Clinical trials: Lung Cancer, completed
Non-small Cell Lung Cancer (NSCLC), Stage IV NSCLC
Phase II Study of Cabazitaxel-XRP6258 in Advanced Non-Small Cell Lung Cancer
Lung cancer is the leading cause of cancer death worldwide and in the United States. The majority of lung cancers are non-small cell lung cancer (NSCLC). The majority of NSCLC cases are advanced at the time of diagnosis.
- Conditions
- Non-small Cell Lung Cancer (NSCLC), Stage IV NSCLC, Metastatic NSCLC
- Trial name
- NCT01438307
- Testing
- Cabazitaxel-XRP6258 (3-week cycle), Cabazitaxel-XRP6258 (5-week cycle)
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
NSCLC (Non-small-cell Lung Cancer)
IBI310 (Anti-CTLA-4) in Combination With Sintilimab in Patients With Non-small-cell Lung Cancer (NSCLC)
This is an open label, multicenter, phase Ib study evaluating IBI310 (anti-CTLA-4) in combination with Sintilimab in patients with advanced, recurrent or metastatic non-small-cell lung cancer (NSCLC)
- Trial name
- NCT05118334
- Testing
- Sintilimab, IBI310
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Lung Cancer
Pneumonitis After Radiotherapy for Lung Cancer
Major goals of radiotherapy include local disease control and improvement of the patients' prognoses. One possible side effect of radiotherapy for lung cancer is radiation pneumonitis.
- Trial name
- PARALUC (NCT04335409)
- Testing
- Questionnaire, Mobile Application
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Schleswig-Holstein
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
Non-small Cell Lung Cancer
Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)
This is a study of the efficacy, pharmacokinetics, and safety of DS-1062a in participants with advanced or metastatic non-small cell lung cancer (NSCLC) with known actionable genomic alterations.
- Trial name
- NCT04484142
- Testing
- DS-1062a
- Where
- 84 sites in United States, France and 8 more
- Volunteers
- 137 people
- Sponsor
- Daiichi Sankyo
Pulmonary Mass
CBCT in Guiding Bronchoscopy in Patients With Lung Lesions
This pilot clinical trial studies how well cone-beam computed tomography (CBCT) works in guiding bronchoscopy in patients with lung lesions.
- Trial name
- NCT02978170
- Testing
- Cone-Beam Computed Tomography
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer, Lung
Adaptive CT Acquisition for Personalised Thoracic Imaging
In this trial, Respiratory Motion Guided (RMG) 4DCBCT will be implemented for the first time on lung cancer patients. RMG-4DCBCT adapts the image acquisition as the patient's breathing changes (i.e.
- Trial name
- ADAPT (NCT04070586)
- Testing
- 4DCBCT images
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- University of Sydney
Lung Cancer
Paclitaxel, Carboplatin, and Dimethylxanthenone Acetic Acid in Treating Patients With Extensive-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01057342
- Testing
- carboplatin, paclitaxel, vadimezan
- Where
- 12 sites in Switzerland
- Volunteers
- 17 people
- Sponsor
- Swiss Cancer Institute
Lung Cancer
VATS Versus Open Pulmonary Lobectomy in the Limelight of OEP
The standard operative approach to pulmonary lesions has been via postero-lateral thoracotomy and direct vision. This technique has some advantages but its morbidity is significant.
- Trial name
- VOLO (NCT02910453)
- Testing
- Pulmonary lobectomy
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Non Small Cell Lung Cancer
Study of Anlotinib Combined With Icotinib as the First-line Treatment in Patients With EGFR Mutation-positive NSCLC
Evaluate the efficacy and safety of Anlotinib plus Icotinib as the first-line treatment in patients with sensitive EGFR mutations advanced non-small cell lung cancer.
- Trial name
- ALTER-L004 (NCT03736837)
- Testing
- Anlotinib Plus Icotinib
- Where
- 5 sites in China
- Volunteers
- 60 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Lung Cancer
S9914: Combination Chemotherapy Plus Filgrastim in Untreated Extensive-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00004137
- Testing
- filgrastim, carboplatin, paclitaxel
- Where
- 85 sites in United States
- Volunteers
- 88 people
- Sponsor
- SWOG Cancer Research Network
Non-Small Cell Lung Cancer
Safety Study of Nivolumab to Treat Advanced or Metastatic Non-small Cell Lung Cancer
A study to evaluate the safety of Nivolumab in participants with advanced or metastatic non-small cell lung cancer
- Trial name
- CheckMate 907 (NCT03090737)
- Testing
- Nivolumab
- Where
- 17 sites in United States, Canada and 3 more
- Volunteers
- 129 people
- Sponsor
- Bristol-Myers Squibb
Lung Cancer
Nano Drug Interventional Therapy Using Digital Subtraction Angiography（DSA） for Lung Carcinoma
The purpose of this study is to evaluate the safety and efficacy of nano drug interventional therapy using digital subtraction angiography（DSA） for lung cancer.
- Trial name
- NCT02449122
- Testing
- interventional therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Non-Small-Cell Lung Cancer
Study of LY573636-Sodium in Patients With Metastatic Non-Small Cell Lung Cancer
The primary objective is to estimate the time to progressive disease for patients who receive LY573636-sodium (hereafter referred to as LY573636) after two previous treatments for metastatic non-small cell lung cancer.
- Trial name
- NCT00363766
- Testing
- LY573636-sodium
- Where
- 7 sites in Germany, Italy
- Volunteers
- 52 people
- Sponsor
- Eli Lilly and Company
Lung Cancer
Feasibility of a Short Home-based Rehabilitation Program for Cancer Patients Waiting for Lung Resection Surgery
The general objectives of this study are to verify the feasibility of a short home-based rehabilitation program for cancer patients prior to lung resection surgery, and to quantify its effects on aerobic capacity, exercise…
- Trial name
- NCT01667237
- Testing
- Home-based pulmonary rehabilitation program
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Lung Cancer
Intratumoral Gene Mediated Cytotoxic Immunotherapy in Patients With Resectable Non-Small Cell Lung Cancer
This is a phase I dose escalation study of CAN-2409 plus prodrug in patients with non-small cell lung cancer (NSCLC). The primary clinical objective of the study is to evaluate the safety of CAN-2409 plus prodrug when combined…
- Trial name
- NCT03131037
- Testing
- CAN-2409 + valacyclovir
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Candel Therapeutics, Inc.
Lung Cancer, Non-small Cell Lung Cancer
Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene
The purpose of this research study is to: see if gefitinib pills can shrink Stage 1 or 2 non-small cell lung cancers before surgery see if your non-small cell lung cancer has a mutation in a certain part of the EGFR gene see if…
- Conditions
- Lung Cancer, Non-small Cell Lung Cancer, Bronchioloalveolar Cancer
- Trial name
- NCT00588445
- Testing
- Gefitinib
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lung Cancer, Untreated Stage IV or Recurrent Squamous Cell Lung Cancers
Albumin-Bound Paclitaxel and Gemcitabine in Patients With Untreated Stage IV or Recurrent Squamous Cell Lung Cancers
The purpose of this study is to test the safety and effectiveness of albumin-bound paclitaxel plus gemcitabine in patients with advanced squamous cell lung cancers.
- Trial name
- NCT02525653
- Testing
- albumin-bound paclitaxel, gemcitabine
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
E7389 in Treating Patients With Recurrent or Progressive Stage IIIB or Stage IV Non-Small Cell Lung Cancer
This phase II trial is studying how well E7389 works in treating patients with recurrent or progressive stage IIIB or stage IV non-small cell lung cancer.
- Conditions
- Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
- Trial name
- NCT00400829
- Testing
- eribulin mesylate
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- National Cancer Institute (NCI)
Smoking Cessation, Lung Cancer
Implementation of a System-level Tobacco Treatment Intervention
The proposed study plans to adapt and study the implementation and effectiveness of integrating Clinical and Community Effort Against Secondhand smoke Exposure (CEASE) into the thoracic oncology setting using mixed methods.
- Trial name
- NCT02816697
- Testing
- CEASE, Usual Care Tobacco Treatment Services
- Where
- 2 sites in United States
- Volunteers
- 263 people
- Sponsor
- Dana-Farber Cancer Institute
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