Clinical trials: Lung Collapse
Cytokine Release Syndrome
Safety and Tolerability Study of IV ST266 in COVID-19 Subjects
The primary aim of the study is to evaluate the safety and tolerability of open-label ST266 given to subjects with confirmed COVID-19 infection through IV administration once a day of 5 consecutive days.
- Trial name
- NCT04720378
- Testing
- ST266
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Postoperative Pain, Postoperative Atelectasis
Erector Spina Block or Parasternal Block Plus Chest Tube Wound Infiltration for Cardiac Surgeries
Pain management is important after coronary artery bypass graft (CABG) surgery. Intravenous morphine is the gold standard for pain relief, but its sedation, cough suppression and decreased bowel movements limit its use.
- Conditions
- Postoperative Pain, Postoperative Atelectasis, Analgesia
- Trial name
- NCT06267443
- Testing
- Comparison of erector spina plane block, parasternal block plus local infiltration to the tube sides for postoperative analgesia
- Volunteers
- 100 people
- Sponsor
- TC Erciyes University
COVID-19, COVID-19 Pneumonia
Study to Verify the Effectiveness and Safety of Isothymol or Carvacrol Compound Against SARS-CoV-2 in COVID-19 Patients
Check the efficacy, safety and tolerability of the compound Modified isothymol against the SARS-CoV-2 agent in patients COVID-19.
- Conditions
- COVID-19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05445089
- Testing
- Carvacrol, Control group
- Where
- Venezuela
- Volunteers
- 600 people
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum
Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS)
This Phase 2 study tests whether adding two immune therapies - nogapendekin alfa-inbakicept (NAI) and off-the-shelf iNKT cell infusions - to standard care can safely help critically ill adults with severe community-acquired…
- Conditions
- Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum, Sepsis, Lymphopenia / Immunoparalysis in Critically Ill Adults
- Trial name
- NCT07492888
- Testing
- Nogapendekin Alfa-Inbakicept (NAI), Allogeneic invariant Natural Killer T (iNKT) Cells (AgenT-797)
- Sponsor
- ImmunityBio, Inc.
Mesenchymal Stromal Cells, Remestemcel-L
MSCs in COVID-19 ARDS
The mortality rate in SARS-CoV-2-related severe ARDS is high despite treatment with antivirals, glucocorticoids, immunoglobulins, and ventilation.
- Conditions
- Mesenchymal Stromal Cells, Remestemcel-L, Acute Respiratory Distress Syndrome, COVID
- Trial name
- NCT04371393
- Testing
- Remestemcel-L
- Where
- 21 sites in United States
- Volunteers
- 223 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sepsis
Prognostic Value of Right Ventricular-pulmonary Arterial Coupling Assessed by Echocardiography in Septic Patients
Sepsis and septic shock are common clinical conditions, representing a significant healthcare challenge due to their high mortality rates and increasing incidence.
- Trial name
- NCT06887140
- Testing
- Echocardiography
- Where
- Vietnam
- Volunteers
- 215 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Pulmonary Atelectasis, Obesity, Morbid
Effects of Individualized PEEP Guided by Driving Pressure on Postoperative Atelectasis in Patients With Morbid Obesity
Atelectasis is a common complication in patients undergoing surgery under general anesthesia, particularly in obese patients. Postoperative atelectasis could last for more than 24h and contribute to a variety of other…
- Trial name
- NCT06181279
- Testing
- Individualized PEEP group, Fixed PEEP group
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Yongtao Sun
Positive End-expiratory Pressure, Hemodynamic Variable
Individualized Positive End-Expiratory Pressure (PEEP) on Oxygenation, Hemodynamics, and Early Postoperative Atelectasis in Laparoscopic Bariatric Surgery
The aim of this study is to evaluate the effectiveness of intraoperative individualized positive end-expiratory pressure (PEEPIND) titration, compared to fixed positive end-expiratory pressure of 5 cmH2O, on oxygenation…
- Conditions
- Positive End-expiratory Pressure, Hemodynamic Variable, Postoperative Atelectasis, Laparoscopic Bariatric Surgery
- Trial name
- NCT06115668
- Testing
- Positive end-expiratory pressure 5 (PEEP 5), Individualized positive end-expiratory pressure (PEEPIND)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
COVID-19, SARS
Modulation of Hyperinflammation in COVID-19
Current treatment recommendations are based on very limited evidence and reliant on the deployment of pharmacological strategies of doubtful efficacy, high toxicity, and near universal shortages of supply.
- Trial name
- NCT04353674
- Testing
- Control group, SLEDD with a L-MOD
- Where
- 2 sites in Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute Respiratory Distress Syndrome, Hemodynamic Instability
Thoracic Fluid Content by Bioimpedance-based Starling System
The Starling system is a completely non-invasive hemodynamic monitoring technique. It is able to measure the thoracic fluid content (TFC). The TFC is supposed to reflect the total content of fluid in the thorax.
- Conditions
- Acute Respiratory Distress Syndrome, Hemodynamic Instability, Shock, Fluid Overload Pulmonary Edema
- Trial name
- TFC-Bio (NCT05676723)
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Bicetre Hospital
Respiration Failure, Cardio Vascular Disease
COMPARE-VENT Feasibility Pilot Study
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20%…
- Conditions
- Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness
- Trial name
- NCT07656259
- Testing
- Volume Controlled Mode, Pressure Controlled Mode
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Atelectasis
Air Test In Diagnosis Of Postoperative Lung Atelectasis
Postoperative pulmonary complication represent asignificant source of morbidity and have greater incidence and costs than cardiac complications alone .Atelectasis is the commonest one.
- Trial name
- NCT04458623
- Testing
- Air Test
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Atelectasis
Effects of Small-dose S-ketamine on Anesthesia-induced Atelectasis in Anesthetized Patients Accessed by Pulmonary Ultrasound
Background: Atelectasis occurs in the majority of patients with general anesthesia, which can lead to postoperative pulmonary complications (PPCs) and affect the postoperative outcome.
- Trial name
- NCT04745286
- Testing
- S-ketamine, normal saline group
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Severe COVID-19 Disease
RAPA-501-Allo Therapy of COVID-19-ARDS
The first-in-human Phase 1 study component will evaluate two dose levels of RAPA-501-ALLO off the shelf cells in patients with COVID-19-related ARDS, with key endpoints of safety, biologic and potential disease-modifying effects.
- Trial name
- NCT04482699
- Testing
- RAPA-501-Allo off-the-shelf Therapy of COVID-19
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rapa Therapeutics LLC
Ventilator-associated Lung Injury, Atelectasis
Comparing Innovative and Traditional Ventilation Strategies on Atelectasis and Prognosis in Elderly Patients
This study was divided into two parts, taking elderly patients undergoing general anesthesia surgery as the research subjects, through factorial design: 1.
- Conditions
- Ventilator-associated Lung Injury, Atelectasis, Postoperative Pulmonary Complications
- Trial name
- NCT06021249
- Testing
- Traditional ventilation strategies, Traditional lung-protective ventilation strategies, Innovative lung-protective ventilation strategies
- Where
- 3 sites in China
- Volunteers
- 304 people
- Sponsor
- Fujian Medical University Union Hospital
Lung Collapse
Open Lung Approach Versus Standard Protective Strategies
The aim of this study was to compare the effects of adding a recruitment maneuver (RM) to low tidal volume (VT) ventilation, with or without an individualized post-RM positive end-expiratory pressure (PEEP) setting in…
- Trial name
- NCT02798133
- Testing
- OLA, RM-5
- Volunteers
- 36 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Neonatal Respiratory Distress
A Study to Evaluate the Use of the Neotech RAM Nasal Cannula for CPAP and Bi-PAP Application in Infants 28-42 Weeks Gestation in a Neonatal Intensive Care Unit (NICU)
This study will explore the RAM Nasal Cannula as a means of providing CPAP and Bi-PAP to infants 28-42 weeks gestation to prevent nasal septal erosion.
- Trial name
- NCT04096235
- Testing
- RAM Nasal Cannula
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Englewood Hospital and Medical Center
to Detect the Incidence of Atelectasis
To Evaluate the Role of Lung Ultrasonography for Detection of Atlelectasis in Robot Assisted Laproscopic Pelvic Sugeries
Pre op ultrasound with chest auscultation and arterial blood gas, after extubation ultrasound with chest auscultation and blood gas, 12hrs chest auscultation with ultasaound, 24 hrs chest auscultation and ultrasound to see…
- Trial name
- NCT03144310
- Testing
- lung ultrasound
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pain, Postoperative, Pulmonary Atelectasis
Paravertebral Block Versus Erector Spinae Plane Block for Modified Radical Mastectomy in Womens.
postoperative pain following Modified radical mastectomy is severe specially after dissection of tissues .paravertebral plane block provides an excellent postoperative analgesia for women's,but it carry the risk of pneumothorax…
- Conditions
- Pain, Postoperative, Pulmonary Atelectasis, Mastectomy
- Trial name
- NCT03614091
- Testing
- Erector spinae plane block, Paravertebral plane block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University