Clinical trials: Lung Disease, Fungal
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia
To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in pediatric patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have demonstrated severe or life-threatening…
- Trial name
- NCT00002317
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Sponsor
- U.S. Bioscience
Bacterial Pneumonia
Comparative Study of Ceftaroline vs. Ceftriaxone in Adults With Community-Acquired Pneumonia
The purpose of the study is to determine if the antibiotic ceftaroline is safe and effective in the treatment of community-acquired pneumonia in adults.
- Trial name
- CAP (NCT00509106)
- Testing
- Ceftaroline fosamil for Injection, Ceftriaxone
- Where
- 134 sites in United States, Argentina and 13 more
- Volunteers
- 622 people
- Sponsor
- Forest Laboratories
Tuberculosis, Pulmonary
The BLAST- 1 Trial - Cephalexin+Amoxicillin-clavulanate for Tuberculosis
The goal of this randomized controlled trial is to study the early bactericidal activity in adult patients with smear-positive pulmonary tuberculosis.
- Trial name
- BLAST (NCT05664568)
- Testing
- Cephalexin, Amoxicillin-Clavulanate 500 Mg-125 Mg Oral Tablet, Standard of care treatment of tuberculosis
- Where
- 3 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Western Sydney Local Health District
Tuberculosis, Pulmonary
Adjunctive NAC in Adult Patients With Pulmonary Tuberculosis
To determine if adjunctive N-acetylcysteine 1200 mg twice a day (BID) accelerates sputum culture conversion and normalization of cellular glutathione in tuberculosis (TB), and to assess its potential effects on lung and immune…
- Trial name
- NAC-TB (NCT03702738)
- Testing
- N-acetyl cysteine
- Where
- Tanzania
- Volunteers
- 110 people
- Sponsor
- The Aurum Institute NPC
Pneumonia, Pneumocystis Carinii, HIV Infections
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
To compare the safety and effectiveness of drug therapy with aerosolized pentamidine (PEN) with that of conventional therapy, sulfamethoxazole plus trimethoprim (SMX/TMP) in the treatment of Pneumocystis carinii pneumonia (PCP)…
- Trial name
- NCT00000715
- Testing
- Pentamidine isethionate, Sulfamethoxazole-Trimethoprim
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Phase 2a EBA Trial of AZD5847
The purpose of this study is to assess the early bacterial activity (EBA) from day 0 to day 14 of Astra Zeneca Drug (AZD5847) at four different doses and schedules (500 mg once daily, 500 mg twice daily, 1200 mg once daily, and…
- Trial name
- NCT01516203
- Testing
- AZD5847, Ethambutol, isoniazid, pyrazinamide, rifampin
- Where
- South Africa
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Infection, Pneumonia, Ventilator-Associated
Adjunctive Therapy to Antibiotics in the Treatment of S. Aureus Ventilator-Associated Pneumonia With AR-301
AR-301 is being evaluated as an adjunctive treatment of ventilator-associated pneumonia (VAP) due to Staphylococcus aureus (S. aureus) in combination with standard of care (SOC) antibiotic therapy in patients with confirmed S.
- Conditions
- Lung Infection, Pneumonia, Ventilator-Associated, Infection, Bacterial, Staphylococcus Aureus
- Trial name
- AR-301-002 (NCT03816956)
- Testing
- AR-301
- Where
- 45 sites in Belarus, Belgium and 13 more
- Volunteers
- 174 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Pneumococcal Disease
A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 With Influenza Vaccine in Adults ≥ 50 Years of Age
This is a Phase 3, randomized, double-blind study to evaluate the safety and immunogenicity of VAX-31 and seasonal influenza vaccine in pneumococcal-naïve adults ≥ 50 years when the two vaccines are administered at the same visit…
- Trial name
- NCT07365826
- Testing
- 31-valent pneumococcal conjugate vaccine, Seasonal Influenza Vaccine (SIV) (Flublok)
- Where
- 25 sites in United States
- Volunteers
- 1,390 people, healthy volunteers welcome
- Sponsor
- Vaxcyte, Inc.
Tuberculosis, HIV Infections
Pharmacokinetics of Emtricitabine/Tenofovir/Efavirenz in HIV-infected Patients With Tuberculosis
In this pilot study the pharmacokinetics and safety of the antiretroviral combination of co-formulated emtricitabine/tenofovir/efavirenz will be studied in HIV-positive patients with pulmonary tuberculosis (TB) who are…
- Trial name
- PETE (NCT00474435)
- Testing
- Emtricitabine/tenofovir/efavirenz
- Where
- Tanzania
- Volunteers
- 30 people
- Sponsor
- African Poverty Related Infection Oriented Research Initiative
Cystic Fibrosis
Microbiota of the Respiratory Flora in Children With Cystic Fibrosis During the First Year of Life
The goal of this study is characterize the changes in bacterial diversity of the upper respiratory tracts of infants with cystic fibrosis (CF).
- Trial name
- NCT00977158
- Testing
- Throat Swab
- Where
- 2 sites in United States
- Sponsor
- Tufts Medical Center
Invasive Pulmonary Aspergillosis
Evaluation of Exhaled Breath Condensate in the Diagnosis of Invasive Pulmonary Aspergillosis
The purpose of this study is to evaluate the diagnostic potential of biomarkers for invasive pulmonary aspergillosis in exhaled breath condensate.
- Trial name
- NCT01247142
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tuberculosis, Pulmonary
Four Months Moxifloxacin Containing Daily Regimen Study Among New Pulmonary Tuberculosis Patients
The 4-month daily regimen containing moxifloxacin (2HRZEM 7 / 2HRM7) of ICMR-NIRT was studied in 321 sputum positive pulmonary TB patients in a randomised clinical trial.
- Trial name
- NCT05047055
- Testing
- Isoniazid, Rifampicin, Pyrazinamide
- Where
- India
- Volunteers
- 550 people
- Sponsor
- Tuberculosis Research Centre, India
Pneumonia, Pneumocystis Carinii, HIV Infections
A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies
To determine the safety and effectiveness of an investigational drug trimetrexate (TMTX) with leucovorin rescue (LCV) in the treatment of Pneumocystis carinii pneumonia (PCP) in patients who have AIDS, are HIV positive, or are at…
- Trial name
- NCT00001016
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Right Ventricular Dysfunction, Rheumatic Heart Disease
Right Ventricular Echo Assessment in Mitral Valve Replacement
Rheumatic heart disease remains a major health problem in developing countries. It is the most important sequel of rheumatic fever and occurs in about 30% of patients with rheumatic fever.Rheumatic heart disease presents with…
- Trial name
- NCT03549052
- Volunteers
- 120 people
- Sponsor
- Assiut University
Pulmonary Sarcoidosis, Lung Function
Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis
Sarcoidosis is a granulomatous disease for which the molecular and immunologic association with mycobacteria continues to strengthen.
- Trial name
- CLEAR Lung (NCT01169038)
- Testing
- levaquin; ethambutol; rifampin and azithromycin.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University
Invasive Fungal Infection
An Individualized Administration Research of Voriconazole Based on CYP2C19 Gene Polymorphism and TDM
This was a prospective clinical study that all voriconazole-treated adult Chinese patients with invasive pulmonary infection admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University from March 2018 to April 2020.
- Trial name
- NCT04004078
- Testing
- other antifungal agents,breathing machine
- Where
- China
- Volunteers
- 314 people
- Sponsor
- People's Hospital of Zhengzhou University
Nontuberculous Mycobacteria
The Italian REgistry of Pulmonary Non-tuberculous mycobactEria
The Italian registry of pulmonary non-tuberculous mycobacteria (NTM) -IRENE- is an observational, multicenter, prospective, cohort study enrolling consecutive adult patients with either a NTM respiratory infection or…
- Trial name
- IRENE (NCT03339063)
- Where
- 26 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Pulmonary Tuberculosis, Extra Pulmonary Tuberculosis
Tuberculosis Cohort in the North of Paris
Tuberculosis (TB) is the leading cause of death from infectious disease in the world, just behind HIV / AIDS. Since 2005, the department of Seine Saint Denis, the poorest of France with difficult socio-economic conditions, has…
- Trial name
- NCT04236349
- Testing
- immunogenetics
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumonia, Bacterial
Inhaled Amikacin Solution BAY41-6551 as Adjunctive Therapy in the Treatment of Gram-Negative Pneumonia
To demonstrate that as adjunctive therapy to intravenous (IV) antibiotics, BAY 41-6551 400 mg (amikacin as free base) administered as an aerosol by the Pulmonary Drug Delivery System (PDDS) Clinical every 12 hours is safe and…
- Trial name
- INHALE 1 (NCT01799993)
- Testing
- Amikacin Inhalation Solution (BAY41-6551)
- Where
- 65 sites in United States, Australia and 10 more
- Volunteers
- 725 people
- Sponsor
- Bayer
Cystitis, Erysipelas
Hospital at Home for Elderly Acute Ill Patients
Many elderly patients with uncomplicated treatment courses are admitted unnecessarily, which is a burden for the patient and society. Studies show that Hospital at Home (HaH) treatment is an alternative to hospitalization.
- Conditions
- Cystitis, Erysipelas, Pneumonia
- Trial name
- NCT05360914
- Testing
- Hospital at Home (HaH) treatment, Standard hospital admission
- Where
- 3 sites in Denmark
- Volunteers
- 849 people
- Sponsor
- Defactum, Central Denmark Region
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