Clinical trials: Lung Cancer, completed
Lung Cancer, Liver Cancer
Evaluation of Novel Cone-Beam CT for Guidance and Adaptation of Precision Radiotherapy
This is a feasibility study investigating the image quality of a new, high-performance cone beam CT (CBCT) used for on-couch imaging during radiotherapy treatments.
- Conditions
- Lung Cancer, Liver Cancer, Breast Cancer, Other Cancer
- Trial name
- NCT05176860
- Testing
- CBCT Imaging
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Varian, a Siemens Healthineers Company
Lung Cancer
ERAS Compliance and Nutritional Outcomes After Lung Cancer Surgery
This prospective observational study will evaluate the association between ERAS protocol compliance and postoperative nutritional outcomes in 120 patients undergoing lung cancer surgery.
- Trial name
- ERAS-NUTRI (NCT07785791)
- Testing
- Routine ERAS Perioperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa City Hospital
Venous Thrombosis, Neoplasms
Optimal Duration of Anticoagulation Therapy for Low-risk Pulmonary Embolism Patients With Cancer
The primary purpose of this study is to determine the optimal duration of anticoagulation therapy (6 months versus 18 months) with direct oral anticoagulant (DOAC) for cancer-associated low-risk pulmonary embolism patients.
- Conditions
- Venous Thrombosis, Neoplasms, Anticoagulants
- Trial name
- ONCO PE (NCT04724460)
- Testing
- Long DOAC, Short DOAC
- Where
- Japan
- Volunteers
- 179 people
- Sponsor
- Takeshi Morimoto
Non-small Cell Lung Cancer
Comparative Study of the Hypoxia Measured in FAZA and F-miso PET/CT Scan in Patients With Non-small Cell Lung Cancer
The purpose of the study is to compare the intratumoral biodistribution of FAZA and F-miso in patients with non-small cell lung cancer and correlate the results of PET scans with immunohistochemistry.
- Trial name
- RTEP6 (NCT02490696)
- Testing
- Miso PET scan, FAZA PET scan
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Henri Becquerel
Non-Small Cell Lung Cancer Metastatic
Double Immune Checkpoint Inhibitors in PD-L1-positive Stage IV Non-small Lung CancEr
Non Small Cell lung cancer (NSCLC) remains the first cause of death by cancer in the World. For the patients presenting a NSCLC stage IV, the median of survival is about 15 months today.
- Trial name
- DICIPLE (NCT03469960)
- Testing
- Ipilimumab, Nivolumab
- Where
- 47 sites in France
- Volunteers
- 265 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Pulmonary Nodule Persistent, Malignant Neoplasm of the Respiratory System
Assessment of Probe Based Confocal Laser Endo-microscopy for In-vivo Diagnosis of Peripheral Lung Nodules and Masses.
Solitary pulmonary nodule has become a major challenge in respiratory clinical practice. According to published guidelines, their management often requires close CT follow up, PET CT and invasive procedures to obtain a definite…
- Conditions
- Pulmonary Nodule Persistent, Malignant Neoplasm of the Respiratory System, Benign Neoplasms of the Respiratory System
- Trial name
- NODIVEM (NCT01931579)
- Testing
- confocal endo-microscopy
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Rouen
Non Small Cell Lung Cancer, Pulmonary Metastases
Radiofrequency Ablation of Pulmonary Tumors Response Evaluation
The study hypothesis is that the radiofrequency (RF) ablation is a safe and effective treatment for malignant lung tumors.
- Trial name
- RAPTURE (NCT00690703)
- Testing
- RF ablation (Rita Medical Systems Model 1500x)
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 106 people
- Sponsor
- Angiodynamics, Inc.
Malignant Solid Neoplasm, Metastatic Lung Non-Small Cell Carcinoma
Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer
This randomized phase I/II trial studies the side effects and best dose of pembrolizumab when given together with stereotactic body radiation therapy or non-stereotactic wide-field radiation therapy (conventional radiation…
- Conditions
- Malignant Solid Neoplasm, Metastatic Lung Non-Small Cell Carcinoma, Stage IV Lung Non-Small Cell Cancer AJCC v7
- Trial name
- NCT02444741
- Testing
- 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer, Small Cell
Regulatory Hycamtin(Oral) PMS
Non-interventional, open-label, single group, multicentric post-marketing surveillance to monitor the safety and effectiveness of Topotecan administered in Korean patients according to the prescribing information
- Trial name
- Hycamtin PMS (NCT01037023)
- Testing
- Topotecan
- Where
- 2 sites in South Korea
- Volunteers
- 92 people
- Sponsor
- GlaxoSmithKline
Gynecologic Cancer, Colorectal Cancer
Long-Term Follow-up Study of Subjects Treated With Autologous T Cells Using the Sleeping Beauty System to Express TCRs
Long-Term Follow-Up Study for Subjects Enrolled in the Phase I/II Study of Autologous T Cells Engineered using the Sleeping Beauty System to Express T cell Receptors (TCRs) Reactive Against Cancer-specific Mutations in Subjects…
- Conditions
- Gynecologic Cancer, Colorectal Cancer, Pancreatic Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05292859
- Testing
- Neoantigen specific TCR-T cell drug product
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Alaunos Therapeutics
Oncology, Melanoma
Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein (GLIMMER-01)
This is a Phase 1/2, first-in-human, open-label, dose escalation and dose-expansion study of E-602, administered alone and in combination with cemiplimab.
- Conditions
- Oncology, Melanoma, Ovarian Cancer, NSCLC
- Trial name
- GLIMMER-01 (NCT05259696)
- Testing
- E-602, Cemiplimab
- Where
- 13 sites in United States
- Volunteers
- 69 people
- Sponsor
- Palleon Pharmaceuticals, Inc.
Carcinoma, Non-Small-Cell Lung
Study of Gefitinib Retreatment in Non-Small Cell Lung Cancer (NSCLC)
A single arm, open label, prospective, phase II trial of Gefitinib retreatment for the advanced or metastatic (IIIb and IV) NSCLC patients who previously responded to gefitinib And progressive disease should be observed with at…
- Trial name
- ReGaiN (NCT00824746)
- Testing
- Gefitinib retreatment
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Chonnam National University Hospital
Glycopyrrolate
Effect of Perioperative Use of Glycopyrrolate on Lung Function in Patients Under General Anesthesia
Gastrointestinal tumor is one of the highest incidence of malignant tumors in our country, with the incidence increasing year by year.
- Trial name
- NCT05693246
- Testing
- Glycopyrrolate, normal saline
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Zhuan Zhang
Non-small Cell Lung Cancer, Carcinoma
Phase 1/2 Study of Ensartinib and Durvalumab, in ALK-rearranged Non-small Cell Lung Cancer
This was a Phase 1/2, open-label, multicenter, single-arm study of combination therapy with ensartinib, an anaplastic lymphoma kinase (ALK) inhibitor, and durvalumab, an anti-programmed cell death ligand 1 (PD-L1) antibody, in…
- Conditions
- Non-small Cell Lung Cancer, Carcinoma, NSCLC
- Trial name
- NCT02898116
- Testing
- Ensartinib, Durvalumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Ludwig Institute for Cancer Research
Lung Cancer
A Novel Lung Function Imaging Modality As a Preoperative Evaluation Tool (LIME)
To evaluate the correlation between pre-surgical 4DCT-ventilation imaging and post-surgical lung function.
- Trial name
- NCT03426306
- Testing
- 4DCT-Ventilation
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of Colorado, Denver
Non-Small-Cell Lung Carcinoma, Neoplasm Recurrence, Local
A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)
This Phase II, multicenter, randomized trial is designed to make preliminary evaluations of the efficacy of combining bevacizumab with chemotherapy (docetaxel or pemetrexed) or Tarceva relative to chemotherapy (docetaxel or…
- Trial name
- NCT00095225
- Testing
- Avastin (bevacizumab), Tarceva (erlotinib HCl)
- Where
- 48 sites in United States
- Volunteers
- 122 people
- Sponsor
- Genentech, Inc.
Lung Cancer, Adherence, Patient
Increasing Adherence to Lung Cancer Screening
Investigators are conducting a pragmatic randomized trial testing the effectiveness of patient and clinician nudge strategies on adherence to lung cancer screening (LCS) \& diagnostic follow-up across eligible primary care…
- Trial name
- NCT05832008
- Testing
- Patient Nudge, Clinician Nudge
- Where
- United States
- Volunteers
- 825 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Lung Cancer
Evaluation of Deployment Capability and Accuracy of an Outside the Scope (OTS), Detachable Catheter System for Ablation of Peripheral Lung Lesions: An Ex-Vivo Human Lung Model Study
A novel OTS detachable probe system carried outside and along the flexible bronchoscope has been developed. Using this novel system, the operator can deploy the probe in the target bronchus and lesion and completely detach the…
- Trial name
- NCT04722432
- Testing
- Outside the Scope (OTS), Detachable Catheter System
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Non-Small-Cell Lung Carcinoma
Feasibility of Cetuximab Associated With Concomitant Radio-Chemotherapy in Patients With Locally Advanced Non Small Cell Lung Cancer
Phase II, randomised, controlled, non comparative study with 2 parallel groups: Arm A: patients will receive induction chemotherapy (cisplatin and docetaxel) followed by a concomitant radio-chemotherapy including 2 cycles of…
- Trial name
- NCT00985855
- Testing
- cisplatin, vinorlebine, cetuximab, cisplatine, etoposide, cetuximab
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Institut de Cancérologie de la Loire
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