Clinical trials: Lung Clearance Index
Cystic Fibrosis
Effects of AD on VI in Patients With CF
This study will investigate the effects of a chest physiotherapy manual technique (autogenic drainage) on ventilation inhomogeneity in patients with cystic fibrosis. Lung clearance index (LCI) is the primary outcome
- Trial name
- NCT03655249
- Testing
- Autogenic drainage, Aerosoltherapy
- Where
- Belgium
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Childhood Asthma
Changes in the Lung Clearance Index in Pediatric Patients With Asthma
The multiple breath washout (MBW) is one of pulmonary function test that displays flow and gas concentration plotted against time, and shows an exponential decay in end-tidal gas concentration (washout curve).
- Trial name
- NCT02678949
- Testing
- Inhaled Fluticasone 50 mcg/twice day, Inhaled Fluticasone 100 mcg/twice day, Inhaled Albuterol
- Where
- Mexico
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Lung Transplantation, Chronic Lung Allograft Dysfunction
Lung Clearance Index and Lung Allograft Dysfunction
The aim of this project is to evaluate the ability of the lung clearance index (LCI) to detect early chronic lung allograft failure (CLAD) in adult lung transplant recipients over a period of 3 years.
- Conditions
- Lung Transplantation, Chronic Lung Allograft Dysfunction, Rejection Lung Transplant
- Trial name
- NCT03850002
- Testing
- Early detection of CLAD by Lung Clearance Index (LCI)
- Sponsor
- University of Zurich
Cystic Fibrosis
Hyperpolarized Xenon MRI in Cystic Fibrosis Pulmonary Exacerbations
The investigators aim to assess whether pulmonary MRI (hyperpolarised 129Xe ventilation imaging [Xe-MRI]) can detect changes in ventilation defects in patients with CF before and after treatment for a pulmonary exacerbation.
- Trial name
- NCT02606487
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
Airway Clearance Therapy on Hyperpolarized 129Xenon and MRI
This is an observational cohort study building on an existing protocol at our institution recruiting CF patients who are 6-21 years old with one or two copies of the F508del CFTR mutation.
- Trial name
- NCT03593434
- Testing
- hyperpolarized Xenon gas
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Lung Disease
Utility of Lung Clearance Index Score as a Noninvasive Marker of Small Airways Disease
To determine the utility and sensitivity of the lung clearance index (LCI) technique as a marker of small airways disease in adults with chronic lung conditions compared to healthy adults, adjusting for age, sex and smoking…
- Trial name
- NCT03241420
- Testing
- lung clearance index (LCI)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Cystic Fibrosis
Evaluation of the Lung Clearance Index
The purpose of this study is to determine the efficacy of a non invasive method of detecting the pulmonary disease in order to initiate treatment against cystic fibrosis as soon as possible.
- Trial name
- LCI (NCT02342951)
- Testing
- Lung clearance index determination
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis
Study of the Effect of Ivacaftor on Lung Clearance Index in Subjects With Cystic Fibrosis and the G551D Mutation
The purpose of this study is to evaluate the effect of ivacaftor (VX-770) on lung clearance index (LCI) in subjects aged 6 years and older with cystic fibrosis (CF) who have the G551D-CFTR mutation on at least 1 allele.
- Trial name
- NCT01262352
- Testing
- Ivacaftor
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 21 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis, Lung Clearance Index
Exploratory Study on Link Between Dynamic Hyperinflation and Lung Clearance Index in Cystic Fibrosis
Recent improvements in cystic fibrosis management have enabled an important subset of patients to maintain normal spirometry. Nevertheless, even in these patients with normal spirometry, chest computed tomography (CT) might…
- Trial name
- ICP2DM (NCT03323983)
- Testing
- data collection
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cystic Fibrosis
A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance Index
The Lung Clearance Index (LCI) is a non invasive measure of lung function that is more sensitive than FEV1. It can be used to measure lung function in children younger than 6 years of age.
- Trial name
- NCT02276898
- Testing
- Hypertonic Saline 7%
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
Effect of Hypertonic Saline on Mucus Clearance in Children Ages 5-12 With Cystic Fibrosis
Previous work demonstrated that inhaled hypertonic saline (HS) reduces exacerbation frequency and improves lung function in adults with cystic fibrosis (CF).
- Trial name
- NCT01031706
- Testing
- Hypertonic Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Pregnancy
Changes in Ventilation Inhomogeneity and Respiratory Function Following Elective Caesarean Section Under Regional Anaesthesia
Pregnancy is associated with physiological changes affecting the cardiorespiratory system as a consequence of an increase in both cardiac output and intra-abdominal pressure.
- Trial name
- VIRCA (NCT02714556)
- Testing
- Physiologic measures of lung function
- Where
- Switzerland
- Sponsor
- Walid HABRE
Cystic Fibrosis in Children
Effect of Lumacaftor/Ivacaftor in Children With Cystic Fibrosis Homozygote for F508del on Small Airway Function
To obtain prospective real world data of the effect of lumacaftor/ivacaftor or tezacaftor/ ivacaftor on small airway disease in children aged 6-18 years with cystic fibrosis (CF) homozygous for F508del.
- Trial name
- ROOTS (NCT04138589)
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Chronic Lung Infection With Pseudomonas Aeruginosa in Cystic Fibrosis
Evaluation of Lung Clearance Index in Cystic Fibrosis (CF) Patients, Infected With P.Aeruginosa
The purpose of the study was to evaluate lung clearance index (LCI) by a standardized procedure in a well characterized study setting and to assess feasibility of LCI as a more sensitive method than forced expiratory volume at 1…
- Trial name
- ELIXIR (NCT02248922)
- Testing
- TIS or TIP
- Where
- 6 sites in Germany
- Volunteers
- 17 people
- Sponsor
- Novartis Pharmaceuticals
Cystic Fibrosis in Children
Determinants of Early Cystic Fibrosis Lung Disease
The overall objective of this study is to determine the impact early nutritional and respiratory indices have on early CF lung disease.
- Trial name
- NCT03579173
- Testing
- Infant PFT, Lung Clearance Index, Passive tidal breathing
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Indiana University
Scleroderma
Lung Clearance Index to Identify Scleroderma Patients at Risk for ILD
This National Jewish Health (NJH) Investigator Initiated pilot study funded by the Shah Foundation will prospectively perform a non invasive lung function test called Lung Clearance Index (LCI) to determine if 50 scleroderma…
- Trial name
- NCT04535245
- Testing
- LCI testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Jewish Health
Cystic Fibrosis
The Effect of rhDNase on Ventilation Inhomogeneity in Patients With Cystic Fibrosis
This study will assess whether rhDNase treatment improves ventilation inhomogeneity as assessed by lung clearance index (LCI) in patients with cystic fibrosis (CF).
- Trial name
- NCT00557089
- Testing
- rhDNAse
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- The Hospital for Sick Children