmonary Nodules
The SEQUENCE Trial
This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd…
- Trial name
- SEQUENCE (NCT06676956)
- Testing
- Linear EBUS first, Robotic-assisted bronchoscopy first
- Where
- 5 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Non Small Cell Lung Cancer, EGFR Gene Mutation
Feasibility of Intratumoral Washing Fluid for Detecting EGFR Mutations in Lung Cancer
The purpose of this study is to evaluate the relevance of intratumoral washing for detection of EGFR mutation (including T790M positivity).
- Trial name
- NCT05517083
- Testing
- Ultarthin bronchoscopy with intratumoral washing
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Pusan National University Hospital
Pulmonary Nodules, Lung Cancer (Diagnosis)
The Percutaneous Interventional Surgery Control System for Pulmonary Nodule Biopsy
This prospective, single-center, non-inferiority, randomized controlled clinical trial aims to evaluate the efficacy and safety of a percutaneous interventional surgical control system in performing percutaneous needle biopsy of…
- Conditions
- Pulmonary Nodules, Lung Cancer (Diagnosis), Percutaneous Needle Biopsy, Transthoracic Needle Biopsy
- Trial name
- NCT07277088
- Testing
- Percutaneous Needle Biopsy with Interventional Surgical Control System, Conventional Manual Percutaneous Needle Biopsy
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Jiayuan Sun
Peripheral Lung Lesions
Comparison of the Diagnostic Accuracy: US-guided Percutaneous Lung Biopsies vs CT-guided in Peripheral Lung Lesions
A non-sponsored prospective randomized single-blind national multicenter interventional study which aims to compare the diagnostic accuracy between US-guided percutaneous lung needle biopsies and CT-guided in peripheral lung…
- Trial name
- SULTAN (NCT06412289)
- Testing
- US-GUIDED PERCUTANEOUS LUNG NEEDLE BIOPSY, CT-GUIDED PERCUTANEOUS LUNG NEEDLE BIOPSY
- Where
- 2 sites in Italy
- Volunteers
- 236 people
- Sponsor
- University Hospital of Ferrara