Clinical trials: Lung Cancer Symptoms
Lung Neoplasm
Ventilation Using Radiographic Examination: Functional Lung Imaging Techniques for the Reduction of Toxicity in Functional Avoidance Radiation Therapy
The goal of this observational validation study is to determine the best implementation of fluoroscopic and CT ventilation imaging in patients having non-stereotactic ablative body radiotherapy (non-SABR) radiotherapy for stages…
- Trial name
- VENTURE (NCT06159660)
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- University of Sydney
Carcinoma, Non-Small-Cell Lung
Palliative Thoracic Radiotherapy Plus BKM120
This study will test whether a drug called BKM120/buparlisib is a safe and effective treatment when given to lung cancer patients having radiotherapy treatment.
- Trial name
- BKM120 (NCT02128724)
- Testing
- BKM120
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Oxford
Brain Metastases, Lung Cancer
An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.
The purpose of this study is to determine the safety, tolerability, and pharmacokinetics (PK) of 2B3-101 both as single agent and in combination with trastuzumab.
- Conditions
- Brain Metastases, Lung Cancer, Breast Cancer, Melanoma
- Trial name
- NCT01386580
- Testing
- 2B3-101, Trastuzumab, 2B3-101 60 mg/m2 every 4 weeks
- Where
- 10 sites in United States, Belgium and 2 more
- Volunteers
- 84 people
- Sponsor
- BBB-Therapeutics B.V.
Metastatic Solid Tumor, Advanced Solid Tumor
A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors
The main purpose of this study is to find out whether the study drug, LY4050784, is safe, tolerable and effective in participants alone or in combination with other anticancer agents.
- Conditions
- Metastatic Solid Tumor, Advanced Solid Tumor, Non-small Cell Lung Cancer, SMARCA4-Deficient Tumor
- Trial name
- NCT06561685
- Testing
- LY4050784, Pembrolizumab, Cisplatin
- Where
- 32 sites in United States, France and 4 more
- Volunteers
- 340 people
- Sponsor
- Eli Lilly and Company
Lung Cancer and Cancer of Digestive System
Benefit Evaluation of Foot Reflexology in Oncology
Chemotherapy with platinum salts is very emetic. The aim of this study is to evaluate the benefits of foot reflexology in nausea and vomiting induced by platinum salts-based chemotherapy in patients with thoracic or digestive…
- Trial name
- REFYO-R (NCT03508180)
- Testing
- INTERVIONNAL, CONTROL
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Infectious Disease, Cancer
Cancer: Rapid Diagnostics and Immune Assessment for SARS-CoV-2 (COVID-19)
People with cancer may be at higher risk of poor outcomes with COVID-19 infection. This observational study aims to describe the clinical course of COVID-19 infection in people with cancer and evaluate the utility of antibody and…
- Conditions
- Infectious Disease, Cancer, Coronavirus Infection
- Trial name
- CARDS (NCT04427280)
- Testing
- Throat/nose swabs, Saliva collection, Blood collection
- Where
- United Kingdom
- Volunteers
- 153 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Metastatic Non-squamous Non Small Cell Lung Cancer
Triplet Combination First Line Treatment in Non Small Cell Lung Cancer (NSCLC)
This is a randomized, open-label, multicenter, phase II study to compare a triplet combination of CBP501, pemetrexed and cisplatin with pemetrexed/cisplatin when administered to patients with locally advanced (stage IIIB with…
- Trial name
- CBP08-02 (NCT00942825)
- Testing
- CBP501 + Cisplatin + Pemetrexed, Cisplatin + Pemetrexed
- Where
- 3 sites in United States
- Volunteers
- 195 people
- Sponsor
- CanBas Co. Ltd.
Lung Neoplasms
The Impact of Physical Activity on the Postoperative Symptoms, Complications, and Quality of Life Among Lung Cancer
The purpose of this study is to examine the impact of physical activity on the postoperative symptoms, complication, and quality of life.
- Trial name
- NCT03705546
- Where
- South Korea
- Volunteers
- 1,050 people
- Sponsor
- Samsung Medical Center
Non-Small Cell Lung Cancer
Pembrolizumab After SBRT Versus Pembrolizumab Alone in Advanced NSCLC
To evaluate the increase in Overall Response Rate (ORR) in the pembrolizumab alone arm compared to the pembrolizumab after SBRT arm at 12 weeks
- Trial name
- PEMBRO-RT (NCT02492568)
- Testing
- pembrolizumab, Stereotactic Body Radiation Therapy
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- The Netherlands Cancer Institute
Lung Cancer (Diagnosis)
Antrodia Cinnamomea Extract Effects on Lung Cancer Patients' Quality of Life During Chemotherapy
This randomized trial will test whether Antrodia cinnamomea supplement improves quality of life in lung cancer patients receiving platinum-based chemotherapy.
- Trial name
- NCT07241182
- Testing
- Antrodia cinnamomea supplement, Turmeric-Probiotic Group
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Carcinoma, Non-small-cell Lung
Iressa Expanded Access Program (EAP)
A program for patients with non small cell lung cancer who may benefit from Iressa, but cannot enter another clinical trial due to them not being eligible, or for whom no trials are available.
- Conditions
- Carcinoma, Non-small-cell Lung, Metastases, Neoplasm
- Trial name
- NCT00034879
- Testing
- ZD1839 (Gefitinib)
- Where
- 626 sites in United States
- Sponsor
- AstraZeneca
Cachexia, Chronic Obstructive Pulmonary Disease
Food Reward in Cachexia Induced by Acute or Chronic Disease
To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer or chronic disease.
- Conditions
- Cachexia, Chronic Obstructive Pulmonary Disease, Non-small Cell Lung Cancer, Pancreatic Cancer
- Trial name
- NCT02798003
- Testing
- Functional magnetic resonance imaging (fMRI)
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Maastricht University Medical Center
Lung Cancer
Palliative Care Teaching Sessions for Family Caregivers of Patients With Non-Small Cell Lung Cancer
RATIONALE: Palliative care teaching sessions may be more effective than standard care in improving caregiver burden, caregiver skills preparedness, quality of life, and distress in family caregivers of patients with non-small…
- Trial name
- NCT00827333
- Testing
- educational intervention, questionnaire administration, end-of-life treatment/management
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- City of Hope Medical Center
Non-small Cell Lung Cancer, Surgery
Anesthesia and Non-small Cell Lung Cancer Recurrence
There has been ongoing debate about the relationship between cancer recurrence and anesthetic management. Therefore, the investigators will test the hypothesis that the recurrence free survival (RFS) after curative resection of…
- Conditions
- Non-small Cell Lung Cancer, Surgery, Anesthesia
- Trial name
- GASTIVA (NCT06330038)
- Testing
- Propofol, Inhaled anesthetics
- Where
- South Korea
- Volunteers
- 5,384 people
- Sponsor
- Samsung Medical Center
Brain and Central Nervous System Tumors, Breast Cancer
Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer
RATIONALE: Radiolabeled drugs such as yttrium Y 90 SMT 487 can locate tumor cells and deliver tumor-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Gastrointestinal Carcinoid Tumor, Islet Cell Tumor
- Trial name
- NCT00006368
- Testing
- yttrium Y 90-edotreotide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Malignant Melanoma, Metastatic, Non Small Cell Lung Cancer Metastatic
Personalized Neo-antigen Vaccine in Advanced Solid Tumors (NeoPepVac)
The primary objective is to assess tolerability and safety of a personalized neo-antigen vaccine containing up to 15 peptides derived from somatic mutation of the individual patient's cancer, with CAF09b as adjuvant.
- Conditions
- Malignant Melanoma, Metastatic, Non Small Cell Lung Cancer Metastatic, Bladder Urothelial Carcinoma, Metastatic
- Trial name
- NeoPepVac (NCT03715985)
- Testing
- EVAX-01-CAF09b
- Where
- 2 sites in Denmark
- Volunteers
- 12 people
- Sponsor
- Herlev Hospital
Metastasis, Metastatic Breast Cancer
The Impact of Radiotherapy on Oligometastatic Cancer
Metastases represent the most threatening challenge in cancer. One of the management strategies for patients with Oligometastatic Cancer (OC) is Stereotactic ABlative Radiotherapy (SABR).
- Conditions
- Metastasis, Metastatic Breast Cancer, Metastatic Prostate Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT05933876
- Testing
- To propose a diagnostic test to determine the viability of Stereotactic ABlative Radiotherapy (SABR)., To propose a diagnostic test to determine the effectiveness of SABR., To propose a diagnostic test for Oligometastatic Cancer (OC).
- Where
- 21 sites in Spain
- Volunteers
- 2,000 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Large Cell Lung Cancer, Neuroendocrine Carcinoma of Lung (Diagnosis)
Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC)
Observational, multicentre, retrospective study on patients taken care according to the national guidelines. The objective is to define, after the diagnosis confirmation, the frequency of PD-L1 expression in patients with…
- Trial name
- EPNEC (NCT03305133)
- Testing
- Immunohistochemistry
- Where
- 28 sites in France
- Volunteers
- 86 people
- Sponsor
- Groupe Francais De Pneumo-Cancerologie
Artificial Intelligence, Lung Diseases
Retrospective Study of Carebot AI CXR Performance in Preclinical Practice
The purpose of this study is to describe the design, methodology and evaluation of the preclinical test of Carebot AI CXR software, and to provide evidence that the investigated medical device meets user requirements in…
- Conditions
- Artificial Intelligence, Lung Diseases, Pneumothorax, Pleural Effusion
- Trial name
- NCT05594485
- Testing
- Carebot AI CXR
- Where
- Czechia
- Volunteers
- 127 people
- Sponsor
- Carebot s.r.o.
Papillomavirus Infections, Coronavirus Disease (COVID-19)
Safety and Immunogenicity of 9-valent Human Papillomavirus (9vHPV) Vaccine Coadministered With Messenger Ribonucleic Acid (mRNA)-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (COVID-19) Vaccine (V503-076)
The purpose of this study to evaluate the safety and immunogenicity of a 2-dose regimen of 9vHPV vaccine, where the first dose is administered concomitantly with a first dose of a 2-dose regimen of mRNA-1273 vaccine versus…
- Trial name
- NCT05119855
- Testing
- 9vHPV Vaccine, mRNA-1273 Vaccine
- Where
- 38 sites in United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
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