Clinical trials: Lung Disease Airways
Bronchiolitis
Treatment of Pediatric Bronchiolitis
Bronchiolitis (BQ) is the acute viral infection of the tract respiratory syndrome in infants that affects the bronchioles of babies under 24 months of age.
- Trial name
- NCT03835936
- Testing
- High frequency compression of the chest wall group, Manual maneuvers physiotherapy group
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Guadarrama Hospital
Pneumonia, Community-Acquired Infections
Helmet Continuous Positive Airway Pressure Versus Oxygen Venturi in Acute Respiratory Failure in CAP: CAPOVeRSO
The purpose of this study is to compare the efficacy of CPAP application by a helmet and O2 administration by a Venturi mask in terms of gas exchanges improvement in patients with acute respiratory failure due to…
- Conditions
- Pneumonia, Community-Acquired Infections, Respiratory Insufficiency, Acute Lung Injury
- Trial name
- CAPOVeRSO (NCT00603564)
- Testing
- Castar Starmed (CPAP) delivered by a helmet
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- University of Milan
Asthma
Elite Sport and Development of Asthma
International studies have shown that elite athletes have a high prevalence of respiratory symptoms and asthma as compared to normal subjects.
- Trial name
- NCT00262587
- Testing
- Seretide
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation
Health Outcomes With CPAP or NIV in Patients With COPD and a Sleep Related Breathing Disorder
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease affecting an estimated 1 in 10 Canadians. Symptoms include persistent shortness of breath, cough and sputum production.
- Conditions
- Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation, Obstructive Sleep Apnea, Hypoventilation
- Trial name
- NCT05623709
- Testing
- Positive airway pressure with continuous positive airway pressure or noninvasive ventilation
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Premature Birth
Prophylactic DR-CPAP on Late Preterm Infants Born by C-section: an RCT
A Pragmatic Randomized Controlled Pilot Trial to Evaluate the Impact of Early Prophylactic Continuous Positive Airway Pressure with or without Supplemental Oxygen in Spontaneously Breathing Late Preterm Newborn Infants Born by…
- Trial name
- PLANT (NCT05204719)
- Testing
- Prophylactic Delivery Room Continuous Positive Airway Pressure
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Uncontrolled Asthma
A Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents With Uncontrolled Asthma
A 52-Week, Multicentre, Randomized, Double-Blind, Parallel Group, Placebo Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents with Asthma Inadequately Controlled on Inhaled…
- Trial name
- STRATOS1 (NCT02161757)
- Testing
- Tralokinumab
- Where
- 243 sites in United States, Argentina and 13 more
- Volunteers
- 1,207 people
- Sponsor
- AstraZeneca
Bronchopulmonary Dysplasia, Prematurity
Impact of Extended CPAP on Bronchopulmonary Dysplasia
The purpose of this pilot study is to compare if keeping infants on CPAP (continuous positive airway pressure) support for an extended period of time until they are 32 weeks corrected gestational age or 1250 grams (approximately…
- Trial name
- NCT05547139
- Testing
- Protocolized weaning of respiratory support
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
COVID-19
Clinical and Electronic Record for Patients With COVID-19 Treated With the Assisted Breathing Helmet - ELMO in Ceará
Continuous positive airway pressure (CPAP) with a helmet-like interface has been described as a safe strategy, with minimal contamination of the environment, improving the oxygenation of patients with acute respiratory failure…
- Trial name
- COVID-19 (NCT05375799)
- Testing
- Clinical Observation
- Where
- Brazil
- Volunteers
- 2,000 people
- Sponsor
- Escola de Saúde Pública do Ceará
Asthma, Allergic
Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma
Asthma is a condition where small inhaled particles can cause inflammation in the lung leading to constriction of airways and wheeze.
- Trial name
- NCT05740748
- Testing
- Tezepelumab
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- McMaster University
Stroke
Applicability of Techniques of Lung Expansion
The survival of patients with lesions in the central nervous system is usually accompanied by physical and mental sequelae. These impairments favor the prolonged restriction to the bed, which may contribute with changes in…
- Trial name
- NCT02613832
- Testing
- EPAP, Breath Stacking
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Chronic Obstructive Pulmonary Disease (COPD)
Evaluation of the Effect of PUR118 on Ozone Induced Airway Inflammation in Healthy Normal Volunteers
This trial in healthy subjects will assess PUR118's effect on attenuating ozone induced airway inflammation. This trial will establish the tolerability of PUR118 in healthy normal volunteers.
- Trial name
- NCT01690949
- Testing
- PUR118
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pulmatrix Inc.
Cystic Fibrosis, Pulmonary Disease, Chronic Obstructive
Comparison of Two Treatment Regimens to Reduce PA Infection in Children With Cystic Fibrosis
Cystic fibrosis (CF) is a chronic disease that significantly affects an individual's lung function. Antibiotic medications have been proven effective at reducing Pseudomonas aeruginosa (PA) infection, which is one of the main…
- Trial name
- EPIC (NCT00097773)
- Testing
- Tobramycin solution for inhalation (TOBI), Oral ciprofloxacin
- Where
- 54 sites in United States
- Volunteers
- 304 people
- Sponsor
- Seattle Children's Hospital
Asthma, Lung Diseases, Obstructive
Genetics of Airway Responsiveness and Lung Function
To perform a genome-wide search for genes affecting two phenotypes related to asthma and chronic obstructive pulmonary disease (COPD) in a Chinese population.
- Conditions
- Asthma, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00005537
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pneumonia
Effectiveness of OLE Airway Clearance Therapy in ICU Patients With Pulmonary Infections
This study aims to explore the application of Electrical Impedance Tomography (EIT) in evaluating the effectiveness of OLE (Oscillatory Lung Expansion) airway clearance therapy for ICU patients with pulmonary infections.
- Trial name
- NCT07395297
- Testing
- Oscillatory Lung Expansion (OLE) Therapy
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Chinese PLA General Hospital
Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO)
The purpose of this study is to research the differences of small airways function between subjects with diagnosis of chronic obstructive pulmonary disease(COPD) and asthma-COPD overlap(ACO).The assessment of quality of life is…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome, Small Airway Disease, Quality of Life
- Trial name
- NCT03563001
- Testing
- Budesonide(160ug) and Formoterol(4.5ug) bid
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Cystic Fibrosis
Should Any One Airway Clearance Technique be Recommended for People With Cystic Fibrosis?
The study was to evaluate the long term effects, over one year, of five airway clearance techniques used by people with cystic fibrosis (active cycle of breathing techniques, autogenic drainage, positive expiratory pressure and…
- Trial name
- ACT (NCT00890370)
- Testing
- Airway clearance technique
- Volunteers
- 75 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Idiopathic Pulmonary Fibrosis, Small Airways Disease
Small Airways Disease Functional Assessment in Idiopathic Pulmonary Fibrosis (SWIFT-IPF)
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, fibrosing, and progressive lung disease of unknown cause, whose incidence increases proportionally from the age of 60. It is characterized by a poor prognosis.
- Trial name
- SWIFT-IPF (NCT07312305)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Milan
Cystic Fibrosis
Comparative Effects of Mechanical and Manual Airway Clearance Techniques in Cystic Fibrosis
This study will help to establish evidence-based physiotherapy on postural drainage and ACBT against flutter with ACBT is better to improve sleep quality, adherence, dyspnea in patients with cystic fibrosis and which method can…
- Trial name
- NCT07062939
- Testing
- postural drainage with ACBT, flutter with ACBT
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Riphah International University
Respiratory Distress Syndrome, Newborn, Infant, Premature, Diseases
Airway Flow of RAM Cannula With BCPAP in Infants
The RAM Cannula interface is used as routine interface for newborn infants receiving CPAP treatment for respiratory distress. Compared to the standard systems that have been used for more than 50 years, the interface has high…
- Conditions
- Respiratory Distress Syndrome, Newborn, Infant, Premature, Diseases, Infant, Newborn, Diseases
- Trial name
- NCT06697912
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Pneumonia, Airway Clearance
The Effectiveness of Different Nebulized Solutions on Airway Clearance Function in Patients With Pneumonia
Pneumonia is a significant global and national health issue, particularly posing a notable threat to elderly population. Accumulation of sputum in pneumonia patients often results in impaired airway clearance, negatively…
- Trial name
- NCT07586345
- Testing
- Nebulization therapy
- Volunteers
- 80 people
- Sponsor
- Chen, Yao-Hsiang
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