Clinical trials: Lung Disease Airways
Obstructive Sleep Apnea
Pathophysiology of the Upper Airway in Patients With COPD and Concomitant OSA
The purpose of study is to evaluate the physiologic effects of pulmonary tissue/structural changes associated with COPD and upper airway inflammation on upper airway collapsibility.
- Trial name
- NCT02567448
- Testing
- Sleep and pulmonary physiologic measurements
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies
A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation
Respiratory distress syndrome (RDS) is the main cause of respiratory failure in preterm neonates, its incidence varying from 80% to 25% depending on gestational age.When optimal prenatal care is provided, the best approach to…
- Trial name
- NCT03181958
- Testing
- NHFOV, NCPAP, NIPPV
- Where
- China
- Volunteers
- 1,493 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Chronic Obstructive Pulmonary Disease
Study to Assess the Effect of Formoterol and Beclomethasone Dipropionate in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The objective of this study is to evaluate the effect of the combination of formoterol and beclometasone dipropionate on central and peripheral airway dimensions in COPD patients using Computational Fluid Dynamics (CFD).
- Trial name
- NCT01204034
- Testing
- Inuvair
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- University Hospital, Antwerp
Asthma, Wheezing
Swiss Paediatric Airway Cohort
The Swiss Paediatric Airway Cohort (SPAC) is a national, prospective clinical cohort of children and adolescents who visit physicians in Switzerland for recurrent wheeze, cough, and exercise- or sleep-related respiratory…
- Conditions
- Asthma, Wheezing, Cough, Exercise Induced Bronchospasm
- Trial name
- SPAC (NCT03505216)
- Where
- 12 sites in Austria, Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University of Bern
Asthma, Reactive Airway Disease
Single Oral Dose of Dexamethasone Versus Five Days of Prednisone in Adult Asthma
This study seeks to compare the effectiveness of a single dose of oral dexamethasone versus 5 days of oral prednisone in the treatment of mild to moderate asthma exacerbations to prevent relapse with an unscheduled return visit…
- Trial name
- NCT01241006
- Testing
- Dexamethasone, Prednisone
- Where
- United States
- Volunteers
- 376 people
- Sponsor
- Alameda County Medical Center
Cough, Cough Variant Asthma
MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough
The aim of the study is to assess the prevalence of bronchial hyperresponsiveness (BHR) in non-smoking adults with chronic cough and the prevalence of BHR in patients with upper airway cough syndrome (UACS) and gastroesophageal…
- Conditions
- Cough, Cough Variant Asthma, Upper-Airway Cough Syndrome, GERD
- Trial name
- NCT03363698
- Testing
- Cough variant asthma treatment
- Where
- Poland
- Volunteers
- 55 people
- Sponsor
- Medical University of Warsaw
Asthma
Prevalence and Reversibility of Lung Hyperinflation in Asthma
The aim of this observational study is to evaluate the pulmonary hyperinflation and its immediate reversibility to a short acting beta2 agonist test in uncontrolled persistent asthmatic patients with dyspnea.
- Trial name
- Dist'air2 (NCT01573364)
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma
A Study To Assess The Effect Of PF-03893787 On Lung Function Following An Allergen Challenge In Asthmatic Subjects
PF-03893787, a novel anti-inflammatory agent should attenuate the effect of a bronchial allergen challenge on lung function and hence provide proof of mechanism for this agent.
- Trial name
- NCT00856687
- Testing
- PF-03893787, Montelukast
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Pfizer
Asthma, Bronchial Hyperreactivity
Early Antiinflammatory Treatment of Asthma
The inflammatory process that leads to the development of asthma may be present before the onset of asthma symptoms and cause a certain degree of airway hyperresponsiveness.
- Trial name
- EATA (NCT00567463)
- Testing
- Fluticasone
- Where
- Canada
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Laval University
Lung Diseases
Breath Analysis by Ion Mobility Spectrometry
Recognition of disease specific clusters of volatile organic compounds in patients with different lung diseases, using breath analysis with ion mobility spectrometry.
- Trial name
- NCT00632307
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lung Clinic Hemer
COPD Exacerbation, COPD
Impulse Oscillometry in COPD Exacerbation
This study aimed to evaluate small airway function during ECOPD and recovery periods using IOS. In this prospective single-center study, patients with ECOPD underwent evaluation of their pulmonary functions using IOS and…
- Trial name
- NCT07185581
- Testing
- Impulse Oscillometry
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Deniz Bilici
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
Quantitative Chest CT and Multi-Omics to Distinguish Asthma From COPD and Predict Treatment Response
This study aims to improve the diagnosis and treatment prediction of asthma and chronic obstructive pulmonary disease (COPD) by combining quantitative chest computed tomography (CT) imaging with multi-omics data.
- Trial name
- CTOMICS (NCT07602192)
- Where
- 2 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
Acute Lung Injury
Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial
The main hypothesis are: 1. Passive and Active-Passive airway conditioning devices reduce the incidence of ventilator associated pneumonia 2.
- Trial name
- AirconVAP (NCT01150864)
- Testing
- Airway Conditioning
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Università degli Studi dell'Insubria
Pulmonary Disease, Chronic Obstructive
Postmarketing Surveillance Study of Atrovent® Inhalets in Chronic Obstructive Airways Disease
To obtain further information on the tolerability of Atrovent® inhalets in the treatment of Chronic Obstructive Airways Disease under conditions of daily practice
- Trial name
- NCT02238132
- Testing
- ATROVENT® inhalets
- Volunteers
- 374 people
- Sponsor
- Boehringer Ingelheim
Asthma, Rhinitis
Study of Asthma and Nasal Steroids
The trial will study the effectiveness of nasal steroids for the treatment of chronic rhinitis and/or sinusitis on asthma control.
- Conditions
- Asthma, Rhinitis, Sinusitis
- Trial name
- STAN (NCT01118312)
- Testing
- Mometasone Furoate monohydrate
- Where
- 19 sites in United States
- Volunteers
- 388 people
- Sponsor
- JHSPH Center for Clinical Trials
Pneumonia, Pleural Effusion
Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation
The objective of this study is to assess whether there is a difference between a care protocol with the use of incentive spirometry (Voldyne ®) and another with the application of NIV (non invasive ventilation with single-level…
- Conditions
- Pneumonia, Pleural Effusion, Atelectasis
- Trial name
- NCT01416519
- Testing
- Continuous Positive Airway Pressure (CPAP) facial mask, Assisted deep inspiration technique
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Santa Casa de Votuporanga
Lung Cancer, Thoracic Cancer
Investigating Radiation-Induced Injury to Airways and Pulmonary Vasculature in Lung Stereotactic Ablative Body Radiotherapy (SAbR)
We will conduct a prospective clinical study involving up to 40 non-Small Cell Lung Cancer (nSCLC) patients to determine dose thresholds for central and peripheral BSS elements.
- Trial name
- NCT05459311
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center
COPD
The Effect of High Dose N-acetylcysteine on Airtrapping and Airway Resistance in Chronic Obstructive Pulmonary Disease (COPD) Patients
This study is to investigate the add-on effect of high dose NAC (600mg tablet twice daily) on reduction of airtrapping and airway resistance in stable COPD patients as well as to study it's effect in reducing exacerbation…
- Trial name
- NCT01136239
- Testing
- N-acetycysteine (600mg twice daily)
- Where
- China
- Volunteers
- 133 people
- Sponsor
- Kwong Wah Hospital
Pulmonary Disease, Chronic Obstructive
Symbicort in Airway Predominant Chronic Obstructive Pulmonary Disease (COPD)
The main objective of the study is to see if using anti-inflammatory to patients with airway disease chronic obstructive pulmonary disease (COPD) phenotype will be more effective than using these treatments in patients with loss…
- Trial name
- SACOPD (NCT01253473)
- Testing
- Budesonide, budesonide/formoterol, Ipratropium/albuterol
- Where
- 7 sites in United States
- Volunteers
- 46 people
- Sponsor
- National Jewish Health
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