Clinical trials: Lung Disease Chronic
Chronic Obstructive Pulmonary Disease
GECo: Implementation and Effectiveness of COPD Self Management Action Plans in Low and Middle Income Countries
This study will randomise people with clinically significant COPD (GOLD Grade B-D) to usual care or provision of a self-management action plan supported by monthly follow-up visits from a community health worker trained in the…
- Trial name
- GECo2 (NCT03359915)
- Testing
- COPD Self-Management Plan
- Where
- 3 sites in Nepal, Peru and 1 more
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease
Inspiratory Muscle Training Combined With General Exercise Training in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a frequent disease, with increasing prevalence. Pulmonary rehabilitation through general exercise training (GET) is a corner stone of COPD care.
- Trial name
- IMTGET (NCT02392715)
- Testing
- Inspiratory muscle training with Threshold by respironics
- Volunteers
- 80 people
- Sponsor
- Hôpital Riviera-Chablais, Vaud-Valais
Pulmonary Vascular Disease, Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Exercise Performance on Ambient Air vs. Low-Flow Liquid Oxygen Therapy in Chronic Lung Diseases
The investigators aim to study the effect of liquid oxygen therapy (4l/min, nasal) )in Swiss residents with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary…
- Conditions
- Pulmonary Vascular Disease, Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Pulmonary Arterial Hypertension (PAH)
- Trial name
- NCT07777367
- Testing
- 6-minute walk distance (6MWD) test on ambient conditions, 6-minute walk distance (6MWD) test with supplemental oxygen (LOX)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Silvia Ulrich Somaini
Childhood Cancer, Cerebral Palsy
GoalKeeper: Intelligent Information Sharing for Children With Medical Complexity
This proposal addresses the major challenge of improving health outcomes for children with cancer and other complex conditions, for whom the effectiveness of outpatient care depends on care coordination across a diverse group of…
- Conditions
- Childhood Cancer, Cerebral Palsy, Chronic Lung Disease, Congenital Heart Disease
- Trial name
- GoalKeeper (NCT03620071)
- Testing
- GoalKeeper, Standard Care
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Stanford University
Uremia; Chronic, Cardiovascular Diseases (CVD)
Prevention and Management of Cardiovascular and Cerebrovascular Complications in Maintenance Hemodialysis (MHD) Patients
Background and Purpose: This clinical study aims to explore and validate two innovative treatment strategies to address two major challenges faced by patients on maintenance hemodialysis (uremia): the high incidence of…
- Conditions
- Uremia; Chronic, Cardiovascular Diseases (CVD), Cerebrovascular Disorders, Intradialytic Hypotension
- Trial name
- NCT07335471
- Testing
- Continuous High-Glucose Infusion and Regular Hemoperfusion in Maintenance Hemodialysis
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Healthy, COPD
Effects of BFR Interventions in Healthy Individuals and Individuals With COPD
The purpose of the study is to investigate the effect of different blood flow restriction (BFR) interventions on muscle function and adaptations both in healthy well-trained individuals and individuals diagnosed with COPD.
- Trial name
- NCT05734534
- Testing
- BFR during training, BFR during rest
- Where
- Denmark
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Transplant; Failure, Kidney, Renal Disease, End Stage
Oral Paricalcitol in Kidney Transplant Recipients
This study is being done to find out whether patients who receive a kidney transplant can benefit from taking the medication paricalcitol (trade name Zemplar®) as compared to kidney transplant recipients not taking this…
- Conditions
- Transplant; Failure, Kidney, Renal Disease, End Stage, Hyperparathyroidism, Secondary
- Trial name
- NCT00587158
- Testing
- Paricalcitol, Corticosteroid Avoidance Immune Suppression Protocol
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Chronic Beryllium Disease
Targeting Oxidative Stress in Chronic Beryllium Disease
The purpose of this study is to understand if a drug called mesalamine helps to control inflammation associated with chronic beryllium disease (CBD).
- Trial name
- NCT01088243
- Testing
- Mesalamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Jewish Health
Lung Diseases, Obstructive
Method of Oxygen Delivery and the Effect on Transcutaneous PaCO2
Infants of < 1500 grams of birth weight who require a > 1 week mechanical ventilation (breathing machine) or CPAP [continuous positive airway pressure] (oxygen at a high flow through the nose) may have prolonged oxygen…
- Trial name
- NCT00135252
- Testing
- nasal cannula oxygen delivery, supplemental oxygen delivery by hood
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- The University of Texas Health Science Center, Houston
Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
The purpose of the study is to evaluate whether treatment with ibrutinib as a monotherapy results in a clinically significant improvement in progression free survival (PFS) as compared to treatment with ofatumumab in patients…
- Trial name
- RESONATE™ (NCT01578707)
- Testing
- ofatumumab, ibrutinib
- Where
- 76 sites in United States, Australia and 8 more
- Volunteers
- 391 people
- Sponsor
- Pharmacyclics LLC.
Preventive Care
Impact of a Health Intervention on Some Indicators in the Care of Chronic Complex Patient (CCP).
The aim of this study is to assess the effectiveness of proactive and integrated healthcare program for chronic complex patients (CCP).
- Trial name
- CCP (NCT03091036)
- Testing
- Proactive healthcare intervention
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- María José del Olmo Rubio
COPD
Diaphragm Release Manual Technique Efficacy in COPD Patients
The aims of this study are to evaluate the effects of Diaphragm Release Manual Technique on diaphragm mobility, chest wall kinematics and functional capacity of COPD patients.
- Trial name
- NCT02212184
- Testing
- Manual Diaphragm Release Technique
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Helga Cecília Muniz de Souza
Chronic Obstructive Pulmonary Disease, Health Status
Secondary Prevention of Problems in Health Status in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to determine the effectiveness of an intervention conducted by a pulmonary nurse in patients with COPD.
- Trial name
- NCT00940355
- Testing
- Intervention pulmonary nurse
- Where
- Netherlands
- Volunteers
- 303 people
- Sponsor
- Radboud University Medical Center
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)
Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD)…
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
- Trial name
- CRESCENDO-SLP (NCT05237505)
- Testing
- bi-level positive pressure non invasive ventilation, Oxygen gas
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of California, San Diego
Asthenia, COVID-19
Efficacy of the Therapy With BRAINMAX® Using fMRI for the Treatment of Patients With Asthenia After COVID-19
to assess executive network using resting-state fMRI and patterns of brain activation using task fMRI with a cognitive paradigm, against the background of taking the drug in comparison with placebo in patients with post-COVID…
- Conditions
- Asthenia, COVID-19, Functional MRI, Cognitive Impairment
- Trial name
- NCT05939622
- Testing
- Structural and functional MRI, Ethyl methyl hydroxypyridine succinate + Meldonium
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Promomed, LLC
COPD
Non-interventional Study Related to Fixed LAMA/LABA/ICS Triple Therapy
This is a prospective non-interventional trial to measure the health related quality of life of patients with chronic obstructive pulmonary disease (COPD) on a fixed LAMA/LABA/ICS triple therapy (Trimbow®) and characterisation of…
- Trial name
- TriOptimize (NCT04355546)
- Testing
- Non-interventional
- Where
- United Kingdom
- Volunteers
- 94 people
- Sponsor
- Chiesi UK
Chronic Obstructive Pulmonary Disease
A Study for the Assessment of the Words Used by Patients and Physicians to Express the Symptoms of Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in lung function and increased symptoms such as breathlessness/dyspnoea, cough and expectoration.
- Trial name
- COPD Language (NCT01219946)
- Where
- 32 sites in Greece
- Volunteers
- 700 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
SCOPE-Study: Salzburg Chronic Obstructive Pulmonary Disease- Exercise and Oxygen Study
Chronic obstructive pulmonary disease (COPD) is number four of the leading causes of death in the USA and Europe. Moreover, among the top five causes of death, this disease is the only one with increasing mortality rates.
- Trial name
- SCOPE (NCT01150383)
- Testing
- Physical exercise training with supplemental oxygen, Physical exercise training with "room air supplementation"
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Paracelsus Medical University
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this study is to demonstrate the efficacy of inhaled treprostinil compared to placebo in improving exercise ability as measured by change from baseline in 6-Minute Walk Distance (6MWD) following 12 weeks…
- Trial name
- PERFECT (NCT03496623)
- Testing
- Inhaled treprostinil solution
- Where
- 76 sites in United States, Argentina and 2 more
- Volunteers
- 188 people
- Sponsor
- United Therapeutics
Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Pulmonary Embolism
Prevalence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism : (Preva-CTEPH)
The prevalence of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE) varies widely (0.4% to 8.8%) in the literature.
- Trial name
- Preva-CTEPH (NCT03719027)
- Testing
- Study population
- Where
- 4 sites in France
- Volunteers
- 2,003 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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