Clinical trials: Lung Disease Airways
Lung Cancer, Chronic Obstructive Airway Disease
Early Detection of Lung Tumors by Sniffer Dogs - Evaluation of Sensitivity and Specificity
Some groups reported that sniffer dogs can be applied to detect lung cancer in the exhaled breath of patients. Therefore, breath samples (BS) of patients are collected.
- Trial name
- NCT01141842
- Testing
- exhalation analysis of breath sample
- Where
- 2 sites in Germany
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Schillerhoehe Hospital
Pulmonary Disease
Cryospray Therapy Versus Standard of Care for Benign Airway Stenosis (CryoStasis)
Benign central airway stenosis (BCAS) is an important cause of both pulmonary morbidity and mortality. Notable causes include post-intubation stenosis, collagen vascular diseases, airway trauma, infectious and idiopathic…
- Trial name
- NCT04996173
- Testing
- Spray cryotherapy, Ballon Dilation, Radial Incision
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Obstructive Airway Disease
Safety and Efficacy of Inhaled Sedation in Management of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Brief Summary (Plain Language) This study tests whether using a device called AnaConDa® to give a mild gas medicine (isoflurane) helps people with severe flare-ups of chronic obstructive pulmonary disease (COPD) breathe more…
- Trial name
- NCT07191470
- Testing
- The Anaesthetic Conserving Device (AnaConDa)
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Pandit Bhagwat Dayal Sharma, PGIMS, Rohtak
Copd, COVID-19
Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19
The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanatomical small airway structure…
- Conditions
- Copd, COVID-19, Asthma, Small Airways Disease
- Trial name
- PASSPORT (NCT04716023)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Imperial College London
Bronchiectasis Adult
Respiratory Physiotherapy for Patients With Bronchiectasis
Study design: observational, retrospective Population: 270 patients diagnosed with bronchiectasis (BX) treated at the Respiratory Physiotherapy Unit of the Rehabilitation Service of the A Coruña and Cee Health Area.
- Trial name
- PhysioBX (NCT07733323)
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- Yolanda Sanesteban Hermida
Asthma
Repeat Dose Study of GSK3772847 in Participants With Moderate to Severe Asthma With Allergic Fungal Airway Disease (AFAD)
This study is multicenter, double-blinded parallel group design, where participants with moderate to severe asthma with AFAD will be enrolled.
- Trial name
- NCT03393806
- Testing
- GSK3772847
- Where
- 18 sites in France, Netherlands and 2 more
- Volunteers
- 17 people
- Sponsor
- GlaxoSmithKline
Asthma
Study on the Effects of an AMP Challenge on Asthmatic Patients Following Treatment With Fluticasone Propionate
Inhaling AMP causes an inflammatory response in the lung. This study will investigate whether 5-days of treatment with fluticasone propionate protects the lung from responding to the AMP in this way.
- Trial name
- NCT00400855
- Testing
- Fluticasone propionate
- Where
- 2 sites in New Zealand
- Volunteers
- 49 people
- Sponsor
- GlaxoSmithKline
Severe Asthma
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma.
- Trial name
- NCT07139899
- Testing
- Hyperpolarized Xenon 129
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Bastiaan Driehuys
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants
The primary aim of this study is to quantify and compare changes in lung volumes (as measured by functional residual capacity) in premature infants stable on continuous positive airway pressure (CPAP), and then randomized to two…
- Trial name
- NCT02249143
- Testing
- CPAP and room air
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Asthma
Early Airway Response to Allergen in Asthmatics (MK-0000-176)
This study will assess the Early Airway Response (EAR) associated change in forced expiratory volume in one second (FEV1) and plasma 9α-11ß-PGF2 ('9P') after single dose pretreatment of nedocromil, montelukast, and mometasone.
- Trial name
- NCT01061333
- Testing
- Nedocromil, Comparator: Montelukast, Comparator: Mometasone
- Volunteers
- 16 people
- Sponsor
- Merck Sharp & Dohme LLC
Cystic Fibrosis
Positive Expiratory Pressure During Inhalation of Hypertonic Saline in Patients With Cystic Fibrosis
This trial aims to analyze whether the inhalation of hypertonic saline combined with a positive expiratory pressure (PEP) device increases the amount of sputum expectorated during the chest physiotherapy session ( inhalation +…
- Trial name
- NCT02303808
- Testing
- INHALATION WITH PEP DEVICE (Acapella Duet)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad San Jorge
Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema
O2 Versus CPAP Treatment Of Patients Undergoing SIPE Therapy (OCTOPUS)
In swimming induced pulmonary edema (SIPE), there is a lack of knowledge regarding optimal treatment. The present study was designed to assess the benefit of continuous positive airway pressure (CPAP) compared to oxygen as a…
- Conditions
- Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema, Lung Diseases
- Trial name
- OCTOPUS (NCT04307615)
- Testing
- Oxygen + continuous positive airway pressure (CPAP), Oxygen
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Dalarna County Council, Sweden
COPD
A Safety, Tolerability and Efficacy Study in Chronic Obstructive Pulmonary Disease (COPD) Patients With QBM076.
This was a 2 Part study. Part 1 was a safety and tolerability study in GOLD I-III COPD patients. Part 2 was an efficacy study in GOLD I-III COPD patients.
- Trial name
- NCT01972776
- Testing
- QBM076
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
Bronchiolitis
The Effectiveness of AAD and IPV to Treat Hospitalized Infants (<2years) With Acute Viral Bronchiolitis.
The purpose of this study is to investigate the effectiveness of two airway clearance techniques; Intrapulmonary Percussive Ventilation and Assisted Autogenic Drainage in hospitalized infants under the age of 2 with acute viral…
- Trial name
- NCT02126748
- Testing
- inhalation 4ml hypertonic saline 3% 3x/day, Intrapulmonary Percussive Ventilation, Assisted Autogenic Drainage
- Where
- Belgium
- Volunteers
- 103 people
- Sponsor
- Vrije Universiteit Brussel
Asthma, Respiratory Disease
Airway Remodeling and Rhinovirus in Asthmatics
Human rhinovirus is also called the "common cold virus" because it causes at least half of all of the common colds experienced each year.
- Trial name
- ARRA (NCT05775952)
- Testing
- HRV-39
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Lung Cancer, Malignant Mesothelioma
Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease
RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.
- Conditions
- Lung Cancer, Malignant Mesothelioma, Metastatic Cancer, Nonmalignant Neoplasm
- Trial name
- NCT00733252
- Testing
- bronchoscopic and lung imaging studies, diagnostic bronchoscopy, histopathologic examination
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Acute Respiratory Distress Syndrome, Acute Lung Injury
Pressure Opening With Electrical Impedance Tomography
Acute lung injury and ARDS (acute respiratory distress syndrome) are characterized by lung inhomogeneity, leading to a different distribution of the tidal volume (and pressure) within the lung.
- Trial name
- POET (NCT05825534)
- Testing
- EIT monitoring
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Asthma, Allergies and Obesity
The Relation Between Obesity, Adipose Tissue Content of Fatty Acids and Systemic and Airway Inflammation
Obesity has been recognized as a risk factors for developing asthma. In a cohort of 5384 children aged 15-17, we aim to: 1. To investigate the association of asthma prevalence at age 15-17 with body mass index (BMI) at age 15-17…
- Trial name
- NCT01229787
- Where
- Cyprus
- Volunteers
- 5,384 people, healthy volunteers welcome
- Sponsor
- Cyprus International Institute for Environment and Public Health
Pulmonary Infection, Pulmonary Nodule
COMBO Endoscopy Oropharyngeal Airway in Sedated Fiberoptic Bronchoscopy for Patients: A Simon Two-Stage Trial
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing fiberoptic bronchoscopy with propofol.
- Conditions
- Pulmonary Infection, Pulmonary Nodule, Endotracheal Tumour, Bronchiectasis
- Trial name
- NCT07063290
- Testing
- the COMBO Endoscopy Oropharyngeal Airway
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zhejiang University
Asthma
Investigation of Novel Procedure for Methacholine Challenge Testing
The study will compare a novel volumetric method (performed with the Aerogen Solo vibrating mesh nebulizer) with the standard two-minute tidal breathing protocol (performed with the Wright jet nebulizer) for methacholine…
- Trial name
- NCT02965482
- Testing
- Wright Nebulizer, Aerogen Solo Nebulizer
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Saskatchewan